flurazepam has been researched along with Drug Withdrawal Symptoms in 40 studies
Flurazepam: A benzodiazepine derivative used mainly as a hypnotic.
flurazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a 2-(diethylamino)ethyl group, 2-fluorophenyl group and chloro group at positions 1, 5 and 7, respectively. It is a partial agonist of GABAA receptors and used for the treatment of insomnia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hypnotic efficacy and safety of 3 weeks of daily doses of 2 mg lorazepam or 30 mg flurazepam were compared in a double-blind cross-over study in eight chronic insomniacs between the ages of 29 and 60 years." | 9.06 | Comparison of lorazepam and flurazepam as hypnotic agents in chronic insomniacs. ( Chang, H; McClure, DJ; Olah, A; Pecknold, JC; Walsh, J; Wilson, R, 1988) |
| " The effects of the calcium channel blocking agent, nitrendipine, were studied on seizures in mice produced during withdrawal from chronic benzodiazepine treatment and on the development of tolerance to benzodiazepines." | 7.68 | Nitrendipine decreases benzodiazepine withdrawal seizures but not the development of benzodiazepine tolerance or withdrawal signs. ( Bowhay, AR; Dolin, SJ; Little, HJ; Patch, TL; Rabbani, M; Siarey, RJ, 1990) |
| "Hypnotic efficacy and safety of 3 weeks of daily doses of 2 mg lorazepam or 30 mg flurazepam were compared in a double-blind cross-over study in eight chronic insomniacs between the ages of 29 and 60 years." | 5.06 | Comparison of lorazepam and flurazepam as hypnotic agents in chronic insomniacs. ( Chang, H; McClure, DJ; Olah, A; Pecknold, JC; Walsh, J; Wilson, R, 1988) |
| "Eleven patients suffering from chronic insomnia were given 30 mg flurazepam for 28 nights." | 5.05 | A clinical study of flurazepam. ( Garnett, D; Gillin, JC; Greenblatt, DJ; Mendelson, WB; Weingartner, H, 1982) |
| " The effects of the calcium channel blocking agent, nitrendipine, were studied on seizures in mice produced during withdrawal from chronic benzodiazepine treatment and on the development of tolerance to benzodiazepines." | 3.68 | Nitrendipine decreases benzodiazepine withdrawal seizures but not the development of benzodiazepine tolerance or withdrawal signs. ( Bowhay, AR; Dolin, SJ; Little, HJ; Patch, TL; Rabbani, M; Siarey, RJ, 1990) |
| "A male patient with chronic insomnia experienced withdrawal symptoms when flurazepam (30 mg h." | 3.66 | Withdrawal symptoms after long-term treatment with therapeutic doses of flurazepam: a case report. ( Berlin, RM; Conell, LJ, 1983) |
| "Some withdrawal symptoms were distinct from those of anxiety (e." | 2.66 | Withdrawal reaction after long-term therapeutic use of benzodiazepines. ( Busto, U; Cappell, H; Naranjo, CA; Sanchez-Craig, M; Sellers, EM; Sykora, K, 1986) |
| "Rebound insomnia, a worsening of sleep compared with pretreatment levels, has been reported upon discontinuation of short half-life benzodiazepine hypnotics." | 2.38 | Rebound insomnia: a critical review. ( Gillin, JC; Johnson, LC; Spinweber, CL, 1989) |
| "Flurazepam is a long elimination half-life drug, and there is significant daytime sedation during short term use; with continued use this effect diminishes." | 2.36 | Sleep laboratory studies of hypnotic drugs: efficacy and withdrawal effects. ( Kales, A; Kales, JD, 1983) |
| "The diagnosis and treatment of insomnia is a major clinical issue." | 2.36 | Rational basis for the use of sleeping pills. ( Dement, WC, 1983) |
| "To assess pharmacodynamic and pharmacokinetic properties of acute, subchronic and withdrawn quazepam, a single-blind, longitudinal study was run in eight male, healthy young volunteers." | 1.28 | Longitudinal study on pharmacodynamics and pharmacokinetics of acute, steady-state and withdrawn quazepam. ( Kauert, G; Klausnitzer, W; Schaffler, K; Wauschkuhn, CH, 1989) |
| " Some loss of effectiveness was noted during long-term use of both doses of quazepam and, to a lesser extent, of flurazepam." | 1.26 | Quazepam and flurazepam: long-term use and extended withdrawal. ( Bixler, EO; Jacoby, J; Kales, A; Kales, JD; Soldatos, CR; Vela-Bueno, A, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 32 (80.00) | 18.7374 |
| 1990's | 3 (7.50) | 18.2507 |
| 2000's | 2 (5.00) | 29.6817 |
| 2010's | 3 (7.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Blednov, YA | 1 |
| Benavidez, JM | 1 |
| Black, M | 1 |
| Mayfield, J | 1 |
| Harris, RA | 1 |
| Shen, G | 2 |
| Van Sickle, BJ | 1 |
| Tietz, EI | 4 |
| Earl, DE | 1 |
| Das, P | 1 |
| Gunning, WT | 1 |
| Song, J | 1 |
| Greenfield, LJ | 1 |
| Xiang, K | 1 |
| Kales, A | 6 |
| Kales, JD | 6 |
| Shader, RI | 1 |
| Conell, LJ | 2 |
| Berlin, RM | 2 |
| Mitler, MM | 1 |
| Seidel, WF | 1 |
| van den Hoed, J | 1 |
| Greenblatt, DJ | 2 |
| Dement, WC | 2 |
| Feldbaum, JS | 1 |
| Olajide, D | 1 |
| Lader, M | 1 |
| Scharf, MB | 2 |
| Feil, P | 1 |
| Pearlman, T | 1 |
| Adam, K | 1 |
| Oswald, I | 1 |
| Mendelson, WB | 1 |
| Weingartner, H | 1 |
| Garnett, D | 1 |
| Gillin, JC | 2 |
| Rosenberg, HC | 2 |
| Chiu, TH | 2 |
| Rogalski, CJ | 1 |
| Lahmeyer, HW | 1 |
| Bixler, EO | 4 |
| Soldatos, CR | 3 |
| Vela-Bueno, A | 1 |
| Jacoby, J | 1 |
| Ladewig, D | 1 |
| Reigel, CE | 1 |
| Bourn, WM | 1 |
| Poisbeau, P | 1 |
| Williams, SR | 1 |
| Mody, I | 1 |
| Cannizzaro, G | 1 |
| Provenzano, PM | 1 |
| Brucato, A | 1 |
| Gianguzza, S | 1 |
| Becker, CE | 1 |
| Roe, R | 1 |
| Scott, R | 1 |
| Tong, T | 1 |
| Boerner, U | 1 |
| Luce, J | 1 |
| Dolin, SJ | 1 |
| Patch, TL | 1 |
| Rabbani, M | 1 |
| Siarey, RJ | 1 |
| Bowhay, AR | 1 |
| Little, HJ | 1 |
| Schaffler, K | 1 |
| Kauert, G | 1 |
| Wauschkuhn, CH | 1 |
| Klausnitzer, W | 1 |
| Spinweber, CL | 1 |
| Johnson, LC | 1 |
| Jacoby, JA | 1 |
| Brubaker, BH | 1 |
| Busto, U | 1 |
| Sellers, EM | 1 |
| Naranjo, CA | 1 |
| Cappell, H | 1 |
| Sanchez-Craig, M | 1 |
| Sykora, K | 1 |
| McClure, DJ | 1 |
| Walsh, J | 1 |
| Chang, H | 1 |
| Olah, A | 1 |
| Wilson, R | 1 |
| Pecknold, JC | 1 |
| Fleming, JA | 1 |
| Rungta, K | 1 |
| Isomura, T | 1 |
| McMillan, MJ | 1 |
| Tan, TL | 1 |
| Hussey, HH | 1 |
| Banerjee, U | 1 |
5 reviews available for flurazepam and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
Sleep laboratory studies of hypnotic drugs: efficacy and withdrawal effects.
Topics: Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Anxiety; Dose-Response Relationship, Drug; Fl | 1983 |
Rational basis for the use of sleeping pills.
Topics: Anxiety; Chronic Disease; Flurazepam; Humans; Hypnotics and Sedatives; Kinetics; Sleep; Sleep Initia | 1983 |
Rebound insomnia: a critical review.
Topics: Anti-Anxiety Agents; Flurazepam; Humans; Sleep Initiation and Maintenance Disorders; Sleep Stages; S | 1989 |
Time course for development of benzodiazepine tolerance and physical dependence.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Diazepam; Drug Tolerance; Flumazenil; Flurazepam; H | 1985 |
Rebound insomnia and elimination half-life: assessment of individual subject response.
Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Clinical Trials as Topic; Dose-Response Relationship, D | 1985 |
5 trials available for flurazepam and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
Comparative hypnotic effects of flurazepam, triazolam, and placebo: a long-term simultaneous nighttime and daytime study.
Topics: Adult; Anti-Anxiety Agents; Female; Flurazepam; Humans; Male; Middle Aged; Sleep; Sleep Stages; Subs | 1984 |
A clinical study of flurazepam.
Topics: Clinical Trials as Topic; Cognition; Drug Evaluation; Electroencephalography; Flurazepam; Humans; Ps | 1982 |
Rebound insomnia and elimination half-life: assessment of individual subject response.
Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Clinical Trials as Topic; Dose-Response Relationship, D | 1985 |
Withdrawal reaction after long-term therapeutic use of benzodiazepines.
Topics: Adolescent; Adult; Aged; Anxiety; Benzodiazepines; Diazepam; Double-Blind Method; Female; Flurazepam | 1986 |
Comparison of lorazepam and flurazepam as hypnotic agents in chronic insomniacs.
Topics: Adult; Arousal; Chronic Disease; Clinical Trials as Topic; Double-Blind Method; Electroencephalograp | 1988 |
31 other studies available for flurazepam and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
Role of interleukin-1 receptor signaling in the behavioral effects of ethanol and benzodiazepines.
Topics: Alcohol Drinking; Animals; Avoidance Learning; Behavior, Animal; Benzodiazepines; Ethanol; Female; F | 2015 |
Calcium/calmodulin-dependent protein kinase II mediates hippocampal glutamatergic plasticity during benzodiazepine withdrawal.
Topics: Animals; Behavior, Animal; Benzodiazepines; Biophysical Phenomena; Biophysics; Calcium-Calmodulin-De | 2010 |
Regulation of Ca²⁺/calmodulin-dependent protein kinase II signaling within hippocampal glutamatergic postsynapses during flurazepam withdrawal.
Topics: Animals; CA1 Region, Hippocampal; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Dendritic Spin | 2012 |
Benzodiazepine withdrawal-induced glutamatergic plasticity involves up-regulation of GluR1-containing alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors in Hippocampal CA1 neurons.
Topics: Adaptor Proteins, Signal Transducing; Animals; Benzodiazepines; Cell Membrane; Cytoplasm; Flurazepam | 2007 |
Benzodiazepine-induced hippocampal CA1 neuron alpha-amino-3-hydroxy-5-methylisoxasole-4-propionic acid (AMPA) receptor plasticity linked to severity of withdrawal anxiety: differential role of voltage-gated calcium channels and N-methyl-D-aspartic acid re
Topics: Animals; Anxiety; Benzodiazepines; Calcium Channels, L-Type; Disease Models, Animal; Dizocilpine Mal | 2007 |
Choice of benzodiazepines.
Topics: Aged; Anti-Anxiety Agents; Anxiety; Chlordiazepoxide; Diazepam; Flurazepam; Half-Life; Humans; Liver | 1981 |
Benzodiazepines in clinical medicine: discussion.
Topics: Anti-Anxiety Agents; Diazepam; Flurazepam; Half-Life; Humans; Protein Binding; Substance Withdrawal | 1981 |
Withdrawal after substitution of a short-acting for a long-acting benzodiazepine.
Topics: Anti-Anxiety Agents; Anxiety; Chronic Disease; Delayed-Action Preparations; Diazepam; Flurazepam; Ha | 1983 |
Inadvertent benzodiazepine withdrawal.
Topics: Anti-Anxiety Agents; Flurazepam; Humans; Male; Middle Aged; Sleep Initiation and Maintenance Disorde | 1984 |
Depression following withdrawal from long-term benzodiazepine use: a report of four cases.
Topics: Adult; Anti-Anxiety Agents; Depressive Disorder; Diazepam; Female; Flurazepam; Humans; Lorazepam; Ma | 1984 |
Acute effects of drug administration and withdrawal on the benzodiazepine receptor.
Topics: Animals; Benzodiazepines; Cerebral Cortex; Clonazepam; Diazepam; Flurazepam; Humans; Lorazepam; Male | 1983 |
Withdrawal symptoms after long-term treatment with flurazepam.
Topics: Anxiety Disorders; Depressive Disorder; Diazepam; Flurazepam; Humans; Sleep Initiation and Maintenan | 1984 |
Effects of lormetazepam and of flurazepam on sleep.
Topics: Aged; Anti-Anxiety Agents; Benzodiazepines; Double-Blind Method; Female; Flurazepam; Half-Life; Huma | 1984 |
An antagonist-induced benzodiazepine abstinence syndrome.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Cats; Flumazenil; Flurazepam; Humans; Substance Withdra | 1982 |
Withdrawal symptoms after long-term treatment with therapeutic doses of flurazepam: a case report.
Topics: Adult; Chronic Disease; Flurazepam; Humans; Male; Sleep Initiation and Maintenance Disorders; Substa | 1983 |
Effect of the hypnotic flurazepam on the sleep of pentazocine and heroin addicts during withdrawal.
Topics: Adolescent; Adult; Flurazepam; Heroin Dependence; Humans; Male; Methadone; Middle Aged; Pentazocine; | 1983 |
Quazepam and flurazepam: long-term use and extended withdrawal.
Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Drug Evaluation; Flurazepam; Half-Life; Humans; Middle | 1982 |
Systematic review of the benzodiazepines. Guidelines for data sheets on diazepam, chlordiazepoxide, medazepam, clorazepate, lorazepam, oxazepam, temazepam, triazolam, nitrazepam, and flurazepam. Committee on the Review of Medicines.
Topics: Benzodiazepines; Chlordiazepoxide; Clorazepate Dipotassium; Diazepam; Flurazepam; Humans; Lorazepam; | 1980 |
[Does a rebound insomnia following benzodiazepine administration exist?].
Topics: Benzodiazepines; Diazepam; Flunitrazepam; Flurazepam; Humans; Nitrazepam; Sleep Initiation and Maint | 1980 |
Effects of barbital or diazepam withdrawal on seizure thresholds to bicuculline, picrotoxin and flurazepam.
Topics: Animals; Barbital; Bicuculline; Convulsants; Diazepam; Flurazepam; Male; Picrotoxin; Rats; Rats, Spr | 1995 |
Silent GABAA synapses during flurazepam withdrawal are region-specific in the hippocampal formation.
Topics: Animals; Flurazepam; GABA Modulators; Hippocampus; Patch-Clamp Techniques; Rats; Receptors, GABA-A; | 1997 |
Influence of the suspension of continued treatment with flurazepam and amobarbital on two discrimination learning schedules.
Topics: Acoustic Stimulation; Amobarbital; Animals; Anti-Anxiety Agents; Discrimination Learning; Flurazepam | 1977 |
Rational drug therapy of alcoholism with sedative hypnotic drugs! Is this possible?
Topics: Administration, Oral; Alcoholism; Antipsychotic Agents; Anxiety; Barbiturates; Community Mental Heal | 1975 |
Nitrendipine decreases benzodiazepine withdrawal seizures but not the development of benzodiazepine tolerance or withdrawal signs.
Topics: Animals; Benzodiazepines; Calcium Channels; Carbolines; Drug Tolerance; Flurazepam; Male; Mice; Nitr | 1990 |
Longitudinal study on pharmacodynamics and pharmacokinetics of acute, steady-state and withdrawn quazepam.
Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Electrooculography; Flurazepam; Hemo | 1989 |
Adverse reactions to benzodiazepine hypnotics: spontaneous reporting system.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Anti-Anxiety Agents; Female; Flurazepam; Humans; Hypnot | 1987 |
Withdrawal regimen for triazolam-dependent patients.
Topics: Diazepam; Flurazepam; Humans; Sleep Initiation and Maintenance Disorders; Substance Withdrawal Syndr | 1986 |
Quazepam: sleep laboratory studies of effectiveness and withdrawal.
Topics: Anti-Anxiety Agents; Benzodiazepines; Flurazepam; Humans; Sleep Initiation and Maintenance Disorders | 1985 |
Chronic hypnotic-drug use. Ineffectiveness, drug-withdrawal insomnia, and dependence.
Topics: Adult; Age Factors; Aged; Amobarbital; Chloral Hydrate; Chronic Disease; Dreams; Drug Therapy, Combi | 1974 |
Editorial: Insomnia.
Topics: Apnea; Chronic Disease; Flurazepam; Humans; Hypnotics and Sedatives; Iatrogenic Disease; Male; Middl | 1974 |
Programmed self-administration of potentially addictive drugs in young rats and its effects on learning.
Topics: Amphetamine; Animals; Avoidance Learning; Behavior, Animal; Drug Tolerance; Ethanol; Extinction, Psy | 1974 |