Page last updated: 2024-11-07

fluprednisolone and Intraocular Pressure

fluprednisolone has been researched along with Intraocular Pressure in 17 studies

Fluprednisolone: A synthetic glucocorticoid with anti-inflammatory properties.

Intraocular Pressure: The pressure of the fluids in the eye.

Research Excerpts

ExcerptRelevanceReference
"Data collected from all patients with anterior scleritis who used difluprednate as a single treatment agent from January 1, 2018, to January 1, 2020, including demographics, scleritis type, presence of nodules or necrosis, changes in scleritis activity, intraocular pressure (IOP), number of difluprednate drops used, best-corrected visual acuity (BCVA), and lens status."8.12Effectiveness of Difluprednate for the Treatment of Anterior Scleritis. ( Berkenstock, MK; Burkholder, BM; Liberman, P; Thorne, JE, 2022)
" All patients responded well to the cessation of difluprednate and/or use of topical antiglaucomatous agents and no eyes required glaucoma surgery."8.12Risk of Elevated Intraocular Pressure With Difluprednate in Patients With Non-Infectious Uveitis. ( Jones, L; Kodati, S; Kumar, A; Sen, HN; Yakin, M, 2022)
"To compare intraocular pressure (IOP) outcomes between 2 common, commercially available corticosteroid drops: difluprednate ophthalmic emulsion 0."7.85Comparison of prednisolone acetate 1.0% and difluprednate ophthalmic emulsion 0.05% after cataract surgery: Incidence of postoperative steroid-induced ocular hypertension. ( Ernest, P; McBain, M; Mian, SI; Musch, DC; Niziol, LM; Person, E; Tijunelis, MA, 2017)
"Twenty-seven patients (35 eyes) undergoing treatment with difluprednate 4 times daily for 3 weeks for noninfectious uveitic cystoid macular edema were reviewed for visual acuity, intraocular pressure, optical coherence tomography, and fluorescein angiography results."7.85RESOLUTION OF NONINFECTIOUS UVEITIC CYSTOID MACULAR EDEMA WITH TOPICAL DIFLUPREDNATE. ( Bena, J; Feiler, DL; Lowder, CY; Pichi, F; Srivastava, SK, 2017)
"To evaluate the efficacy and safety of treatment of diabetic macular edema (persistent type) with difluprednate ophthalmic emulsion 0."7.83Efficacy and safety of topical difluprednate in persistent diabetic macular edema. ( Kaur, S; Sachdev, N; Singh, S; Yangzes, S, 2016)
"To identify changes in intraocular pressure (IOP) after vitreoretinal surgical procedures in eyes that received either difluprednate ophthalmic emulsion 0."7.80Incidence of steroid-induced ocular hypertension after vitreoretinal surgery with difluprednate versus prednisolone acetate. ( Connors, DB; Fine, HF; Jeng, KW; Prenner, JL; Roth, D; Wheatley, HM, 2014)
"To evaluate the clinical effect of topical difluprednate in pediatric patients for treatment of noninfectious uveitis."7.78Efficacy and potential complications of difluprednate use for pediatric uveitis. ( Herlihy, E; Ongchin, S; Slabaugh, MA; van Gelder, RN, 2012)
" Safety included evaluation of adverse events."6.82Difluprednate versus prednisolone acetate for inflammation following cataract surgery in pediatric patients: a randomized safety and efficacy study. ( Gedif, K; Lambert, SR; Markwardt, K; O'Halloran, H; Plager, DA; Roarty, J; VanderVeen, D; Wilson, ME, 2016)
"In this high-dose pulsed-therapy regimen, difluprednate reduced inflammation more effectively than prednisolone acetate, resulting in more rapid return of vision."5.15A multicenter randomized controlled fellow eye trial of pulse-dosed difluprednate 0.05% versus prednisolone acetate 1% in cataract surgery. ( Donnenfeld, ED; Fiore, J; Gobbo, A; Holland, EJ; Perry, HD; Prince, J; Sandoval, HP; Shull, ER; Solomon, KD, 2011)
"Data collected from all patients with anterior scleritis who used difluprednate as a single treatment agent from January 1, 2018, to January 1, 2020, including demographics, scleritis type, presence of nodules or necrosis, changes in scleritis activity, intraocular pressure (IOP), number of difluprednate drops used, best-corrected visual acuity (BCVA), and lens status."4.12Effectiveness of Difluprednate for the Treatment of Anterior Scleritis. ( Berkenstock, MK; Burkholder, BM; Liberman, P; Thorne, JE, 2022)
" All patients responded well to the cessation of difluprednate and/or use of topical antiglaucomatous agents and no eyes required glaucoma surgery."4.12Risk of Elevated Intraocular Pressure With Difluprednate in Patients With Non-Infectious Uveitis. ( Jones, L; Kodati, S; Kumar, A; Sen, HN; Yakin, M, 2022)
"Patients treated with difluprednate or loteprednol had statistically similar resolution of their AC cell grade and corneal edema at 1 day, 1 week, and 1 month postoperatively (P>0."3.88Comparison of Efficacy of Difluprednate 0.05% and Loteprednol Gel 0.5% After Cataract Surgery. ( Abessi, B; Brooksby, L; Schultze, RL, 2018)
"To compare intraocular pressure (IOP) outcomes between 2 common, commercially available corticosteroid drops: difluprednate ophthalmic emulsion 0."3.85Comparison of prednisolone acetate 1.0% and difluprednate ophthalmic emulsion 0.05% after cataract surgery: Incidence of postoperative steroid-induced ocular hypertension. ( Ernest, P; McBain, M; Mian, SI; Musch, DC; Niziol, LM; Person, E; Tijunelis, MA, 2017)
"Twenty-seven patients (35 eyes) undergoing treatment with difluprednate 4 times daily for 3 weeks for noninfectious uveitic cystoid macular edema were reviewed for visual acuity, intraocular pressure, optical coherence tomography, and fluorescein angiography results."3.85RESOLUTION OF NONINFECTIOUS UVEITIC CYSTOID MACULAR EDEMA WITH TOPICAL DIFLUPREDNATE. ( Bena, J; Feiler, DL; Lowder, CY; Pichi, F; Srivastava, SK, 2017)
"To evaluate the efficacy and safety of treatment of diabetic macular edema (persistent type) with difluprednate ophthalmic emulsion 0."3.83Efficacy and safety of topical difluprednate in persistent diabetic macular edema. ( Kaur, S; Sachdev, N; Singh, S; Yangzes, S, 2016)
"To identify changes in intraocular pressure (IOP) after vitreoretinal surgical procedures in eyes that received either difluprednate ophthalmic emulsion 0."3.80Incidence of steroid-induced ocular hypertension after vitreoretinal surgery with difluprednate versus prednisolone acetate. ( Connors, DB; Fine, HF; Jeng, KW; Prenner, JL; Roth, D; Wheatley, HM, 2014)
"To evaluate the clinical effect of topical difluprednate in pediatric patients for treatment of noninfectious uveitis."3.78Efficacy and potential complications of difluprednate use for pediatric uveitis. ( Herlihy, E; Ongchin, S; Slabaugh, MA; van Gelder, RN, 2012)
" Safety included evaluation of adverse events."2.82Difluprednate versus prednisolone acetate for inflammation following cataract surgery in pediatric patients: a randomized safety and efficacy study. ( Gedif, K; Lambert, SR; Markwardt, K; O'Halloran, H; Plager, DA; Roarty, J; VanderVeen, D; Wilson, ME, 2016)
" Difluprednate provides effective treatment for anterior uveitis and requires less frequent dosing than prednisolone acetate."2.75Durezol (Difluprednate Ophthalmic Emulsion 0.05%) compared with Pred Forte 1% ophthalmic suspension in the treatment of endogenous anterior uveitis. ( Crockett, RS; Davanzo, R; Flynn, TE; Foster, CS; McLeod, K; Vogel, R, 2010)
" In this regard, the present study was conducted with the aim of studying the efficacy of using fixed drug combination (Difluprednate and Moxifloxacin) in reducing ocular inflammation and pain in post-operative patients undergoing cataract surgery."1.46Safety of Fixed drug Combination in Post -Operative Cataract Patients, at Tertiary Care Centre - In South India. ( Anuradha, A; Nishath, S; Rashmi, G; Shilpa, R; Vidyadevi, M, 2017)
"Current treatment of glaucoma relies on administration of daily drops or eye surgery."1.43Inducible scAAV2.GRE.MMP1 lowers IOP long-term in a large animal model for steroid-induced glaucoma gene therapy. ( Borrás, T; Buie, LK; Spiga, MG, 2016)

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (5.88)29.6817
2010's14 (82.35)24.3611
2020's2 (11.76)2.80

Authors

AuthorsStudies
Liberman, P1
Burkholder, BM1
Thorne, JE1
Berkenstock, MK1
Yakin, M1
Kumar, A1
Kodati, S1
Jones, L1
Sen, HN1
Tijunelis, MA1
Person, E1
Niziol, LM1
Musch, DC1
Ernest, P1
McBain, M1
Mian, SI1
Abessi, B1
Brooksby, L1
Schultze, RL1
Vidyadevi, M1
Anuradha, A1
Rashmi, G1
Shilpa, R1
Nishath, S1
Kakimoto, H1
Takamura, Y1
Arimura, S1
Miyake, S1
Matsumura, T1
Gozawa, M1
Iwasaki, K1
Morioka, M1
Yamada, Y1
Inatani, M1
Sheppard, JD1
Toyos, MM1
Kempen, JH1
Kaur, P1
Foster, CS2
Jeng, KW1
Fine, HF1
Wheatley, HM1
Roth, D1
Connors, DB1
Prenner, JL1
Kaur, S1
Yangzes, S1
Singh, S1
Sachdev, N1
Borrás, T1
Buie, LK1
Spiga, MG1
Wilson, ME1
O'Halloran, H1
VanderVeen, D1
Roarty, J1
Plager, DA1
Markwardt, K1
Gedif, K1
Lambert, SR1
Feiler, DL1
Srivastava, SK1
Pichi, F1
Bena, J1
Lowder, CY1
Davanzo, R1
Flynn, TE1
McLeod, K1
Vogel, R1
Crockett, RS1
Birnbaum, AD1
Jiang, Y1
Tessler, HH1
Goldstein, DA1
Donnenfeld, ED1
Holland, EJ1
Solomon, KD1
Fiore, J1
Gobbo, A1
Prince, J1
Sandoval, HP1
Shull, ER1
Perry, HD1
Slabaugh, MA1
Herlihy, E1
Ongchin, S1
van Gelder, RN1
Bradshaw, SE1
Shankar, P1
Maini, R1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Phase 3 Multicenter, Randomized, Double-Masked Study of the Safety and Efficacy of Difluprednate 0.05% Ophthalmic Emulsion Compared to Prednisolone Acetate 1% Ophthalmic Suspension in the Treatment of Endogenous Anterior Uveitis[NCT01201798]Phase 3111 participants (Actual)Interventional2010-10-31Completed
[NCT00501579]Phase 30 participants InterventionalCompleted
A Randomized, Masked Multi-center Safety & Efficacy Study of the Effects of Preoperative & Postoperative Cataract Surgery Use of Difluprednate Ophthalmic Emulsion, 0.05% Compared to Prednisolone Acetate Ophthalmic Suspension 1% on Visual Acuity & Corneal [NCT01244334]Phase 452 participants (Actual)Interventional2009-03-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Proportion of Subjects Who Discontinued Due to Lack of Efficacy

Lack of efficacy was defined as those subjects who discontinued study participation either due to treatment failure or an adverse event with a preferred term of iridocyclitis, iritis, uveitis, or vitritis. Proportion is reported as percentage of subjects. (NCT01201798)
Timeframe: Time to Event

InterventionPercentage of subjects (Number)
Durezol0
Pred Forte14.9

Change From Baseline (Day 0) in Anterior Chamber Cell Grade at All Time Points Other Than Day 14

Inflammatory cells in the anterior chamber were assessed by the investigator during slit lamp examination and graded on a 5-point scale, with 0 = ≤ 1 cell count; 1 = 2 to 10 cell count; 2 = 11 to 20 cell count; 3 = 21 to 50 cell count; and 4 = > 50 cell count. (NCT01201798)
Timeframe: Baseline (Day 0), Day 3, Day 7, Day 21, Day 28, Day 35, Day 42

,
InterventionUnits on a scale (Mean)
Baseline (Day 0)Day 3Day 7Day 21Day 28Day 35Day 42
Durezol2.6-1.1-1.8-2.4-2.3-2.3-2.3
Pred Forte2.6-1.0-1.6-2.1-2.1-2.1-2.1

Change From Baseline (Day 0) in Anterior Chamber Cell Grade at Day 14

Inflammatory cells in the anterior chamber were assessed by the investigator during slit lamp examination and graded on a 5-point scale, with 0 = ≤ 1 cell count; 1 = 2 to 10 cell count; 2 = 11 to 20 cell count; 3 = 21 to 50 cell count; and 4 = > 50 cell count. (NCT01201798)
Timeframe: Baseline (Day 0), Day 14

,
InterventionUnits on a scale (Mean)
Baseline (Day 0)Day 14
Durezol2.6-2.2
Pred Forte2.6-2.0

Change From Baseline (Day 0) in Anterior Chamber Flare Grade at All Time Points

Anterior chamber flare (protein escaping from dialated vessels) was assessed by the investigator during slit lamp examination and graded on a 5-point scale, with 0 = none; 1 = mild (trace to clearly noticeable, visible); 2 = moderate; 3 = marked; and 4 = severe. (NCT01201798)
Timeframe: Baseline (Day 0), Day 3, Day 7, Day 14, Day 21, Day 28, Day 35, Day 42

,
InterventionUnits on a scale (Mean)
Baseline (Day 0)Day 3Day 7Day 14Day 21Day 28Day 35Day 42
Durezol2.2-1.1-1.6-2.0-2.0-2.0-2.0-2.0
Pred Forte2.3-1.2-1.6-1.9-2.0-2.0-2.0-2.0

Change From Baseline (Day 0) in Slit-Lamp Total Sign Score at All Visits

The following signs were each graded on a 0 - 3 scale (0 = absent; 1 = mild; 2 = moderate; 3 = severe): posterior synechia, hypopyon, limbal injection, and keratic precipitates. Peripheral synechia was graded by the combined number of clock hours affected (0 = absent; 1 = < 3 hrs; 2 = 3-6 hours; 3 = > 6 hours). The total sign score was calculated as the sum of the 5 individual sign scores, the anterior chamber cell grade and the anterior chamber flare grade. The minimum/best total sign score was 0, and the maximum/worst total sign score was 23. (NCT01201798)
Timeframe: Baseline (Day 0), Day 3, Day 7, Day 14, Day 21, Day 28, Day 35, Day 42

,
InterventionUnits on a scale (Mean)
Baseline (Day 0)Day 3Day 7Day 14Day 21Day 28Day 35Day 42
Durezol7.1-3.5-5.2-6.1-6.5-6.4-6.3-6.2
Pred Forte7.3-3.6-5.0-5.8-6.2-6.2-6.2-6.3

Change From Baseline (Day 0) in Visual Analog Scale (VAS) Total Symptom Score at All Time Points

The following symptoms were each graded by the subject according to a 0-100 visual analog scale (VAS) using a mark on a 100 mm line (0 = absent, 100 = maximal): eye pain, photophobia, blurred vision, and lacrimation. The total symptom score was calculated as the sum of the 4 individual symptom scores. (NCT01201798)
Timeframe: Baseline (Day 0), Day 3, Day 7, Day 14, Day 21, Day 28, Day 35, Day 42

,
InterventionUnits on a scale (Mean)
Baseline (Day 0)Day 3Day 7Day 14Day 21Day 28Day 35Day 42
Durezol186.7-88.4-108.2-133.3-138.8-140.1-143.9-146.2
Pred Forte203.2-88.4-123.8-137.4-149.5-152.4-147.3-155.5

Proportion of Subjects With Anterior Chamber Cell Count ≤5 and Flare Grade of 0

Inflammatory cells in the anterior chamber were assessed by the investigator during slit lamp examination and recorded based on actual cell count. Anterior chamber flare (protein escaping from dialated vessels) was assessed by the investigator during slit lamp examination and graded on a 5-point scale, with 0 = none; 1 = mild (trace to clearly noticeable, visible); 2 = moderate; 3 = marked; and 4 = severe. Proportion is reported as percentage of subjects. (NCT01201798)
Timeframe: Day 3, Day 7, Day 14, Day 21, Day 28, Day 35, Day 42

,
InterventionPercentage of subjects (Number)
Day 3Day 7Day 14Day 21Day 28Day 35Day 42
Durezol13.041.378.382.680.482.680.4
Pred Forte14.940.461.776.676.676.678.7

Proportion of Subjects With Anterior Chamber Cell Count of 0

Inflammatory cells in the anterior chamber were assessed by the investigator during slit lamp examination and recorded based on actual cell count. Proportion is reported as a percentage of subjects. (NCT01201798)
Timeframe: Day 3, Day 7, Day 14, Day 21, Day 28, Day 35, Day 42

,
InterventionPercentage of subjects (Number)
Day 3Day 7Day 14Day 21Day 28Day 35Day 42
Durezol13.021.752.273.973.969.669.6
Pred Forte2.121.338.348.963.863.868.1

Proportion of Subjects With Anterior Chamber Cell Grade ≤1

As assessed by the investigator during slit lamp examination. Anterior chamber cell grade was graded on a 5-point scale, with 0 = no cells; 1 = 1 to 10 cells; 2 = 11 to 20 cells; 3 = 21 to 50 cells; and 4 = more than 50 cells. Proportion is reported as percentage of subjects. (NCT01201798)
Timeframe: Day 3, Day 7, Day 14, Day 21, Day 28, Day 35, Day 42

,
InterventionPercentage of subjects (Number)
Day 3Day 7Day 14Day 21Day 28Day 35Day 42
Durezol50.087.093.593.593.593.591.3
Pred Forte57.480.985.189.487.285.185.1

Proportion of Subjects With Anterior Chamber Cell Grade of 0

Inflammatory cells in the anterior chamber were assessed by the investigator during slit lamp examination and graded on a 5-point scale, with 0 = ≤ 1 cell count; 1 = 2 to 10 cell count; 2 = 11 to 20 cell count; 3 = 21 to 50 cell count; and 4 = > 50 cell count. Proportion is reported as percentage of subjects. (NCT01201798)
Timeframe: Day 3, Day 7, Day 14, Day 21, Day 28, Day 35, Day 42

,
InterventionPercentage of subjects (Number)
Day 3Day 7Day 14Day 21Day 28Day 35Day 42
Durezol15.234.865.284.880.478.376.1
Pred Forte6.425.555.363.870.270.274.5

Trials

4 trials available for fluprednisolone and Intraocular Pressure

ArticleYear
Difluprednate 0.05% versus prednisolone acetate 1% for endogenous anterior uveitis: a phase III, multicenter, randomized study.
    Investigative ophthalmology & visual science, 2014, May-06, Volume: 55, Issue:5

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analysis of Variance; Anterior Chamber; Anti-Inflammator

2014
Difluprednate versus prednisolone acetate for inflammation following cataract surgery in pediatric patients: a randomized safety and efficacy study.
    Eye (London, England), 2016, Volume: 30, Issue:9

    Topics: Administration, Topical; Aphakia, Postcataract; Cataract; Cataract Extraction; Child, Preschool; Dou

2016
Durezol (Difluprednate Ophthalmic Emulsion 0.05%) compared with Pred Forte 1% ophthalmic suspension in the treatment of endogenous anterior uveitis.
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2010, Volume: 26, Issue:5

    Topics: Adult; Anterior Chamber; Anti-Inflammatory Agents; Emulsions; Female; Fluprednisolone; Glucocorticoi

2010
A multicenter randomized controlled fellow eye trial of pulse-dosed difluprednate 0.05% versus prednisolone acetate 1% in cataract surgery.
    American journal of ophthalmology, 2011, Volume: 152, Issue:4

    Topics: Aged; Aged, 80 and over; Cell Count; Cornea; Corneal Edema; Double-Blind Method; Endothelium, Cornea

2011

Other Studies

13 other studies available for fluprednisolone and Intraocular Pressure

ArticleYear
Effectiveness of Difluprednate for the Treatment of Anterior Scleritis.
    American journal of ophthalmology, 2022, Volume: 235

    Topics: Adolescent; Adult; Aged; Female; Fluprednisolone; Glucocorticoids; Humans; Intraocular Pressure; Mid

2022
Risk of Elevated Intraocular Pressure With Difluprednate in Patients With Non-Infectious Uveitis.
    American journal of ophthalmology, 2022, Volume: 240

    Topics: Child; Fluprednisolone; Glaucoma; Glucocorticoids; Humans; Intraocular Pressure; Retrospective Studi

2022
Comparison of prednisolone acetate 1.0% and difluprednate ophthalmic emulsion 0.05% after cataract surgery: Incidence of postoperative steroid-induced ocular hypertension.
    Journal of cataract and refractive surgery, 2017, Volume: 43, Issue:2

    Topics: Cataract Extraction; Fluprednisolone; Glucocorticoids; Humans; Incidence; Intraocular Pressure; Ocul

2017
Comparison of Efficacy of Difluprednate 0.05% and Loteprednol Gel 0.5% After Cataract Surgery.
    Eye & contact lens, 2018, Volume: 44 Suppl 2

    Topics: Aged; Aged, 80 and over; Anterior Chamber; Anti-Inflammatory Agents; Cataract Extraction; Cornea; Co

2018
Safety of Fixed drug Combination in Post -Operative Cataract Patients, at Tertiary Care Centre - In South India.
    Nepalese journal of ophthalmology : a biannual peer-reviewed academic journal of the Nepal Ophthalmic Society : NEPJOPH, 2017, Volume: 9, Issue:18

    Topics: Anti-Bacterial Agents; Cataract Extraction; Dose-Response Relationship, Drug; Drug Combinations; End

2017
Effect of 0.05% Difluprednate Ophthalmic Emulsion on Proinflammatory Cytokine Levels After Retinal Laser Photocoagulation in Rabbits.
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2018, Volume: 34, Issue:5

    Topics: Animals; Aqueous Humor; Cytokines; Emulsions; Fluprednisolone; Intraocular Pressure; Laser Coagulati

2018
Incidence of steroid-induced ocular hypertension after vitreoretinal surgery with difluprednate versus prednisolone acetate.
    Retina (Philadelphia, Pa.), 2014, Volume: 34, Issue:10

    Topics: Emulsions; Female; Fluprednisolone; Glucocorticoids; Humans; Incidence; Intraocular Pressure; Male;

2014
Efficacy and safety of topical difluprednate in persistent diabetic macular edema.
    International ophthalmology, 2016, Volume: 36, Issue:3

    Topics: Aged; Diabetic Retinopathy; Female; Fluprednisolone; Follow-Up Studies; Glucocorticoids; Humans; Int

2016
Inducible scAAV2.GRE.MMP1 lowers IOP long-term in a large animal model for steroid-induced glaucoma gene therapy.
    Gene therapy, 2016, Volume: 23, Issue:5

    Topics: Animals; Dependovirus; Disease Models, Animal; Fluprednisolone; Genetic Therapy; Genetic Vectors; Gl

2016
RESOLUTION OF NONINFECTIOUS UVEITIC CYSTOID MACULAR EDEMA WITH TOPICAL DIFLUPREDNATE.
    Retina (Philadelphia, Pa.), 2017, Volume: 37, Issue:5

    Topics: Administration, Topical; Adult; Aged; Female; Fluorescein Angiography; Fluprednisolone; Glucocortico

2017
Elevation of intraocular pressure in patients with uveitis treated with topical difluprednate.
    Archives of ophthalmology (Chicago, Ill. : 1960), 2011, Volume: 129, Issue:5

    Topics: Administration, Topical; Adolescent; Adult; Child; Fluprednisolone; Glucocorticoids; Humans; Intraoc

2011
Efficacy and potential complications of difluprednate use for pediatric uveitis.
    American journal of ophthalmology, 2012, Volume: 153, Issue:5

    Topics: Administration, Topical; Adolescent; Aqueous Humor; Cataract; Child; Female; Fluprednisolone; Glucoc

2012
Topical steroid and antibiotic combination therapy in red eye conditions.
    The British journal of general practice : the journal of the Royal College of General Practitioners, 2006, Volume: 56, Issue:525

    Topics: Anti-Inflammatory Agents; Betamethasone; Contraindications; Drug Combinations; Eye Diseases; Flupred

2006