fluprednisolone has been researched along with Innate Inflammatory Response in 15 studies
Fluprednisolone: A synthetic glucocorticoid with anti-inflammatory properties.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Difluprednate administered twice a day was at least as effective as prednisolone acetate administered 4 times a day for inflammatory treatment after cataract surgery." | 9.51 | Difluprednate 0.05% twice a day vs prednisolone acetate 1% 4 times a day for cataract postsurgical inflammation treatment: noninferiority trial. ( Del Papa, M; Ferroni, C; Ferroni, V; Idiart, C; Kaufer, R; Marino, F; Masseroni, M; Nuñez, M; Passerini, MS; Valvecchia, G; Zaldívar, R, 2022) |
| "Difluprednate given 2 or 4 times a day cleared postoperative inflammation and reduced pain rapidly and effectively." | 9.14 | Difluprednate ophthalmic emulsion 0.05% for postoperative inflammation and pain. ( Cooke, DL; Crockett, RS; Korenfeld, MS; Silverstein, SM; Vogel, R, 2009) |
| " Safety included evaluation of adverse events." | 6.82 | Difluprednate versus prednisolone acetate for inflammation following cataract surgery in pediatric patients: a randomized safety and efficacy study. ( Gedif, K; Lambert, SR; Markwardt, K; O'Halloran, H; Plager, DA; Roarty, J; VanderVeen, D; Wilson, ME, 2016) |
| "Difluprednate administered twice a day was at least as effective as prednisolone acetate administered 4 times a day for inflammatory treatment after cataract surgery." | 5.51 | Difluprednate 0.05% twice a day vs prednisolone acetate 1% 4 times a day for cataract postsurgical inflammation treatment: noninferiority trial. ( Del Papa, M; Ferroni, C; Ferroni, V; Idiart, C; Kaufer, R; Marino, F; Masseroni, M; Nuñez, M; Passerini, MS; Valvecchia, G; Zaldívar, R, 2022) |
| "In this high-dose pulsed-therapy regimen, difluprednate reduced inflammation more effectively than prednisolone acetate, resulting in more rapid return of vision." | 5.15 | A multicenter randomized controlled fellow eye trial of pulse-dosed difluprednate 0.05% versus prednisolone acetate 1% in cataract surgery. ( Donnenfeld, ED; Fiore, J; Gobbo, A; Holland, EJ; Perry, HD; Prince, J; Sandoval, HP; Shull, ER; Solomon, KD, 2011) |
| "Difluprednate given 2 or 4 times a day cleared postoperative inflammation and reduced pain rapidly and effectively." | 5.14 | Difluprednate ophthalmic emulsion 0.05% for postoperative inflammation and pain. ( Cooke, DL; Crockett, RS; Korenfeld, MS; Silverstein, SM; Vogel, R, 2009) |
| "Patients treated with difluprednate or loteprednol had statistically similar resolution of their AC cell grade and corneal edema at 1 day, 1 week, and 1 month postoperatively (P>0." | 3.88 | Comparison of Efficacy of Difluprednate 0.05% and Loteprednol Gel 0.5% After Cataract Surgery. ( Abessi, B; Brooksby, L; Schultze, RL, 2018) |
| "The effect of THS-201, a new intra-articular steroid, on inflammations was examined using acute, subacute and chronic experimental models, and the antiinflammatory action of THS-201 was compared with those of reference steroids such as triamcinolone acetonide (TA), methylprednisolone acetate (MPA), hydrocortisone acetate (HA) and halopredone (HP)." | 3.67 | [Anti-inflammatory effect of THS-201, a new intra-articular steroid]. ( Hashimoto, Y; Kiniwa, M; Masuda, H; Miyake, H; Yamamoto, N, 1986) |
| " Safety included evaluation of adverse events." | 2.82 | Difluprednate versus prednisolone acetate for inflammation following cataract surgery in pediatric patients: a randomized safety and efficacy study. ( Gedif, K; Lambert, SR; Markwardt, K; O'Halloran, H; Plager, DA; Roarty, J; VanderVeen, D; Wilson, ME, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (33.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (6.67) | 29.6817 |
| 2010's | 8 (53.33) | 24.3611 |
| 2020's | 1 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Valvecchia, G | 1 |
| Kaufer, R | 1 |
| Ferroni, C | 1 |
| Zaldívar, R | 1 |
| Masseroni, M | 1 |
| Idiart, C | 1 |
| Ferroni, V | 1 |
| Marino, F | 1 |
| Nuñez, M | 1 |
| Del Papa, M | 1 |
| Passerini, MS | 1 |
| Abessi, B | 1 |
| Brooksby, L | 1 |
| Schultze, RL | 1 |
| Knych, HK | 1 |
| Harrison, L | 1 |
| Chouicha, N | 1 |
| Kass, PH | 1 |
| Trahan, RA | 1 |
| Byron, CR | 1 |
| Dahlgren, LA | 1 |
| Pleasant, RS | 1 |
| Werre, SR | 1 |
| Sato, K | 1 |
| Iwasaki, K | 1 |
| Nagai, N | 1 |
| Yamashita, Y | 1 |
| Chikazawa, S | 1 |
| Hoshi, F | 1 |
| Kanai, K | 1 |
| Wilson, ME | 2 |
| O'Halloran, H | 2 |
| VanderVeen, D | 2 |
| Roarty, J | 2 |
| Plager, DA | 2 |
| Markwardt, K | 1 |
| Gedif, K | 1 |
| Lambert, SR | 2 |
| Kaur, S | 1 |
| Sukhija, J | 1 |
| Korenfeld, MS | 1 |
| Silverstein, SM | 1 |
| Cooke, DL | 1 |
| Vogel, R | 1 |
| Crockett, RS | 1 |
| Donnenfeld, ED | 1 |
| Holland, EJ | 1 |
| Solomon, KD | 1 |
| Fiore, J | 1 |
| Gobbo, A | 1 |
| Prince, J | 1 |
| Sandoval, HP | 1 |
| Shull, ER | 1 |
| Perry, HD | 1 |
| Navarro, J | 1 |
| Girard, J | 1 |
| Lacour, C | 1 |
| Unkovic, J | 1 |
| Lafille, C | 1 |
| Kiniwa, M | 1 |
| Yamamoto, N | 1 |
| Hashimoto, Y | 1 |
| Miyake, H | 1 |
| Masuda, H | 1 |
| Vogt, JH | 1 |
| Svindland, HB | 1 |
| Kindermann, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Prospective, Multi-center, Controlled, Double-blind Study to Evaluate the Efficacy and Tolerability of a Steroid/Antibiotic Associated Treatment Following Cataract Extraction by Means of Phaco-emulsification[NCT02973880] | Phase 3 | 180 participants (Actual) | Interventional | 2017-10-15 | Completed | ||
| A Phase 3 Multicenter, Randomized, Double-Masked, Placebo-Controlled Study of the Safety and Efficacy of Difluprednate in the Treatment of Inflammation Following Ocular Surgery[NCT00429923] | Phase 3 | 219 participants (Actual) | Interventional | Completed | |||
| A Phase 3 Multicenter, Randomized, Double-Masked, Placebo-Controlled Study of the Safety and Efficacy of Difluprednate in the Treatment of Inflammation Following Ocular Surgery[NCT00430092] | Phase 3 | 219 participants (Actual) | Interventional | Completed | |||
| A Randomized, Masked Multi-center Safety & Efficacy Study of the Effects of Preoperative & Postoperative Cataract Surgery Use of Difluprednate Ophthalmic Emulsion, 0.05% Compared to Prednisolone Acetate Ophthalmic Suspension 1% on Visual Acuity & Corneal [NCT01244334] | Phase 4 | 52 participants (Actual) | Interventional | 2009-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Measured on a 0 to 4 scale: 0 is ≤ 1 cell; 1 is 2-10 cells; 2 is 11-20 cells; 3 is 21-50 cells; 4 is > 50 cells." (NCT00429923)
Timeframe: Day 8 (QID)
| Intervention | participants (Number) |
|---|---|
| Proportion of subjects w/AC cell grade=0 on Day 8 | |
| Difluprednate 0.05% BID | 0 |
| Difluprednate 0.05% QID | 19 |
| Placebo | 13 |
"Measured on a 0 to 4 scale: 0 is ≤ 1 cell; 1 is 2-10 cells; 2 is 11-20 cells; 3 is 21-50 cells; 4 is > 50 cells." (NCT00430092)
Timeframe: Day 8 (QID)
| Intervention | participants (Number) |
|---|---|
| Proportion of Subjects w/AC cell grade=0 on Day 8 | |
| Difluprednate 0.05% BID | 0 |
| Difluprednate 0.05% QID | 18 |
| Placebo | 7 |
5 trials available for fluprednisolone and Innate Inflammatory Response
| Article | Year |
|---|---|
Difluprednate 0.05% twice a day vs prednisolone acetate 1% 4 times a day for cataract postsurgical inflammation treatment: noninferiority trial.
Topics: Cataract; Eye Diseases; Fluprednisolone; Humans; Inflammation; Phacoemulsification; Postoperative Co | 2022 |
Comparison of early posttreatment effects of two steroidal anti-inflammatory ophthalmic drugs on the ocular inflammatory response induced by paracentesis in healthy canine eyes.
Topics: Animals; Anti-Inflammatory Agents; Aqueous Humor; Betamethasone; Blood-Aqueous Barrier; Dinoprostone | 2019 |
Difluprednate versus prednisolone acetate for inflammation following cataract surgery in pediatric patients: a randomized safety and efficacy study.
Topics: Administration, Topical; Aphakia, Postcataract; Cataract; Cataract Extraction; Child, Preschool; Dou | 2016 |
Difluprednate ophthalmic emulsion 0.05% for postoperative inflammation and pain.
Topics: Adult; Aged; Aged, 80 and over; Anterior Chamber; Cell Count; Double-Blind Method; Emulsions; Female | 2009 |
Difluprednate ophthalmic emulsion 0.05% for postoperative inflammation and pain.
Topics: Adult; Aged; Aged, 80 and over; Anterior Chamber; Cell Count; Double-Blind Method; Emulsions; Female | 2009 |
Difluprednate ophthalmic emulsion 0.05% for postoperative inflammation and pain.
Topics: Adult; Aged; Aged, 80 and over; Anterior Chamber; Cell Count; Double-Blind Method; Emulsions; Female | 2009 |
Difluprednate ophthalmic emulsion 0.05% for postoperative inflammation and pain.
Topics: Adult; Aged; Aged, 80 and over; Anterior Chamber; Cell Count; Double-Blind Method; Emulsions; Female | 2009 |
Difluprednate ophthalmic emulsion 0.05% for postoperative inflammation and pain.
Topics: Adult; Aged; Aged, 80 and over; Anterior Chamber; Cell Count; Double-Blind Method; Emulsions; Female | 2009 |
Difluprednate ophthalmic emulsion 0.05% for postoperative inflammation and pain.
Topics: Adult; Aged; Aged, 80 and over; Anterior Chamber; Cell Count; Double-Blind Method; Emulsions; Female | 2009 |
Difluprednate ophthalmic emulsion 0.05% for postoperative inflammation and pain.
Topics: Adult; Aged; Aged, 80 and over; Anterior Chamber; Cell Count; Double-Blind Method; Emulsions; Female | 2009 |
Difluprednate ophthalmic emulsion 0.05% for postoperative inflammation and pain.
Topics: Adult; Aged; Aged, 80 and over; Anterior Chamber; Cell Count; Double-Blind Method; Emulsions; Female | 2009 |
Difluprednate ophthalmic emulsion 0.05% for postoperative inflammation and pain.
Topics: Adult; Aged; Aged, 80 and over; Anterior Chamber; Cell Count; Double-Blind Method; Emulsions; Female | 2009 |
A multicenter randomized controlled fellow eye trial of pulse-dosed difluprednate 0.05% versus prednisolone acetate 1% in cataract surgery.
Topics: Aged; Aged, 80 and over; Cell Count; Cornea; Corneal Edema; Double-Blind Method; Endothelium, Cornea | 2011 |
10 other studies available for fluprednisolone and Innate Inflammatory Response
| Article | Year |
|---|---|
Comparison of Efficacy of Difluprednate 0.05% and Loteprednol Gel 0.5% After Cataract Surgery.
Topics: Aged; Aged, 80 and over; Anterior Chamber; Anti-Inflammatory Agents; Cataract Extraction; Cornea; Co | 2018 |
Expression of inflammatory and structural matrix genes in synovial fluid following intra-articular administration of isoflupredone acetate to exercised horses.
Topics: Animals; Anti-Inflammatory Agents; Female; Fluprednisolone; Gene Expression Regulation; Horse Diseas | 2018 |
In vitro effects of three equimolar concentrations of methylprednisolone acetate, triamcinolone acetonide, and isoflupredone acetate on equine articular tissue cocultures in an inflammatory environment.
Topics: Animals; Cartilage, Articular; Coculture Techniques; Dinoprostone; Female; Fluprednisolone; Glycosam | 2018 |
Difluprednate versus prednisolone acetate for inflammation following cataract surgery in pediatric patients: a randomized safety and efficacy study.
Topics: Anti-Inflammatory Agents; Cataract; Cataract Extraction; Child; Double-Blind Method; Fluprednisolone | 2017 |
Difluprednate versus prednisolone acetate for inflammation following cataract surgery in pediatric patients: a randomized safety and efficacy study.
Topics: Anti-Inflammatory Agents; Cataract; Cataract Extraction; Child; Double-Blind Method; Fluprednisolone | 2017 |
Pharmacological study of a new anti-inflammatory steroid, difluprednate (CM 9155).
Topics: Administration, Topical; Adrenal Glands; Animals; Anti-Inflammatory Agents; Edema; Fluprednisolone; | 1978 |
[Anti-inflammatory effect of THS-201, a new intra-articular steroid].
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Arthritis; Arthritis, Experimental; Flup | 1986 |
[Therapy with cortisone, cortisonoids and ACTH].
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Cortisone; Fluprednisolone; Humans; Inflammati | 1972 |
[Melkersson-Rosenthal-syndrome. A case treated with local corticoid injections].
Topics: Adult; Aged; Dental Pulp Diseases; Diagnosis, Differential; Facial Paralysis; Female; Fluprednisolon | 1970 |
[On the cortisone withdrawal syndrome].
Topics: Adrenal Insufficiency; Aged; Arthritis, Rheumatoid; Female; Fluprednisolone; Glucocorticoids; Humans | 1967 |