fluphenazine has been researched along with Lesch-Nyhan Syndrome in 3 studies
Lesch-Nyhan Syndrome: An inherited disorder transmitted as a sex-linked trait and caused by a deficiency of an enzyme of purine metabolism; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE. Affected individuals are normal in the first year of life and then develop psychomotor retardation, extrapyramidal movement disorders, progressive spasticity, and seizures. Self-destructive behaviors such as biting of fingers and lips are seen frequently. Intellectual impairment may also occur but is typically not severe. Elevation of uric acid in the serum leads to the development of renal calculi and gouty arthritis. (Menkes, Textbook of Child Neurology, 5th ed, pp127)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (66.67) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Buitelaar, JK | 1 |
| Jankovic, J | 1 |
| Caskey, TC | 1 |
| Stout, JT | 1 |
| Butler, IJ | 1 |
| Goldstein, M | 1 |
| Anderson, LT | 1 |
| Reuben, R | 1 |
| Dancis, J | 1 |
1 review available for fluphenazine and Lesch-Nyhan Syndrome
| Article | Year |
|---|---|
Self-injurious behaviour in retarded children: clinical phenomena and biological mechanisms.
Topics: Antipsychotic Agents; Brain; Dopamine; Female; Fluphenazine; Humans; Intellectual Disability; Lesch- | 1993 |
1 trial available for fluphenazine and Lesch-Nyhan Syndrome
| Article | Year |
|---|---|
Self-mutilation in Lesch-Nyhan disease is caused by dopaminergic denervation.
Topics: Adolescent; Clinical Trials as Topic; Dopamine; Double-Blind Method; Fluphenazine; Humans; Infant; L | 1985 |
1 other study available for fluphenazine and Lesch-Nyhan Syndrome
| Article | Year |
|---|---|
Lesch-Nyhan syndrome: a study of motor behavior and cerebrospinal fluid neurotransmitters.
Topics: Carbidopa; Catecholamines; Child; Child, Preschool; Fluphenazine; Glycols; Homovanillic Acid; Humans | 1988 |