fluphenazine and Depressive Disorder studies

Depressive Disorder: An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent.

Research Excerpts

Excerpt	Relevance	Reference
"Neuropeptide Y (a recently discovered brain peptide that is colocalized with norepinephrine within some adrenergic central nervous system neurons) was measured in the cerebrospinal fluid (CSF) from patients with major affective disorder, chronic schizophrenia, and in normal volunteers."	7.67	Cerebrospinal fluid neuropeptide Y in depression and schizophrenia. ( Berrettini, WH; Doran, AR; Kelsoe, J; Pickar, D; Roy, A, 1987)
" All patients had been diagnosed as having schizophrenia or schizoaffective disorder, all were receiving stable doses of fluphenazine decanoate, and all had received benztropine mesylate in an attempt to rule out neuroleptic-induced akinesia."	5.06	Adjunctive imipramine in the treatment of postpsychotic depression. A controlled trial. ( Cooper, TB; Fagerstrom, R; Morgan, V; Rifkin, A; Siris, SG, 1987)
"Neuropeptide Y (a recently discovered brain peptide that is colocalized with norepinephrine within some adrenergic central nervous system neurons) was measured in the cerebrospinal fluid (CSF) from patients with major affective disorder, chronic schizophrenia, and in normal volunteers."	3.67	Cerebrospinal fluid neuropeptide Y in depression and schizophrenia. ( Berrettini, WH; Doran, AR; Kelsoe, J; Pickar, D; Roy, A, 1987)
"The authors present four patients with Gilbert's Syndrome and concurrent psychiatric illness."	1.29	Idiopathic unconjugated hyperbilirubinemia (Gilbert's syndrome) and concurrent psychotropic drug administration. ( Dorevitch, A; Durst, R; Jabotinsky-Rubin, K; Kikinzon, L; Tur-Kaspa, R, 1993)
"Two cases of agranulocytosis occurring after addition of a butyrophenone to a course of phenothiazine treatment are reported and possible mechanisms for this interaction are discussed."	1.28	Two cases of agranulocytosis on addition of a butyrophenone to a long-standing course of phenothiazine treatment. ( Kehoe, R; Young, A, 1989)

Research

Studies (39)

Authors

Clinical Trials (2)

Trial Overview

Trial Outcomes

Change in Abdominal Fat (DEXA).

Timeframe	Studies, this research(%)	All Research%
pre-1990	28 (71.79)	18.7374
1990's	9 (23.08)	18.2507
2000's	1 (2.56)	29.6817
2010's	1 (2.56)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Preskorn, SH	1
CAMBA, ME	1
PARDO, RF	1
GANDARALAMAS, M	1
ABOAB, R	1
Dunlop, BW	1
Sternberg, M	1
Phillips, LS	1
Andersen, J	1
Duncan, E	1
Mandel, MR	1
Severe, JB	1
Schooler, NR	2
Gelenberg, AJ	1
Mieske, M	1
Hogan, TP	1
Awad, AG	1
Siris, SG	10
Rifkin, A	3
Reardon, GT	2
November, M	1
Kane, JM	1
Garbutt, JC	1
Loosen, PT	1
Wistedt, B	1
Palmstierna, T	1
Valle-Jones, JC	2
Craven, JR	1
Wallis, TD	1
Schiff, AA	2
Johnson, DA	3
Mauri, MC	1
Bravin, S	1
Mantero, M	1
Invernizzi, G	1
Hogarty, GE	1
McEvoy, JP	1
Ulrich, RF	1
DiBarry, AL	1
Bartone, P	1
Cooley, S	1
Hammill, K	1
Carter, M	1
Munetz, MR	1
Perel, J	1
Bermanzohn, PC	1
Mason, SE	2
Shuwall, MA	1
Steingard, S	1
Allen, M	1
Durst, R	2
Jabotinsky-Rubin, K	1
Dorevitch, A	1
Kikinzon, L	1
Tur-Kaspa, R	1
Schramm, M	1
Falkai, P	1
Feldmann, N	1
Knable, MB	1
Bayer, TA	1
Sinclair, JM	1
Walsh, MR	1
Signer, SF	1
Weinstein, RP	1
Munoz, RA	1
Bayardo, JF	1
Katz, MR	1
Saben, LR	1
Robinson, S	1
Rosca, P	1
Shai, U	1
Ghinea, C	1
Schmidt, U	1
Nir, I	1
Gingerich, S	2
Breier, A	1
Young, A	1
Kehoe, R	1
Hirsch, SR	2
Jolley, AG	1
Adan, F	3
Cutler, J	1
Owen, K	1
Mason, S	1
Lang, MP	1
Galdi, J	1
Bonato, RR	1
Cohen, M	1
Mandeli, J	2
Aronson, A	1
Casey, E	2
Strahan, A	2
Lee, A	1
Cooper, TB	2
Berrettini, WH	1
Doran, AR	1
Kelsoe, J	1
Roy, A	1
Pickar, D	1
Morgan, V	1
Fagerstrom, R	1
Blum, A	1
Curson, DA	1
Barnes, TR	1
Bamber, RW	1
Platt, SD	1
Duffy, JC	1
Hinterhuber, H	1
Neumann, R	1
Doddi, SR	1
Hall, KS	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Phase IV Study of Ramelteon as an Adjunct Therapy in Non-Diabetic Patients With Schizophrenia[NCT00595504]	Phase 4	25 participants (Actual)	Interventional	2008-01-31	Completed
Study of add-on Ramelteon Therapy on Sleep and Circadian Rhythm Disruption in Patients With Schizophrenia[NCT03075657]	Phase 4	120 participants (Actual)	Interventional	2017-05-01	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

A comparison between the ramelteon group and the placebo group of change in abdominal fat measured by a DEXA scan, assessed at Baseline and Week 8. (NCT00595504)
Timeframe: Baseline and Week 8

Change in Insulin Resistance as Measured by the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR).

Intervention	g (Mean)
Ramelteon	3934.86
Placebo (Sugar Pill)	5120.92

A comparison between the ramelteon group and the placebo group of change in insulin resistance measured by the homeostatic model assessment of insulin resistance (HOMA-IR), assessed at Baseline and Week 8. (NCT00595504)
Timeframe: Baseline and Week 8

Change in Waist Circumference

Intervention	HOMA score (Mean)
Ramelteon	2.4
Placebo (Sugar Pill)	2.36

A comparison between the ramelteon group and the placebo group in change in waist circumference (measured in cm) measured at Baseline and Week 8. (NCT00595504)
Timeframe: Baseline and Week 8

Article	Year
CNS drug development. Part I: The early period of CNS drugs. Journal of psychiatric practice, 2010, Volume: 16, Issue:5 Topics: Antidepressive Agents, Tricyclic; Antipsychotic Agents; Anxiety Disorders; Bipolar Disorder; Central	2010
The use of depot neuroleptics: clinical experience in the United States. The Journal of clinical psychiatry, 1984, Volume: 45, Issue:5 Pt 2 Topics: Administration, Oral; Adult; Clinical Trials as Topic; Depressive Disorder; Drug Administration Sche	1984
Antipsychotic medication: clinical guidelines for maintenance therapy. The Journal of clinical psychiatry, 1985, Volume: 46, Issue:5 Pt 2 Topics: Administration, Oral; Ambulatory Care; Anti-Anxiety Agents; Antipsychotic Agents; Basal Ganglia Dise	1985

Article	Year
Development and prediction of postpsychotic depression in neuroleptic-treated schizophrenics. Archives of general psychiatry, 1982, Volume: 39, Issue:2 Topics: Adolescent; Adult; Antipsychotic Agents; Clinical Trials as Topic; Depressive Disorder; Double-Blind	1982
Comparative side effects of imipramine, benztropine, or their combination in patients receiving fluphenazine decanoate. The American journal of psychiatry, 1983, Volume: 140, Issue:8 Topics: Adult; Benztropine; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Drug Therapy	1983
The use of depot neuroleptics: clinical experience in the United States. The Journal of clinical psychiatry, 1984, Volume: 45, Issue:5 Pt 2 Topics: Administration, Oral; Adult; Clinical Trials as Topic; Depressive Disorder; Drug Administration Sche	1984
A dramatic behavioral response to thyrotropin-releasing hormone following low-dose neuroleptics. Psychoneuroendocrinology, 1984, Volume: 9, Issue:3 Topics: Adult; Borderline Personality Disorder; Clinical Trials as Topic; Depressive Disorder; Double-Blind	1984
Depressive symptoms in chronic schizophrenic patients after withdrawal of long-acting neuroleptics. The Journal of clinical psychiatry, 1983, Volume: 44, Issue:10 Topics: Adult; Depressive Disorder; Double-Blind Method; Female; Flupenthixol; Fluphenazine; Humans; Male; P	1983
Mixed anxiety/depressive illness in general practice. A therapeutic comparison of nomifensine with fluphenazine/nortriptyline. Acta psychiatrica Scandinavica, 1983, Volume: 68, Issue:6 Topics: Adolescent; Adult; Aged; Anxiety Disorders; Depressive Disorder; Double-Blind Method; Drug Combinati	1983
Studies of depressive symptoms in schizophrenia. The British journal of psychiatry : the journal of mental science, 1981, Volume: 139 Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Female;	1981
Pharmacotherapy of impaired affect in recovering schizophrenic patients. Archives of general psychiatry, 1995, Volume: 52, Issue:1 Topics: Adolescent; Adult; Ambulatory Care; Antipsychotic Agents; Anxiety Disorders; Basal Ganglia Diseases;	1995
Maintenance imipramine therapy for secondary depression in schizophrenia. A controlled trial. Archives of general psychiatry, 1994, Volume: 51, Issue:2 Topics: Adult; Antipsychotic Agents; Benztropine; Delayed-Action Preparations; Depressive Disorder; Double-B	1994
A study of the pharmacologic treatment of medication-compliant schizophrenics who relapse. The Journal of clinical psychiatry, 1994, Volume: 55, Issue:11 Topics: Adult; Antipsychotic Agents; Depressive Disorder; Double-Blind Method; Drug Therapy, Combination; Fe	1994
Treatment of anxiety/depressive conditions in the elderly: a double-blind comparative study of Motival and amitriptyline. Age and ageing, 1975, Volume: 4, Issue:4 Topics: Aged; Amitriptyline; Anxiety Disorders; Clinical Trials as Topic; Depressive Disorder; Double-Blind	1975
A.E. Bennett award paper. Experimental approaches to human stress research: assessment of neurobiological mechanisms of stress in volunteers and psychiatric patients. Biological psychiatry, 1989, Volume: 26, Issue:5 Topics: Adrenocorticotropic Hormone; Adult; Arousal; beta-Endorphin; Blood Glucose; Clinical Trials as Topic	1989
The dysphoric syndrome in schizophrenia and its implications for relapse. The British journal of psychiatry. Supplement, 1989, Issue:5 Topics: Adult; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Female; Fluphenazine; Fol	1989
Relationship of adverse drug reactions to length of hospital-stay in genetically subgrouped schizophrenics. Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1988, Volume: 33, Issue:9 Topics: Antipsychotic Agents; Chlorpromazine; Clinical Trials as Topic; Depressive Disorder; Double-Blind Me	1988
Postpsychotic depression and negative symptoms: an investigation of syndromal overlap. The American journal of psychiatry, 1988, Volume: 145, Issue:12 Topics: Adolescent; Adult; Aged; Benztropine; Clinical Trials as Topic; Depressive Disorder; Double-Blind Me	1988
Adjunctive imipramine in the treatment of postpsychotic depression. A controlled trial. Archives of general psychiatry, 1987, Volume: 44, Issue:6 Topics: Adult; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Drug Therapy, Combination	1987
Long-term depot maintenance of chronic schizophrenic out-patients: the seven year follow-up of the Medical Research Council fluphenazine/placebo trial. II. The incidence of compliance problems, side-effects, neurotic symptoms and depression. The British journal of psychiatry : the journal of mental science, 1985, Volume: 146 Topics: Clinical Trials as Topic; Delayed-Action Preparations; Depressive Disorder; Double-Blind Method; Dys	1985

Article	Year
[FLUPHENAZINE DIHYDROCHLORIDE]. El Dia medico, 1964, Mar-09, Volume: 36 Topics: Achlorhydria; Anxiety; Anxiety Disorders; Depression; Depressive Disorder; Dyspepsia; Feeding and Ea	1964
[FLUPHANAZINE IN TENSION AND DEPRESSION]. Revista brasileira de medicina, 1963, Volume: 20 Topics: Anxiety; Anxiety Disorders; Depression; Depressive Disorder; Fluphenazine; Humans; Mental Disorders;	1963
Disturbed glucose metabolism among patients taking olanzapine and typical antipsychotics. Psychopharmacology bulletin, 2003,Summer, Volume: 37, Issue:3 Topics: Antipsychotic Agents; Benzodiazepines; Chlorpromazine; Cohort Studies; Depressive Disorder; Diabetes	2003
Pharmacotherapy and suicide risk in schizophrenia. Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1983, Volume: 28, Issue:4 Topics: Adult; Antipsychotic Agents; Depressive Disorder; Drug Therapy, Combination; Female; Fluphenazine; H	1983
Depression in schizophrenia: clinical and pharmacological variables. Schizophrenia research, 1995, Volume: 14, Issue:3 Topics: Adolescent; Adult; Age Factors; Aged; Depressive Disorder; Dexamethasone; Female; Fluphenazine; Halo	1995
Idiopathic unconjugated hyperbilirubinemia (Gilbert's syndrome) and concurrent psychotropic drug administration. Pharmacopsychiatry, 1993, Volume: 26, Issue:2 Topics: Adult; Antidepressive Agents, Tricyclic; Depressive Disorder; Female; Fluphenazine; Gilbert Disease;	1993
Reduced tyrosine kinase receptor C mRNA levels in the frontal cortex of patients with schizophrenia. Neuroscience letters, 1998, Nov-27, Volume: 257, Issue:2 Topics: Adult; Aged; Antipsychotic Agents; Bipolar Disorder; Cerebellum; Depressive Disorder; Female; Fluphe	1998
Pseudocyesis in organic mood disorders. Six cases. Psychosomatics, 1992,Summer, Volume: 33, Issue:3 Topics: Adult; Aged; Antidepressive Agents; Antipsychotic Agents; Delusions; Depressive Disorder; Diagnosis,	1992
Serum melatonin levels in schizophrenic and schizoaffective hospitalized patients. Acta psychiatrica Scandinavica, 1991, Volume: 84, Issue:3 Topics: Adult; Chlorpromazine; Circadian Rhythm; Depressive Disorder; Drug Therapy, Combination; Female; Flu	1991
Serum melatonin levels in schizophrenic and schizoaffective hospitalized patients. Acta psychiatrica Scandinavica, 1991, Volume: 84, Issue:3 Topics: Adult; Chlorpromazine; Circadian Rhythm; Depressive Disorder; Drug Therapy, Combination; Female; Flu	1991
Serum melatonin levels in schizophrenic and schizoaffective hospitalized patients. Acta psychiatrica Scandinavica, 1991, Volume: 84, Issue:3 Topics: Adult; Chlorpromazine; Circadian Rhythm; Depressive Disorder; Drug Therapy, Combination; Female; Flu	1991
Serum melatonin levels in schizophrenic and schizoaffective hospitalized patients. Acta psychiatrica Scandinavica, 1991, Volume: 84, Issue:3 Topics: Adult; Chlorpromazine; Circadian Rhythm; Depressive Disorder; Drug Therapy, Combination; Female; Flu	1991
Patients' and caregivers' adaptation to improvement in schizophrenia. Hospital & community psychiatry, 1990, Volume: 41, Issue:5 Topics: Adult; Assertiveness; Depressive Disorder; Drug Therapy, Combination; Family; Female; Fluphenazine;	1990
Two cases of agranulocytosis on addition of a butyrophenone to a long-standing course of phenothiazine treatment. The British journal of psychiatry : the journal of mental science, 1989, Volume: 154 Topics: Agranulocytosis; Antipsychotic Agents; Chlorpromazine; Clomipramine; Depressive Disorder; Dose-Respo	1989
Trials of adjunctive alprazolam in "negative symptom" patients. Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1989, Volume: 34, Issue:4 Topics: Adult; Alprazolam; Depressive Disorder; Drug Therapy, Combination; Fluphenazine; Hallucinations; Hum	1989
Adjunctive imipramine maintenance treatment in schizophrenic patients with remitted postpsychotic depression. The American journal of psychiatry, 1989, Volume: 146, Issue:11 Topics: Adult; Benztropine; Depressive Disorder; Double-Blind Method; Drug Therapy, Combination; Fluphenazin	1989
The significance of depression in the prediction of relapse in chronic schizophrenia. The British journal of psychiatry : the journal of mental science, 1988, Volume: 152 Topics: Adult; Depressive Disorder; Female; Flupenthixol; Fluphenazine; Humans; Male; Middle Aged; Recurrenc	1988
Continuation and maintenance treatment trials of adjunctive imipramine therapy in patients with postpsychotic depression. The Journal of clinical psychiatry, 1988, Volume: 49, Issue:11 Topics: Benztropine; Depressive Disorder; Drug Therapy, Combination; Fluphenazine; Humans; Imipramine; Psych	1988
Patterns of plasma imipramine-desipramine concentrations in patients receiving concomitant fluphenazine decanoate. The Journal of clinical psychiatry, 1988, Volume: 49, Issue:2 Topics: Adult; Depressive Disorder; Desipramine; Dose-Response Relationship, Drug; Drug Interactions; Drug T	1988
Cerebrospinal fluid neuropeptide Y in depression and schizophrenia. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1987, Volume: 1, Issue:1 Topics: Biomarkers; Depressive Disorder; Female; Fluphenazine; Humans; Male; Neuropeptide Y; Reference Value	1987
Is postpsychotic depression a primary affective disorder? The Journal of clinical psychiatry, 1986, Volume: 47, Issue:9 Topics: Depressive Disorder; Fluphenazine; Humans; Psychotic Disorders; Schizophrenia	1986
[Depressive syndromes within the scope of schizophrenic psychoses]. Wiener medizinische Wochenschrift (1946), 1985, Sep-30, Volume: 135, Issue:18 Topics: Depressive Disorder; Fluphenazine; Hallucinations; Humans; Long-Term Care; Male; Models, Psychologic	1985
Stability of the postpsychotic depression syndrome. The Journal of clinical psychiatry, 1986, Volume: 47, Issue:2 Topics: Adult; Depressive Disorder; Female; Fluphenazine; Humans; Male; Middle Aged; Outcome and Process Ass	1986

fluphenazine and Depressive Disorder