fluorouracil has been researched along with Wounds and Injuries in 4 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Wounds and Injuries: Damage inflicted on the body as the direct or indirect result of an external force, with or without disruption of structural continuity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The objective was to establish the safety and efficacy of intralesional 5-fluorouracil (5-FU) for the treatment of keloids and hypertrophic scars." | 9.30 | Comparison of efficacy and safety of intralesional triamcinolone and combination of triamcinolone with 5-fluorouracil in the treatment of keloids and hypertrophic scars: Randomised control trial. ( Ahmad, S; Khalid, FA; Mehrose, MY; Mujahid, AM; Rehman, SU; Saleem, M; Tarar, MN; Yousaf, MA, 2019) |
| " We aimed to compare the efficacy and safety of TAC alone and in combination with 5-FU for the treatment of hypertrophic scars and keloids." | 6.55 | Efficacy and safety of triamcinolone acetonide alone and in combination with 5-fluorouracil for treating hypertrophic scars and keloids: a systematic review and meta-analysis. ( Fan, B; Feng, S; Lin, W; Ren, Y; Wei, Z; Zhou, X, 2017) |
| "The objective was to establish the safety and efficacy of intralesional 5-fluorouracil (5-FU) for the treatment of keloids and hypertrophic scars." | 5.30 | Comparison of efficacy and safety of intralesional triamcinolone and combination of triamcinolone with 5-fluorouracil in the treatment of keloids and hypertrophic scars: Randomised control trial. ( Ahmad, S; Khalid, FA; Mehrose, MY; Mujahid, AM; Rehman, SU; Saleem, M; Tarar, MN; Yousaf, MA, 2019) |
| " We aimed to compare the efficacy and safety of TAC alone and in combination with 5-FU for the treatment of hypertrophic scars and keloids." | 2.55 | Efficacy and safety of triamcinolone acetonide alone and in combination with 5-fluorouracil for treating hypertrophic scars and keloids: a systematic review and meta-analysis. ( Fan, B; Feng, S; Lin, W; Ren, Y; Wei, Z; Zhou, X, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Khalid, FA | 1 |
| Mehrose, MY | 1 |
| Saleem, M | 1 |
| Yousaf, MA | 1 |
| Mujahid, AM | 1 |
| Rehman, SU | 1 |
| Ahmad, S | 1 |
| Tarar, MN | 1 |
| Ren, Y | 1 |
| Zhou, X | 1 |
| Wei, Z | 1 |
| Lin, W | 1 |
| Fan, B | 1 |
| Feng, S | 1 |
| Ottewell, PD | 1 |
| Duckworth, CA | 1 |
| Varro, A | 1 |
| Dimaline, R | 1 |
| Wang, TC | 1 |
| Watson, AJ | 1 |
| Dockray, GJ | 1 |
| Pritchard, DM | 1 |
| Anderson, FE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy of Post-Surgical Intralesional Injection With Triamcinolone Versus Triamcinolone Plus Fluorouracil in the Treatment of Keloids[NCT04710719] | 7 participants (Actual) | Interventional | 2021-02-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for fluorouracil and Wounds and Injuries
| Article | Year |
|---|---|
Efficacy and safety of triamcinolone acetonide alone and in combination with 5-fluorouracil for treating hypertrophic scars and keloids: a systematic review and meta-analysis.
Topics: Anti-Inflammatory Agents; Cicatrix, Hypertrophic; Drug Therapy, Combination; Female; Fluorouracil; H | 2017 |
Warts. Fact and fiction.
Topics: Antiviral Agents; Bleomycin; Cryosurgery; Fluorouracil; Formaldehyde; Humans; Interferons; Papilloma | 1985 |
1 trial available for fluorouracil and Wounds and Injuries
| Article | Year |
|---|---|
Comparison of efficacy and safety of intralesional triamcinolone and combination of triamcinolone with 5-fluorouracil in the treatment of keloids and hypertrophic scars: Randomised control trial.
Topics: Adult; Body Piercing; Burns; Cicatrix, Hypertrophic; Double-Blind Method; Drug Therapy, Combination; | 2019 |
1 other study available for fluorouracil and Wounds and Injuries
| Article | Year |
|---|---|
Gastrin increases murine intestinal crypt regeneration following injury.
Topics: Animals; Benzodiazepinones; Cell Line; Cell Proliferation; Colitis; Dextran Sulfate; Enteritis; Enzy | 2006 |