fluorouracil has been researched along with Vesico-Ureteral Reflux in 1 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Vesico-Ureteral Reflux: Retrograde flow of urine from the URINARY BLADDER into the URETER. This is often due to incompetence of the vesicoureteral valve leading to ascending bacterial infection into the KIDNEY.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Between 1992 and 2010, 81 pregnant patients with breast cancer were treated in a single-arm, institutional review board-approved study with 5-fluorouracil, doxorubicin, and cyclophosphamide (FAC) in the adjuvant or neoadjuvant setting." | 3.80 | Outcomes of children exposed in utero to chemotherapy for breast cancer. ( Barnett, CM; Hodge, S; Hortobagyi, GN; Litton, JK; Milbourne, A; Murthy, RK; Ramirez, MM; Rimes, SA; Theriault, RL; Valero, V, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Murthy, RK | 1 |
| Theriault, RL | 1 |
| Barnett, CM | 1 |
| Hodge, S | 1 |
| Ramirez, MM | 1 |
| Milbourne, A | 1 |
| Rimes, SA | 1 |
| Hortobagyi, GN | 1 |
| Valero, V | 1 |
| Litton, JK | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Multimodality Treatment of Primary Breast Cancer Occurring Concomitant With Pregnancy[NCT00510367] | Early Phase 1 | 61 participants (Actual) | Interventional | 2001-08-07 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 other study available for fluorouracil and Vesico-Ureteral Reflux
| Article | Year |
|---|---|
Outcomes of children exposed in utero to chemotherapy for breast cancer.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Child; Clubfoot; Congenital | 2014 |