fluorouracil has been researched along with Ventricular Fibrillation in 10 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Ventricular Fibrillation: A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (400-600/min) in HEART VENTRICLES. Such asynchronous ventricular quivering or fibrillation prevents any effective cardiac output and results in unconsciousness (SYNCOPE). It is one of the major electrocardiographic patterns seen with CARDIAC ARREST.
| Excerpt | Relevance | Reference |
|---|---|---|
| "5-Fluorouracil is a key element to the treatment of colon cancer." | 6.66 | Various Manifestations of 5-Fluorouracil Cardiotoxicity: A Multicenter Case Series and Review of Literature. ( Allison, JD; Birnbaum, G; Khalid, U; Tanavin, T; Yang, Y, 2020) |
| "Capecitabine is a member of the fluoropyrimidine family of chemotherapeutic agents that selectively delivers 5-fluorouracil (5-FU) to tumors." | 5.38 | Ventricular fibrillation as a likely consequence of capecitabine-induced coronary vasospasm. ( Rather, A; Shah, A; Shah, NR, 2012) |
| "5-Fluorouracil is a key element to the treatment of colon cancer." | 2.66 | Various Manifestations of 5-Fluorouracil Cardiotoxicity: A Multicenter Case Series and Review of Literature. ( Allison, JD; Birnbaum, G; Khalid, U; Tanavin, T; Yang, Y, 2020) |
| "Capecitabine is a member of the fluoropyrimidine family of chemotherapeutic agents that selectively delivers 5-fluorouracil (5-FU) to tumors." | 1.38 | Ventricular fibrillation as a likely consequence of capecitabine-induced coronary vasospasm. ( Rather, A; Shah, A; Shah, NR, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (10.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 7 (70.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Allison, JD | 1 |
| Tanavin, T | 1 |
| Yang, Y | 1 |
| Birnbaum, G | 1 |
| Khalid, U | 1 |
| Fradley, MG | 1 |
| Barrett, CD | 1 |
| Clark, JR | 1 |
| Francis, SA | 1 |
| Knott, K | 1 |
| Starling, N | 1 |
| Rasheed, S | 1 |
| Foran, J | 1 |
| Cafferkey, C | 1 |
| Rosen, S | 1 |
| Nicholson, A | 1 |
| Baksi, J | 1 |
| Lyon, A | 1 |
| Lai, S | 1 |
| Marshall, JL | 1 |
| Morrissey, RL | 1 |
| Ray, JC | 1 |
| Cho, P | 1 |
| Dragon, M | 1 |
| Graham, CG | 1 |
| Shah, NR | 1 |
| Shah, A | 1 |
| Rather, A | 1 |
| Kounis, NG | 1 |
| Tsigkas, GG | 1 |
| Almpanis, G | 1 |
| Mazarakis, A | 1 |
| Ozturk, MA | 1 |
| Ozveren, O | 1 |
| Cinar, V | 1 |
| Erdik, B | 1 |
| Oyan, B | 1 |
| McLachlan, SA | 1 |
| Millward, MJ | 1 |
| Toner, GC | 1 |
| Guiney, MJ | 1 |
| Bishop, JF | 1 |
| Glaser, E | 1 |
| Luquel, L | 1 |
| Thomas, O | 1 |
| Larminat, JM | 1 |
| Offenstadt, G | 1 |
3 reviews available for fluorouracil and Ventricular Fibrillation
| Article | Year |
|---|---|
Various Manifestations of 5-Fluorouracil Cardiotoxicity: A Multicenter Case Series and Review of Literature.
Topics: Adult; Antimetabolites, Antineoplastic; Cardiotoxicity; Colonic Neoplasms; Disease Progression; Elec | 2020 |
Kounis syndrome is likely culprit of coronary vasospasm induced by capecitabine.
Topics: Antimetabolites, Antineoplastic; Coronary Vasospasm; Deoxycytidine; Fluorouracil; Humans; Male; Vent | 2012 |
Takotsubo syndrome: an underdiagnosed complication of 5-fluorouracil mimicking acute myocardial infarction.
Topics: Amiodarone; Anti-Arrhythmia Agents; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemoth | 2013 |
7 other studies available for fluorouracil and Ventricular Fibrillation
| Article | Year |
|---|---|
Ventricular fibrillation cardiac arrest due to 5-fluorouracil cardiotoxicity.
Topics: Antineoplastic Agents; Carcinoma, Squamous Cell; Coronary Angiography; Coronary Vasospasm; Defibrill | 2013 |
A case of Takotsubo syndrome following 5-fluorouracil chemotherapy.
Topics: Cardiotoxicity; Electrocardiography; Fluorouracil; Humans; Magnetic Resonance Imaging; Male; Middle | 2014 |
Rechallenging 5-Fluorouracil in a Patient With Capecitabine-Induced Ventricular Fibrillation.
Topics: Antimetabolites, Antineoplastic; Capecitabine; Defibrillators, Implantable; Fluorouracil; Heart Arre | 2015 |
A Case of 5-Fluorouracil-Induced Cardiac Arrest.
Topics: Antimetabolites, Antineoplastic; Chest Pain; Female; Fluorouracil; Heart Arrest; Humans; Middle Aged | 2016 |
Ventricular fibrillation as a likely consequence of capecitabine-induced coronary vasospasm.
Topics: Adult; Antimetabolites, Antineoplastic; Capecitabine; Colorectal Neoplasms; Coronary Vasospasm; Defi | 2012 |
The spectrum of 5-fluorouracil cardiotoxicity.
Topics: Adenoma; Aged; Carcinoma, Squamous Cell; Combined Modality Therapy; Digestive System Neoplasms; Fema | 1994 |
[Ventricular fibrillation of a favourable course during perfusion with fluorouracil].
Topics: Carcinoma, Squamous Cell; Fluorouracil; Humans; Male; Middle Aged; Ventricular Fibrillation | 1989 |