fluorouracil has been researched along with Vasospasm, Intracranial in 1 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Vasospasm, Intracranial: Constriction of arteries in the SKULL due to sudden, sharp, and often persistent smooth muscle contraction in blood vessels. Intracranial vasospasm results in reduced vessel lumen caliber, restricted blood flow to the brain, and BRAIN ISCHEMIA that may lead to hypoxic-ischemic brain injury (HYPOXIA-ISCHEMIA, BRAIN).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fluorouracil (5-FU) is a commonly used chemotherapeutic agent in many cancers." | 1.62 | 5-Fluorouracil associated neurovascular toxicities. ( Dumas, B; Horta, L; Ozer, M; Sadrzadeh, H, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ozer, M | 1 |
| Dumas, B | 1 |
| Horta, L | 1 |
| Sadrzadeh, H | 1 |
1 other study available for fluorouracil and Vasospasm, Intracranial
| Article | Year |
|---|---|
5-Fluorouracil associated neurovascular toxicities.
Topics: Adult; Antimetabolites, Antineoplastic; Female; Fluorouracil; Humans; Male; Middle Aged; Nervous Sys | 2021 |