fluorouracil has been researched along with Vaginal Diseases in 9 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Vaginal Diseases: Pathological processes of the VAGINA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The ulcers were mostly singular and measured 0." | 5.28 | Chronic ulcerations following topical therapy with 5-fluorouracil for vaginal human papillomavirus-associated lesions. ( Helmkamp, BF; Krebs, HB, 1991) |
| "The ulcers were mostly singular and measured 0." | 1.28 | Chronic ulcerations following topical therapy with 5-fluorouracil for vaginal human papillomavirus-associated lesions. ( Helmkamp, BF; Krebs, HB, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (88.89) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dungar, CF | 1 |
| Wilkinson, EJ | 1 |
| Smotkin, D | 1 |
| Bornstein, J | 1 |
| Sova, Y | 1 |
| Atad, J | 1 |
| Lurie, M | 1 |
| Abramovici, H | 1 |
| Stefanon, B | 1 |
| Pallucca, A | 1 |
| Merola, M | 1 |
| Bandieramonte, G | 1 |
| Holmes, MM | 1 |
| Weaver, SH | 1 |
| Vermillion, ST | 1 |
| Syed, TA | 1 |
| Qureshi, ZA | 1 |
| Ahmad, SA | 1 |
| Ali, SM | 1 |
| Brodman, M | 1 |
| Dottino, P | 1 |
| Friedman, F | 1 |
| Heller, D | 1 |
| Bleiweiss, I | 1 |
| Sperling, R | 1 |
| Krebs, HB | 1 |
| Helmkamp, BF | 1 |
| Goodman, A | 1 |
| Zukerberg, LR | 1 |
| Nikrui, N | 1 |
| Scully, RE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Multicenter Observational and Feasibility Study of Excision of Superficially Invasive Squamous Cell Carcinoma (SISCCA) of the Anal Canal and Perianus in HIV-Infected Persons[NCT02437851] | Phase 2 | 16 participants (Actual) | Interventional | 2015-04-30 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for fluorouracil and Vaginal Diseases
| Article | Year |
|---|---|
Human papillomavirus infection of the vagina.
Topics: Acetates; Acetic Acid; Biopsy; Colposcopy; Cryosurgery; Diagnosis, Differential; DNA, Viral; Electro | 1993 |
Vaginal adenosis and clear cell carcinoma after 5-fluorouracil treatment for condylomas.
Topics: Adenocarcinoma; Adult; Condylomata Acuminata; Female; Fluorouracil; Humans; Vaginal Diseases; Vagina | 1991 |
3 trials available for fluorouracil and Vaginal Diseases
| Article | Year |
|---|---|
Treatment with 5-fluorouracil of 35 patients with clinical or subclinical HPV infection of the vagina.
Topics: Administration, Topical; Adult; Antimetabolites, Antineoplastic; Female; Fluorouracil; Follow-Up Stu | 1996 |
A randomized, double-blind, placebo-controlled trial of 5-fluorouracil for the treatment of cervicovaginal human papillomavirus.
Topics: Administration, Intravaginal; Adolescent; Adult; Antimetabolites, Antineoplastic; Double-Blind Metho | 1999 |
Management of intravaginal warts in women with 5-fluorouracil (1%) in vaginal hydrophilic gel: a placebo-controlled double-blind study.
Topics: Administration, Intravaginal; Adolescent; Adult; Antimetabolites; Double-Blind Method; Female; Fluor | 2000 |
4 other studies available for fluorouracil and Vaginal Diseases
| Article | Year |
|---|---|
Vaginal columnar cell metaplasia. An acquired adenosis associated with topical 5-fluorouracil therapy.
Topics: Adult; Epithelial Cells; Epithelium; Female; Fluorouracil; Humans; Metaplasia; Middle Aged; Papillom | 1995 |
Development of vaginal adenosis following combined 5-fluorouracil and carbon dioxide laser treatments for diffuse vaginal condylomatosis.
Topics: Adult; Combined Modality Therapy; Condylomata Acuminata; Female; Fluorouracil; Humans; Laser Therapy | 1993 |
Human papillomavirus-associated lesions of the vagina and cervix. Treatment with a laser and topical 5-fluorouracil.
Topics: Administration, Topical; Biopsy; Clinical Protocols; Combined Modality Therapy; DNA; Female; Fluorou | 1992 |
Chronic ulcerations following topical therapy with 5-fluorouracil for vaginal human papillomavirus-associated lesions.
Topics: Administration, Intravaginal; Adolescent; Adult; Aged; Cervix Uteri; Chronic Disease; Female; Fluoro | 1991 |