fluorouracil has been researched along with Uveitis in 8 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Uveitis: Inflammation of part or all of the uvea, the middle (vascular) tunic of the eye, and commonly involving the other tunics (sclera and cornea, and the retina). (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine the effect of intraoperative application of 5-fluorouracil (5-FU) on the long-term outcome of trabeculectomy in uveitis-related glaucoma." | 7.70 | Long-term follow-up of trabeculectomy with intraoperative 5-fluorouracil for uveitis-related glaucoma. ( Lightman, S; McCluskey, P; Shaer, B; Towler, HM, 2000) |
| "Twenty-one eyes of 18 patients with uncontrolled glaucoma and intraocular inflammatory disease had glaucoma filtering surgery with postoperative subconjunctival 5-fluorouracil (5-FU)." | 7.68 | Glaucoma filtering surgery with postoperative 5-fluorouracil in patients with intraocular inflammatory disease. ( Lowder, CY; Meisler, DM; Patitsas, CJ; Rockwood, EJ, 1992) |
| " Cyclosporine A devices were prepared for the treatment of uveitis." | 4.79 | Review: implants. ( Ashton, P; Blandford, DL; Jaffe, GJ; Martin, DF; Nussenblatt, RB; Pearson, PA, 1994) |
| "A retrospective chart review of 44 eyes of 44 patients with uveitic glaucoma who underwent trabeculectomy with mitomycin C or 5-fluorouracil." | 3.71 | Trabeculectomy with antiproliferative agents in uveitic glaucoma. ( Beck, AD; Ceballos, EM; Lynn, MJ, 2002) |
| "To determine the effect of intraoperative application of 5-fluorouracil (5-FU) on the long-term outcome of trabeculectomy in uveitis-related glaucoma." | 3.70 | Long-term follow-up of trabeculectomy with intraoperative 5-fluorouracil for uveitis-related glaucoma. ( Lightman, S; McCluskey, P; Shaer, B; Towler, HM, 2000) |
| "Twenty-one eyes of 18 patients with uncontrolled glaucoma and intraocular inflammatory disease had glaucoma filtering surgery with postoperative subconjunctival 5-fluorouracil (5-FU)." | 3.68 | Glaucoma filtering surgery with postoperative 5-fluorouracil in patients with intraocular inflammatory disease. ( Lowder, CY; Meisler, DM; Patitsas, CJ; Rockwood, EJ, 1992) |
| "In a search for alternative therapeutic methods other than corticosteroids and cytostatics, the effect of a dialyzable leukocyte extract (DLE), the antimetabolite 5-fluorouracil and the immunosuppressive agent cyclosporin A in corticosteroid-resistant idiopathic uveitis was studied." | 3.68 | [Alternatives to steroid therapy in chronic uveitis]. ( Fricke, B; Fricke, HJ; Friedrich, R; Illessy, A; Klein, S; Schröder, KD, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (37.50) | 18.7374 |
| 1990's | 3 (37.50) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ceballos, EM | 1 |
| Beck, AD | 1 |
| Lynn, MJ | 1 |
| NEWELL, FW | 1 |
| Smaliukh, NV | 1 |
| Ashton, P | 1 |
| Blandford, DL | 1 |
| Pearson, PA | 1 |
| Jaffe, GJ | 1 |
| Martin, DF | 1 |
| Nussenblatt, RB | 1 |
| Towler, HM | 1 |
| McCluskey, P | 1 |
| Shaer, B | 1 |
| Lightman, S | 1 |
| Pen'kov, MA | 1 |
| Sharlaĭ, VR | 1 |
| Patitsas, CJ | 1 |
| Rockwood, EJ | 1 |
| Meisler, DM | 1 |
| Lowder, CY | 1 |
| Klein, S | 1 |
| Fricke, HJ | 1 |
| Fricke, B | 1 |
| Friedrich, R | 1 |
| Illessy, A | 1 |
| Schröder, KD | 1 |
1 review available for fluorouracil and Uveitis
| Article | Year |
|---|---|
Review: implants.
Topics: Animals; Cyclosporine; Cytomegalovirus Retinitis; Delayed-Action Preparations; Drug Implants; Filter | 1994 |
7 other studies available for fluorouracil and Uveitis
| Article | Year |
|---|---|
Trabeculectomy with antiproliferative agents in uveitic glaucoma.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antibiotics, Antineoplastic; Antimetabolites, Antineopla | 2002 |
ANTICANCER AGENTS.
Topics: Alkylating Agents; Aminopterin; Antineoplastic Agents; Chemotherapy, Cancer, Regional Perfusion; Cor | 1964 |
[Experimental study of the efficacy of ftorafur phonophoresis in simulated allergic uveitis].
Topics: Animals; Chinchilla; Fluorouracil; Hypersensitivity; Tegafur; Ultrasonics; Uveitis | 1983 |
Long-term follow-up of trabeculectomy with intraoperative 5-fluorouracil for uveitis-related glaucoma.
Topics: Adolescent; Adult; Aged; Antimetabolites; Child; Female; Fluorouracil; Follow-Up Studies; Glaucoma; | 2000 |
[Remote results of the use of immunosuppressive agents in complex treatment of severe forms of uveitis].
Topics: Adolescent; Adult; Aged; Child; Cyclophosphamide; Drug Therapy, Combination; Female; Fluorouracil; F | 1976 |
Glaucoma filtering surgery with postoperative 5-fluorouracil in patients with intraocular inflammatory disease.
Topics: Adolescent; Adult; Aged; Cataract Extraction; Conjunctiva; Female; Fluorouracil; Follow-Up Studies; | 1992 |
[Alternatives to steroid therapy in chronic uveitis].
Topics: Adrenal Cortex Hormones; Adult; Cell Extracts; Child; Chronic Disease; Cyclosporins; Fluorouracil; H | 1990 |