fluorouracil has been researched along with Uterine Cervical Dysplasia in 21 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Uterine Cervical Dysplasia: Abnormal development of immature squamous EPITHELIAL CELLS of the UTERINE CERVIX, a term used to describe premalignant cytological changes in the cervical EPITHELIUM. These atypical cells do not penetrate the epithelial BASEMENT MEMBRANE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In response to repeated observations of cervical cancers in HIV-infected women, moderate and severe cervical dysplasia were designated as early symptomatic HIV infection (Category B) by the Centers for Disease Control and Prevention (CDC) in 1993, and invasive cervical cancer as an AIDS-defining condition (Category C)." | 2.43 | Cervical screening and management of cervical intraepithelial neoplasia in HIV-positive women. ( Bradbeer, C; Danso, D; Lyons, F, 2006) |
| "5-fluorouracil was associated with a 74% success rate as the initial treatment modality for high-grade vaginal dysplasia." | 1.46 | Topical 5-Fluorouracil for Women With High-Grade Vaginal Intraepithelial Neoplasia. ( Feldman, S; Fiascone, S; Vitonis, AF, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (19.05) | 18.7374 |
| 1990's | 7 (33.33) | 18.2507 |
| 2000's | 6 (28.57) | 29.6817 |
| 2010's | 3 (14.29) | 24.3611 |
| 2020's | 1 (4.76) | 2.80 |
| Authors | Studies |
|---|---|
| Desravines, N | 1 |
| Hsu, CH | 1 |
| Mohnot, S | 1 |
| Sahasrabuddhe, V | 1 |
| House, M | 1 |
| Sauter, E | 1 |
| O'Connor, S | 1 |
| Bauman, JE | 1 |
| Chow, HS | 1 |
| Rahangdale, L | 2 |
| Fiascone, S | 1 |
| Vitonis, AF | 1 |
| Feldman, S | 1 |
| Mutombo, AB | 1 |
| Simoens, C | 1 |
| Tozin, R | 1 |
| Bogers, J | 1 |
| Van Geertruyden, JP | 1 |
| Jacquemyn, Y | 1 |
| Lippmann, QK | 1 |
| Garcia, K | 1 |
| Budwit, D | 1 |
| Smith, JS | 1 |
| van Le, L | 1 |
| Moore, DH | 1 |
| González Sánchez, JL | 1 |
| Flores Murrieta, G | 1 |
| Chávez Brambila, J | 1 |
| Deolarte Manzano, JM | 1 |
| Andrade Manzano, AF | 1 |
| Ait Menguellet, S | 1 |
| Collinet, P | 1 |
| Houfflin Debarge, V | 1 |
| Nayama, M | 1 |
| Vinatier, D | 1 |
| Leroy, JL | 1 |
| Danso, D | 1 |
| Lyons, F | 1 |
| Bradbeer, C | 1 |
| Pride, GL | 1 |
| Chuprevich, TW | 1 |
| Sillman, FH | 1 |
| Boyce, JG | 1 |
| Macasaet, MA | 1 |
| Nicastri, AD | 1 |
| Woolfson, AD | 3 |
| McCafferty, DF | 3 |
| McCarron, PA | 3 |
| Price, JH | 3 |
| Husseinzadeh, N | 1 |
| Guoth, JG | 1 |
| Jayawardena, DS | 1 |
| Sidhu, HK | 1 |
| Biggart, D | 1 |
| Thompson, W | 1 |
| Maiman, M | 1 |
| Watts, DH | 1 |
| Andersen, J | 1 |
| Clax, P | 1 |
| Merino, M | 1 |
| Kendall, MA | 1 |
| Hanna, L | 1 |
| Epperson, WJ | 1 |
| Krebs, HB | 1 |
| Kirwan, P | 1 |
| Naftalin, NJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Multicenter Observational and Feasibility Study of Excision of Superficially Invasive Squamous Cell Carcinoma (SISCCA) of the Anal Canal and Perianus in HIV-Infected Persons[NCT02437851] | Phase 2 | 16 participants (Actual) | Interventional | 2015-04-30 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for fluorouracil and Uterine Cervical Dysplasia
| Article | Year |
|---|---|
Efficacy of commercially available biological agents for the topical treatment of cervical intraepithelial neoplasia: a systematic review.
Topics: Administration, Topical; Antimetabolites, Antineoplastic; Biological Factors; Female; Fluorouracil; | 2019 |
Combined chemotherapy and radiation therapy for cervical cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Clinical Trials, Phase III as Topic; Comb | 2004 |
Cervical screening and management of cervical intraepithelial neoplasia in HIV-positive women.
Topics: Antiretroviral Therapy, Highly Active; Female; Fluorouracil; Follow-Up Studies; Forecasting; HIV Inf | 2006 |
Preventing cervical cancer by treating genital warts in men. Why male sex partners need androscopy.
Topics: Adult; Condylomata Acuminata; Cryosurgery; Desiccation; Female; Fluorouracil; Humans; Interferons; L | 1990 |
4 trials available for fluorouracil and Uterine Cervical Dysplasia
| Article | Year |
|---|---|
Topical 5-fluorouracil for treatment of cervical intraepithelial neoplasia 2: a randomized controlled trial.
Topics: Administration, Intravaginal; Administration, Topical; Adolescent; Adult; Antimetabolites, Antineopl | 2014 |
A randomised controlled trial evaluating a novel cytotoxic drug delivery system for the treatment of cervical intraepithelial neoplasia.
Topics: Administration, Topical; Antimetabolites, Antineoplastic; Double-Blind Method; Drug Delivery Systems | 1997 |
Vaginal 5-fluorouracil for high-grade cervical dysplasia in human immunodeficiency virus infection: a randomized trial.
Topics: Administration, Intravaginal; Adult; Antimetabolites, Antineoplastic; CD4 Lymphocyte Count; Female; | 1999 |
Prophylactic topical 5-fluorouracil following treatment of human papillomavirus-associated lesions of the vulva and vagina.
Topics: Administration, Intravaginal; Administration, Topical; Carcinoma in Situ; Combined Modality Therapy; | 1986 |
13 other studies available for fluorouracil and Uterine Cervical Dysplasia
| Article | Year |
|---|---|
Feasibility of 5-fluorouracil and imiquimod for the topical treatment of cervical intraepithelial neoplasias (CIN) 2/3.
Topics: Adult; Feasibility Studies; Female; Fluorouracil; Humans; Imiquimod; Papillomaviridae; Papillomaviru | 2023 |
Topical 5-Fluorouracil for Women With High-Grade Vaginal Intraepithelial Neoplasia.
Topics: Administration, Intravaginal; Antimetabolites, Antineoplastic; Dissection; Female; Fluorouracil; Hum | 2017 |
Anti-cancer agents. Cream reduces reappearance of cervical lesions.
Topics: Administration, Topical; Adult; Antimetabolites, Antineoplastic; CD4 Lymphocyte Count; Female; Fluor | 2000 |
[Topical 5-fluorouracil for treatment of vaginal intraepithelial neoplasms].
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Female; Fluorouracil; Humans; Middl | 2002 |
Management of multicentric lesions of the lower genital tract.
Topics: Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Cryosurgery; Female; Fluorouracil; Humans; | 2007 |
Topical 5-fluorouracil treatment of transformation zone intraepithelial neoplasia of cervix and vagina.
Topics: Administration, Topical; Carcinoma in Situ; Female; Fluorouracil; Humans; Uterine Cervical Dysplasia | 1982 |
5-fluorouracil/chemosurgery for intraepithelial neoplasia of the lower genital tract.
Topics: Adult; Aged; Carcinoma in Situ; Female; Fluorouracil; Genital Neoplasms, Female; Humans; Methods; Mi | 1981 |
Autoradiographic imaging of the distribution of 5-fluorouracil through cervical tissue following in vitro surface application of a bioadhesive cervical patch.
Topics: Antimetabolites, Antineoplastic; Autoradiography; Biocompatible Materials; Cervix Uteri; Delayed-Act | 1995 |
Liquid scintillation spectrometry of 5-fluorouracil in cervical tissue following in vitro surface application of a bioadhesive cervical patch.
Topics: Adhesives; Cervix Uteri; Drug Delivery Systems; Female; Fluorouracil; Humans; Scintillation Counting | 1994 |
Subclinical cervicovaginal human papillomavirus infections associated with cervical condylomata and dysplasia. Treatment outcomes.
Topics: Adolescent; Adult; Condylomata Acuminata; Female; Fluorouracil; Genital Diseases, Female; Humans; La | 1994 |
5-FU for cervical intraepithelia neoplasia.
Topics: Administration, Intravaginal; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Female; Fluor | 2000 |
5-FU for maintenance therapy of cervical lesions.
Topics: Administration, Intravaginal; Antimetabolites, Antineoplastic; Female; Fluorouracil; HIV Infections; | 1999 |
Topical 5-fluorouracil in the treatment of vaginal intraepithelial neoplasia.
Topics: Administration, Topical; Adult; Female; Fluorouracil; Humans; Middle Aged; Uterine Cervical Dysplasi | 1985 |