fluorouracil has been researched along with Ulcer in 14 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Ulcer: A lesion on the surface of the skin or a mucous surface, produced by the sloughing of inflammatory necrotic tissue.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The ulcers were mostly singular and measured 0." | 5.28 | Chronic ulcerations following topical therapy with 5-fluorouracil for vaginal human papillomavirus-associated lesions. ( Helmkamp, BF; Krebs, HB, 1991) |
| "A model animal of oral mucositis was prepared by injecting an acetic acid aqueous solution into the buccal mucosa of rats to which a 5-FU solution had been previously administered." | 1.56 | A Rat Model of Oral Mucositis Induced by Cancer Chemotherapy for Quantitative Experiments. ( Kawamata, R; Makino, K; Takeuchi, I, 2020) |
| "The ulcer was relieved by conservative medical treatment." | 1.39 | [A case of an ulcer of the sigmoid colon during chemotherapy with FOLFOX4 and bevacizumab for recurrence of rectal carcinoma]. ( Hirata, K; Mizushima, Y; Okuya, K, 2013) |
| "The ulcers were mostly singular and measured 0." | 1.28 | Chronic ulcerations following topical therapy with 5-fluorouracil for vaginal human papillomavirus-associated lesions. ( Helmkamp, BF; Krebs, HB, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (14.29) | 18.7374 |
| 1990's | 4 (28.57) | 18.2507 |
| 2000's | 3 (21.43) | 29.6817 |
| 2010's | 3 (21.43) | 24.3611 |
| 2020's | 2 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Panda, SS | 1 |
| Girgis, AS | 1 |
| Thomas, SJ | 1 |
| Capito, JE | 1 |
| George, RF | 1 |
| Salman, A | 1 |
| El-Manawaty, MA | 1 |
| Samir, A | 1 |
| Takeuchi, I | 1 |
| Kawamata, R | 1 |
| Makino, K | 1 |
| Li, Y | 1 |
| Xu, T | 1 |
| Qian, W | 1 |
| Lu, X | 1 |
| Hu, C | 1 |
| Babacan, T | 1 |
| Turkbeyler, IH | 1 |
| Dag, MS | 1 |
| Dilli, I | 1 |
| Balakan, O | 1 |
| Altundag, K | 1 |
| Okuya, K | 1 |
| Mizushima, Y | 1 |
| Hirata, K | 1 |
| FALKSON, G | 1 |
| SCHULZ, EJ | 1 |
| Sonis, ST | 2 |
| Lindquist, L | 1 |
| Van Vugt, A | 1 |
| Stewart, AA | 1 |
| Stam, K | 1 |
| Qu, GY | 1 |
| Iwata, KK | 1 |
| Haley, JD | 1 |
| McAtee, N | 1 |
| Brooks, C | 1 |
| Dela Rosa, T | 1 |
| Bos, AM | 1 |
| van der Graaf, WT | 1 |
| Willemse, PH | 1 |
| El-Malt, M | 1 |
| Ceelen, W | 1 |
| van den Broecke, C | 1 |
| Cuvelier, C | 1 |
| Van Belle, S | 1 |
| De Neve, W | 1 |
| de Hemptinne, B | 1 |
| Pattyn, P | 1 |
| Yamasaki, T | 1 |
| Sugito, M | 1 |
| Yoshikawa, I | 1 |
| Kume, K | 1 |
| Narita, R | 1 |
| Otsuki, M | 1 |
| Costa, JW | 1 |
| Evitts, SM | 1 |
| Lindquist, LE | 1 |
| Nicolson, M | 1 |
| Krebs, HB | 1 |
| Helmkamp, BF | 1 |
| Fennelly, JJ | 1 |
| Fitzgerald, MX | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized Phase II Study of Recombinant Human Epidermal Growth Factor (rhEGF) on Oral Mucositis Induced by Intensive Chemotherapy for Hematologic Malignancies[NCT00845819] | Phase 2 | 138 participants (Actual) | Interventional | 2009-02-28 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
14 other studies available for fluorouracil and Ulcer
| Article | Year |
|---|---|
Synthesis, pharmacological profile and 2D-QSAR studies of curcumin-amino acid conjugates as potential drug candidates.
Topics: Amino Acids; Analgesics; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; An | 2020 |
A Rat Model of Oral Mucositis Induced by Cancer Chemotherapy for Quantitative Experiments.
Topics: Animals; Antineoplastic Agents; Body Weight; Disease Models, Animal; Fluorouracil; Leukocyte Count; | 2020 |
Radiation-induced nasopharyngeal ulcers after intensity modulated radiotherapy in primary nasopharyngeal carcinoma patients: A dose-volume-outcome analysis.
Topics: Adult; Aged; Antineoplastic Agents; Chemotherapy, Adjuvant; Cisplatin; Combined Modality Therapy; De | 2018 |
Cetuximab-induced esophageal ulcer: the first report in literature.
Topics: Abdomen, Acute; Adenocarcinoma; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemother | 2014 |
[A case of an ulcer of the sigmoid colon during chemotherapy with FOLFOX4 and bevacizumab for recurrence of rectal carcinoma].
Topics: Aged; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab | 2013 |
SKIN CHANGES CAUSED BY CANCER CHEMOTHERAPY.
Topics: Alopecia; Anti-Bacterial Agents; Antibiotics, Antitubercular; Antineoplastic Agents; Cyclophosphamid | 1964 |
Prevention of chemotherapy-induced ulcerative mucositis by transforming growth factor beta 3.
Topics: Animals; Cell Cycle; Cell Division; CHO Cells; Cricetinae; Disease Models, Animal; DNA; Epithelial C | 1994 |
Cryotherapy reduces fluorouracil-related side effects.
Topics: Adult; Antimetabolites, Antineoplastic; Colostomy; Cryotherapy; Female; Fluorouracil; Humans; Male; | 1995 |
A new conservative approach to extravasation of anthracyclines with dimethylsulfoxide and dexrazoxane.
Topics: Adult; Anti-Inflammatory Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; C | 2001 |
Healing of experimental colonic anastomoses: effects of combined preoperative high-dose radiotherapy and intraperitoneal 5-fluorouracil.
Topics: Anastomosis, Surgical; Animals; Antimetabolites, Antineoplastic; Body Weight; Colon; Colonic Disease | 2001 |
Ileocecal ulcer caused by chemotherapy.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Colonoscopy; Fluorouracil; Humans; | 2002 |
Effect of epidermal growth factor on ulcerative mucositis in hamsters that receive cancer chemotherapy.
Topics: Animals; Cell Division; Cricetinae; Epidermal Growth Factor; Epithelial Cells; Epithelium; Fluoroura | 1992 |
Chronic ulcerations following topical therapy with 5-fluorouracil for vaginal human papillomavirus-associated lesions.
Topics: Administration, Intravaginal; Adolescent; Adult; Aged; Cervix Uteri; Chronic Disease; Female; Fluoro | 1991 |
The value of fluorinated pyrimidines in advanced malignancy.
Topics: Adult; Breast Neoplasms; Colonic Neoplasms; Diarrhea; Female; Floxuridine; Fluorouracil; Humans; Leu | 1968 |