fluorouracil has been researched along with Tympanic Membrane Perforation in 1 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Tympanic Membrane Perforation: A temporary or persistent opening in the eardrum (TYMPANIC MEMBRANE). Clinical signs depend on the size, location, and associated pathological condition.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The mean patency of tympanic membrane perforations following incisional myringotomy was significantly longer in the 5-fluorouracil-treated group (11." | 3.73 | [The effect of topical application of 5-fluorouracil on patency times after incisional myringotomy of guinea pig tympanic membrane]. ( Ateş, G; Aydin, S; Bozkurt, Z; Eken, M; Evren, C; Sanli, A, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Eken, M | 1 |
| Evren, C | 1 |
| Ateş, G | 1 |
| Bozkurt, Z | 1 |
| Sanli, A | 1 |
| Aydin, S | 1 |
1 other study available for fluorouracil and Tympanic Membrane Perforation
| Article | Year |
|---|---|
[The effect of topical application of 5-fluorouracil on patency times after incisional myringotomy of guinea pig tympanic membrane].
Topics: Administration, Topical; Animals; Antimetabolites; Disease Models, Animal; Fluorouracil; Guinea Pigs | 2006 |