fluorouracil has been researched along with Tumour Lysis Syndrome in 11 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 57-year-old woman developed severe tumor lysis syndrome characterized by acute hyperuricemic nephropathy, hyperphosphatemia, hyperkalemia, and hypocalcemia after therapy with cyclophosphamide, methotrexate, and 5-fluorouracil for metastatic infiltrating ductal carcinoma of the breast involving the chest wall, lungs, pleurae, and liver." | 3.67 | Tumor lysis syndrome in nonhematopoietic neoplasms. ( Barton, JC, 1989) |
| "A huge ascending colon cancer measuring 10 cm in diameter and with peritoneal dissemination was diagnosed." | 1.42 | [Tumor lysis syndrome after FOLFIRI+cetuximab for ascending colon cancer]. ( Hashiguchi, K; Kuramoto, T; Matsuyama, S; Tanaka, R, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (9.09) | 18.7374 |
| 1990's | 3 (27.27) | 18.2507 |
| 2000's | 3 (27.27) | 29.6817 |
| 2010's | 3 (27.27) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Launay, M | 1 |
| Guitton, J | 1 |
| Balluet, R | 1 |
| Moreau, A | 1 |
| Phelip, JM | 1 |
| Tholance, Y | 1 |
| Gonzalo, P | 1 |
| Gouveia, HS | 1 |
| Lopes, SO | 1 |
| Faria, AL | 1 |
| Matsuyama, S | 1 |
| Kuramoto, T | 1 |
| Tanaka, R | 1 |
| Hashiguchi, K | 1 |
| Bercovitz, RS | 1 |
| Greffe, BS | 1 |
| Hunger, SP | 1 |
| Kurt, M | 1 |
| Eren, OO | 1 |
| Engin, H | 1 |
| Güler, N | 1 |
| Hentrich, M | 1 |
| Schiel, X | 1 |
| Scheidt, B | 1 |
| Reitmeier, M | 1 |
| Hoffmann, U | 1 |
| Lutz, L | 1 |
| Han, HS | 1 |
| Park, SR | 1 |
| Kim, SY | 1 |
| Park, YI | 1 |
| Lee, JS | 1 |
| Kook, MC | 1 |
| Choi, IJ | 1 |
| Kim, CG | 1 |
| Lee, JR | 1 |
| Cho, SJ | 1 |
| Kim, NK | 1 |
| Stéphan, F | 1 |
| Etienne, MC | 1 |
| Wallays, C | 1 |
| Milano, G | 1 |
| Clergue, F | 1 |
| Shamseddine, AI | 1 |
| Khalil, AM | 1 |
| Wehbeh, MH | 1 |
| Khalil, A | 1 |
| Chammas, M | 1 |
| Shamseddine, A | 1 |
| Seoud, M | 1 |
| Barton, JC | 1 |
11 other studies available for fluorouracil and Tumour Lysis Syndrome
| Article | Year |
|---|---|
Clinical considerations for DPD deficiency testing in advanced cancer patients: tumor lysis syndrome should be considered as a major interference.
Topics: Dihydropyrimidine Dehydrogenase Deficiency; Dihydrouracil Dehydrogenase (NADP); Fluorouracil; Humans | 2022 |
Management of tumour lysis syndrome during first-line palliative chemotherapy for high-volume colorectal cancer.
Topics: Adenocarcinoma; Allopurinol; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Diag | 2018 |
[Tumor lysis syndrome after FOLFIRI+cetuximab for ascending colon cancer].
Topics: Aged, 80 and over; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothec | 2015 |
Acute tumor lysis syndrome in a 7-month-old with hepatoblastoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Disseminated Intravascular Coagulation; F | 2010 |
Tumor lysis syndrome following a single dose of capecitabine.
Topics: Adult; Antimetabolites, Antineoplastic; Breast Neoplasms; Capecitabine; Deoxycytidine; Female; Fluor | 2004 |
Fatal tumor lysis syndrome after irinotecan/5-FU/folinic acid/bevacizumab-containing therapy in a patient heavily pretreated for metastatic colon cancer.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Prot | 2008 |
Tumor lysis syndrome after capecitabine plus cisplatin treatment in advanced gastric cancer.
Topics: Adenocarcinoma; Adult; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protoco | 2008 |
Depressed hepatic dihydropyrimidine dehydrogenase activity and fluorouracil-related toxicities.
Topics: Adenocarcinoma; Adult; Antimetabolites, Antineoplastic; Brain Diseases; Cecal Neoplasms; Dihydrourac | 1995 |
Acute tumor lysis syndrome with squamous cell carcinoma of the vulva.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Female; F | 1993 |
Fatal acute tumor lysis syndrome following treatment of vulvar carcinoma: case report.
Topics: Aged; Carcinoma, Squamous Cell; Cisplatin; Diabetes Complications; Fatal Outcome; Female; Fluorourac | 1998 |
Tumor lysis syndrome in nonhematopoietic neoplasms.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Breast Neoplasms; Carcinoma, Intraductal, | 1989 |