fluorouracil has been researched along with Transfusion Reaction in 5 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Transfusion Reaction: Complications of BLOOD TRANSFUSION. Included adverse reactions are common allergic and febrile reactions; hemolytic (delayed and acute) reactions; and other non-hemolytic adverse reactions such as infections and adverse immune reactions related to immunocompatibility.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a multicentre trial of adjuvant chemotherapy in gastric adenocarcinoma, a number of patients developed chronic haemolysis and renal failure following long-term treatment with 5-fluorouracil and mitomycin-C." | 3.66 | Intravascular haemolysis and renal impairment after blood transfusion in two patients on long-term 5-fluorouracil and mitomycin-C. ( Brookes, VS; Fielding, JW; Howell, A; Jones, BG; Newman, CE, 1980) |
| "Following gastrectomy for locally advanced adenocarcinomas, three patients developed microangiopathic hemolytic anemia and renal failure shortly after completing courses of adjuvant chemotherapy with mitomycin and 5-FU." | 3.66 | Microangiopathic hemolytic anemia, renal failure, and noncardiogenic pulmonary edema: a chemotherapy-induced syndrome. ( Band, PR; Bettez, P; Giroux, L; Gruber, J; Jolivet, J; Laurin, S, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jones, BG | 1 |
| Fielding, JW | 1 |
| Newman, CE | 1 |
| Howell, A | 1 |
| Brookes, VS | 1 |
| Jolivet, J | 1 |
| Giroux, L | 1 |
| Laurin, S | 1 |
| Gruber, J | 1 |
| Bettez, P | 1 |
| Band, PR | 1 |
| Carbone, PP | 1 |
| Goldfinger, D | 1 |
| McGinniss, MH | 1 |
1 trial available for fluorouracil and Transfusion Reaction
| Article | Year |
|---|---|
Second Joint Working Conference: National Cancer Institute Chemotherapy Program. Working session report: clinical trials.
Topics: Antineoplastic Agents; Blood Platelets; Brain Neoplasms; Breast Neoplasms; Clinical Trials as Topic; | 1972 |
4 other studies available for fluorouracil and Transfusion Reaction
| Article | Year |
|---|---|
Intravascular haemolysis and renal impairment after blood transfusion in two patients on long-term 5-fluorouracil and mitomycin-C.
Topics: Adenocarcinoma; Adult; Anemia, Macrocytic; Brain Edema; Disseminated Intravascular Coagulation; Fema | 1980 |
Microangiopathic hemolytic anemia, renal failure, and noncardiogenic pulmonary edema: a chemotherapy-induced syndrome.
Topics: Adenocarcinoma; Adult; Anemia, Hemolytic; Drug Therapy, Combination; Female; Fluorouracil; Humans; K | 1983 |
[Delayed post-transfusional hemolysis, leukemoid syndrome, autoimmune hemolytic anemia. Coordinating Committee for the Specific Study of Anemias under the chairmanship of H. Rochant].
Topics: Anemia, Aplastic; Anemia, Hemolytic, Autoimmune; Autoimmune Diseases; Colonic Neoplasms; Female; Flu | 1987 |
Rh-incompatible platelet transfusions--risks and consequences of sensitizing immunosuppressed patients.
Topics: Adolescent; Adult; Aged; Anemia, Aplastic; Antibodies; Antibody Formation; Blood Group Incompatibili | 1971 |