fluorouracil has been researched along with Thymoma in 8 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Thymoma: A neoplasm originating from thymic tissue, usually benign, and frequently encapsulated. Although it is occasionally invasive, metastases are extremely rare. It consists of any type of thymic epithelial cell as well as lymphocytes that are usually abundant. Malignant lymphomas that involve the thymus, e.g., lymphosarcoma, Hodgkin's disease (previously termed granulomatous thymoma), should not be regarded as thymoma. (From Stedman, 25th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To predict tumor sensitivity to 5-fluorouracil (5-FU) in thymoma, we investigated the mRNA levels of thymidylate synthase (TS), the key enzyme that catalyzes the methylation of deoxyuridine monophosphate, and correlates with the resistance of 5-FU and dihydropyrimidine dehydrogenase (DPD), which degrades 5-FU in thymoma." | 3.72 | Thymidylate synthase and dihydropyrimidine dehydrogenase mRNA levels in thymoma. ( Fujii, Y; Fukai, I; Kaji, M; Kiriyama, M; Sasaki, H; Yamakawa, Y; Yano, M, 2003) |
| "Thymic carcinoma is a rare anterior mediastinal neoplasm." | 1.32 | Concurrent chemoradiotherapy for unresectable thymic carcinoma. ( Chen, YY; Eng, HL; Huang, CH; Tang, Y, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (25.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Leelakanok, N | 1 |
| Geary, SM | 1 |
| Salem, AK | 1 |
| Heine, A | 1 |
| Schmiedel, A | 1 |
| Menschik, T | 1 |
| Held, SA | 1 |
| Erdmann, C | 1 |
| Brossart, P | 1 |
| Rajan, A | 1 |
| Giaccone, G | 1 |
| Sasaki, H | 1 |
| Fukai, I | 1 |
| Kiriyama, M | 1 |
| Kaji, M | 1 |
| Yano, M | 1 |
| Yamakawa, Y | 1 |
| Fujii, Y | 1 |
| Chen, YY | 1 |
| Huang, CH | 1 |
| Tang, Y | 1 |
| Eng, HL | 1 |
| Tampellini, M | 1 |
| Alabiso, I | 1 |
| Sculli, CM | 1 |
| Barberis, M | 1 |
| Giachino, D | 1 |
| Berruti, A | 1 |
| Dogliotti, L | 1 |
| Donovan, PJ | 1 |
| Foley, JF | 1 |
| Sagara, N | 1 |
| Kurooka, K | 1 |
| Mori, K | 1 |
| Kayama, H | 1 |
| Haeno, Y | 1 |
| Hara, S | 1 |
| Yasutomi, M | 1 |
1 review available for fluorouracil and Thymoma
| Article | Year |
|---|---|
Chemotherapy for thymic tumors: induction, consolidation, palliation.
Topics: Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Cisplatin; Clinical Trials as Topic; C | 2011 |
7 other studies available for fluorouracil and Thymoma
| Article | Year |
|---|---|
Antitumor Efficacy and Toxicity of 5-Fluorouracil-Loaded Poly(Lactide Co-glycolide) Pellets.
Topics: Animals; Antimetabolites, Antineoplastic; Colonic Neoplasms; Delayed-Action Preparations; Drug Carri | 2018 |
Regression of liver metastases after treatment with oxaliplatin/capecitabine and development of a progressive multifocal leukoencephalopathy in a patient with advanced thymoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Deoxycytidine; Fluorouracil; Humans; L | 2013 |
Thymidylate synthase and dihydropyrimidine dehydrogenase mRNA levels in thymoma.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Dihydrouracil Dehydrogenase (NADP); | 2003 |
Concurrent chemoradiotherapy for unresectable thymic carcinoma.
Topics: Aged; Antineoplastic Agents; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Doxorubicin; Fe | 2004 |
Stage IB malignant thymoma in a Lynch syndrome patient with multiple cancers: response to incidental administration of oxaliplatin and 5-fluorouracil.
Topics: Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms, Hereditary Nonpolyposis; Femal | 2006 |
Chemotherapy in invasive thymomas: five case reports.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Dacarbazine; Doxorubicin; Female; | 1986 |
[A case of non-resectable thymoma which responded to the administration of adriamycin, vindesine and 5-FU].
Topics: Antineoplastic Combined Chemotherapy Protocols; Doxorubicin; Female; Fluorouracil; Humans; Middle Ag | 1986 |