fluorouracil has been researched along with Thiamine Deficiency in 8 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Thiamine Deficiency: A nutritional condition produced by a deficiency of THIAMINE in the diet, characterized by anorexia, irritability, and weight loss. Later, patients experience weakness, peripheral neuropathy, headache, and tachycardia. In addition to being caused by a poor diet, thiamine deficiency in the United States most commonly occurs as a result of alcoholism, since ethanol interferes with thiamine absorption. In countries relying on polished rice as a dietary staple, BERIBERI prevalence is very high. (From Cecil Textbook of Medicine, 19th ed, p1171)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fluorouracil-induced leukoencephalopathy is a rare complication and has been reported to present as confusion, oculomotor abnormality, ataxia, and parkinsonism; however, there is no previous report of a presentation mimicking neuroleptic malignant syndrome." | 8.31 | Fluorouracil-induced leukoencephalopathy mimicking neuroleptic malignant syndrome: a case report. ( Hemachudha, P; Phuenpathom, W; Pongpitakmetha, T; Rattanawong, W, 2023) |
| "Gastrointestinal cancer and its treatment using fluorouracil-based anticancer agents are risk factors for thiamine deficiency (TD)." | 7.96 | Potential thiamine deficiency in elderly patients with gastrointestinal cancer undergoing chemotherapy . ( Iimura, Y; Kuroda, S; Momo, K; Yasu, T, 2020) |
| "Fluorouracil-induced leukoencephalopathy is a rare complication and has been reported to present as confusion, oculomotor abnormality, ataxia, and parkinsonism; however, there is no previous report of a presentation mimicking neuroleptic malignant syndrome." | 4.31 | Fluorouracil-induced leukoencephalopathy mimicking neuroleptic malignant syndrome: a case report. ( Hemachudha, P; Phuenpathom, W; Pongpitakmetha, T; Rattanawong, W, 2023) |
| "Gastrointestinal cancer and its treatment using fluorouracil-based anticancer agents are risk factors for thiamine deficiency (TD)." | 3.96 | Potential thiamine deficiency in elderly patients with gastrointestinal cancer undergoing chemotherapy . ( Iimura, Y; Kuroda, S; Momo, K; Yasu, T, 2020) |
| " Wernicke's encephalopathy is an acute, neuropsychiatric syndrome resulting from thiamine deficiency, and has significant morbidity and mortality." | 3.75 | A case of Wernicke's encephalopathy following fluorouracil-based chemotherapy. ( Chang, HJ; Cho, IJ; Choi, MY; Lee, KE; Lee, SN; Mun, YC; Nam, EM; Seong, CM; Won, HS, 2009) |
| "Patients with breast cancer may show an increased requirement for thiamin particularly when treated with 5-fluorouracil, and a number of metabolic disturbances in which ascorbic acid may play a central role." | 1.26 | Nutrition and breast cancer. ( Dickerson, JW, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (25.00) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 3 (37.50) | 2.80 |
| Authors | Studies |
|---|---|
| Hemachudha, P | 1 |
| Rattanawong, W | 1 |
| Pongpitakmetha, T | 1 |
| Phuenpathom, W | 1 |
| Iimura, Y | 2 |
| Kurokawa, T | 1 |
| Nojima, M | 1 |
| Kanemoto, Y | 1 |
| Yazawa, K | 1 |
| Tsurita, G | 1 |
| Kuroda, S | 2 |
| Yasu, T | 1 |
| Momo, K | 1 |
| Cho, IJ | 1 |
| Chang, HJ | 1 |
| Lee, KE | 1 |
| Won, HS | 1 |
| Choi, MY | 1 |
| Nam, EM | 1 |
| Mun, YC | 1 |
| Lee, SN | 1 |
| Seong, CM | 1 |
| Aksoy, M | 1 |
| Basu, TK | 1 |
| Brient, J | 1 |
| Dickerson, JW | 2 |
| Kondo, K | 1 |
| Fujiwara, M | 1 |
| Murase, M | 1 |
| Kodera, Y | 1 |
| Akiyama, S | 1 |
| Ito, K | 1 |
| Takagi, H | 1 |
| Moore, DH | 1 |
| Fowler, WC | 1 |
| Crumpler, LS | 1 |
8 other studies available for fluorouracil and Thiamine Deficiency
| Article | Year |
|---|---|
Fluorouracil-induced leukoencephalopathy mimicking neuroleptic malignant syndrome: a case report.
Topics: Aged; Colonic Neoplasms; Fluorouracil; Humans; Leukoencephalopathies; Male; Neuroleptic Malignant Sy | 2023 |
Potential thiamine deficiency and neurological symptoms in patients receiving chemotherapy for gastrointestinal cancer.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Female; Fluorouracil; Folic Acid; G | 2020 |
Potential thiamine deficiency in elderly patients with gastrointestinal cancer undergoing chemotherapy
.
Topics: Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Female; Fluorouracil; Gastrointestinal Neo | 2020 |
A case of Wernicke's encephalopathy following fluorouracil-based chemotherapy.
Topics: Acute Disease; Antimetabolites, Antineoplastic; Female; Fluorouracil; Humans; Magnetic Resonance Ima | 2009 |
Thiamin status of patients treated with drug combinations containing 5-fluorouracil.
Topics: Adult; Aged; Drug Therapy, Combination; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasms; | 1980 |
Severe acute metabolic acidosis and Wernicke's encephalopathy following chemotherapy with 5-fluorouracil and cisplatin: case report and review of the literature.
Topics: Acidosis; Acute Disease; Adult; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Female; F | 1996 |
Nutrition and breast cancer.
Topics: Animals; Ascorbic Acid; Bone Neoplasms; Breast Neoplasms; Calcium; Dietary Fats; Feeding Behavior; F | 1979 |
5-Fluorouracil neurotoxicity.
Topics: Adult; Carcinoma, Squamous Cell; Female; Fluorouracil; Humans; Middle Aged; Nervous System Diseases; | 1990 |