fluorouracil has been researched along with Taste Disorder, Anterior Tongue in 7 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Forty-five consecutive breast cancer patients, eligible for adjuvant CT with cyclophosphamide, epirubicin or methotrexate, and 5-fluorouracil were followed before, during, 6 months and 1 year after CT and were compared to a control group of 31 breast cancer patients not receiving adjuvant CT." | 3.74 | Oral mucosal lesions, microbial changes, and taste disturbances induced by adjuvant chemotherapy in breast cancer patients. ( Bergmann, OJ; Brünner, N; Jensen, SB; Mouridsen, HT; Nauntofte, B; Reibel, J, 2008) |
| "Literature search for metallic taste and chemotherapy was performed in PubMed up to September 2014, resulting in 184 articles of which 13 articles fulfilled the inclusion criteria: English publications addressing metallic taste in cancer patients treated with FDA-approved chemotherapy." | 2.52 | Metallic taste in cancer patients treated with chemotherapy. ( IJpma, I; Renken, RJ; Reyners, AK; Ter Horst, GJ, 2015) |
| "Taste disorders are common adverse effects of cancer chemotherapy that can reduce quality of life and impair nutritional status." | 1.56 | Drinking Ice-Cold Water Reduces the Severity of Anticancer Drug-Induced Taste Dysfunction in Mice. ( Hirayama, A; Hirose, F; Iwata, S; Kawabata, Y; Oike, A; Osaki, A; Sanematsu, K; Shigemura, N; Takai, S; Wada, N; Watanabe, Y; Yamada, Y; Yamazoe, J, 2020) |
| "Taste disorders are frequent occurrences among those patients under the FOLFOX-FOLFIRI regimen for colorectal cancer." | 1.35 | [Development of taste disorders following FOLFOX-FOLFIRI therapy and its effects on the QOL of patients with colorectal cancer]. ( Adachi, M; Iida, A; Mori, K; Sakakibara, T; Sugawara, S; Sugiura, M; Takimoto, N; Yamamura, K, 2009) |
| " It was found that acute taste disorders develop frequently among patients on a high dosage of 5-FU or a taxane-containing regimen." | 1.35 | [Incidence of taste disorder associated with cancer patients undergoing chemotherapy on an ambulatory basis]. ( Adachi, M; Iida, A; Mori, K; Sugawara, S; Sugiura, M; Takimoto, N; Yamamura, K, 2009) |
| "Patients complaining from taste disorders during RCT exhibited a significant decrease of taste function assessed with both natural and electric stimuli." | 1.33 | Confocal microscopy of the peripheral gustatory system: comparison between healthy subjects and patients suffering from taste disorders during radiochemotherapy. ( Bombor, I; Fietkau, R; Guthoff, RF; Hummel, T; Just, T; Pau, HW, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (57.14) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Osaki, A | 1 |
| Sanematsu, K | 1 |
| Yamazoe, J | 1 |
| Hirose, F | 1 |
| Watanabe, Y | 1 |
| Kawabata, Y | 1 |
| Oike, A | 1 |
| Hirayama, A | 1 |
| Yamada, Y | 1 |
| Iwata, S | 1 |
| Takai, S | 1 |
| Wada, N | 1 |
| Shigemura, N | 1 |
| Cohen, PR | 1 |
| IJpma, I | 1 |
| Renken, RJ | 1 |
| Ter Horst, GJ | 1 |
| Reyners, AK | 1 |
| Jensen, SB | 1 |
| Mouridsen, HT | 1 |
| Bergmann, OJ | 1 |
| Reibel, J | 1 |
| Brünner, N | 1 |
| Nauntofte, B | 1 |
| Takimoto, N | 2 |
| Sugawara, S | 2 |
| Iida, A | 2 |
| Sakakibara, T | 1 |
| Mori, K | 2 |
| Sugiura, M | 2 |
| Yamamura, K | 2 |
| Adachi, M | 2 |
| Just, T | 1 |
| Pau, HW | 1 |
| Bombor, I | 1 |
| Guthoff, RF | 1 |
| Fietkau, R | 1 |
| Hummel, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Changes in Sense of Taste of Patients Submitted to Hematopoietic Stem Cell Transplantation[NCT03498950] | 80 participants (Actual) | Interventional | 2016-02-29 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for fluorouracil and Taste Disorder, Anterior Tongue
| Article | Year |
|---|---|
Topical application of 5-fluorouracil 5 percent cream associated with severe neutropenia: discussion of a case and review of systemic reactions after topical treatment with 5-fluorouracil.
Topics: Administration, Cutaneous; Aged; Angioedema; Antimetabolites, Antineoplastic; Cheilitis; Fluorouraci | 2018 |
Metallic taste in cancer patients treated with chemotherapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Doxorubicin; Fluorouracil; Humans; | 2015 |
5 other studies available for fluorouracil and Taste Disorder, Anterior Tongue
| Article | Year |
|---|---|
Drinking Ice-Cold Water Reduces the Severity of Anticancer Drug-Induced Taste Dysfunction in Mice.
Topics: Animals; Cell Proliferation; Cisplatin; Disease Models, Animal; Docetaxel; Fluorouracil; Head and Ne | 2020 |
Oral mucosal lesions, microbial changes, and taste disturbances induced by adjuvant chemotherapy in breast cancer patients.
Topics: Adult; Aged; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents, Al | 2008 |
[Development of taste disorders following FOLFOX-FOLFIRI therapy and its effects on the QOL of patients with colorectal cancer].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Female; Fl | 2009 |
[Incidence of taste disorder associated with cancer patients undergoing chemotherapy on an ambulatory basis].
Topics: Adult; Aged; Aged, 80 and over; Ambulatory Care; Antimetabolites, Antineoplastic; Appetite; Data Col | 2009 |
Confocal microscopy of the peripheral gustatory system: comparison between healthy subjects and patients suffering from taste disorders during radiochemotherapy.
Topics: Adult; Aged; Antineoplastic Agents; Cell Count; Cisplatin; Epithelium; Female; Fluorouracil; Head an | 2005 |