Page last updated: 2024-10-27

fluorouracil and Systolic Heart Failure

fluorouracil has been researched along with Systolic Heart Failure in 1 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Research Excerpts

ExcerptRelevanceReference
" Patients are now surviving long enough for the adverse cardiovascular effects of some cancer therapies to become apparent."2.44Chemotherapy and cardiotoxicity. ( Broder, H; Gottlieb, RA; Lepor, NE, 2008)

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Broder, H1
Gottlieb, RA1
Lepor, NE1

Reviews

1 review available for fluorouracil and Systolic Heart Failure

ArticleYear
Chemotherapy and cardiotoxicity.
    Reviews in cardiovascular medicine, 2008,Spring, Volume: 9, Issue:2

    Topics: Age of Onset; Anthracyclines; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplas

2008