fluorouracil has been researched along with Stomach Ulcer in 13 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Stomach Ulcer: Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Gastric ulceration resulted from regional (infusion) chemotherapy when high doses of 5-fluorouracil were accidently infused into the stomach during hepatic artery infusions." | 3.66 | Partial protection of the gastric toxicity of regional 5-fluorouracil infusion by thymidine and cimetidine. ( Al-Jurf, AS, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (46.15) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (23.08) | 29.6817 |
| 2010's | 4 (30.77) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yoshioka, T | 1 |
| Fukuda, A | 1 |
| Araki, O | 1 |
| Ogawa, S | 1 |
| Hanyu, Y | 1 |
| Matsumoto, Y | 1 |
| Yamaga, Y | 1 |
| Nakanishi, Y | 1 |
| Kawada, K | 1 |
| Sakai, Y | 1 |
| Chiba, T | 1 |
| Seno, H | 1 |
| Aksinenko, SG | 1 |
| Suslov, NI | 1 |
| Povet'eva, TN | 1 |
| Nesterova, YV | 1 |
| Kharina, TG | 1 |
| Kravtsova, SS | 1 |
| Chon, YE | 1 |
| Seong, J | 1 |
| Kim, BK | 1 |
| Cha, J | 1 |
| Kim, SU | 1 |
| Park, JY | 1 |
| Ahn, SH | 1 |
| Han, KH | 1 |
| Chon, CY | 1 |
| Shin, SK | 1 |
| Kim, DY | 1 |
| Fukuhara, K | 1 |
| Terakura, M | 1 |
| Katsuragi, K | 1 |
| Segura Huerta, A | 1 |
| Pérez-Fidalgo, JA | 1 |
| López-Tendero, P | 1 |
| Gironés Sarrió, R | 1 |
| Aparicio Urtasun, J | 1 |
| NICOD, JL | 1 |
| Kotani, T | 1 |
| Nakagiri, A | 1 |
| Murashima, Y | 1 |
| Takeuchi, K | 1 |
| Al-Jurf, AS | 1 |
| Sartori, S | 1 |
| Trevisani, L | 1 |
| Nielsen, I | 1 |
| Tassinari, D | 1 |
| Panzini, I | 1 |
| Abbasciano, V | 1 |
| Narsete, T | 1 |
| Ansfield, F | 1 |
| Wirtanen, G | 1 |
| Ramirez, G | 1 |
| Wolberg, W | 1 |
| Jarrett, F | 1 |
| Orlovskaia, LA | 1 |
| Guleva, MN | 1 |
| Palasz, M | 1 |
| Athanassiades, S | 1 |
| Deligeorge, H | 1 |
| Kalachanis, N | 1 |
| Paraskevas, G | 1 |
2 reviews available for fluorouracil and Stomach Ulcer
| Article | Year |
|---|---|
[Severe gastric and duodenal ulcer after chemotherapy of mFOLFOX6 and bevacizumab].
Topics: Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherap | 2011 |
[Effect of some drugs in the development and exacerbation of gastric and duodenal ulcer].
Topics: Adrenocorticotropic Hormone; Aspirin; Caffeine; Catecholamines; Duodenal Ulcer; Fluorouracil; Glucoc | 1974 |
1 trial available for fluorouracil and Stomach Ulcer
| Article | Year |
|---|---|
Randomized trial of omeprazole or ranitidine versus placebo in the prevention of chemotherapy-induced gastroduodenal injury.
Topics: Adult; Aged; Anti-Ulcer Agents; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Duodenal | 2000 |
10 other studies available for fluorouracil and Stomach Ulcer
| Article | Year |
|---|---|
Bmi1 marks gastric stem cells located in the isthmus in mice.
Topics: Acetic Acid; Animals; Biomarkers; Cell Differentiation; Cell Lineage; Cell Proliferation; Disease Mo | 2019 |
Antitoxic Activity of Extract from Salix Viminalis Leaves under Conditions of 5-Fluorouracil Treatment.
Topics: Animals; Antimetabolites, Antineoplastic; Blood Cell Count; Bone Marrow; Carcinoma, Lewis Lung; Cyto | 2015 |
Gastroduodenal complications after concurrent chemoradiation therapy in patients with hepatocellular carcinoma: endoscopic findings and risk factors.
Topics: Adult; Antimetabolites, Antineoplastic; Carcinoma, Hepatocellular; Chemoradiotherapy; Duodenal Ulcer | 2011 |
[Thirteen years' survival in a patient with isolated skin metastases of a gastric carcinoma. What kind of disease is that?].
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Signet Ring Cell; Cisplatin; Cobalt Radio | 2003 |
[STOMACH ULCERS DUE TO DRUGS].
Topics: Adrenal Cortex Hormones; Cortisone; Duodenal Ulcer; Fluorouracil; Geriatrics; Oxyphenbutazone; Salic | 1964 |
Prophylactic effect of lafutidine against the adverse reaction induced in rat stomach by repeated administration of 5-fluorouracil.
Topics: Acetamides; Animals; Anti-Ulcer Agents; Cimetidine; Dinoprostone; Drug Interactions; Fluorouracil; G | 2007 |
Partial protection of the gastric toxicity of regional 5-fluorouracil infusion by thymidine and cimetidine.
Topics: Animals; Cimetidine; Dogs; Fluorouracil; Gastric Acid; Gastric Mucosa; Guanidines; Infusions, Intra- | 1982 |
Gastric ulceration in patients receiving intrahepatic infusion of 5-fluorouracil.
Topics: Adult; Aged; Catheterization; Female; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arteria | 1977 |
[Use of antimetabolites in treating callous perforating stomach ulcers].
Topics: Antimetabolites, Antineoplastic; Callosities; Female; Fluorouracil; Humans; Injections, Intralymphat | 1985 |
Pathologic changes in the gastroduodenal mucosa after intra-arterial infusion of 5-fluorouracil.
Topics: Animals; Arteries; Catheterization; Dogs; Duodenum; Fluorouracil; Gastric Mucosa; Gastrointestinal H | 1973 |