fluorouracil has been researched along with Spinal Cord Neoplasms in 5 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Spinal Cord Neoplasms: Benign and malignant neoplasms which occur within the substance of the spinal cord (intramedullary neoplasms) or in the space between the dura and spinal cord (intradural extramedullary neoplasms). The majority of intramedullary spinal tumors are primary CNS neoplasms including ASTROCYTOMA; EPENDYMOMA; and LIPOMA. Intramedullary neoplasms are often associated with SYRINGOMYELIA. The most frequent histologic types of intradural-extramedullary tumors are MENINGIOMA and NEUROFIBROMA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Twenty-one patients with recurrent malignant central nervous system gliomas were treated with a combination of 5-fluorouracil, CCNU, hydroxyurea, and 6-mercaptopurine." | 7.67 | Treatment of recurrent brain stem gliomas and other central nervous system tumors with 5-fluorouracil, CCNU, hydroxyurea, and 6-mercaptopurine. ( Edwards, MS; Fulton, D; Levin, V; Prados, M; Rodriguez, LA; Silver, P, 1988) |
| "5FC, 5-fluorocytosineBBB, Basso, Beattie, and BresnahanCD, cytosine deaminaseDP, diastolic blood pressureGCV, ganciclovir; hNSCs, human neural stem cellsISCG, intramedullary spinal cord gliomasMAP, mean arterial blood pressureNSCs, neural stem cellsSP, systolic blood pressureTK, thymidine kinase." | 3.83 | Targeted Treatment of Experimental Spinal Cord Glioma With Dual Gene-Engineered Human Neural Stem Cells. ( Abd-El-Barr, M; Aljuboori, Z; Anderson, JE; Chi, JH; Han, I; Haragopal, H; Kim, SU; Lee, HJ; Ropper, AE; Sidman, RL; Snyder, EY; Teng, YD; Viapiano, MS; Zeng, X, 2016) |
| "Twenty-one patients with recurrent malignant central nervous system gliomas were treated with a combination of 5-fluorouracil, CCNU, hydroxyurea, and 6-mercaptopurine." | 3.67 | Treatment of recurrent brain stem gliomas and other central nervous system tumors with 5-fluorouracil, CCNU, hydroxyurea, and 6-mercaptopurine. ( Edwards, MS; Fulton, D; Levin, V; Prados, M; Rodriguez, LA; Silver, P, 1988) |
| "Patients with cancer commonly suffer neurologic disabilities." | 2.37 | Neurologic complications of systemic cancer. ( Patchell, RA; Posner, JB, 1985) |
| "We report a case of breast cancer with spinal and vertebral lesions." | 1.32 | [Successful combination therapy with 5'-DFUR and MPA for breast cancer with spinal and vertebral metastases]. ( Hashiguchi, H; Hirooka, Y; Kamasako, A; Nozaka, K; Ohgami, Y; Otani, S; Takebayashi, M; Tanida, O; Toyota, N; Wakatsuki, T, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (60.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ropper, AE | 1 |
| Zeng, X | 1 |
| Haragopal, H | 1 |
| Anderson, JE | 1 |
| Aljuboori, Z | 1 |
| Han, I | 1 |
| Abd-El-Barr, M | 1 |
| Lee, HJ | 1 |
| Sidman, RL | 1 |
| Snyder, EY | 1 |
| Viapiano, MS | 1 |
| Kim, SU | 1 |
| Chi, JH | 1 |
| Teng, YD | 1 |
| WILSON, WL | 1 |
| DELAGARZA, JG | 1 |
| Otani, S | 1 |
| Toyota, N | 1 |
| Nozaka, K | 1 |
| Wakatsuki, T | 1 |
| Takebayashi, M | 1 |
| Kamasako, A | 1 |
| Tanida, O | 1 |
| Hashiguchi, H | 1 |
| Ohgami, Y | 1 |
| Hirooka, Y | 1 |
| Rodriguez, LA | 1 |
| Prados, M | 1 |
| Fulton, D | 1 |
| Edwards, MS | 1 |
| Silver, P | 1 |
| Levin, V | 1 |
| Patchell, RA | 1 |
| Posner, JB | 1 |
1 review available for fluorouracil and Spinal Cord Neoplasms
| Article | Year |
|---|---|
Neurologic complications of systemic cancer.
Topics: Arachnoid; Bacterial Infections; Brain; Brain Neoplasms; Cerebrovascular Disorders; Cisplatin; Disse | 1985 |
4 other studies available for fluorouracil and Spinal Cord Neoplasms
| Article | Year |
|---|---|
Targeted Treatment of Experimental Spinal Cord Glioma With Dual Gene-Engineered Human Neural Stem Cells.
Topics: Animals; Cytosine Deaminase; Flucytosine; Fluorouracil; Ganciclovir; Genetic Engineering; Genetic Th | 2016 |
SYSTEMIC CHEMOTHERAPY FOR CNS METASTASES OF SOLID TUMORS.
Topics: Adenocarcinoma; Brain Neoplasms; Breast Neoplasms; Cyclophosphamide; Drug Therapy; Floxuridine; Fluo | 1965 |
[Successful combination therapy with 5'-DFUR and MPA for breast cancer with spinal and vertebral metastases].
Topics: Adenocarcinoma, Scirrhous; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Combine | 2004 |
Treatment of recurrent brain stem gliomas and other central nervous system tumors with 5-fluorouracil, CCNU, hydroxyurea, and 6-mercaptopurine.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Brain Stem; Chil | 1988 |