fluorouracil has been researched along with Skin Ulcer in 24 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Skin Ulcer: An ULCER of the skin and underlying tissues.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The lesions of 5 patients with multiple cutaneous metastases were treated topically, 5 days per week, with 5-fluorouracil in the morning and imiquimod at night." | 9.16 | Topical treatment of cutaneous metastases of malignant melanoma using combined imiquimod and 5-fluorouracil. ( Desmedt, E; Florin, V; Mortier, L; Vercambre-Darras, S, 2012) |
| "Twenty-five patients with vitiligo were subjected to microneedling of 2 patches of vitiligo with dermapen, then application of 5-fluorouracil to 1 patch and tacrolimus on the other patch." | 7.88 | Comparison between the efficacy of microneedling combined with 5-fluorouracil vs microneedling with tacrolimus in the treatment of vitiligo. ( Al-Saeid, H; Elgarhy, L; Ibrahim, Z; Mina, M, 2018) |
| "Uterine metastases of the breast cancer caused obstructive nephropathy." | 5.35 | [A case of stage IV breast cancer with large cancer ulcer responding to combination therapy of capecitabine and medroxyprogesterone acetate and cyclophosphamide]. ( Hasegawa, N; Iimura, Y; Kaneko, H; Kawabata, M; Konishi, K; Shoji, Y, 2009) |
| " The dosage should be reduced or therapeutic regimen changed." | 5.34 | [Unilateral acral necrosis as a minor form of hand-foot syndrome. Patient with unilateral acral necrosis secondary to capecitabine therapy for metastatic breast cancer]. ( Ockenfels, HM; Saborowski, A; Sauter, C, 2007) |
| "The lesions of 5 patients with multiple cutaneous metastases were treated topically, 5 days per week, with 5-fluorouracil in the morning and imiquimod at night." | 5.16 | Topical treatment of cutaneous metastases of malignant melanoma using combined imiquimod and 5-fluorouracil. ( Desmedt, E; Florin, V; Mortier, L; Vercambre-Darras, S, 2012) |
| "Twenty-five patients with vitiligo were subjected to microneedling of 2 patches of vitiligo with dermapen, then application of 5-fluorouracil to 1 patch and tacrolimus on the other patch." | 3.88 | Comparison between the efficacy of microneedling combined with 5-fluorouracil vs microneedling with tacrolimus in the treatment of vitiligo. ( Al-Saeid, H; Elgarhy, L; Ibrahim, Z; Mina, M, 2018) |
| "An 83-year-old Caucasian man with cutaneous T-cell lymphoma developed an aggressive squamous cell carcinoma of the left forearm, which recurred and metastasized after Mohs micrographic surgery and systemic chemotherapy with cis-platin and 5-fluorouracil." | 3.70 | Invasive squamous cell carcinoma with sporotrichoid metastasis in a patient with cutaneous T cell lymphoma treated with chronic extracorporeal photopheresis. ( Beer, R; Elizeri, Y; Gmyrek, R; Grossman, ME; Oster, MW; Schneiderman, P; Silvers, DN, 1999) |
| "A 59-year-old man undergoing systemic 5-fluorouracil treatment for metastatic adenocarcinoma of the stomach developed ocular lesions consisting of bilateral conjunctival ulcers and ulcerative blepharitis leading to ankyloblepharon." | 3.67 | Ankyloblepharon associated with systemic 5-fluorouracil treatment. ( Helm, CJ; Insler, MS, 1987) |
| "Rectal squamous cell carcinoma is a rare tumour; it management should be based on anal curative and conservative intent chemoradiation." | 2.53 | [Rectal squamous cell carcinoma treatment: Retrospective experience in two French university hospitals, review and proposals]. ( Bosset, JF; Huguet, F; Loganadane, G; Schernberg, A; Servagi-Vernat, S; Touboul, E, 2016) |
| "5 fluorouracil therapy was terminated and the patients were shifted to interferon therapy subsequently." | 1.51 | Severe necrotising inflammatory skin reaction to topical 5-fluorouracil. ( Gokhale, NS, 2019) |
| "The treatment of anal cancer is based on concomitant radiotherapy and chemotherapy and is associated with a nonnegligible rate of local severe toxicities that can strongly impair the quality of life." | 1.39 | Predictive factors for early and late local toxicities in anal cancer treated by radiotherapy in combination with or without chemotherapy. ( Benezery, K; Doyen, J; Follana, P; Francois, E; Gal, J; Gérard, JP; Hannoun-Levi, JM; Ortholan, C, 2013) |
| "Uterine metastases of the breast cancer caused obstructive nephropathy." | 1.35 | [A case of stage IV breast cancer with large cancer ulcer responding to combination therapy of capecitabine and medroxyprogesterone acetate and cyclophosphamide]. ( Hasegawa, N; Iimura, Y; Kaneko, H; Kawabata, M; Konishi, K; Shoji, Y, 2009) |
| " The dosage should be reduced or therapeutic regimen changed." | 1.34 | [Unilateral acral necrosis as a minor form of hand-foot syndrome. Patient with unilateral acral necrosis secondary to capecitabine therapy for metastatic breast cancer]. ( Ockenfels, HM; Saborowski, A; Sauter, C, 2007) |
| "Chemotherapy is safe and effective treatment for patients with infected malignant breast ulcers and does not cause systemic sepsis." | 1.30 | Chemotherapy is a safe and effective initial therapy for infected malignant breast and chest wall ulcers. ( Braverman, AS; Dauphin, S; el Tamer, M; Katz, S; Sohn, C; Wait, R, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (29.17) | 18.7374 |
| 1990's | 2 (8.33) | 18.2507 |
| 2000's | 6 (25.00) | 29.6817 |
| 2010's | 9 (37.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gokhale, NS | 1 |
| Mina, M | 1 |
| Elgarhy, L | 1 |
| Al-Saeid, H | 1 |
| Ibrahim, Z | 1 |
| Doyen, J | 1 |
| Benezery, K | 1 |
| Follana, P | 1 |
| Ortholan, C | 1 |
| Gérard, JP | 1 |
| Hannoun-Levi, JM | 1 |
| Gal, J | 1 |
| Francois, E | 1 |
| Peguero, J | 1 |
| Khanfar, A | 1 |
| Mannem, S | 1 |
| Willis, M | 1 |
| Markowtiz, A | 1 |
| Imran, F | 1 |
| Harman, K | 1 |
| Schernberg, A | 1 |
| Servagi-Vernat, S | 1 |
| Loganadane, G | 1 |
| Touboul, E | 1 |
| Bosset, JF | 1 |
| Huguet, F | 1 |
| Konishi, K | 1 |
| Hasegawa, N | 1 |
| Kaneko, H | 1 |
| Iimura, Y | 1 |
| Shoji, Y | 1 |
| Kawabata, M | 1 |
| Florin, V | 1 |
| Desmedt, E | 1 |
| Vercambre-Darras, S | 1 |
| Mortier, L | 1 |
| Tsuboi, K | 1 |
| Kawase, Y | 1 |
| Okochi, O | 1 |
| Hattori, M | 1 |
| Takami, Y | 1 |
| Takeda, S | 1 |
| Mizuno, A | 1 |
| Sato, Y | 1 |
| Uno, Y | 1 |
| Hayashi, T | 1 |
| Sasada, Y | 1 |
| Takamura, S | 1 |
| Kozaki, K | 1 |
| Barrick, B | 1 |
| Matthys, B | 1 |
| Fraga, G | 1 |
| Wetzig, T | 1 |
| Beckheinrich, P | 1 |
| Rytter, M | 1 |
| Haustein, UF | 1 |
| Okamoto, N | 1 |
| Maruta, M | 1 |
| Maeda, K | 1 |
| Masumori, K | 1 |
| Kato, R | 1 |
| Kakagia, D | 1 |
| Trichas, M | 1 |
| Papadopoulos, N | 1 |
| Tsalkidis, A | 1 |
| Jivannakis, T | 1 |
| Tamiolakis, D | 1 |
| Lambert, T | 1 |
| Mullinax, K | 1 |
| Smith, J | 1 |
| Sauter, C | 1 |
| Saborowski, A | 1 |
| Ockenfels, HM | 1 |
| Carter, DM | 1 |
| Balin, AK | 1 |
| Tsuji, T | 1 |
| Nakagawa, K | 1 |
| Hamada, T | 1 |
| Ryan, RF | 1 |
| Litwin, MS | 1 |
| Krementz, ET | 1 |
| Blair, WF | 1 |
| Kilpatrick, WC | 1 |
| Saiki, JH | 1 |
| Atler, EJ | 1 |
| Dauphin, S | 1 |
| Katz, S | 1 |
| el Tamer, M | 1 |
| Wait, R | 1 |
| Sohn, C | 1 |
| Braverman, AS | 1 |
| Gmyrek, R | 1 |
| Beer, R | 1 |
| Elizeri, Y | 1 |
| Oster, MW | 1 |
| Silvers, DN | 1 |
| Schneiderman, P | 1 |
| Grossman, ME | 1 |
| Insler, MS | 1 |
| Helm, CJ | 1 |
| Cherrick, HM | 1 |
| Weissman, D | 1 |
| Nordlund, JJ | 1 |
| Klaus, SN | 1 |
2 reviews available for fluorouracil and Skin Ulcer
| Article | Year |
|---|---|
[Rectal squamous cell carcinoma treatment: Retrospective experience in two French university hospitals, review and proposals].
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Carcin | 2016 |
Dermatological aspects of aging.
Topics: Adult; Aged; Aging; Animals; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Dermatitis; Female; Fl | 1983 |
1 trial available for fluorouracil and Skin Ulcer
| Article | Year |
|---|---|
Topical treatment of cutaneous metastases of malignant melanoma using combined imiquimod and 5-fluorouracil.
Topics: Administration, Topical; Aged; Aged, 80 and over; Aminoquinolines; Antineoplastic Agents; Antineopla | 2012 |
21 other studies available for fluorouracil and Skin Ulcer
| Article | Year |
|---|---|
Severe necrotising inflammatory skin reaction to topical 5-fluorouracil.
Topics: Administration, Ophthalmic; Antimetabolites, Antineoplastic; Conjunctival Neoplasms; Drug Eruptions; | 2019 |
Comparison between the efficacy of microneedling combined with 5-fluorouracil vs microneedling with tacrolimus in the treatment of vitiligo.
Topics: Administration, Cutaneous; Cosmetic Techniques; Dermatologic Agents; Female; Fluorouracil; Humans; H | 2018 |
Predictive factors for early and late local toxicities in anal cancer treated by radiotherapy in combination with or without chemotherapy.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Anus Neoplasms; Brac | 2013 |
Impending Carotid Blowout Syndrome.
Topics: Angiography; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Caro | 2015 |
A perplexing case.
Topics: Aged, 80 and over; Drug Eruptions; Fluorouracil; Genital Diseases, Male; Groin; Humans; Male; Skin U | 2016 |
[A case of stage IV breast cancer with large cancer ulcer responding to combination therapy of capecitabine and medroxyprogesterone acetate and cyclophosphamide].
Topics: Adenocarcinoma, Scirrhous; Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Age | 2009 |
[Cetuximab-associated skin ulceration in patient with metastatic colorectal cancer: a case report].
Topics: Aged, 80 and over; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combine | 2011 |
Ulcerated plaques in the pelvic region of an adult female.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Breast Neoplasms; Capecitabine; Carcinoma, D | 2012 |
Erosion of psoriatic plaques: an uncommon side-effect of neoadjuvant 5-fluorouracil treatment of colon cancer.
Topics: Aged; Antineoplastic Agents; Chemotherapy, Adjuvant; Colonic Neoplasms; Drug Eruptions; Fluorouracil | 2002 |
[A case of locally extended rectal carcinoma quickly responding to local intraarterial infusion therapy].
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; | 2003 |
Ulcerative locally advanced breast cancer: the efficacy of combined anthracycline-based and hormonal therapy.
Topics: Aged; Aged, 80 and over; Anthracyclines; Antineoplastic Combined Chemotherapy Protocols; Breast Neop | 2004 |
A case of an adverse reaction to topical 5-fluorouracil in irradiated skin.
Topics: Administration, Cutaneous; Aged; Antimetabolites, Antineoplastic; Carcinoma, Squamous Cell; Diagnosi | 2006 |
[Unilateral acral necrosis as a minor form of hand-foot syndrome. Patient with unilateral acral necrosis secondary to capecitabine therapy for metastatic breast cancer].
Topics: Aged; Antimetabolites, Antineoplastic; Breast Neoplasms; Capecitabine; Deoxycytidine; Erythema; Fema | 2007 |
Different effects of topically applied 5-fluorouracil on hairy and hairless mice.
Topics: Animals; Dihydroxyphenylalanine; Fluorouracil; Hyperplasia; Hypertrophy; Melanocytes; Mice; Mice, Ha | 1984 |
A new concept in the management of Marjolin's ulcers.
Topics: Administration, Topical; Adult; Carcinoma, Squamous Cell; Cicatrix; Female; Fluorouracil; Humans; Ma | 1981 |
Extravasation of chemotherapeutic agents.
Topics: Aged; Antineoplastic Agents; Doxorubicin; Female; Fluorouracil; Humans; Infusions, Parenteral; Male; | 1980 |
Chemotherapy is a safe and effective initial therapy for infected malignant breast and chest wall ulcers.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Ci | 1997 |
Invasive squamous cell carcinoma with sporotrichoid metastasis in a patient with cutaneous T cell lymphoma treated with chronic extracorporeal photopheresis.
Topics: Aged; Aged, 80 and over; Amputation, Surgical; Antineoplastic Combined Chemotherapy Protocols; Carci | 1999 |
Ankyloblepharon associated with systemic 5-fluorouracil treatment.
Topics: Adenocarcinoma; Blepharitis; Eyelid Diseases; Fluorouracil; Humans; Male; Middle Aged; Skin Ulcer; S | 1987 |
Effects of topically applied 5-fluorouracil in the Syrian hamster.
Topics: Administration, Topical; Animals; Cheek; Cricetinae; Erythema; Fluorouracil; Mouth Mucosa; Necrosis; | 1974 |
Successful topical treatment of an unusual ulcer with fluorouracil.
Topics: Diagnosis, Differential; Facial Dermatoses; Fluorouracil; Humans; Male; Skin; Skin Neoplasms; Skin U | 1972 |