fluorouracil has been researched along with Skin Aging in 8 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Skin Aging: The process of aging due to changes in the structure and elasticity of the skin over time. It may be a part of physiological aging or it may be due to the effects of ultraviolet radiation, usually through exposure to sunlight.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The antimetabolite 5-fluorouracil (5-FU) is used for topical treatment of actinic keratosis." | 5.19 | Five percent 5-fluorouracil in a cream or for superficial peels in the treatment of advanced photoaging of the forearms: a randomized comparative study. ( Bagatin, E; Guimarães, CO; Miot, HA, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 4 (50.00) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Korgavkar, K | 1 |
| Lee, KC | 1 |
| Weinstock, MA | 1 |
| Guimarães, CO | 1 |
| Miot, HA | 1 |
| Bagatin, E | 1 |
| Poon, F | 1 |
| Kang, S | 2 |
| Chien, AL | 1 |
| Sachs, DL | 1 |
| Hammerberg, C | 1 |
| Helfrich, Y | 1 |
| Karimipour, D | 1 |
| Orringer, J | 1 |
| Johnson, T | 1 |
| Hamilton, TA | 1 |
| Fisher, G | 1 |
| Voorhees, JJ | 1 |
| Wiest, LG | 1 |
| Stolz, W | 1 |
| Schroeder, JA | 1 |
| Lemperle, G | 1 |
| Rullan, PP | 1 |
| Gauthier-Hazan, N | 1 |
| Draelos, ZD | 1 |
| Lawrence, N | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| CSP #562 - The VA Keratinocyte Carcinoma Chemoprevention Trial[NCT00847912] | Phase 4 | 954 participants (Actual) | Interventional | 2009-06-26 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT00847912)
Timeframe: date of randomization to last visit before end of study follow up (6/30/2013), assessed up to four years
| Intervention | participants (Number) |
|---|---|
| Arm 1: 5-fluorouracil | 182 |
| Arm 2: Placebo, Vehicle Control | 177 |
Diagnosis of the first Primary Basil Cell Carcinoma (BCC) or primary Squamous Cell Carcinoma (SCC) on the face or ears that was removed surgically. (NCT00847912)
Timeframe: From randomization to last visit prior to end of study date (6/30/2013), assessed up to four years
| Intervention | years (Median) |
|---|---|
| Arm 1: 5-fluorouracil | 3.37 |
| Arm 2: Placebo, Vehicle Control | 3.52 |
4 reviews available for fluorouracil and Skin Aging
| Article | Year |
|---|---|
Mechanisms and treatments of photoaging.
Topics: Administration, Topical; Animals; Fluorouracil; Humans; Immunosuppressive Agents; Retinoids; Skin Ag | 2015 |
Avoiding and treating dermal filler complications.
Topics: Adipose Tissue; Adrenal Cortex Hormones; Animals; Autoimmune Diseases; Biocompatible Materials; Catt | 2006 |
Therapeutic skin care in the mature patient.
Topics: Acne Vulgaris; Fluorouracil; Humans; Hydrogen-Ion Concentration; Retinoids; Skin Aging; Skin Care; S | 1997 |
New and emerging treatments for photoaging.
Topics: Adult; Ascorbic Acid; Child; Dermabrasion; Fluorouracil; Humans; Laser Therapy; Rhytidoplasty; Skin | 2000 |
3 trials available for fluorouracil and Skin Aging
| Article | Year |
|---|---|
Effect of Topical Fluorouracil Cream on Photodamage: Secondary Analysis of a Randomized Clinical Trial.
Topics: Administration, Cutaneous; Dermatologic Agents; Ear; Face; Female; Fluorouracil; Follow-Up Studies; | 2017 |
Five percent 5-fluorouracil in a cream or for superficial peels in the treatment of advanced photoaging of the forearms: a randomized comparative study.
Topics: Administration, Cutaneous; Aged; Aged, 80 and over; Biomarkers; Biopsy; Chemexfoliation; Collagen Ty | 2014 |
Topical fluorouracil for actinic keratoses and photoaging: a clinical and molecular analysis.
Topics: Administration, Topical; Aged; Aged, 80 and over; Dose-Response Relationship, Drug; Drug Administrat | 2009 |
1 other study available for fluorouracil and Skin Aging
| Article | Year |
|---|---|
Electron microscopic documentation of late changes in permanent fillers and clinical management of granulomas in affected patients.
Topics: Allopurinol; Biocompatible Materials; Biopsy; Dermatologic Agents; Drug Combinations; Drug Therapy, | 2009 |