fluorouracil has been researched along with Sjogren's Syndrome in 2 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Sjogren's Syndrome: Chronic inflammatory and autoimmune disease in which the salivary and lacrimal glands undergo progressive destruction by lymphocytes and plasma cells resulting in decreased production of saliva and tears. The primary form, often called sicca syndrome, involves both KERATOCONJUNCTIVITIS SICCA and XEROSTOMIA. The secondary form includes, in addition, the presence of a connective tissue disease, usually rheumatoid arthritis.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tenti, S | 1 |
| Correale, P | 1 |
| Conca, R | 1 |
| Pastina, P | 1 |
| Fioravanti, A | 1 |
| Hareyama, M | 1 |
| Nagakura, H | 1 |
| Tamakawa, M | 1 |
| Hyodo, K | 1 |
| Asakura, K | 1 |
| Horikoshi, T | 1 |
| Oouchi, A | 1 |
| Shido, M | 1 |
| Morita, K | 1 |
2 other studies available for fluorouracil and Sjogren's Syndrome
| Article | Year |
|---|---|
Occurrence of Sjögren syndrome in a long-term survivor patient with metastatic colon carcinoma treated with GOLFIG regimen.
Topics: Adjuvants, Immunologic; Administration, Metronomic; Aged; Antineoplastic Combined Chemotherapy Proto | 2012 |
Severe reaction after chemoradiotherapy of nasopharyngeal carcinoma with collagen disease.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Collagen Diseases; Combined Modality Ther | 1995 |