fluorouracil has been researched along with Shock, Cardiogenic in 15 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Shock, Cardiogenic: Shock resulting from diminution of cardiac output in heart disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fulminant myocarditis is a rare but potentially life-threatening illness caused by 5-fluorouracil cardiotoxicity." | 7.83 | Rapid Extracorporeal Membrane Oxygenation Overcomes Fulminant Myocarditis Induced by 5‑Fluorouracil. ( Amraotkar, AR; DeFilippis, AP; Grubb, KJ; Pachika, A, 2016) |
| "5-Fluorouracil is a key element to the treatment of colon cancer." | 6.66 | Various Manifestations of 5-Fluorouracil Cardiotoxicity: A Multicenter Case Series and Review of Literature. ( Allison, JD; Birnbaum, G; Khalid, U; Tanavin, T; Yang, Y, 2020) |
| "Fulminant myocarditis is a rare but potentially life-threatening illness caused by 5-fluorouracil cardiotoxicity." | 3.83 | Rapid Extracorporeal Membrane Oxygenation Overcomes Fulminant Myocarditis Induced by 5‑Fluorouracil. ( Amraotkar, AR; DeFilippis, AP; Grubb, KJ; Pachika, A, 2016) |
| " Two of the patients could not be treated with 5-FU any more because they had developed a myocardial ischemia, which was most likely caused by fluorouracil." | 3.78 | 5-FU-induced cardiac toxicity--an underestimated problem in radiooncology? ( Hautmann, MG; Kölbl, O; Steger, F, 2012) |
| "5-Fluorouracil is a key element to the treatment of colon cancer." | 2.66 | Various Manifestations of 5-Fluorouracil Cardiotoxicity: A Multicenter Case Series and Review of Literature. ( Allison, JD; Birnbaum, G; Khalid, U; Tanavin, T; Yang, Y, 2020) |
| "Capecitabine is an orally administered prodrug that converts preferentially to 5-FU within tumors, resulting in enhanced concentrations of 5-FU in tumor tissue." | 2.49 | Capecitabine induces both cardiomyopathy and multifocal cerebral leukoencephalopathy. ( Endo, A; Nakashima, R; Takahashi, N; Tanabe, K; Yoshida, Y, 2013) |
| "5-Fluorouracil (5FU) cardiotoxicity is thought to be an infrequent toxic effect, usually related to coronary vasospasm." | 2.38 | [Cardiotoxicity of continuous intravenous infusion of 5-fluorouracil: clinical study, prevention and physiopathology. Apropos of 13 cases]. ( Bachaud, JM; Bugat, R; Chevreau, C; de Forni, M; Delay, M; Sorbette, F, 1990) |
| "Unfortunately, acute pulmonary edema with lethal cardiogenic shock occurred during the ninth course of treatment, in spite of intensive medical treatment." | 1.30 | Toxic cardiogenic shock in a patient receiving weekly 24-h infusion of high-dose 5-fluorouracil and leucovorin. ( Chen, PM; Chiou, TJ; Fan, FS; Hsieh, RK; Liu, JH; Tung, SL; Wang, WS; Yen, CC, 1998) |
| " Experimental studies suggest that this adverse effect could be due to myocardial accumulation of 5-FU leading to depletion of high energy phosphate compounds." | 1.28 | Acute myocardiotoxicity during 5-fluorouracil therapy. ( Escudier, B; Leclercq, B; Misset, B; Nitenberg, G; Rivara, D; Rougier, P, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (6.67) | 18.7374 |
| 1990's | 5 (33.33) | 18.2507 |
| 2000's | 3 (20.00) | 29.6817 |
| 2010's | 5 (33.33) | 24.3611 |
| 2020's | 1 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Allison, JD | 1 |
| Tanavin, T | 1 |
| Yang, Y | 1 |
| Birnbaum, G | 1 |
| Khalid, U | 1 |
| Endo, A | 1 |
| Yoshida, Y | 1 |
| Nakashima, R | 1 |
| Takahashi, N | 1 |
| Tanabe, K | 1 |
| Rateesh, S | 1 |
| Shekar, K | 1 |
| Naidoo, R | 1 |
| Mittal, D | 1 |
| Bhaskar, B | 1 |
| Amraotkar, AR | 1 |
| Pachika, A | 1 |
| Grubb, KJ | 1 |
| DeFilippis, AP | 1 |
| To, AC | 1 |
| Looi, KL | 1 |
| Damianovich, D | 1 |
| Taylor, GB | 1 |
| Sidebotham, D | 1 |
| White, HD | 1 |
| Ferté, C | 1 |
| Gomez Roca, C | 1 |
| Loriot, Y | 1 |
| Bahleda, R | 1 |
| Moldovan, C | 1 |
| Cohen, A | 1 |
| Izzedine, H | 1 |
| Soria, JC | 1 |
| Ederhy, S | 1 |
| Steger, F | 1 |
| Hautmann, MG | 1 |
| Kölbl, O | 1 |
| Bakouboula, B | 1 |
| Morel, O | 1 |
| Douchet, MP | 1 |
| Chauvin, M | 1 |
| Rodríguez Roldán, JM | 1 |
| Lara Alvarez, MA | 1 |
| López Martínez, J | 1 |
| Díaz Abad, R | 1 |
| Caballero Campo, M | 1 |
| Del Nogal Sáez, F | 1 |
| Wang, WS | 1 |
| Hsieh, RK | 1 |
| Chiou, TJ | 1 |
| Liu, JH | 1 |
| Fan, FS | 1 |
| Yen, CC | 1 |
| Tung, SL | 1 |
| Chen, PM | 1 |
| de Forni, M | 1 |
| Bugat, R | 1 |
| Sorbette, F | 1 |
| Delay, M | 1 |
| Bachaud, JM | 1 |
| Chevreau, C | 1 |
| Mazet, C | 1 |
| Dellinger, A | 1 |
| Vital Durand, D | 1 |
| Adnaoui, M | 1 |
| Fournier, G | 1 |
| Levrat, R | 1 |
| Misset, B | 1 |
| Escudier, B | 1 |
| Leclercq, B | 1 |
| Rivara, D | 1 |
| Rougier, P | 1 |
| Nitenberg, G | 1 |
| Dieudonne, P | 1 |
| Dumont, MA | 1 |
| McKendall, GR | 1 |
| Shurman, A | 1 |
| Anamur, M | 1 |
| Most, AS | 1 |
3 reviews available for fluorouracil and Shock, Cardiogenic
| Article | Year |
|---|---|
Various Manifestations of 5-Fluorouracil Cardiotoxicity: A Multicenter Case Series and Review of Literature.
Topics: Adult; Antimetabolites, Antineoplastic; Cardiotoxicity; Colonic Neoplasms; Disease Progression; Elec | 2020 |
Capecitabine induces both cardiomyopathy and multifocal cerebral leukoencephalopathy.
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Capecitabine; Cardiomyopathies; Colorectal Neoplasm | 2013 |
[Cardiotoxicity of continuous intravenous infusion of 5-fluorouracil: clinical study, prevention and physiopathology. Apropos of 13 cases].
Topics: Adult; Aged; Angina Pectoris; Dose-Response Relationship, Drug; Electrocardiography; Female; Fluorou | 1990 |
12 other studies available for fluorouracil and Shock, Cardiogenic
| Article | Year |
|---|---|
Use of extracorporeal membrane oxygenation for mechanical circulatory support in a patient with 5-fluorouracil induced acute heart failure.
Topics: Adenocarcinoma; Adult; Antimetabolites, Antineoplastic; Cardiotoxicity; Colorectal Neoplasms; Extrac | 2015 |
Rapid Extracorporeal Membrane Oxygenation Overcomes Fulminant Myocarditis Induced by 5‑Fluorouracil.
Topics: Acute Disease; Anus Neoplasms; Carcinoma, Squamous Cell; Coronary Angiography; Electrocardiography; | 2016 |
A case of cardiogenic shock caused by capecitabine treatment.
Topics: Adenocarcinoma, Mucinous; Antimetabolites, Antineoplastic; Appendiceal Neoplasms; Biomarkers; Biopsy | 2008 |
Reversible cardiogenic shock following 5-fluorouracil infusion.
Topics: Antimetabolites, Antineoplastic; Fluorouracil; Humans; Infusions, Intravenous; Male; Middle Aged; Sh | 2010 |
5-FU-induced cardiac toxicity--an underestimated problem in radiooncology?
Topics: Aged; Antimetabolites, Antineoplastic; Carcinoma; Cardiotoxins; Chemoradiotherapy; Electrocardiograp | 2012 |
[Reversible cardiogenic shock under 5-fluorouracil treatment].
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Car | 2005 |
[Myocardial necrosis and cardiogenic shock with normal coronaries: cardiotoxicity due to 5-FU or catecholamine cardiomyopathy].
Topics: Antimetabolites, Antineoplastic; Cardiomyopathies; Catecholamines; Coronary Angiography; Coronary Ve | 2006 |
Toxic cardiogenic shock in a patient receiving weekly 24-h infusion of high-dose 5-fluorouracil and leucovorin.
Topics: Acute Disease; Antineoplastic Combined Chemotherapy Protocols; Colectomy; Drug Administration Schedu | 1998 |
[Cardiogenic shock caused by 5-fluorouracil].
Topics: Fluorouracil; Humans; Male; Middle Aged; Shock, Cardiogenic | 1990 |
Acute myocardiotoxicity during 5-fluorouracil therapy.
Topics: Adult; Cardiomyopathies; Colonic Neoplasms; Fluorouracil; Hemodynamics; Humans; Infusions, Intraveno | 1990 |
[Reversible cardiogenic shock due to 5FU. Apropos of a case report].
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Cardiovascular Agents; Fluorouracil; | 1990 |
Toxic cardiogenic shock associated with infusion of 5-fluorouracil.
Topics: Electrocardiography; Fluorouracil; Hemodynamics; Humans; Infusions, Intravenous; Male; Middle Aged; | 1989 |