fluorouracil has been researched along with Sex Disorders in 5 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To study the sexual effects of the 2-year adjuvant goserelin (Zoladex [Zeneca AB, Södertälje, Sweden]) alone, tamoxifen alone, and Zoladex and tamoxifen in combination (ZT) versus no adjuvant endocrine therapy among premenopausal breast cancer patients with or without chemotherapy in a controlled clinical trial (a European multicenter trial: Zoladex in Premenopausal Breast Cancer Patients)." | 5.09 | Effect of endocrine treatment on sexuality in premenopausal breast cancer patients: a prospective randomized study. ( Berglund, G; Bolund, C; Nystedt, M; Rutquist, LE; Sjödén, PO, 2001) |
| "Treatment of rectal cancer over the last two decades has evolved with changes in techniques of surgery and radiation based on national and international trials." | 2.44 | Total mesorectal excision and management of rectal cancer. ( Phang, PT; Pinsk, I, 2007) |
| "The management of distal rectal cancer is in evolution." | 2.40 | Sphincter preservation in rectal cancer. Local excision followed by postoperative radiation therapy. ( Willett, CG, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, K | 1 |
| He, X | 1 |
| Tong, S | 1 |
| Zheng, Y | 1 |
| Watanabe, T | 1 |
| Nagawa, H | 1 |
| Pinsk, I | 1 |
| Phang, PT | 1 |
| Willett, CG | 1 |
| Berglund, G | 1 |
| Nystedt, M | 1 |
| Bolund, C | 1 |
| Sjödén, PO | 1 |
| Rutquist, LE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Patient Reported Outcomes Following Cancer of the Rectum[NCT04936581] | 200 participants (Anticipated) | Observational | 2021-09-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for fluorouracil and Sex Disorders
| Article | Year |
|---|---|
Total mesorectal excision and management of rectal cancer.
Topics: Adenocarcinoma; Anastomosis, Surgical; Antineoplastic Agents; Combined Modality Therapy; Disease Man | 2007 |
Sphincter preservation in rectal cancer. Local excision followed by postoperative radiation therapy.
Topics: Abdomen; Anal Canal; Antimetabolites, Antineoplastic; Carcinoma; Chemotherapy, Adjuvant; Colostomy; | 1998 |
1 trial available for fluorouracil and Sex Disorders
| Article | Year |
|---|---|
Effect of endocrine treatment on sexuality in premenopausal breast cancer patients: a prospective randomized study.
Topics: Adult; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Breast Neopl | 2001 |
2 other studies available for fluorouracil and Sex Disorders
| Article | Year |
|---|---|
Risk factors for sexual dysfunction after rectal cancer surgery in 948 consecutive patients: A prospective cohort study.
Topics: Adenocarcinoma; Adult; Age Factors; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Ch | 2021 |
Sphincter preservation in locally advanced rectal cancer due to the addition of continuous infusion 5-FU to preoperative radiation therapy or advances in surgical techniques?
Topics: Anal Canal; Antimetabolites, Antineoplastic; Combined Modality Therapy; Fluorouracil; Humans; Lymph | 2004 |