fluorouracil has been researched along with Severe Combined Immunodeficiency in 3 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Severe Combined Immunodeficiency: Group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. It is inherited as an X-linked or autosomal recessive defect. Mutations occurring in many different genes cause human Severe Combined Immunodeficiency (SCID).
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, Y | 1 |
| Zhong, X | 1 |
| Liu, T | 1 |
| Ge, Z | 1 |
| Goan, SR | 1 |
| Fichtner, I | 1 |
| Just, U | 1 |
| Karawajew, L | 1 |
| Schultze, W | 1 |
| Krause, KP | 1 |
| von Harsdorf, S | 1 |
| von Schilling, C | 1 |
| Herrmann, F | 1 |
| Watson, SA | 1 |
| Michaeli, D | 1 |
| Grimes, S | 1 |
| Morris, TM | 1 |
| Varro, A | 1 |
| Clarke, PA | 1 |
| Smith, AM | 1 |
| Justin, TA | 1 |
| Hardcastle, JD | 1 |
3 other studies available for fluorouracil and Severe Combined Immunodeficiency
| Article | Year |
|---|---|
[The study on the effects of the oil from Hippophae rhamnoides in hematopoiesis].
Topics: Animals; Blood Cell Count; Drugs, Chinese Herbal; Erythrocyte Count; Female; Fluorouracil; Hematopoi | 2003 |
The severe combined immunodeficient-human peripheral blood stem cell (SCID-huPBSC) mouse: a xenotransplant model for huPBSC-initiated hematopoiesis.
Topics: Adult; Animals; Antibody Formation; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone | 1995 |
A comparison of an anti-gastrin antibody and cytotoxic drugs in the therapy of human gastric ascites in SCID mice.
Topics: Animals; Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Ascites; Cancer Vac | 1999 |