fluorouracil has been researched along with Seizures in 20 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| " She was under treatment by fluorouracil, leucovorin, oxaliplatin, and docetaxel regimen and thrombocytopenia regimen after tumor progression, but developed unconsciousness, irritability, and headache shortly after initiation of treatment." | 8.31 | Posterior reversible encephalopathy syndrome triggered by FLOT (5-fluorouracil, oxaliplatin, docetaxel, and calcium levofolinate) chemotherapy and thrombocytopenia (docetaxel and cisplatin) chemotherapy. ( Xie, L, 2023) |
| " She was under treatment by fluorouracil, leucovorin, oxaliplatin, and docetaxel regimen and thrombocytopenia regimen after tumor progression, but developed unconsciousness, irritability, and headache shortly after initiation of treatment." | 4.31 | Posterior reversible encephalopathy syndrome triggered by FLOT (5-fluorouracil, oxaliplatin, docetaxel, and calcium levofolinate) chemotherapy and thrombocytopenia (docetaxel and cisplatin) chemotherapy. ( Xie, L, 2023) |
| "These findings suggest that the combination of 5-FU and cefepime exacerbates early-onset convulsive seizures and elicits delayed-onset convulsive status epilepticus." | 3.91 | 5-Fluorouracil exacerbates cefepime-induced convulsions in pentylenetetrazol-kindled mice. ( Aso, H; Suemaru, K; Watanabe, M; Yoshikawa, M, 2019) |
| "We report the cases of 2 breast cancer patients who received capecitabine(CAP)and concomitant anticonvulsant therapy with either phenytoin(PHT)or valproate(VPA)for brain metastasis." | 3.80 | [Effect of capecitabine therapy on the blood levels of antiepileptic drugs - report of two cases]. ( Ibayashi, Y; Jotoku, H; Takahashi, M; Takasaki, M; Tanaka, H; Watanabe, K, 2014) |
| " We describe the case of a colon cancer patient who underwent adjuvant treatment with capecitabine and oxaliplatin and was admitted to the hospital with seizures and brain edema." | 3.80 | [Blindness and symmetrical neurological deficit in a patient with colon cancer receiving adjuvant chemotherapy: is it always cancer?]. ( Fennig, S; Greenberg, G; Leshem, Y; Talianski, E; Wolf, I, 2014) |
| " We report the case of a 64-year-old woman with breast cancer who developed severe symptomatic hyponatraemia with a generalised seizure and convulsions after a second cycle of adjuvant chemotherapy with 5-fluouracil, epirubicin and cyclophosphamide." | 3.77 | Cyclophosphamide-induced symptomatic hyponatraemia. ( Bruining, DM; de Graaf, H; Hoogendoorn, M; van Roon, EN, 2011) |
| "We report a 37-year-old patient with gastric cancer who suffered two distinct episodes of generalized tonic-clonic seizures during ongoing chemotherapy with cisplatin and 5-fluorouracil." | 3.73 | [Relapsing reversible posterior leukoencephalopathy after chemotherapy with cisplatin and 5-fluorouracil]. ( Aktas, O; Dieste, FJ; Kreitsch, P; Paul, F; Vogel, HP; Zipp, F, 2006) |
| "A few days after starting the first cycle of treatment with capecitabine, a 50-year-old female with metastatic breast cancer experienced serious adverse events consisting of severe hematological, gastrointestinal and neurological toxicity." | 1.56 | Posterior reversible encephalopathy syndrome: A rare neurotoxicity after capecitabine. ( Amadori, E; Barone, D; Bartolini, G; Frassineti, GL; Monti, M; Ruscelli, S, 2020) |
| " Neurotoxic signs such as hyperesthesia and/or excitement, as well as convulsions, were observed in both FBAL x HCl and FA x Na groups; these toxic signs were also found in the UFT group." | 1.32 | Neurotoxic effects of alpha-fluoro-beta-alanine (FBAL) and fluoroacetic acid (FA) on dogs. ( Ariyoshi, T; Yada, H; Yamashita, K, 2004) |
| "Fluorouracil can cause both acute and delayed neurotoxicity." | 1.31 | Fluorouracil-induced neurotoxicity. ( Ali, II; Dafer, RM; Pirzada, NA, 2000) |
| "The phenytoin dosage was decreased and the symptoms resolved." | 1.31 | Phenytoin and fluorouracil interaction. ( Brodribb, TR; Gilbar, PJ, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (20.00) | 18.7374 |
| 1990's | 3 (15.00) | 18.2507 |
| 2000's | 6 (30.00) | 29.6817 |
| 2010's | 5 (25.00) | 24.3611 |
| 2020's | 2 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Xie, L | 1 |
| Suemaru, K | 1 |
| Yoshikawa, M | 1 |
| Aso, H | 1 |
| Watanabe, M | 1 |
| Monti, M | 1 |
| Barone, D | 1 |
| Amadori, E | 1 |
| Bartolini, G | 1 |
| Ruscelli, S | 1 |
| Frassineti, GL | 1 |
| Tanaka, H | 1 |
| Jotoku, H | 1 |
| Takasaki, M | 1 |
| Ibayashi, Y | 1 |
| Watanabe, K | 1 |
| Takahashi, M | 1 |
| Leshem, Y | 1 |
| Fennig, S | 1 |
| Talianski, E | 1 |
| Greenberg, G | 1 |
| Wolf, I | 1 |
| Hoehn, R | 1 |
| Lamparter, J | 1 |
| Pfeiffer, N | 1 |
| Vossmerbaeumer, U | 1 |
| Bruining, DM | 1 |
| van Roon, EN | 1 |
| de Graaf, H | 1 |
| Hoogendoorn, M | 1 |
| Yamashita, K | 1 |
| Yada, H | 1 |
| Ariyoshi, T | 1 |
| Elkiran, ET | 1 |
| Altundag, K | 1 |
| Beyazit, Y | 1 |
| Guler, N | 1 |
| Kars, A | 1 |
| Paul, F | 1 |
| Aktas, O | 1 |
| Dieste, FJ | 1 |
| Kreitsch, P | 1 |
| Vogel, HP | 1 |
| Zipp, F | 1 |
| Neuwelt, EA | 1 |
| Barnett, PA | 1 |
| Glasberg, M | 1 |
| Frenkel, EP | 1 |
| Weh, HJ | 1 |
| Bittner, S | 1 |
| Hoffknecht, M | 1 |
| Hossfeld, DK | 1 |
| Yeh, KH | 1 |
| Cheng, AL | 1 |
| Vreken, P | 1 |
| Van Kuilenburg, AB | 1 |
| Meinsma, R | 1 |
| van Gennip, AH | 1 |
| Pirzada, NA | 1 |
| Ali, II | 1 |
| Dafer, RM | 1 |
| Sharma, A | 1 |
| Raina, V | 1 |
| Gilbar, PJ | 1 |
| Brodribb, TR | 1 |
| Ndiritu, CG | 1 |
| Enos, LR | 1 |
| Koenig, H | 1 |
| Patel, A | 1 |
| Carlisle, H | 1 |
| Spector, RG | 1 |
20 other studies available for fluorouracil and Seizures
| Article | Year |
|---|---|
Posterior reversible encephalopathy syndrome triggered by FLOT (5-fluorouracil, oxaliplatin, docetaxel, and calcium levofolinate) chemotherapy and thrombocytopenia (docetaxel and cisplatin) chemotherapy.
Topics: Calcium; Cisplatin; Docetaxel; Edema; Female; Fluorouracil; Headache; Humans; Leucovorin; Middle Age | 2023 |
5-Fluorouracil exacerbates cefepime-induced convulsions in pentylenetetrazol-kindled mice.
Topics: Animals; Anti-Bacterial Agents; Cefepime; Convulsants; Disease Models, Animal; Fluorouracil; Kindlin | 2019 |
Posterior reversible encephalopathy syndrome: A rare neurotoxicity after capecitabine.
Topics: Capecitabine; Female; Fluorouracil; Humans; Magnetic Resonance Imaging; Middle Aged; Neurotoxicity S | 2020 |
[Effect of capecitabine therapy on the blood levels of antiepileptic drugs - report of two cases].
Topics: Anticonvulsants; Antimetabolites, Antineoplastic; Brain Neoplasms; Breast Neoplasms; Capecitabine; D | 2014 |
[Blindness and symmetrical neurological deficit in a patient with colon cancer receiving adjuvant chemotherapy: is it always cancer?].
Topics: Antineoplastic Combined Chemotherapy Protocols; Blindness; Brain Neoplasms; Capecitabine; Chemothera | 2014 |
Seizures following subconjunctival 5-FU therapy.
Topics: Aged; Alkylating Agents; Antimetabolites; Combined Modality Therapy; Conjunctiva; Fibrosis; Fluorour | 2011 |
Cyclophosphamide-induced symptomatic hyponatraemia.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Breast Neoplasms; Cyclophosphami | 2011 |
Neurotoxic effects of alpha-fluoro-beta-alanine (FBAL) and fluoroacetic acid (FA) on dogs.
Topics: Administration, Oral; Animals; beta-Alanine; Dogs; Fluoroacetates; Fluorouracil; Hyperesthesia; Male | 2004 |
Fluorouracil-induced neurotoxicity presenting with generalized tonic-clonic seizure.
Topics: Adenocarcinoma; Anticonvulsants; Antimetabolites, Antineoplastic; Fluorouracil; Humans; Male; Middle | 2004 |
[Relapsing reversible posterior leukoencephalopathy after chemotherapy with cisplatin and 5-fluorouracil].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug-Related Side Effects and Adve | 2006 |
Pharmacology and neurotoxicity of cis-diamminedichloroplatinum, bleomycin, 5-fluorouracil, and cyclophosphamide administration following osmotic blood-brain barrier modification.
Topics: Animals; Bleomycin; Blood-Brain Barrier; Brain; Cisplatin; Cyclophosphamide; Dogs; Fluorouracil; Man | 1983 |
Neurotoxicity following weekly therapy with folinic acid and high-dose 5-fluorouracil 24-h infusion in patients with gastrointestinal malignancies.
Topics: Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Epilepsy, Complex Partial; Female | 1993 |
High-dose 5-fluorouracil infusional therapy is associated with hyperammonaemia, lactic acidosis and encephalopathy.
Topics: Acidosis; Ammonia; Antimetabolites, Antineoplastic; Brain Diseases; Coma; Diagnosis, Differential; E | 1997 |
Dihydropyrimidine dehydrogenase (DPD) deficiency: identification and expression of missense mutations C29R, R886H and R235W.
Topics: Adult; Antimetabolites, Antineoplastic; Cloning, Molecular; Dihydrouracil Dehydrogenase (NADP); DNA, | 1997 |
Fluorouracil-induced neurotoxicity.
Topics: Aged; Antimetabolites, Antineoplastic; Ataxia; Confusion; Esophageal Neoplasms; Fluorouracil; Humans | 2000 |
Generalised seizures following ondansetron.
Topics: Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Epi | 2001 |
Phenytoin and fluorouracil interaction.
Topics: Aged; Anticonvulsants; Antidotes; Antimetabolites, Antineoplastic; Colonic Neoplasms; Drug Interacti | 2001 |
Adverse reactions to drugs in a veterinary hospital.
Topics: Amphotericin B; Anaphylaxis; Animals; Cat Diseases; Cats; Cattle; Cattle Diseases; Chloral Hydrate; | 1977 |
The acute cerebellar syndrome in 5-fluorouracil chemotherapy: a manifestation of fluoroacetate intoxication.
Topics: Alanine; Animals; Brain Chemistry; Cats; Cerebellar Ataxia; Citrates; Citric Acid Cycle; Fluoroaceta | 1970 |
The effect of anti-metabolites on leptazol induced fits in rats.
Topics: Animals; Antimetabolites; Azathioprine; Brain; Cytarabine; Daunorubicin; Fluorouracil; Folic Acid; F | 1971 |