Page last updated: 2024-10-27

fluorouracil and Sclerosis

fluorouracil has been researched along with Sclerosis in 8 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Sclerosis: A pathological process consisting of hardening or fibrosis of an anatomical structure, often a vessel or a nerve.

Research Excerpts

ExcerptRelevanceReference
"Intraperitoneal chemotherapy with mitomycin C and 5-fluorouracil has been used to rescue patients from peritoneal carcinomatosis after perforated cystadenocarcinoma of the large bowel or appendix."7.68Histologic changes induced by intraperitoneal chemotherapy with 5-fluorouracil and mitomycin C in patients with peritoneal carcinomatosis from cystadenocarcinoma of the colon or appendix. ( Jaffe, G; Landy, D; Pascal, R; Sugarbaker, PH, 1990)
"5-Fluorouracil is a pyrimidine analogue that inhibits DNA synthesis and is commonly used in the treatment of carcinomas of the breast, gastrointestinal tract and genitourinary tract."6.40Sclerosing canaliculitis after 5-fluorouracil breast cancer chemotherapy. ( Bentley, CR; Lee, V; Olver, JM, 1998)
"Intraperitoneal chemotherapy with mitomycin C and 5-fluorouracil has been used to rescue patients from peritoneal carcinomatosis after perforated cystadenocarcinoma of the large bowel or appendix."3.68Histologic changes induced by intraperitoneal chemotherapy with 5-fluorouracil and mitomycin C in patients with peritoneal carcinomatosis from cystadenocarcinoma of the colon or appendix. ( Jaffe, G; Landy, D; Pascal, R; Sugarbaker, PH, 1990)
"5-Fluorouracil is a pyrimidine analogue that inhibits DNA synthesis and is commonly used in the treatment of carcinomas of the breast, gastrointestinal tract and genitourinary tract."2.40Sclerosing canaliculitis after 5-fluorouracil breast cancer chemotherapy. ( Bentley, CR; Lee, V; Olver, JM, 1998)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19901 (12.50)18.7374
1990's5 (62.50)18.2507
2000's1 (12.50)29.6817
2010's1 (12.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lawal, TO1
Farris, AB1
El-Rayes, BF1
Subramanian, RM1
Kim, HS1
Aihara, H1
Maruoka, H1
Kiyozaki, H1
Konishi, F1
Zinzani, PL1
Bendandi, M1
Frezza, G1
Gherlinzoni, F1
Merla, E1
Salvucci, M1
Magagnoli, M1
Babini, L1
Tura, S1
Lee, V1
Bentley, CR1
Olver, JM1
Martelli, MP1
Martelli, M1
Pescarmona, E1
De Sanctis, V1
Donato, V1
Palombi, F1
Todisco, E1
Rendina, EA1
Pau, FM1
Mandelli, F1
Todeschini, G1
Ambrosetti, A1
Meneghini, V1
Pizzolo, G1
Menestrina, F1
Chilosi, M1
Benedetti, F1
Veneri, D1
Cetto, GL1
Perona, G1
Sugarbaker, PH1
Landy, D1
Jaffe, G1
Pascal, R1
Markman, M1

Reviews

2 reviews available for fluorouracil and Sclerosis

ArticleYear
Sclerosing canaliculitis after 5-fluorouracil breast cancer chemotherapy.
    Eye (London, England), 1998, Volume: 12 ( Pt 3a)

    Topics: Aged; Antimetabolites, Antineoplastic; Breast Neoplasms; Dacryocystorhinostomy; Female; Fluorouracil

1998
Intracavitary chemotherapy.
    Critical reviews in oncology/hematology, 1985, Volume: 3, Issue:3

    Topics: Absorption; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Ascitic

1985

Trials

2 trials available for fluorouracil and Sclerosis

ArticleYear
Primary Mediastinal B-cell lymphoma with sclerosis: clinical and therapeutic evaluation of 22 patients.
    Leukemia & lymphoma, 1996, Volume: 21, Issue:3-4

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Combined Modality Therapy; Cycloph

1996
MACOP-B and involved field radiation therapy is an effective therapy for primary mediastinal large B-cell lymphoma with sclerosis.
    Annals of oncology : official journal of the European Society for Medical Oncology, 1998, Volume: 9, Issue:9

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Combined Modality Ther

1998

Other Studies

4 other studies available for fluorouracil and Sclerosis

ArticleYear
Oxaliplatin-induced hepatoportal sclerosis, portal hypertension, and variceal bleeding successfully treated with transjugular intrahepatic portosystemic shunt.
    Clinical colorectal cancer, 2012, Volume: 11, Issue:3

    Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Colo

2012
Sclerosing encapsulating peritonitis (SEP) as a delayed complication of continuous hyperthermic peritoneal perfusion (CHPP): report of a case.
    Surgery today, 2003, Volume: 33, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Cancer, Regional Perfusion; Cisplatin;

2003
Mediastinal large-B-cell lymphoma with sclerosis: a clinical study of 21 patients.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1990, Volume: 8, Issue:5

    Topics: Adolescent; Adult; Age Factors; Antineoplastic Combined Chemotherapy Protocols; B-Lymphocytes; Bleom

1990
Histologic changes induced by intraperitoneal chemotherapy with 5-fluorouracil and mitomycin C in patients with peritoneal carcinomatosis from cystadenocarcinoma of the colon or appendix.
    Cancer, 1990, Apr-01, Volume: 65, Issue:7

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Appendiceal Neoplasms; Colonic Neoplasm

1990