fluorouracil has been researched along with Sclerosis in 8 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Sclerosis: A pathological process consisting of hardening or fibrosis of an anatomical structure, often a vessel or a nerve.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Intraperitoneal chemotherapy with mitomycin C and 5-fluorouracil has been used to rescue patients from peritoneal carcinomatosis after perforated cystadenocarcinoma of the large bowel or appendix." | 7.68 | Histologic changes induced by intraperitoneal chemotherapy with 5-fluorouracil and mitomycin C in patients with peritoneal carcinomatosis from cystadenocarcinoma of the colon or appendix. ( Jaffe, G; Landy, D; Pascal, R; Sugarbaker, PH, 1990) |
| "5-Fluorouracil is a pyrimidine analogue that inhibits DNA synthesis and is commonly used in the treatment of carcinomas of the breast, gastrointestinal tract and genitourinary tract." | 6.40 | Sclerosing canaliculitis after 5-fluorouracil breast cancer chemotherapy. ( Bentley, CR; Lee, V; Olver, JM, 1998) |
| "Intraperitoneal chemotherapy with mitomycin C and 5-fluorouracil has been used to rescue patients from peritoneal carcinomatosis after perforated cystadenocarcinoma of the large bowel or appendix." | 3.68 | Histologic changes induced by intraperitoneal chemotherapy with 5-fluorouracil and mitomycin C in patients with peritoneal carcinomatosis from cystadenocarcinoma of the colon or appendix. ( Jaffe, G; Landy, D; Pascal, R; Sugarbaker, PH, 1990) |
| "5-Fluorouracil is a pyrimidine analogue that inhibits DNA synthesis and is commonly used in the treatment of carcinomas of the breast, gastrointestinal tract and genitourinary tract." | 2.40 | Sclerosing canaliculitis after 5-fluorouracil breast cancer chemotherapy. ( Bentley, CR; Lee, V; Olver, JM, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (12.50) | 18.7374 |
| 1990's | 5 (62.50) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lawal, TO | 1 |
| Farris, AB | 1 |
| El-Rayes, BF | 1 |
| Subramanian, RM | 1 |
| Kim, HS | 1 |
| Aihara, H | 1 |
| Maruoka, H | 1 |
| Kiyozaki, H | 1 |
| Konishi, F | 1 |
| Zinzani, PL | 1 |
| Bendandi, M | 1 |
| Frezza, G | 1 |
| Gherlinzoni, F | 1 |
| Merla, E | 1 |
| Salvucci, M | 1 |
| Magagnoli, M | 1 |
| Babini, L | 1 |
| Tura, S | 1 |
| Lee, V | 1 |
| Bentley, CR | 1 |
| Olver, JM | 1 |
| Martelli, MP | 1 |
| Martelli, M | 1 |
| Pescarmona, E | 1 |
| De Sanctis, V | 1 |
| Donato, V | 1 |
| Palombi, F | 1 |
| Todisco, E | 1 |
| Rendina, EA | 1 |
| Pau, FM | 1 |
| Mandelli, F | 1 |
| Todeschini, G | 1 |
| Ambrosetti, A | 1 |
| Meneghini, V | 1 |
| Pizzolo, G | 1 |
| Menestrina, F | 1 |
| Chilosi, M | 1 |
| Benedetti, F | 1 |
| Veneri, D | 1 |
| Cetto, GL | 1 |
| Perona, G | 1 |
| Sugarbaker, PH | 1 |
| Landy, D | 1 |
| Jaffe, G | 1 |
| Pascal, R | 1 |
| Markman, M | 1 |
2 reviews available for fluorouracil and Sclerosis
| Article | Year |
|---|---|
Sclerosing canaliculitis after 5-fluorouracil breast cancer chemotherapy.
Topics: Aged; Antimetabolites, Antineoplastic; Breast Neoplasms; Dacryocystorhinostomy; Female; Fluorouracil | 1998 |
Intracavitary chemotherapy.
Topics: Absorption; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Ascitic | 1985 |
2 trials available for fluorouracil and Sclerosis
| Article | Year |
|---|---|
Primary Mediastinal B-cell lymphoma with sclerosis: clinical and therapeutic evaluation of 22 patients.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Combined Modality Therapy; Cycloph | 1996 |
MACOP-B and involved field radiation therapy is an effective therapy for primary mediastinal large B-cell lymphoma with sclerosis.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Combined Modality Ther | 1998 |
4 other studies available for fluorouracil and Sclerosis
| Article | Year |
|---|---|
Oxaliplatin-induced hepatoportal sclerosis, portal hypertension, and variceal bleeding successfully treated with transjugular intrahepatic portosystemic shunt.
Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Colo | 2012 |
Sclerosing encapsulating peritonitis (SEP) as a delayed complication of continuous hyperthermic peritoneal perfusion (CHPP): report of a case.
Topics: Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Cancer, Regional Perfusion; Cisplatin; | 2003 |
Mediastinal large-B-cell lymphoma with sclerosis: a clinical study of 21 patients.
Topics: Adolescent; Adult; Age Factors; Antineoplastic Combined Chemotherapy Protocols; B-Lymphocytes; Bleom | 1990 |
Histologic changes induced by intraperitoneal chemotherapy with 5-fluorouracil and mitomycin C in patients with peritoneal carcinomatosis from cystadenocarcinoma of the colon or appendix.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Appendiceal Neoplasms; Colonic Neoplasm | 1990 |