Page last updated: 2024-10-27

fluorouracil and Sclerosis, Systemic

fluorouracil has been researched along with Sclerosis, Systemic in 10 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Research Excerpts

ExcerptRelevanceReference
"Twelve patients with systemic sclerosis according to American Rheumatism Association criteria were treated with intravenous 5-fluorouracil."1.27A new promising treatment in systemic sclerosis: 5-fluorouracil. ( Alarcón, GS; Casas, JA; Subauste, CP, 1987)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19905 (50.00)18.7374
1990's2 (20.00)18.2507
2000's1 (10.00)29.6817
2010's1 (10.00)24.3611
2020's1 (10.00)2.80

Authors

AuthorsStudies
El-Hout, S1
Lopez, L1
Schaeverbeke, T1
Richez, C1
Kostine, M1
Truchetet, ME1
Monfort, JB1
Mathian, A1
Amoura, Z1
Francès, C1
Barbaud, A1
Senet, P1
Benomar, S1
Boutayeb, S1
Benzekri, L1
Senouci, K1
Errihani, H1
Hassam, B1
Akama, H1
Casas, JA2
Saway, PA1
Villarreal, I1
Nolte, C1
Menajovsky, BL1
Escudero, EE1
Blackburn, WD2
Alarcón, GS3
Subauste, CP2
Barton, JC1
Saway, DA1
Fallahi, S1
Jakes, JT1
Malaviya, AN1
Singh, RR1
Dhar, A1
Gupta, YK1
Kumar, A1
Agarwal, P1
Mathur, R1
Bhide, NK1
Schuppli, R2

Trials

2 trials available for fluorouracil and Sclerosis, Systemic

ArticleYear
5-fluorouracil in the treatment of scleroderma: a randomised, double blind, placebo controlled international collaborative study.
    Annals of the rheumatic diseases, 1990, Volume: 49, Issue:11

    Topics: Adult; Double-Blind Method; Female; Fluorouracil; Humans; Male; Scleroderma, Systemic; Time Factors

1990
5-Fluorouracil in progressive systemic sclerosis: is it safe?
    Annals of the rheumatic diseases, 1988, Volume: 47, Issue:11

    Topics: Clinical Trials as Topic; Fluorouracil; Humans; Scleroderma, Systemic

1988

Other Studies

8 other studies available for fluorouracil and Sclerosis, Systemic

ArticleYear
Rapidly progressive interstitial lung disease under FOLFOX treatment for colorectal cancer associated with systemic sclerosis: two case reports.
    Rheumatology (Oxford, England), 2021, 02-01, Volume: 60, Issue:2

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Female; Fluorouracil; Hu

2021
[Cancers associated with systemic sclerosis involving anti-RNA polymerase III antibodies].
    Annales de dermatologie et de venereologie, 2018, Volume: 145, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Autoantibodies; Autoantigens; Carcinoma; Carcinoma,

2018
[Limited 5-fluorouracil-induced systemic scleroderma].
    Annales de dermatologie et de venereologie, 2009, Volume: 136, Issue:11

    Topics: Adult; Antimetabolites, Antineoplastic; Calcium Channel Blockers; Colectomy; Colonic Neoplasms; Fema

2009
Systemic sclerosis possibly caused by 5-fluorouracil.
    New York state journal of medicine, 1991, Volume: 91, Issue:1

    Topics: Age Factors; Aged; Fluorouracil; Humans; Male; Scleroderma, Systemic

1991
Thrombotic thrombocytopenic purpura in systemic sclerosis.
    The Journal of rheumatology, 1989, Volume: 16, Issue:10

    Topics: Adult; Female; Fluorouracil; Humans; Purpura, Thrombotic Thrombocytopenic; Scleroderma, Systemic

1989
A new promising treatment in systemic sclerosis: 5-fluorouracil.
    Annals of the rheumatic diseases, 1987, Volume: 46, Issue:10

    Topics: Adult; Female; Fluorouracil; Humans; Middle Aged; Scleroderma, Systemic

1987
[Practical use of immunosuppressive and cytostatic drugs in dermatological diseases].
    Minerva medica, 1970, Jul-11, Volume: 61, Issue:55

    Topics: Antineoplastic Agents; Azathioprine; Condylomata Acuminata; Fluorouracil; Humans; Immunosuppressive

1970
[Treatment of dermatologic lesions using immunosuppressive agents and cytostatics].
    Munchener medizinische Wochenschrift (1950), 1970, Mar-20, Volume: 112, Issue:12

    Topics: Antineoplastic Agents; Azathioprine; Dermatomyositis; Fluorouracil; Humans; Immunosuppressive Agents

1970