fluorouracil has been researched along with Sclerosis, Systemic in 10 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Twelve patients with systemic sclerosis according to American Rheumatism Association criteria were treated with intravenous 5-fluorouracil." | 1.27 | A new promising treatment in systemic sclerosis: 5-fluorouracil. ( Alarcón, GS; Casas, JA; Subauste, CP, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (50.00) | 18.7374 |
| 1990's | 2 (20.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| El-Hout, S | 1 |
| Lopez, L | 1 |
| Schaeverbeke, T | 1 |
| Richez, C | 1 |
| Kostine, M | 1 |
| Truchetet, ME | 1 |
| Monfort, JB | 1 |
| Mathian, A | 1 |
| Amoura, Z | 1 |
| Francès, C | 1 |
| Barbaud, A | 1 |
| Senet, P | 1 |
| Benomar, S | 1 |
| Boutayeb, S | 1 |
| Benzekri, L | 1 |
| Senouci, K | 1 |
| Errihani, H | 1 |
| Hassam, B | 1 |
| Akama, H | 1 |
| Casas, JA | 2 |
| Saway, PA | 1 |
| Villarreal, I | 1 |
| Nolte, C | 1 |
| Menajovsky, BL | 1 |
| Escudero, EE | 1 |
| Blackburn, WD | 2 |
| Alarcón, GS | 3 |
| Subauste, CP | 2 |
| Barton, JC | 1 |
| Saway, DA | 1 |
| Fallahi, S | 1 |
| Jakes, JT | 1 |
| Malaviya, AN | 1 |
| Singh, RR | 1 |
| Dhar, A | 1 |
| Gupta, YK | 1 |
| Kumar, A | 1 |
| Agarwal, P | 1 |
| Mathur, R | 1 |
| Bhide, NK | 1 |
| Schuppli, R | 2 |
2 trials available for fluorouracil and Sclerosis, Systemic
| Article | Year |
|---|---|
5-fluorouracil in the treatment of scleroderma: a randomised, double blind, placebo controlled international collaborative study.
Topics: Adult; Double-Blind Method; Female; Fluorouracil; Humans; Male; Scleroderma, Systemic; Time Factors | 1990 |
5-Fluorouracil in progressive systemic sclerosis: is it safe?
Topics: Clinical Trials as Topic; Fluorouracil; Humans; Scleroderma, Systemic | 1988 |
8 other studies available for fluorouracil and Sclerosis, Systemic
| Article | Year |
|---|---|
Rapidly progressive interstitial lung disease under FOLFOX treatment for colorectal cancer associated with systemic sclerosis: two case reports.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Female; Fluorouracil; Hu | 2021 |
[Cancers associated with systemic sclerosis involving anti-RNA polymerase III antibodies].
Topics: Antineoplastic Combined Chemotherapy Protocols; Autoantibodies; Autoantigens; Carcinoma; Carcinoma, | 2018 |
[Limited 5-fluorouracil-induced systemic scleroderma].
Topics: Adult; Antimetabolites, Antineoplastic; Calcium Channel Blockers; Colectomy; Colonic Neoplasms; Fema | 2009 |
Systemic sclerosis possibly caused by 5-fluorouracil.
Topics: Age Factors; Aged; Fluorouracil; Humans; Male; Scleroderma, Systemic | 1991 |
Thrombotic thrombocytopenic purpura in systemic sclerosis.
Topics: Adult; Female; Fluorouracil; Humans; Purpura, Thrombotic Thrombocytopenic; Scleroderma, Systemic | 1989 |
A new promising treatment in systemic sclerosis: 5-fluorouracil.
Topics: Adult; Female; Fluorouracil; Humans; Middle Aged; Scleroderma, Systemic | 1987 |
[Practical use of immunosuppressive and cytostatic drugs in dermatological diseases].
Topics: Antineoplastic Agents; Azathioprine; Condylomata Acuminata; Fluorouracil; Humans; Immunosuppressive | 1970 |
[Treatment of dermatologic lesions using immunosuppressive agents and cytostatics].
Topics: Antineoplastic Agents; Azathioprine; Dermatomyositis; Fluorouracil; Humans; Immunosuppressive Agents | 1970 |