fluorouracil has been researched along with Scleroderma, Systemic in 10 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Scleroderma, Systemic: A chronic multi-system disorder of CONNECTIVE TISSUE. It is characterized by SCLEROSIS in the SKIN, the LUNGS, the HEART, the GASTROINTESTINAL TRACT, the KIDNEYS, and the MUSCULOSKELETAL SYSTEM. Other important features include diseased small BLOOD VESSELS and AUTOANTIBODIES. The disorder is named for its most prominent feature (hard skin), and classified into subsets by the extent of skin thickening: LIMITED SCLERODERMA and DIFFUSE SCLERODERMA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Twelve patients with systemic sclerosis according to American Rheumatism Association criteria were treated with intravenous 5-fluorouracil." | 1.27 | A new promising treatment in systemic sclerosis: 5-fluorouracil. ( Alarcón, GS; Casas, JA; Subauste, CP, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (50.00) | 18.7374 |
| 1990's | 2 (20.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| El-Hout, S | 1 |
| Lopez, L | 1 |
| Schaeverbeke, T | 1 |
| Richez, C | 1 |
| Kostine, M | 1 |
| Truchetet, ME | 1 |
| Monfort, JB | 1 |
| Mathian, A | 1 |
| Amoura, Z | 1 |
| Francès, C | 1 |
| Barbaud, A | 1 |
| Senet, P | 1 |
| Benomar, S | 1 |
| Boutayeb, S | 1 |
| Benzekri, L | 1 |
| Senouci, K | 1 |
| Errihani, H | 1 |
| Hassam, B | 1 |
| Akama, H | 1 |
| Casas, JA | 2 |
| Saway, PA | 1 |
| Villarreal, I | 1 |
| Nolte, C | 1 |
| Menajovsky, BL | 1 |
| Escudero, EE | 1 |
| Blackburn, WD | 2 |
| Alarcón, GS | 3 |
| Subauste, CP | 2 |
| Barton, JC | 1 |
| Saway, DA | 1 |
| Fallahi, S | 1 |
| Jakes, JT | 1 |
| Malaviya, AN | 1 |
| Singh, RR | 1 |
| Dhar, A | 1 |
| Gupta, YK | 1 |
| Kumar, A | 1 |
| Agarwal, P | 1 |
| Mathur, R | 1 |
| Bhide, NK | 1 |
| Schuppli, R | 2 |
2 trials available for fluorouracil and Scleroderma, Systemic
| Article | Year |
|---|---|
5-fluorouracil in the treatment of scleroderma: a randomised, double blind, placebo controlled international collaborative study.
Topics: Adult; Double-Blind Method; Female; Fluorouracil; Humans; Male; Scleroderma, Systemic; Time Factors | 1990 |
5-Fluorouracil in progressive systemic sclerosis: is it safe?
Topics: Clinical Trials as Topic; Fluorouracil; Humans; Scleroderma, Systemic | 1988 |
8 other studies available for fluorouracil and Scleroderma, Systemic
| Article | Year |
|---|---|
Rapidly progressive interstitial lung disease under FOLFOX treatment for colorectal cancer associated with systemic sclerosis: two case reports.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Female; Fluorouracil; Hu | 2021 |
[Cancers associated with systemic sclerosis involving anti-RNA polymerase III antibodies].
Topics: Antineoplastic Combined Chemotherapy Protocols; Autoantibodies; Autoantigens; Carcinoma; Carcinoma, | 2018 |
[Limited 5-fluorouracil-induced systemic scleroderma].
Topics: Adult; Antimetabolites, Antineoplastic; Calcium Channel Blockers; Colectomy; Colonic Neoplasms; Fema | 2009 |
Systemic sclerosis possibly caused by 5-fluorouracil.
Topics: Age Factors; Aged; Fluorouracil; Humans; Male; Scleroderma, Systemic | 1991 |
Thrombotic thrombocytopenic purpura in systemic sclerosis.
Topics: Adult; Female; Fluorouracil; Humans; Purpura, Thrombotic Thrombocytopenic; Scleroderma, Systemic | 1989 |
A new promising treatment in systemic sclerosis: 5-fluorouracil.
Topics: Adult; Female; Fluorouracil; Humans; Middle Aged; Scleroderma, Systemic | 1987 |
[Practical use of immunosuppressive and cytostatic drugs in dermatological diseases].
Topics: Antineoplastic Agents; Azathioprine; Condylomata Acuminata; Fluorouracil; Humans; Immunosuppressive | 1970 |
[Treatment of dermatologic lesions using immunosuppressive agents and cytostatics].
Topics: Antineoplastic Agents; Azathioprine; Dermatomyositis; Fluorouracil; Humans; Immunosuppressive Agents | 1970 |