fluorouracil has been researched along with Scalp Dermatoses in 18 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Scalp Dermatoses: Skin diseases involving the SCALP.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A cumulative meta-analysis was performed to determine the efficacy of imiquimod 5% cream, which presents a new alternative topical therapy for actinic keratosis, and to compare it to 5-fluorouracil for the treatment of actinic keratosis lesions of the face and scalp." | 8.82 | Evaluation of the effectiveness of imiquimod and 5-fluorouracil for the treatment of actinic keratosis: Critical review and meta-analysis of efficacy studies. ( Davey, V; Gupta, AK; Mcphail, H, 2005) |
| "At 12 months after the end of treatment in patients with multiple actinic keratosis lesions on the head, 5% fluorouracil cream was the most effective of four field-directed treatments." | 5.30 | Randomized Trial of Four Treatment Approaches for Actinic Keratosis. ( Arits, AHMM; Essers, BAB; Jansen, MHE; Kelleners-Smeets, NWJ; Kessels, JPHM; Kouloubis, N; Mosterd, K; Nelemans, PJ; Quaedvlieg, PJF; Steijlen, PM; van Pelt, HPA, 2019) |
| "It is timely to compare the efficacy and tolerability of 2 actinic keratosis (AK) therapies--5% 5-fluorouracil (5-FU) cream and imiquimod cream." | 5.12 | Comparison of 5% 5-fluorouracil cream and 5% imiquimod cream in the management of actinic keratoses on the face and scalp. ( Tanghetti, E; Werschler, P, 2007) |
| "A cumulative meta-analysis was performed to determine the efficacy of imiquimod 5% cream, which presents a new alternative topical therapy for actinic keratosis, and to compare it to 5-fluorouracil for the treatment of actinic keratosis lesions of the face and scalp." | 4.82 | Evaluation of the effectiveness of imiquimod and 5-fluorouracil for the treatment of actinic keratosis: Critical review and meta-analysis of efficacy studies. ( Davey, V; Gupta, AK; Mcphail, H, 2005) |
| "Giant seborrheic keratosis was observed on the frontal scalp of a 44-year-old man." | 1.29 | Giant seborrheic keratosis on the frontal scalp treated with topical fluorouracil. ( Morita, A; Tsuji, T, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (16.67) | 18.7374 |
| 1990's | 1 (5.56) | 18.2507 |
| 2000's | 6 (33.33) | 29.6817 |
| 2010's | 7 (38.89) | 24.3611 |
| 2020's | 1 (5.56) | 2.80 |
| Authors | Studies |
|---|---|
| Raza, SA | 1 |
| Ali, FR | 1 |
| Fine, JD | 1 |
| Dewan, A | 1 |
| Miller, JL | 1 |
| Petersen Vitello Kalil, CL | 1 |
| Herman Reinehr, CP | 1 |
| de Mattos Milman, L | 1 |
| Bakos, RM | 1 |
| Mazzella, C | 1 |
| Greco, V | 1 |
| Costa, C | 1 |
| Scalvenzi, M | 1 |
| Russo, D | 1 |
| Savastano, R | 1 |
| Staibano, S | 1 |
| Fabbrocini, G | 1 |
| Jansen, MHE | 1 |
| Kessels, JPHM | 1 |
| Nelemans, PJ | 1 |
| Kouloubis, N | 1 |
| Arits, AHMM | 1 |
| van Pelt, HPA | 1 |
| Quaedvlieg, PJF | 1 |
| Essers, BAB | 1 |
| Steijlen, PM | 1 |
| Kelleners-Smeets, NWJ | 1 |
| Mosterd, K | 1 |
| Stockfleth, E | 1 |
| Sibbring, GC | 1 |
| Alarcon, I | 1 |
| Kaur, RR | 1 |
| Alikhan, A | 1 |
| Maibach, HI | 1 |
| Black, JM | 1 |
| Hodari, KT | 1 |
| Rogers, N | 1 |
| Farris, PK | 1 |
| Lewis, AT | 1 |
| Boh, EE | 1 |
| Jury, CS | 1 |
| Ramraka-Jones, VS | 1 |
| Gudi, V | 1 |
| Herd, RM | 1 |
| Smith, SR | 1 |
| Morhenn, VB | 1 |
| Piacquadio, DJ | 1 |
| Gupta, AK | 2 |
| Davey, V | 1 |
| Mcphail, H | 1 |
| Laing, ME | 1 |
| Laing, TA | 1 |
| Mulligan, NJ | 1 |
| Keane, FM | 1 |
| Tanghetti, E | 1 |
| Werschler, P | 1 |
| Baum, EW | 1 |
| Sams, WM | 1 |
| Monheit, GD | 1 |
| Lane-Brown, MM | 1 |
| Tsuji, T | 1 |
| Morita, A | 1 |
| Weiss, JS | 1 |
| Jorizzo, JL | 1 |
| Winton, GB | 1 |
| Salasche, SJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Topical Ingenol Mebutate Versus 5% 5-fluorouracil Versus 5% Imiquimod Versus Photodynamic Therapy in Treatment of Actinic Keratosis: a Multi-centre Randomized Efficacy and Cost-effectiveness Study[NCT02281682] | Phase 4 | 624 participants (Actual) | Interventional | 2014-11-30 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for fluorouracil and Scalp Dermatoses
| Article | Year |
|---|---|
New Topical Treatment Options for Actinic Keratosis: A Systematic Review.
Topics: Administration, Cutaneous; Aminoquinolines; Dermatologic Agents; Diterpenes; Drug Combinations; Faci | 2016 |
Comparison of topical 5-fluorouracil formulations in actinic keratosis treatment.
Topics: Administration, Cutaneous; Clinical Trials as Topic; Dermatologic Agents; Facial Dermatoses; Fluorou | 2010 |
Evaluation of the effectiveness of imiquimod and 5-fluorouracil for the treatment of actinic keratosis: Critical review and meta-analysis of efficacy studies.
Topics: Adjuvants, Immunologic; Aminoquinolines; Clinical Trials, Phase III as Topic; Confidence Intervals; | 2005 |
5-fluorouracil 0.5% cream for multiple actinic or solar keratoses of the face and anterior scalp.
Topics: Facial Dermatoses; Fluorouracil; Humans; Keratosis; Scalp Dermatoses | 2001 |
4 trials available for fluorouracil and Scalp Dermatoses
| Article | Year |
|---|---|
Randomized Trial of Four Treatment Approaches for Actinic Keratosis.
Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Diterpenes; Female; Fluorouracil; Follow-Up Studies; G | 2019 |
A randomized trial of topical 5% 5-fluorouracil (Efudix cream) in the treatment of actinic keratoses comparing daily with weekly treatment.
Topics: Aged; Aged, 80 and over; Antimetabolites; Drug Administration Schedule; Facial Dermatoses; Female; F | 2005 |
Bilateral comparison of the efficacy and tolerability of 3% diclofenac sodium gel and 5% 5-fluorouracil cream in the treatment of actinic keratoses of the face and scalp.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites, Antineoplastic; Diclofenac; Facial Dermato | 2006 |
Comparison of 5% 5-fluorouracil cream and 5% imiquimod cream in the management of actinic keratoses on the face and scalp.
Topics: Administration, Topical; Adult; Aminoquinolines; Disease Management; Erythema; Facial Dermatoses; Fl | 2007 |
10 other studies available for fluorouracil and Scalp Dermatoses
| Article | Year |
|---|---|
Comparison of efficacy of field treatments for actinic keratoses.
Topics: Adult; Aminolevulinic Acid; Diterpenes; Fluorouracil; Humans; Imiquimod; Keratosis, Actinic; Photoch | 2020 |
Occurrence of Acute Cerebellar Syndrome After Topical Application of Fluorouracil.
Topics: Acute Disease; Administration, Topical; Cerebellar Diseases; Fluorouracil; Humans; Immunosuppressive | 2017 |
Combination Therapies: Laser-Assisted Delivery of 5-Fluorouracil.
Topics: Aged; Aged, 80 and over; Combined Modality Therapy; Dermatologic Agents; Facial Dermatoses; Female; | 2019 |
Management of clinical and subclinical actinic keratoses with histological and immunohistochemical assessments by confocal microscopy.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites, Antineoplastic; Diclofenac; Fluorouracil; | 2018 |
Exudative, nonhealing scalp: a complication of systemic chemotherapy with capecitabine and bevacizumab.
Topics: Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherap | 2011 |
Eosinophilic pustular folliculitis induced by chemotherapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Drug Eruptions; | 2006 |
Angiolymphoid hyperplasia with eosinophilia. The disease and a comparison of treatment modalities.
Topics: Biopsy; Bleomycin; Cryosurgery; Eosinophilic Granuloma; Female; Fluorouracil; Humans; Microscopy, El | 1982 |
Scalp and nail psoriasis.
Topics: Dermatologic Agents; Fluorouracil; Humans; Nail Diseases; Psoriasis; Scalp Dermatoses | 1980 |
Giant seborrheic keratosis on the frontal scalp treated with topical fluorouracil.
Topics: Administration, Cutaneous; Adult; Fluorouracil; Gentamicins; Humans; Keratosis, Seborrheic; Male; Oc | 1995 |
Dermabrasion of the scalp as a treatment for actinic damage.
Topics: Aged; Alopecia; Dermabrasion; Fluorouracil; Humans; Keratosis; Male; Middle Aged; Scalp Dermatoses; | 1986 |