fluorouracil has been researched along with Sarcoma in 81 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Sarcoma: A connective tissue neoplasm formed by proliferation of mesodermal cells; it is usually highly malignant.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment with salazinic acid (25 and 50 mg/kg) and 5-Fluorouracil (20 mg/kg) started 24-hours after inoculation and was performed for 7 days." | 5.91 | Histological evaluation of the liver of mice with sarcoma-180 treated with salazinic acid. ( Aguiar Júnior, FCA; Falcão, EPS; Lira, MADC; Melo, SJ; Silva, MMD; Silva, WKM, 2023) |
| "Metastasizing epithelioid sarcoma (ES) is an extremely aggressive tumor, because conventional chemotherapy and irradiation are largely ineffective." | 5.35 | Paclitaxel (Taxol)-induced apoptosis in human epithelioid sarcoma cell lines is enhanced by upregulation of CD95 ligand (FasL/Apo-1L). ( Gabbert, HE; Grinstein, E; Haremza, J; Heikaus, S; Mahotka, C; Matuszek, KS; Ramp, U; Reinecke, P; Suschek, CV, 2008) |
| "Of the 14 evaluable patients (11 with breast carcinoma and three with sarcoma), one patient with breast carcinoma achieved a partial remission and a second patient with breast carcinoma remained stable." | 5.26 | Amphotericin B and combination chemotherapy in the treatment of refractory metastatic breast carcinoma and sarcoma. ( Blumenschein, GR; Buzdar, AU; Krutchik, AN; Sinkovics, JG, 1978) |
| " Swiss mice inoculated with hepatoma HepA(22) or sarcoma 180 (S(180)) cells were treated with ShD or 5-fluorouracil (5Fu)." | 3.78 | Shikonin derivatives protect immune organs from damage and promote immune responses in vivo in tumour-bearing mice. ( BaoJie, G; GuangZhi, Y; LiHua, L; Long, S; Wei, X; Yang, Z; YanYong, H; YingLi, W, 2012) |
| " Meyer by hot water extraction and DEAE-cellulose chromatography was tested for its anticancer activity alone and in combination with 5-fluorouracil (5-FU) in Sarcoma-180 (S180) tumor-bearing mice by intragastric administration." | 3.76 | Antitumor activities and immunomodulatory effects of ginseng neutral polysaccharides in combination with 5-fluorouracil. ( Chen, Y; Fan, Y; Han, H; Ni, W; Tai, G; Wang, B; Zhang, X; Zhou, Y, 2010) |
| " Adenocarcinoma patients receive mitomycin C and 5-fluorouracil; sarcoma patients receive cisplatin and doxorubicin." | 3.69 | Intraperitoneal chemotherapy for treatment and prevention of peritoneal carcinomatosis and sarcomatosis. ( Sugarbaker, PH, 1994) |
| "Eleven patients with osteogenic sarcoma (9), Hodgkin disease (1), and mesenchymal sarcoma (1), were treated with 5-fluorouracil (5-FU) and cisplatin (DDP)." | 3.66 | 5-fluorouracil and cis-platinum in the treatment of refractory solid tumors: a pediatric oncology group phase I-II study. ( Chan, R; Dyment, PG; Land, VJ; Starling, K; Strandjord, SE, 1981) |
| "Antibody against a breast carcinoma antigen was present in patients with breast carcinoma and other cancer more often (P less than ." | 2.64 | Immunology and adjuvant chemoimmunotherapy of breast cancer. ( Morton, DL; Ramming, KP; Silver, HK; Sparks, FC; Wile, AG; Wolk, RW, 1976) |
| "The pharmacokinetic advantage of a novel system to noninvasively isolate the hepatic venous outflow and infuse high doses of chemotherapy (doxorubicin or 5-FU) is discussed and compared with intravenous infusion and intra-arterial infusion without hepatic venous detoxification." | 2.39 | Isolated liver perfusion for liver metastases: pharmacokinetic advantage? ( Dixon, K; Ravikumar, TS, 1996) |
| "Treatment with salazinic acid (25 and 50 mg/kg) and 5-Fluorouracil (20 mg/kg) started 24-hours after inoculation and was performed for 7 days." | 1.91 | Histological evaluation of the liver of mice with sarcoma-180 treated with salazinic acid. ( Aguiar Júnior, FCA; Falcão, EPS; Lira, MADC; Melo, SJ; Silva, MMD; Silva, WKM, 2023) |
| "Fatigue was a prominent long-lasting symptom in these patients." | 1.37 | Health-related quality of life in long-term survivors after high-dose chemoradiotherapy followed by surgery in esophageal cancer. ( Aarstad, AK; Aarstad, HJ; Hjermstad, MJ; Hurmuzlu, M; Viste, A, 2011) |
| "The incidence of gallbladder cancer (GBC) in the US is 1." | 1.35 | Gallbladder cancer (GBC): 10-year experience at Memorial Sloan-Kettering Cancer Centre (MSKCC). ( Abou-Alfa, GK; Blumgart, LH; Capanu, M; D'Angelica, M; Dematteo, RP; Duffy, A; Fong, Y; Huitzil, D; Jarnagin, W; O'Reilly, EM, 2008) |
| "Metastasizing epithelioid sarcoma (ES) is an extremely aggressive tumor, because conventional chemotherapy and irradiation are largely ineffective." | 1.35 | Paclitaxel (Taxol)-induced apoptosis in human epithelioid sarcoma cell lines is enhanced by upregulation of CD95 ligand (FasL/Apo-1L). ( Gabbert, HE; Grinstein, E; Haremza, J; Heikaus, S; Mahotka, C; Matuszek, KS; Ramp, U; Reinecke, P; Suschek, CV, 2008) |
| "In addition, 5FC treatment of bone sarcomas caused a significant reduction in cancer-induced bone destruction (P < 0." | 1.32 | Direct and bystander killing of sarcomas by novel cytosine deaminase fusion gene. ( Clohisy, DR; Goblirsch, M; Lewis, V; Lynch, C; Mantyh, P; Orchard, P; Pan, W; Ramnaraine, M, 2003) |
| "Fifty-three patients with localized esophageal cancer received concurrent chemoradiotherapy followed by brachytherapy." | 1.30 | High-dose-rate brachytherapy boost following concurrent chemoradiotherapy for esophageal carcinoma. ( Dokiya, T; Oki, Y; Yorozu, A, 1999) |
| "5-Fluorouracil (FUra) is a clinically useful antineoplastic agent." | 1.27 | Phase I and clinical pharmacological evaluation of biochemical modulation of 5-fluorouracil with N-(phosphonacetyl)-L-aspartic acid. ( Casper, ES; Martin, DS; Vale, K; Williams, LJ; Young, CW, 1983) |
| " Our results show that all five drugs exhibited a dose-response relationship against tumor cells and GM-CFUC." | 1.27 | Differential cytotoxic activity of chemotherapy agents on colony-forming cells from human tumors and normal bone marrow in vitro. ( Ajani, JA; Baker, FL; Blaauw, AA; Dicke, KA; Spitzer, G; Thielvoldt, D; Tomasovic, B; Umbach, G; Zander, AR, 1985) |
| " The therapy is to be used effectfully only then, when indication, dosage and control of the patients are performed critically and exactly." | 1.26 | [Chemotherapy of malignant solid tumors]. ( Knöll, P; Siering, H, 1980) |
| "One of the responding patients with colon cancer and two with breast cancer had failed to respond to prior therapy with 5-FU; one of the responding patients with breast cancer had previously received an inadequate trial of a similar regimen." | 1.26 | Phase II trial of combination therapy with continuous-infusion PALA and bolus-injection 5-FU. ( Ervin, TJ; Kufe, DW; Meshad, MW; Weiss, GR, 1982) |
| "A case of abdominal wall epithelioid sarcoma, studied by light and electron microscopy over a 3-year period, is presented." | 1.26 | Epithelioid sarcoma: case report with ultrastructural review, histogenetic discussion, and chemotherapeutic data. ( Bloustein, PA; Silverberg, SG; Waddell, WR, 1976) |
| "Of the 14 evaluable patients (11 with breast carcinoma and three with sarcoma), one patient with breast carcinoma achieved a partial remission and a second patient with breast carcinoma remained stable." | 1.26 | Amphotericin B and combination chemotherapy in the treatment of refractory metastatic breast carcinoma and sarcoma. ( Blumenschein, GR; Buzdar, AU; Krutchik, AN; Sinkovics, JG, 1978) |
| "The treatment of breast and ovarian cancer brought the best results, improved by a synchronisation therapy." | 1.26 | [Five years treatment of advanced solid malignomas with a combination of four cytostatic drugs (author's transl)]. ( Siebner, H; Weber, W, 1976) |
| "Seventeen patients with primary liver cancer were also treated with adriamycin." | 1.26 | Adriamycin in the treatment of cancer. ( Falkson, G; Falkson, HC; van der Merwe, AM; van Dyk, JJ, 1976) |
| "All 14 patients with breast carcinoma underwent remission and in 6 this was complete." | 1.25 | Seventy-five cases of solid tumours treated by a modified quadruple chemotherapy regime. ( Hanham, IW; Newton, KA; Westbury, G, 1971) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 60 (74.07) | 18.7374 |
| 1990's | 6 (7.41) | 18.2507 |
| 2000's | 8 (9.88) | 29.6817 |
| 2010's | 5 (6.17) | 24.3611 |
| 2020's | 2 (2.47) | 2.80 |
| Authors | Studies |
|---|---|
| Zou, ZR | 1 |
| Yi, YH | 1 |
| Wu, HM | 1 |
| Wu, JH | 1 |
| Liaw, CC | 1 |
| Lee, KH | 1 |
| Lira, MADC | 1 |
| Silva, MMD | 1 |
| Silva, WKM | 1 |
| Falcão, EPS | 1 |
| Aguiar Júnior, FCA | 1 |
| Melo, SJ | 1 |
| da Conceição de Lira, MA | 1 |
| da Silva, MM | 1 |
| Rocha, TA | 1 |
| de Moura, DF | 1 |
| Santos Costa, EC | 1 |
| Dos Santos Maia, M | 1 |
| Scotti, L | 1 |
| Scotti, MT | 1 |
| de Lourdes Lacerda Buril, M | 1 |
| Pereira, EC | 1 |
| de Aguiar Júnior, FCA | 1 |
| de Britto Lira Nogueira, MC | 1 |
| da Silva Santos, NP | 1 |
| da Silva Falcão, EP | 1 |
| de Melo, SJ | 1 |
| Gao, X | 1 |
| Sanderson, SM | 1 |
| Dai, Z | 1 |
| Reid, MA | 1 |
| Cooper, DE | 1 |
| Lu, M | 1 |
| Richie, JP | 1 |
| Ciccarella, A | 1 |
| Calcagnotto, A | 1 |
| Mikhael, PG | 1 |
| Mentch, SJ | 1 |
| Liu, J | 1 |
| Ables, G | 1 |
| Kirsch, DG | 1 |
| Hsu, DS | 1 |
| Nichenametla, SN | 1 |
| Locasale, JW | 1 |
| Cai, B | 1 |
| Chen, H | 1 |
| Sun, H | 2 |
| Wan, P | 1 |
| Pan, J | 1 |
| Duffy, A | 1 |
| Capanu, M | 1 |
| Abou-Alfa, GK | 1 |
| Huitzil, D | 1 |
| Jarnagin, W | 1 |
| Fong, Y | 1 |
| D'Angelica, M | 1 |
| Dematteo, RP | 1 |
| Blumgart, LH | 1 |
| O'Reilly, EM | 1 |
| Ni, W | 1 |
| Zhang, X | 1 |
| Wang, B | 1 |
| Chen, Y | 1 |
| Han, H | 1 |
| Fan, Y | 1 |
| Zhou, Y | 1 |
| Tai, G | 1 |
| Hurmuzlu, M | 1 |
| Aarstad, HJ | 1 |
| Aarstad, AK | 1 |
| Hjermstad, MJ | 1 |
| Viste, A | 1 |
| Long, S | 1 |
| GuangZhi, Y | 1 |
| BaoJie, G | 1 |
| Wei, X | 1 |
| YanYong, H | 1 |
| YingLi, W | 1 |
| Yang, Z | 1 |
| LiHua, L | 1 |
| MACLEOD, RM | 1 |
| KING, CE | 1 |
| HOLLANDER, VP | 1 |
| KNOCK, FE | 1 |
| KASBEKAR, DK | 1 |
| GREENBERG, DM | 1 |
| BRINDLEY, CO | 1 |
| MCBRIDE, TJ | 1 |
| NOBLE, LC | 1 |
| CARR, MA | 1 |
| HULL, K | 1 |
| OLESON, JJ | 1 |
| MOORE, JG | 1 |
| VANCAMPENHOUT, JL | 1 |
| BRANDKAMP, WW | 1 |
| FALKSON, G | 2 |
| SNYMAN, HJ | 1 |
| KARNOFSKY, DA | 1 |
| MYHRE, K | 1 |
| FJAERLI, J | 1 |
| SAKURAI, Y | 1 |
| CRESSY, NL | 1 |
| SCHELL, HW | 1 |
| MCALISTER, WH | 1 |
| Ramnaraine, M | 2 |
| Pan, W | 2 |
| Goblirsch, M | 1 |
| Lynch, C | 1 |
| Lewis, V | 1 |
| Orchard, P | 1 |
| Mantyh, P | 1 |
| Clohisy, DR | 2 |
| Lutz, NW | 1 |
| Naser-Hijazi, B | 1 |
| Koroma, S | 1 |
| Berger, MR | 1 |
| Hull, WE | 1 |
| Stepanova, EV | 1 |
| Bokhian, BIu | 1 |
| Petrovichev, NN | 1 |
| Lichinitzer, MR | 1 |
| Heikaus, S | 1 |
| Matuszek, KS | 1 |
| Suschek, CV | 1 |
| Ramp, U | 1 |
| Reinecke, P | 1 |
| Grinstein, E | 1 |
| Haremza, J | 1 |
| Gabbert, HE | 1 |
| Mahotka, C | 1 |
| Brocard, H | 1 |
| Akoun, G | 1 |
| Turpin, G | 1 |
| Gendre, JP | 1 |
| Siering, H | 2 |
| Knöll, P | 1 |
| Presant, CA | 1 |
| Ardalan, B | 1 |
| Multhauf, P | 1 |
| Chan, C | 1 |
| Staples, R | 1 |
| Green, L | 1 |
| Browning, S | 1 |
| Carr, BI | 1 |
| Chang, FF | 1 |
| Thayer, W | 1 |
| Bedikian, AY | 1 |
| Chen, TT | 1 |
| Khankhanian, N | 1 |
| Heilbrun, LK | 1 |
| McBride, CM | 1 |
| McMurtrey, MJ | 1 |
| Bodey, GP | 1 |
| Bobchev, T | 1 |
| Tsekov, V | 1 |
| Casper, ES | 1 |
| Vale, K | 1 |
| Williams, LJ | 1 |
| Martin, DS | 1 |
| Young, CW | 1 |
| Land, VJ | 1 |
| Dyment, PG | 1 |
| Starling, K | 1 |
| Strandjord, SE | 1 |
| Chan, R | 1 |
| Erlichman, C | 1 |
| Donehower, RC | 1 |
| Speyer, JL | 1 |
| Klecker, R | 1 |
| Chabner, BA | 1 |
| Weiss, GR | 1 |
| Ervin, TJ | 1 |
| Meshad, MW | 1 |
| Kufe, DW | 1 |
| Jurga, L | 1 |
| Mrinák, J | 1 |
| Ponist, J | 1 |
| Sefara, P | 1 |
| Berc, A | 1 |
| Kelm, C | 1 |
| Henneking, K | 1 |
| Zimmermann, T | 1 |
| Vollerthun, M | 1 |
| Padberg, W | 1 |
| Sugarbaker, PH | 1 |
| Zalupski, MM | 1 |
| Baker, LH | 1 |
| Borden, EC | 1 |
| Wadler, S | 1 |
| Ravikumar, TS | 1 |
| Dixon, K | 1 |
| Yorozu, A | 1 |
| Dokiya, T | 1 |
| Oki, Y | 1 |
| Sadahiro, S | 1 |
| Makuuchi, H | 1 |
| Suzuki, T | 1 |
| Tokunaga, N | 1 |
| Ishizu, K | 1 |
| Tajima, T | 1 |
| Tanner, AR | 1 |
| Bolton, PM | 1 |
| Powell, LW | 1 |
| Bloustein, PA | 1 |
| Silverberg, SG | 1 |
| Waddell, WR | 1 |
| Oberfield, RA | 1 |
| Merrin, CE | 1 |
| Murphy, GP | 1 |
| Chavaudra, N | 1 |
| Malaise, EP | 1 |
| Pinedo, HM | 1 |
| Kenis, Y | 1 |
| Krutchik, AN | 1 |
| Buzdar, AU | 1 |
| Blumenschein, GR | 1 |
| Sinkovics, JG | 1 |
| Felsch, G | 1 |
| Barthel, E | 1 |
| Sparks, FC | 1 |
| Wile, AG | 1 |
| Ramming, KP | 1 |
| Silver, HK | 1 |
| Wolk, RW | 1 |
| Morton, DL | 1 |
| Siebner, H | 1 |
| Weber, W | 1 |
| Dowell, KE | 1 |
| Armstrong, DM | 1 |
| Aust, JB | 1 |
| Cruz, AB | 1 |
| Smith, JP | 2 |
| Rutledge, F | 2 |
| van Dyk, JJ | 1 |
| van der Merwe, AM | 1 |
| Falkson, HC | 1 |
| Ajani, JA | 1 |
| Blaauw, AA | 1 |
| Spitzer, G | 1 |
| Baker, FL | 1 |
| Tomasovic, B | 1 |
| Umbach, G | 1 |
| Thielvoldt, D | 1 |
| Zander, AR | 1 |
| Dicke, KA | 1 |
| Bolla, M | 1 |
| Borgel, J | 1 |
| Winckel, P | 1 |
| Vrousos, C | 1 |
| Swiercz, P | 1 |
| Gary-Bobo, J | 1 |
| Hellriegel, W | 1 |
| Sutow, WW | 1 |
| Richard, JM | 1 |
| Sancho, H | 1 |
| Ringkjob, R | 1 |
| Watt, J | 1 |
| Costanzi, JJ | 1 |
| Coltman, CA | 1 |
| Malkasian, GD | 1 |
| Decker, DG | 1 |
| Jorgensen, EO | 1 |
| Webb, MJ | 1 |
| Hall, TC | 2 |
| Hill, GJ | 1 |
| Larsen, RR | 1 |
| Nathanson, L | 1 |
| Schilling, A | 1 |
| Miller, S | 1 |
| Moore, GE | 1 |
| Bross, ID | 1 |
| Ausmans, R | 1 |
| Nadler, S | 1 |
| Jones, R | 1 |
| Slack, N | 1 |
| Rimm, AA | 1 |
| Morrone, G | 1 |
| Krementz, ET | 1 |
| Kokame, GM | 1 |
| Mannes, P | 1 |
| Derriks, R | 1 |
| Moens, R | 1 |
| Heynen, E | 1 |
| O'Brien, PH | 1 |
| Artz, CP | 1 |
| Ferguson, DJ | 1 |
| Harper, PV | 1 |
| Buchheim, E | 1 |
| Chevrel, B | 1 |
| Chevrel, JP | 1 |
| Hanham, IW | 1 |
| Newton, KA | 1 |
| Westbury, G | 1 |
| Mitchell, MS | 1 |
| DeConti, RC | 1 |
| Grant, JP | 1 |
| Harper PV FERGUSON, DJ | 1 |
| Sato, Y | 1 |
| Morita, M | 1 |
| Watanabe, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase II Trial of Dose Escalated Proton Beam Therapy or Photon Therapy for Resectable and Unresectable Esophageal Cancer[NCT03234842] | Phase 2 | 0 participants (Actual) | Interventional | 2017-10-30 | Withdrawn (stopped due to non-accrual) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for fluorouracil and Sarcoma
| Article | Year |
|---|---|
[Sarcoma of the uterus].
Topics: Adolescent; Cyclophosphamide; Dactinomycin; Doxorubicin; Drug Therapy, Combination; Female; Fluorour | 1982 |
Isolated liver perfusion for liver metastases: pharmacokinetic advantage?
Topics: Adenocarcinoma; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents; | 1996 |
Chemotherapy of advanced soft-tissue sarcomas in adults.
Topics: Adult; Antineoplastic Agents; Bone Marrow; Clinical Trials as Topic; Cyclophosphamide; Dacarbazine; | 1977 |
The use of cytotoxic drugs in the surgery of malignant disease.
Topics: Abdominal Neoplasms; Alkylating Agents; Animals; Antimetabolites; Antineoplastic Agents; Carcinoma, | 1968 |
Predictive tests in cancer. Tuesday 9 April 1974.
Topics: Age Factors; Breast Neoplasms; Cell Movement; Clinical Enzyme Tests; Colonic Neoplasms; Cytarabine; | 1974 |
[Cytostatic chemotherapy of neoplasms in children].
Topics: Adrenal Cortex Hormones; Aminopterin; Antineoplastic Agents; Asparaginase; Child; Child, Preschool; | 1971 |
7 trials available for fluorouracil and Sarcoma
| Article | Year |
|---|---|
Low-dose, continuous infusion 5-fluorouracil and oral etoposide for the treatment of advanced sarcomas.
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Diarrhea; Drug Administration | 1995 |
Chemotherapy of advanced soft-tissue sarcomas in adults.
Topics: Adult; Antineoplastic Agents; Bone Marrow; Clinical Trials as Topic; Cyclophosphamide; Dacarbazine; | 1977 |
Immunology and adjuvant chemoimmunotherapy of breast cancer.
Topics: Aged; Animals; Antibodies, Neoplasm; BCG Vaccine; Breast Neoplasms; Carcinoma; Chick Embryo; Cycloph | 1976 |
Advances in chemotherapy for gynecologic cancer.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Chlorambucil; Cyclophosphamide; Dactinomycin; Drug | 1975 |
Evaluation of 6,17 alpha-dimethyl-6-dehydroprogesterone for treatment of recurrent and metastatic gynecologic malignancy.
Topics: Adenocarcinoma; Administration, Oral; Adult; Aged; Clinical Trials as Topic; Cyclophosphamide; Drug | 1974 |
Concurrent combination chemotherapy of human solid tumors: experience with a three-drug regimen and review of the literature.
Topics: Adolescent; Adult; Aged; Bone Marrow; Bone Neoplasms; Carcinoma; Child; Child, Preschool; Clinical T | 1969 |
Effects of 5-fluorouracil (NSC-19893) in 389 patients with cancer. Eastern Clinical Drug Evaluation Program.
Topics: Breast Neoplasms; Clinical Trials as Topic; Female; Fluorouracil; Gastrointestinal Neoplasms; Humans | 1968 |
69 other studies available for fluorouracil and Sarcoma
| Article | Year |
|---|---|
Intercedensides A-C, three new cytotoxic triterpene glycosides from the sea cucumber Mensamaria intercedens Lampert.
Topics: Animals; Antineoplastic Agents; China; Drug Screening Assays, Antitumor; Glycosides; Lung Neoplasms; | 2003 |
Histological evaluation of the liver of mice with sarcoma-180 treated with salazinic acid.
Topics: Animals; Fatty Liver; Fluorouracil; Liver; Mice; Sarcoma | 2023 |
Assessment of Cytotoxic/Antitumour Potential and
Topics: Animals; Antineoplastic Agents; Fluorouracil; Humans; Lichens; Mice; Salicylates; Sarcoma | 2023 |
Dietary methionine influences therapy in mouse cancer models and alters human metabolism.
Topics: Animals; Cell Line, Tumor; Colorectal Neoplasms; Diet; Disease Models, Animal; Female; Fluorouracil; | 2019 |
Production of immunoregulatory polysaccharides from Crassostrea hongkongensis and their positive effects as a nutrition factor in modulating the effectiveness and toxicity of 5-FU chemotherapy in mice.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Crassostrea; Dietary Supplements; Dose-Response Re | 2016 |
Gallbladder cancer (GBC): 10-year experience at Memorial Sloan-Kettering Cancer Centre (MSKCC).
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Capecitabine; Chemotherapy, Adjuvan | 2008 |
Antitumor activities and immunomodulatory effects of ginseng neutral polysaccharides in combination with 5-fluorouracil.
Topics: Animals; Antineoplastic Agents, Phytogenic; Chemotherapy, Adjuvant; Drug Synergism; Drug Therapy, Co | 2010 |
Health-related quality of life in long-term survivors after high-dose chemoradiotherapy followed by surgery in esophageal cancer.
Topics: Adenocarcinoma; Adult; Aged; Carcinoma, Squamous Cell; Chemotherapy, Adjuvant; Cisplatin; Dose Fract | 2011 |
Shikonin derivatives protect immune organs from damage and promote immune responses in vivo in tumour-bearing mice.
Topics: Adjuvants, Immunologic; Animals; Antigens, CD19; Antineoplastic Agents, Phytogenic; Boraginaceae; Ca | 2012 |
EFFECT OF CORTICOSTEROIDS ON RIBONUCLEASE AND NUCLEIC ACID CONTENT IN LYMPHOSARCOMA P1798.
Topics: Adrenal Cortex Hormones; Animals; Edetic Acid; Fluorouracil; Glucocorticoids; Lymphoma; Lymphoma, No | 1963 |
COORDINATED SURGICAL-CHEMICAL THERAPY OF CANCER.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cyclophosphamide; DNA; DNA, Neoplasm; Fluorouracil; | 1963 |
STUDIES ON TUMOR RESISTANCE TO 5-FLUOROURACIL.
Topics: Animals; Carbon Isotopes; Carboxy-Lyases; Fluorouracil; Genetics; Lymphoma; Lymphoma, Non-Hodgkin; M | 1963 |
METHODOLOGY OF PRELIMINARY CHEMOTHERAPEUTIC TRIALS IN PATIENTS WITH MALIGNANT SOLID TUMORS.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Bronchial Neoplasms; Colonic Neoplasms; Cyclophosp | 1963 |
CHEMOTHERAPEUTIC STUDIES WITH OSTEOGENIC SARCOMA HE10734.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Carcinoma 256, Walker; Carcinoma, Hepatocellular; Fl | 1964 |
EFFECTS OF IONIZING IRRADIATION AND CHEMOTHERAPEUTIC AGENTS ON HUMAN CHROMOSOMES.
Topics: Antineoplastic Agents; Biomedical Research; Chlorambucil; Choriocarcinoma; Chromosome Aberrations; C | 1964 |
EXPERIENCE WITH CHEMOTHERAPY OF CANCER AT THE UNIVERSITY OF PRETORIA.
Topics: Antineoplastic Agents; Aziridines; Breast Neoplasms; Cyclophosphamide; Dactinomycin; Fluorouracil; H | 1964 |
NONSURGICAL TREATMENT OF PULMONARY CANCER.
Topics: Adenocarcinoma, Bronchiolo-Alveolar; Adrenal Cortex Hormones; Alkylating Agents; Antineoplastic Agen | 1964 |
TREATMENT OF MALIGNANT TUMOURS WITH 5-FLUOROURACIL IN 80 PATIENTS.
Topics: Biomedical Research; Breast Neoplasms; Colonic Neoplasms; Drug Therapy; Esophageal Neoplasms; Female | 1964 |
IN VITRO CULTURE OF YOSHIDA SARCOMA CELLS: METHODS FOR DETERMINING ACQUIRED RESISTANCE TO DRUGS.
Topics: Animals; Antineoplastic Agents; Azaguanine; Culture Media; Cyclophosphamide; Dactinomycin; Drug Tole | 1964 |
EFFECTIVENESS AND TOXICITY OF PROLONGED INFUSIONS OF 5-FLUOROURACIL IN THE TREATMENT OF CANCER.
Topics: Adenocarcinoma; Adenocarcinoma, Bronchiolo-Alveolar; Antineoplastic Agents; Carcinoma; Carcinoma, Sq | 1965 |
COMPARISON OF THE EFFECTS OF CHEMOTHERAPY AND LOCAL IRRADIATION ON THE VASCULARITY OF A TRANSPLANTED MOUSE MAMMARY ADENOCARCINOMA AND A PLEOMORPHIC SARCOMA.
Topics: Adenocarcinoma; Angiography; Animals; Blood Vessels; Fluorouracil; Mammary Neoplasms, Animal; Mammar | 1965 |
Direct and bystander killing of sarcomas by novel cytosine deaminase fusion gene.
Topics: Animals; Bone Neoplasms; Cell Line, Tumor; Cytosine Deaminase; Flucytosine; Fluorouracil; Genetic Th | 2003 |
Fluoropyrimidine chemotherapy in a rat model: comparison of fluorouracil metabolite profiles determined by high-field 19F-NMR spectroscopy of tissues ex vivo with therapy response and toxicity for locoregional vs systemic infusion protocols.
Topics: Animals; Antimetabolites, Antineoplastic; Data Interpretation, Statistical; Drug Therapy; Female; Fl | 2004 |
Osteoclasts direct bystander killing of cancer cells in vitro.
Topics: Animals; Antimetabolites, Antineoplastic; Bone Marrow Cells; Bone Neoplasms; Breast Neoplasms; Cell | 2006 |
[Thymidylate synthase, thymidine phosphorylase and dihydropyrimidine dehydrogenase expression in soft-tissue sarcoma versus capecitabine potential].
Topics: Adult; Antimetabolites, Antineoplastic; Biomarkers, Tumor; Capecitabine; Deoxycytidine; Dihydrouraci | 2005 |
Paclitaxel (Taxol)-induced apoptosis in human epithelioid sarcoma cell lines is enhanced by upregulation of CD95 ligand (FasL/Apo-1L).
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Fas Ligand Protein; fas Receptor; Fl | 2008 |
[Attack treatment of broncho-pleuro-pulmonary cancer by polychemotherapy under the protection of phytohemagglutinin].
Topics: Adenocarcinoma; Adult; Aged; Antibiotics, Antineoplastic; Antineoplastic Agents; Azirines; Betametha | 1967 |
[Chemotherapy of malignant solid tumors].
Topics: Bleomycin; Breast Neoplasms; Bronchial Neoplasms; Cyclophosphamide; Fluorouracil; Humans; Kidney Neo | 1980 |
Continuous five-day infusion of PALA and 5FU: a pilot phase II trial.
Topics: Adult; Aged; Aspartic Acid; Carcinoma; Colonic Neoplasms; Drug Administration Schedule; Drug Eruptio | 1983 |
The natural history of gastric cancer and prognostic factors influencing survival.
Topics: Adenocarcinoma; Adult; Aged; Female; Fluorouracil; Gastrectomy; Humans; Liver Neoplasms; Lymphatic M | 1984 |
Phase I and clinical pharmacological evaluation of biochemical modulation of 5-fluorouracil with N-(phosphonacetyl)-L-aspartic acid.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Aspartic Acid; Blood Cell Count; Carcinoma; Drug Admin | 1983 |
5-fluorouracil and cis-platinum in the treatment of refractory solid tumors: a pediatric oncology group phase I-II study.
Topics: Adolescent; Adult; Child; Cisplatin; Drug Administration Schedule; Drug Evaluation; Drug Therapy, Co | 1981 |
Phase I-phase II trial of N-phosphonacetyl-L-aspartic acid given by intravenous infusion and 5-fluorouracil given by bolus injection.
Topics: Adult; Aged; Antineoplastic Agents; Aspartic Acid; Colonic Neoplasms; Drug Administration Schedule; | 1982 |
Phase II trial of combination therapy with continuous-infusion PALA and bolus-injection 5-FU.
Topics: Adult; Aged; Aspartic Acid; Breast Neoplasms; Carcinoma; Colonic Neoplasms; Drug Evaluation; Drug Th | 1982 |
Non-invasive methods for detection of cardiomyopathy in the course of antineoplastic treatment.
Topics: Antineoplastic Agents; Breast Neoplasms; Cardiomyopathies; Doxorubicin; Drug Therapy, Combination; F | 1982 |
[Palliative therapy of primary liver tumors].
Topics: Adenoma, Bile Duct; Adolescent; Adult; Aged; alpha-Fetoproteins; Angiography; Antineoplastic Combine | 1993 |
Intraperitoneal chemotherapy for treatment and prevention of peritoneal carcinomatosis and sarcomatosis.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Chemotherapy, Adjuvant; Cisplatin; Doxoru | 1994 |
Interferons as biochemical modulators.
Topics: Antineoplastic Agents; Clinical Trials, Phase III as Topic; Colorectal Neoplasms; Drug Synergism; Fl | 1996 |
High-dose-rate brachytherapy boost following concurrent chemoradiotherapy for esophageal carcinoma.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Brac | 1999 |
A novel weekday-on/weekend-off UFT schedule.
Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy | 2000 |
Primary sarcoma of the liver. Report of a case with excellent response to hepatic artery ligation and infusion chemotherapy.
Topics: Aged; Female; Fluorouracil; Hepatic Artery; Humans; Ligation; Liver Neoplasms; Palliative Care; Sarc | 1978 |
Epithelioid sarcoma: case report with ultrastructural review, histogenetic discussion, and chemotherapeutic data.
Topics: Abdominal Muscles; Antineoplastic Agents; Cyclophosphamide; Cytarabine; Drug Therapy, Combination; E | 1976 |
Recent trends in chemotherapy of solid tumors.
Topics: Alkylating Agents; Antibiotics, Antineoplastic; Antineoplastic Agents; Brain Neoplasms; Breast Neopl | 1975 |
Chemotherapy of urogenital cancer.
Topics: Adenocarcinoma; Adult; Child; Cyclophosphamide; Dactinomycin; Doxorubicin; Female; Fluorouracil; Hum | 1976 |
In vitro incorporation of [3H]TdR in human and murine solid tumours. Influence of 5-fluorouracil and/or hyperbaric oxygen on spatial distribution of labelling.
Topics: Animals; Autoradiography; Carcinoma, Squamous Cell; Fluorouracil; Humans; Mice; Neoplasms; Neoplasms | 1979 |
Amphotericin B and combination chemotherapy in the treatment of refractory metastatic breast carcinoma and sarcoma.
Topics: Adult; Aged; Amphotericin B; Antineoplastic Agents; Breast Neoplasms; Cyclophosphamide; Dacarbazine; | 1978 |
[Experiences with cytostatic treatment of malignant tumors].
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Breast Neoplasms; Bronchial Neoplasms; Cyclophos | 1976 |
[Five years treatment of advanced solid malignomas with a combination of four cytostatic drugs (author's transl)].
Topics: Adult; Aged; Breast Neoplasms; Cyclophosphamide; Drug Therapy, Combination; Female; Fluorouracil; Hu | 1976 |
Systemic chemotherapy of advanced head and neck malignancies.
Topics: Adenocarcinoma; Antineoplastic Agents; Carcinoma, Squamous Cell; Cyclophosphamide; Cytarabine; Doxor | 1975 |
Adriamycin in the treatment of cancer.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Cyclophosphamide; Doxorubicin; Drug Therapy, Combi | 1976 |
Differential cytotoxic activity of chemotherapy agents on colony-forming cells from human tumors and normal bone marrow in vitro.
Topics: Antineoplastic Agents; Bleomycin; Breast Neoplasms; Cell Survival; Cells, Cultured; Cisplatin; Doxor | 1985 |
[Combination cisplatin, fluorouracil and low-dose radiotherapy in recurrent soft tissue sarcomas].
Topics: Cisplatin; Combined Modality Therapy; Fluorouracil; Humans; Neoplasm Recurrence, Local; Sarcoma; Sof | 1986 |
[Mitomycin alone and in therapeutic association in the palliative treatment of solid tumors].
Topics: Antineoplastic Agents; Breast Neoplasms; Cobalt Isotopes; Cyclophosphamide; Drug Combinations; Femal | 1971 |
[Esophageal tumors--therapeutic problems].
Topics: Adenocarcinoma; Bleomycin; Carcinoma; Carcinoma, Squamous Cell; Cobalt Isotopes; Esophageal Neoplasm | 1972 |
Malignant gynecologic tumors in children: current approaches to treatment.
Topics: Age Factors; Child; Child, Preschool; Choriocarcinoma; Cyclophosphamide; Dactinomycin; Dysgerminoma; | 1973 |
[Intra-arterial chemotherapy of head and neck tumors: statistical study of 129 cases treated at the Institut Gustave Roussy].
Topics: Adult; Aged; Antineoplastic Agents; Bleomycin; Carcinoma; Carcinoma, Squamous Cell; Facial Neoplasms | 1973 |
Treatment of intracranial gliomas and metastatic carcinomas by local application of cytostatic agents.
Topics: Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Carcinoma; Female; Fluorouracil; Glioblastoma; | 1968 |
Combination chemotherapy using cyclophosphamide, vincristine, methotrexate and 5-fluorouracil in solid tumors.
Topics: Adenocarcinoma; Adult; Carcinoma, Squamous Cell; Cyclophosphamide; Female; Fibrosarcoma; Fluorouraci | 1969 |
Cancer chemotherapy. I. Methods, agents and overall results in 400 patients.
Topics: Adenocarcinoma; Amides; Androgens; Breast Neoplasms; Colonic Neoplasms; Cyclophosphamide; Estrogens; | 1972 |
Regional chemotherapy of cancer of the head and neck.
Topics: Antineoplastic Agents; Carcinoma; Chemotherapy, Cancer, Regional Perfusion; Fluorouracil; Head; Head | 1966 |
[Antineoplastic polychemotherapy in thoracic pathology].
Topics: Adrenalectomy; Aged; Antineoplastic Agents; Breast Neoplasms; Bronchial Neoplasms; Cortisone; Cyclop | 1968 |
Expectations and pitfalls of chemotherapy in a university cancer clinic.
Topics: Breast Neoplasms; Cyclophosphamide; Female; Fluorouracil; Gastrointestinal Neoplasms; Hospitals, Tea | 1972 |
Effective anti-cancer agents selected by suppression of cesium-131 uptake.
Topics: Adrenalectomy; Antineoplastic Agents; Breast Neoplasms; Cesium Isotopes; Cyclophosphamide; Estrogens | 1971 |
[Results of therapy of uterus sarcoma 1954-1968 under special consideration of combined radiotherapy and 5-fluorouracil treatment].
Topics: Adult; Aged; Female; Fluorouracil; Humans; Middle Aged; Neoplasm Metastasis; Radiation-Sensitizing A | 1971 |
[Gallbladder cancer].
Topics: Adenocarcinoma; Adenoma; Carcinoma; Cholelithiasis; Fluorouracil; Gallbladder Neoplasms; Humans; Mel | 1971 |
Seventy-five cases of solid tumours treated by a modified quadruple chemotherapy regime.
Topics: Adolescent; Adult; Aged; Breast Neoplasms; Bronchial Neoplasms; Child; Cyclophosphamide; Female; Flu | 1971 |
Immunosuppression by 5-fluorouracil.
Topics: Adenocarcinoma; Adult; Aged; Antibody Formation; Antigens; Blood Bactericidal Activity; Blood Platel | 1970 |
Effect of chemotherapy on uptake of alkali metals by experimental tumors.
Topics: Animals; Azaserine; Carcinoma; Cesium; Cyclophosphamide; Fluorouracil; In Vitro Techniques; Mammary | 1968 |
[Cancer chemotherapeutic agents].
Topics: Antineoplastic Agents; Fluorouracil; Humans; Nose Neoplasms; Sarcoma | 1969 |