fluorouracil has been researched along with Sarcoma 37 in 3 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Sarcoma 37: An experimental sarcoma of mice.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Oral administration of a liposome-encapsulated agent triggering the synthesis of interferon--poly(I) poly (C)--to mice bearing solid sarcoma 37 was followed by (a) production of an interferon which circulates for a longer period after preliminary administration of "empty" liposomes; (b) lengthening of the period of tumor latency; in some cases tumor failed to appear at all; (c) higher efficacy of radiation treatment which was manifested by a higher inhibition of tumor growth or complete regression; (d) increased antitumor effect of 5-fluorouracil, and (e) suppression of proliferative activity of tumor." | 7.67 | [Effect of combined exposure to an interferon inducer, irradiation and 5-fluorouracil on sarcoma 37 in mice]. ( Ershov, FI; Karakulov, RK; Pelevina, II; Popov, GA; Poverennyĭ, AM, 1984) |
| "Oral administration of a liposome-encapsulated agent triggering the synthesis of interferon--poly(I) poly (C)--to mice bearing solid sarcoma 37 was followed by (a) production of an interferon which circulates for a longer period after preliminary administration of "empty" liposomes; (b) lengthening of the period of tumor latency; in some cases tumor failed to appear at all; (c) higher efficacy of radiation treatment which was manifested by a higher inhibition of tumor growth or complete regression; (d) increased antitumor effect of 5-fluorouracil, and (e) suppression of proliferative activity of tumor." | 3.67 | [Effect of combined exposure to an interferon inducer, irradiation and 5-fluorouracil on sarcoma 37 in mice]. ( Ershov, FI; Karakulov, RK; Pelevina, II; Popov, GA; Poverennyĭ, AM, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Karakulov, RK | 1 |
| Poverennyĭ, AM | 1 |
| Ershov, FI | 1 |
| Popov, GA | 1 |
| Pelevina, II | 1 |
| Meĭren, DV | 1 |
| Belousova, AK | 1 |
| Unemi, N | 1 |
| Harima, K | 1 |
| Daidai, Y | 1 |
| Fujihara, H | 1 |
| Fujii, S | 1 |
3 other studies available for fluorouracil and Sarcoma 37
| Article | Year |
|---|---|
[Effect of combined exposure to an interferon inducer, irradiation and 5-fluorouracil on sarcoma 37 in mice].
Topics: Animals; Cell Cycle; Combined Modality Therapy; Fluorouracil; Interferon Inducers; Liposomes; Mice; | 1984 |
[Mechanism of action of ftorafur, a new antineoplastic agent].
Topics: Animals; Anti-Infective Agents; Antineoplastic Agents; Carbon Radioisotopes; Carcinoma, Ehrlich Tumo | 1972 |
[Experimental studies on antineoplastic action of N 1 -(2'-tetrahydrofuryl)-5-fluorouracil (FT-207)--effect on experimental tumors].
Topics: Animals; Body Weight; Carcinoma, Ehrlich Tumor; Fluorouracil; Furans; Mice; Neoplasms, Experimental; | 1971 |