fluorouracil has been researched along with Sarcoma 180 in 112 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Sarcoma 180: An experimental sarcoma of mice.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The antitumor activity of 5-fluorouracil (FUra) against ascites Sarcoma 180 was significantly enhanced by coadministration of guanosine, and slightly by adenosine, but not by cytidine or uridine." | 7.66 | Relationship between antitumor effect and metabolites of 5-fluorouracil in combination treatment with 5-fluorouracil and guanosine in ascites sarcoma 180 tumor system. ( Hoshi, A; Iigo, M; Kuretani, K, 1983) |
| "The binding of 5-fluorouracil to polybutylcyanoacrylate nanoparticles yielded an enhanced efficacy against Crocker sarcoma S 180 and a higher toxicity of the drug measured by induced leukopenia, body weight loss and premature death." | 7.66 | Comparative study on the cytostatic effects and the tissue distribution of 5-fluorouracil in a free form and bound to polybutylcyanoacrylate nanoparticles in sarcoma 180-bearing mice. ( Hartmann, HR; Kreuter, J, 1983) |
| " To throw light on these questions, we investigated the effects of HBO and 5-fluorouracil (5-FU), individually and in combination, on Sarcoma 180 implants in mice." | 3.71 | Use of 5-FU plus hyperbaric oxygen for treating malignant tumors: evaluation of antitumor effect and measurement of 5-FU in individual organs. ( Furuyama, N; Kouda, K; Nakajima, N; Nunomura, M; Oda, K; Saito, N; Takiguchi, N, 2001) |
| "We examined the antitumor activity and side effects (myelotoxicity, immunocompetent organic toxicity and gastrointestinal toxicity) of combined treatment with the cancer chemotherapy drug 5-fluorouracil (5-FU) and dietary fiber chitosan in sarcoma 180-bearing mice." | 3.70 | Prevention by chitosan of myelotoxicity, gastrointestinal toxicity and immunocompetent organic toxicity induced by 5-fluorouracil without loss of antitumor activity in mice. ( Kimura, Y; Okuda, H, 1999) |
| "HCl], and decaprenoic acid-with anticancer agents were studied in male ICR mice with ascites sarcoma 180 (S180) and in male BALB/c mice with fibrosarcoma Meth A." | 3.67 | Potentiation of anticancer agents by new synthetic isoprenoids. II. Inhibition of the growth of transplantable murine tumors. ( Akiyama, S; Fukawa, H; Ikezaki, K; Kishiye, T; Komiyama, S; Koyama, H; Kuwano, M; Tahara, Y; Takahasi, T; Yamaguchi, T, 1984) |
| " This study provided evidence that the combination of DP and amphotericin B (AmB) significantly potentiated the inhibitory effect of 5-fluorouracil (FU) or methotrexate (MTX) against a panel of transplantable tumors including sarcoma 180, cervical carcinoma U14, and Lewis lung carcinoma in mice." | 3.67 | Potentiation of antimetabolite antitumor activity in vivo by dipyridamole and amphotericin B. ( Cao, SS; Zhen, YS, 1989) |
| "We investigated the relationships between antitumor activity and the inhibition of Thymidylate Synthase (TS) activity after oral administration of 5-fluorouracil (FUra) and its derivatives, FT, UFT, HC-FU, PH-FU and 5'-DFUR, using mainly Sarcoma 180 as an experimental tumor model." | 3.67 | [The significance of measuring inhibition of thymidylate synthase activity as a parameter for antitumor activity of 5-fluorouracil derivatives]. ( Fujii, S; Takeda, S; Uchida, J; Unemi, N; Yamada, Y, 1988) |
| "Combinations of retinol palmitate (RP) and six different anticancer agents were examined to determine their effects on the life-span of mice bearing ascites sarcoma 180 or P388 leukemia." | 3.67 | Potentiation by vitamin A of the action of anticancer agents against murine tumors. ( Akiyama, S; Komiyama, S; Kuwano, M; Nakagawa, M; Ogata, J; Shiraishi, N; Ueda, H; Yamaguchi, T, 1985) |
| " They were then evaluated as potential growth inhibitors of murine Sarcoma 180 cells in culture, of herpes simplex virus type 1 in vitro, and of Streptococcus faecium, a folic acid or deoxythymidine dependent bacterial strain." | 3.66 | Synthesis and biological activities of some uronic acids, uronates, uronamides, and urononitriles of pyrimidine nucleosides. ( Chen, MS; Prusoff, WH; Schinazi, RF, 1978) |
| "The antitumor activity of 5-fluorouracil (FUra) against ascites Sarcoma 180 was significantly enhanced by coadministration of guanosine, and slightly by adenosine, but not by cytidine or uridine." | 3.66 | Relationship between antitumor effect and metabolites of 5-fluorouracil in combination treatment with 5-fluorouracil and guanosine in ascites sarcoma 180 tumor system. ( Hoshi, A; Iigo, M; Kuretani, K, 1983) |
| "The binding of 5-fluorouracil to polybutylcyanoacrylate nanoparticles yielded an enhanced efficacy against Crocker sarcoma S 180 and a higher toxicity of the drug measured by induced leukopenia, body weight loss and premature death." | 3.66 | Comparative study on the cytostatic effects and the tissue distribution of 5-fluorouracil in a free form and bound to polybutylcyanoacrylate nanoparticles in sarcoma 180-bearing mice. ( Hartmann, HR; Kreuter, J, 1983) |
| "Antitumor activity of seven 5-fluorouracil derivatives having carbamoyl linkage with amino acid was examined against L-1210 leukemia, adenocarcinoma 755, ascites sarcoma 180, Ehrlich ascites carcinoma and Lewis lung carcinoma by oral administration." | 3.66 | Antitumor activity of 1-alkoxycarbonylalkylcarbamoyl-5-fluorouracil derivatives by oral administration. ( Ando, N; Hoshi, A; Iigo, M; Inomata, M; Kuretani, K, 1981) |
| "Pharmacokinetics of 1-alkylcarbamoyl-5-fluorouracils was examined in mice bearing sarcoma 180." | 3.66 | Pharmacokinetics of 1-alkylcarbamoyl-5-fluorouracils in plasma and ascites fluid after oral administration in mice. ( Hoshi, A; Iigo, M; Kuretani, K, 1980) |
| " In combination therapy with mitomycin C, bleomycin, cyclophosphamide, and 5-fluorouracil, palmitoyldextran phosphate manifested strong synergistic effects against both Sarcoma 180 ascites and L1210 leukemic tumors." | 3.65 | Dextran derivatives in single and combination chemotherapy against transplantable mouse ascites and solid tumors. ( Kadowaki, M; Matsumoto, T; Mikami, T; Suzuki, M; Suzuki, S, 1977) |
| "The antitumor effects of methotrexate with 5-fluorouracil against the Sarcoma 180 mouse tumor model were found to be schedule dependent." | 3.65 | Schedule-dependent antitumor effects of methotrexate and 5-fluorouracil. ( Bertino, JR; Gupta, VS; Lindquist, CA; Sawicki, WL, 1977) |
| "Sarcoma 180 was used as in vivo model." | 1.38 | In vitro and in vivo anticancer properties of cucurbitacin isolated from Cayaponia racemosa. ( Alves, AP; Chaves, DC; Costa-Lotufo, LV; Dantas, IN; Ferreira, PM; Militão, GC; Monte, FJ; Odorico de Moraes, M; Pessoa, C, 2012) |
| "RPM can reduce the toxic effect of 5-FU and prolong the lifespan of S180-bearing mice." | 1.35 | [Rhizoma Panacis majori reduces toxicity of chemotherapy in S180-bearing mice]. ( Chen, T; Fu, YL; Gong, ZB, 2008) |
| " These effects were also observed in vivo, where the combination with piplartine but not piperine with 5-FU led to a higher tumor growth inhibition." | 1.35 | In vitro and in vivo antitumor effect of 5-FU combined with piplartine and piperine. ( Alves, AP; Bezerra, DP; Costa-Lotufo, LV; de Alencar, NM; de Castro, FO; de Moraes, MO; Elmiro, FJ; Lima, MA; Lima, MW; Mesquita, RO; Pessoa, C; Silveira, ER, 2008) |
| "Biflorin was active against both tumors with a very similar profile." | 1.34 | Antitumor activity of biflorin, an o-naphthoquinone isolated from Capraria biflora. ( Alves, AP; Bezerra, DP; Costa-Lotufo, LV; Fonseca, AM; Lemos, TL; Moraes, MO; Pereira, MR; Pessoa, C; Pessoa, OD; Vasconcellos, MC, 2007) |
| " The bioavailability of UK-21 given p." | 1.28 | Antitumor activity of two novel low immunosuppressive fluoropyrimidines UK-21 and UK-25. ( Kato, T; Kitaichi, K; Koda, A; Mori, H; Sakamoto, O, 1992) |
| "In this study, a new dosage form for antitumor agents--nanocapsules was prepared from biodegradable butylcyanoacrylate (BCA)." | 1.28 | [Studies of 5-fluorouracil nanocapsules]. ( Hu, J; Pan, WS, 1991) |
| " FdUrd, in particular, had a very minor effect on rRNA production even at very toxic drug concentrations." | 1.27 | Correlation between ribosomal RNA production and RNA-directed fluoropyrimidine cytotoxicity. ( Armstrong, RD; Cadman, EC; Takimoto, CH; Tan, YY, 1987) |
| "Tegafur is a typical masked compound transformed into 5-FU by the hepatic drug-metabolizing enzyme P-450." | 1.27 | [Effects of krestin (PSK) on drug-metabolizing enzymes with special reference to the activation of FT-207]. ( Fujita, H; Ikuzawa, M; Kawai, Y; Matsuki, M; Muto, S; Nakajima, S; Ogawa, K; Shimamura, M; Togawa, M; Yoshikumi, C, 1986) |
| " At the dose of 250 mg/kg, all mice treated with 5-Fu died of toxicity but the mice treated with DMS-Fu survived and showed no obvious toxic effect." | 1.27 | [Effect and toxicity of entrapped polysiloxane 5-Fu polycondensate]. ( Fu, NW; Guo, R; Quan, LP; Zhang, LS, 1987) |
| " At the 1st hr after dosing the 5-FU level in the small intestine was close to, but that in other tissues was much lower than, the 5-FU level in the tumor of both types." | 1.26 | Tissue distribution of 5'-deoxy-5-fluorouridine and derived 5-fluorouracil in tumor-bearing mice and rats. ( Fukazawa, H; Hongu, Y; Ichihara, S; Shimizu, H; Suzuki, S, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 78 (69.64) | 18.7374 |
| 1990's | 12 (10.71) | 18.2507 |
| 2000's | 16 (14.29) | 29.6817 |
| 2010's | 6 (5.36) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Schinazi, RF | 1 |
| Chen, MS | 1 |
| Prusoff, WH | 1 |
| Yasumoto, M | 1 |
| Yamawaki, I | 1 |
| Marunaka, T | 1 |
| Hashimoto, S | 1 |
| Lin, TS | 1 |
| Wang, L | 1 |
| Antonini, I | 1 |
| Cosby, LA | 1 |
| Shiba, DA | 1 |
| Kirkpatrick, DL | 1 |
| Sartorelli, AC | 5 |
| Cook, AF | 2 |
| Holman, MJ | 2 |
| Kramer, MJ | 2 |
| Gao, H | 1 |
| Zhang, X | 1 |
| Chen, Y | 2 |
| Shen, H | 1 |
| Pang, T | 1 |
| Sun, J | 1 |
| Xu, C | 1 |
| Ding, J | 2 |
| Li, C | 1 |
| Lu, W | 1 |
| Wu, M | 1 |
| Sun, Q | 1 |
| Yang, C | 1 |
| Chen, D | 3 |
| Lin, L | 1 |
| Xie, Y | 1 |
| Rah, B | 1 |
| Lone, SH | 1 |
| Rasool, RU | 1 |
| Farooq, S | 1 |
| Nayak, D | 1 |
| Chikan, NA | 1 |
| Chakraborty, S | 1 |
| Behl, A | 1 |
| Mondhe, DM | 1 |
| Goswami, A | 1 |
| Bhat, KA | 1 |
| Wang, J | 1 |
| Zou, MJ | 1 |
| Chen, L | 1 |
| Sheng, YL | 1 |
| Zhou, XM | 1 |
| Zhang, XR | 1 |
| Lins, KO | 1 |
| Bezerra, DP | 3 |
| Alves, AP | 4 |
| Alencar, NM | 1 |
| Lima, MW | 2 |
| Torres, VM | 1 |
| Farias, WR | 1 |
| Pessoa, C | 4 |
| de Moraes, MO | 2 |
| Costa-Lotufo, LV | 4 |
| Chen, T | 1 |
| Gong, ZB | 1 |
| Fu, YL | 1 |
| Yan, C | 2 |
| Gu, J | 2 |
| Guo, Y | 1 |
| Luan, Y | 1 |
| Jing, F | 1 |
| Zhang, J | 1 |
| Zou, M | 1 |
| Wang, X | 1 |
| Jia, Y | 1 |
| Liu, N | 1 |
| Mou, J | 1 |
| Xu, W | 1 |
| Militão, GC | 1 |
| Dantas, IN | 1 |
| Ferreira, PM | 1 |
| Chaves, DC | 1 |
| Monte, FJ | 1 |
| Odorico de Moraes, M | 1 |
| Lee, SM | 1 |
| Bala, YS | 1 |
| Lee, WK | 1 |
| Jo, NJ | 1 |
| Chung, I | 1 |
| Fei, XF | 1 |
| Wang, BX | 1 |
| Li, TJ | 1 |
| Tashiro, S | 1 |
| Minami, M | 1 |
| Xing, DJ | 1 |
| Ikejima, T | 1 |
| Suzuki, Y | 1 |
| Ishibiki, Y | 1 |
| Kawai, K | 1 |
| Sasaki, M | 1 |
| Matsuda, M | 1 |
| Watanabe, T | 1 |
| Shirasaka, T | 7 |
| Kamano, T | 2 |
| EL-GHAFFAR, YA | 1 |
| ANIGSTEIN, L | 2 |
| ANIGSTEIN, DM | 2 |
| RENNELS, EG | 2 |
| KNOCK, FE | 1 |
| BOOTH, BA | 3 |
| PALMA, V | 1 |
| REYERS-DEGLIINNOCENTI, I | 1 |
| GARATTINI, S | 1 |
| Lee, S | 1 |
| Lee, YS | 1 |
| Jung, SH | 1 |
| Shin, KH | 1 |
| Kim, BK | 1 |
| Kang, SS | 1 |
| Zhang, SH | 1 |
| Su, J | 1 |
| Zhen, YS | 2 |
| Zhou, G | 1 |
| Xin, H | 1 |
| Sheng, W | 1 |
| Sun, Y | 1 |
| Li, Z | 1 |
| Xu, Z | 1 |
| Yurimoto, S | 1 |
| Miyakawa, A | 1 |
| Okuzawa, A | 1 |
| Sakamoto, S | 1 |
| Sakamoto, K | 1 |
| Hosoda, S | 1 |
| Li, GH | 1 |
| Wang, M | 1 |
| Sun, FJ | 1 |
| Wang, XR | 1 |
| Li, XJ | 1 |
| Yin, GP | 1 |
| Qin, J | 1 |
| de Castro, FO | 1 |
| Silveira, ER | 1 |
| Lima, MA | 1 |
| Elmiro, FJ | 1 |
| de Alencar, NM | 1 |
| Mesquita, RO | 1 |
| Vasconcellos, MC | 1 |
| Fonseca, AM | 1 |
| Pereira, MR | 1 |
| Lemos, TL | 1 |
| Pessoa, OD | 1 |
| Moraes, MO | 1 |
| Creasey, WA | 1 |
| Sasaki, K | 1 |
| Furusawa, S | 1 |
| Monma, K | 1 |
| Takayanagi, G | 1 |
| Browman, GP | 1 |
| Yamaguchi, T | 2 |
| Ikezaki, K | 1 |
| Kishiye, T | 1 |
| Tahara, Y | 1 |
| Koyama, H | 1 |
| Takahasi, T | 1 |
| Fukawa, H | 1 |
| Komiyama, S | 2 |
| Akiyama, S | 2 |
| Kuwano, M | 2 |
| Danysz, A | 1 |
| Wierzba, K | 1 |
| Wutkiewicz, M | 1 |
| Pniewska, A | 1 |
| Pragłowski, T | 1 |
| Burba-Anczewska, I | 1 |
| Nakamura, H | 2 |
| Yu-Qin, W | 1 |
| Miyauchi, S | 1 |
| Nishioka, N | 1 |
| Tanaka, H | 1 |
| Harada, N | 1 |
| Fujii, S | 9 |
| Ishitsuka, H | 3 |
| Miwa, M | 3 |
| Takemoto, K | 1 |
| Fukuoka, K | 1 |
| Itoga, A | 1 |
| Maruyama, HB | 1 |
| Suzuki, S | 2 |
| Hongu, Y | 1 |
| Fukazawa, H | 1 |
| Ichihara, S | 1 |
| Shimizu, H | 1 |
| Iigo, M | 5 |
| Kuretani, K | 7 |
| Hoshi, A | 7 |
| Kreuter, J | 1 |
| Hartmann, HR | 3 |
| Yin, MB | 1 |
| Zakrzewski, SF | 1 |
| Hakala, MT | 1 |
| Kitano, S | 2 |
| Ikenaka, K | 3 |
| Fukushima, M | 4 |
| Maehara, Y | 2 |
| Liang, CM | 1 |
| Donehower, RC | 1 |
| Chabner, BA | 1 |
| Tomita, Y | 1 |
| Himeno, K | 1 |
| Nomoto, K | 1 |
| Endo, H | 1 |
| Hirohata, T | 1 |
| Zakaria, M | 1 |
| Brown, PR | 1 |
| Inomata, M | 1 |
| Ando, N | 1 |
| Bollag, W | 3 |
| Iba, T | 2 |
| Yagi, Y | 2 |
| Kidokoro, A | 2 |
| Fukunaga, M | 1 |
| Uchida, J | 3 |
| Kanazawa, Y | 1 |
| Kurogi, S | 1 |
| Shinohara, S | 1 |
| Noda, Y | 1 |
| Masuda, K | 1 |
| Fukunaga, T | 1 |
| Kimura, Y | 2 |
| Okuda, H | 2 |
| Takiguchi, N | 1 |
| Saito, N | 1 |
| Nunomura, M | 1 |
| Kouda, K | 1 |
| Oda, K | 1 |
| Furuyama, N | 1 |
| Nakajima, N | 1 |
| Takaku, T | 1 |
| Nakajima, S | 3 |
| Volm, M | 2 |
| Kaufmann, M | 1 |
| Mattern, J | 2 |
| Wayss, K | 2 |
| Umezawa, I | 2 |
| Komiyama, K | 2 |
| Kawakubo, Y | 1 |
| Nishiyama, Y | 1 |
| Suzuki, M | 1 |
| Mikami, T | 1 |
| Kadowaki, M | 1 |
| Matsumoto, T | 1 |
| Jato, JG | 1 |
| Lake, LM | 1 |
| Grunden, EE | 1 |
| Johnson, BM | 1 |
| Faufmann, M | 1 |
| Trown, PW | 1 |
| Carissimi, M | 1 |
| de Meglio, P | 1 |
| Gentili, P | 1 |
| Ravenna, F | 1 |
| Shani, J | 1 |
| Berman, JA | 1 |
| Wolf, W | 1 |
| Nakamura, A | 1 |
| Bertino, JR | 1 |
| Sawicki, WL | 1 |
| Lindquist, CA | 1 |
| Gupta, VS | 1 |
| Xu, JP | 1 |
| Sakamoto, O | 1 |
| Mori, H | 1 |
| Kitaichi, K | 1 |
| Koda, A | 1 |
| Kato, T | 1 |
| Tsujinaka, T | 1 |
| Kido, Y | 1 |
| Shiozaki, H | 1 |
| Iijima, S | 1 |
| Homma, T | 1 |
| Sakaue, M | 1 |
| Mori, T | 1 |
| Emi, Y | 1 |
| Kohnoe, S | 1 |
| Yoshida, M | 1 |
| Takahashi, I | 1 |
| Sugimachi, K | 1 |
| Umeno, Y | 1 |
| Takeda, S | 2 |
| Indap, MA | 2 |
| Ambaye, RY | 2 |
| Pan, WS | 1 |
| Hu, J | 1 |
| Naik, SD | 1 |
| Takimoto, CH | 1 |
| Tan, YY | 1 |
| Cadman, EC | 1 |
| Armstrong, RD | 1 |
| Shimamoto, Y | 1 |
| Ohshimo, H | 1 |
| Imaoka, T | 1 |
| Ono, M | 1 |
| Cao, SS | 1 |
| Nishimura, J | 1 |
| Kamiyama, T | 1 |
| Eda, H | 1 |
| Fukuda, H | 1 |
| Fujimoto, K | 1 |
| Fujita, H | 4 |
| Ogawa, K | 2 |
| Ikuzawa, M | 2 |
| Muto, S | 2 |
| Matsuki, M | 2 |
| Shimamura, M | 2 |
| Togawa, M | 2 |
| Yoshikumi, C | 2 |
| Kawai, Y | 2 |
| Tatsumi, K | 1 |
| Hirokawa, Y | 1 |
| Zhibo, Y | 1 |
| Hata, T | 1 |
| Okamoto, M | 2 |
| Takao, A | 2 |
| Severin, E | 1 |
| Hagenhoff, B | 1 |
| Yamada, Y | 1 |
| Unemi, N | 2 |
| Fu, NW | 1 |
| Zhang, LS | 1 |
| Quan, LP | 1 |
| Guo, R | 1 |
| Keniry, M | 1 |
| Benz, C | 1 |
| Shafer, RH | 1 |
| James, TL | 1 |
| Osswald, H | 3 |
| Herrmann, R | 2 |
| Jones, GR | 1 |
| Kitta, D | 1 |
| Kunz, W | 2 |
| Nakagawa, M | 1 |
| Ueda, H | 1 |
| Shiraishi, N | 1 |
| Ogata, J | 1 |
| Ritter, M | 1 |
| Port, R | 1 |
| Kanzawa, F | 2 |
| Merkulov, MF | 1 |
| Leskova, SG | 1 |
| Bulbuk, GA | 1 |
| Marquillo, CL | 1 |
| Esperbén, MT | 1 |
| Harima, K | 1 |
| Daidai, Y | 1 |
| Fujihara, H | 1 |
| Price, KE | 1 |
| Bradner, WT | 1 |
| Buck, RE | 1 |
| Lein, J | 1 |
| Ringleb, D | 1 |
| Krieg, R | 1 |
| Sauer, D | 1 |
| Satter, W | 1 |
| Strider, W | 1 |
| Harvey, C | 1 |
| Nussbaum, AL | 1 |
| Baldini, L | 1 |
| Brambilla, G | 1 |
| Cavanna, M | 1 |
| Parodi, S | 1 |
| Ballweg, H | 1 |
| Schmähl, D | 1 |
| von Wedelstaedt, E | 1 |
| Fox, JJ | 1 |
| Miller, N | 1 |
| Wempen, I | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase III Trial of S-1 and Cisplatin (3 Weekly) Versus S-1 and Oxaliplatin Combination Chemotherapy for First Line Treatment of Advanced Gastric Cancer[NCT01671449] | Phase 3 | 338 participants (Actual) | Interventional | 2012-12-31 | Completed | ||
| A Phase 1b Dose Escalation Trial of PSK®/Placebo With Docetaxel to Treat Metastatic Castration-resistant Prostate Cancer[NCT01685489] | Phase 1 | 0 participants (Actual) | Interventional | 2013-05-31 | Withdrawn (stopped due to funding sequestered) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for fluorouracil and Sarcoma 180
| Article | Year |
|---|---|
High-performance liquid chromatography of nucleotides, nucleosides and bases.
Topics: Animals; Breast Neoplasms; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Defic | 1981 |
[An inducible enzyme: tryptophan pyrrolase].
Topics: Age Factors; Animals; Carcinoma, Ehrlich Tumor; Enzyme Induction; Enzyme Repression; Female; Fetus; | 1971 |
2 trials available for fluorouracil and Sarcoma 180
| Article | Year |
|---|---|
Clinical application of the concept of methotrexate plus 5-FU sequence-dependent "synergy": how good is the evidence?
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; DNA; Drug Synergi | 1984 |
Schedule-dependent inhibition of thymidylate synthase by 5-fluorouracil in gastric cancer.
Topics: Aged; Animals; Combined Modality Therapy; DNA, Neoplasm; Drug Administration Schedule; Drug Stabilit | 1992 |
108 other studies available for fluorouracil and Sarcoma 180
| Article | Year |
|---|---|
Synthesis and biological activities of some uronic acids, uronates, uronamides, and urononitriles of pyrimidine nucleosides.
Topics: Animals; Cell Division; Cells, Cultured; Chick Embryo; Pyrimidine Nucleosides; Sarcoma 180; Simplexv | 1978 |
Studies on antitumor agents, 2. Syntheses and antitumor activities of 1-(tetrahydro-2-furanyl)-5-fluorouracil and 1,3-bis(tetrahydro-2-furanyl)-5-fluorouracil.
Topics: Animals; Antineoplastic Agents; Carcinoma 256, Walker; Carcinoma, Ehrlich Tumor; Fluorouracil; Letha | 1978 |
(o- and p-Nitrobenzyloxycarbonyl)-5-fluorouracil derivatives as potential conjugated bioreductive alkylating agents.
Topics: Animals; Cells, Cultured; Chemical Phenomena; Chemistry; Fluorouracil; Leukemia P388; Mice; Neoplasm | 1986 |
Fluorinated pyrimidine nucleosides. 4. Synthesis and antitumor testing of a series of 2',5'-dideoxy- and 2',3',5'-trideoxynucleosides of 5-fluorouracil.
Topics: Animals; Antineoplastic Agents; Deoxyuridine; Floxuridine; Fluorouracil; Mice; Sarcoma 180; Tegafur | 1980 |
Synthesis and antitumor activity of the hexacyclic camptothecin derivatives.
Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Cell Survival; Drug Screening Assays | 2005 |
Synthesis and activity of Combretastatin A-4 analogues: 1,2,3-thiadiazoles as potent antitumor agents.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell S | 2007 |
Design and Synthesis of Antitumor Heck-Coupled Sclareol Analogues: Modulation of BH3 Family Members by SS-12 in Autophagy and Apoptotic Cell Death.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Cell Line, Tumor; Diterpenes | 2015 |
Synthesis, physicochemical characterization and pharmacological investigation of indolacin-5-fluorouracil-1-ylmethyl ester.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Antimetabolites, Antineoplastic; Carbon-13 Magnetic R | 2016 |
Antitumor properties of a sulfated polysaccharide from the red seaweed Champia feldmannii (Diaz-Pifferer).
Topics: Animals; Antibody Formation; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Dose-Response R | 2009 |
[Rhizoma Panacis majori reduces toxicity of chemotherapy in S180-bearing mice].
Topics: Animals; Antimetabolites, Antineoplastic; Drugs, Chinese Herbal; Female; Fluorouracil; Male; Mice; M | 2008 |
In vivo biodistribution for tumor targeting of 5-fluorouracil (5-FU) loaded N-succinyl-chitosan (Suc-Chi) nanoparticles.
Topics: Animals; Antimetabolites, Antineoplastic; Biological Availability; Chitosan; Drug Carriers; Fluorour | 2010 |
Design, synthesis, and activity evaluation of a new 5-fluorouracil prodrug containing an Asn-Gly-Arg(NO2)COOCH3 tripeptide.
Topics: Animals; Antimetabolites, Antineoplastic; CD13 Antigens; Cell Movement; Cells, Cultured; Collagen; D | 2012 |
In vitro and in vivo anticancer properties of cucurbitacin isolated from Cayaponia racemosa.
Topics: Adolescent; Adult; Animals; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineopla | 2012 |
Antitumor and antiangiogenic active dendrimer/5-fluorouracil conjugates.
Topics: Angiogenesis Inhibitors; Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Chickens; Dendr | 2013 |
Evodiamine, a constituent of Evodiae Fructus, induces anti-proliferating effects in tumor cells.
Topics: Alkaloids; Amino Acid Chloromethyl Ketones; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; b | 2003 |
Effect of combination of TS-1 and low-dose cisplatin on sarcoma-180 mouse sarcoma.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Area Under | 2003 |
The growth-stimulating effect of TSPA and 5-FU on cells of sarcoma 180.
Topics: Animals; Antineoplastic Agents; Fluorouracil; Humans; Sarcoma 180 | 1963 |
Growth inhibition of sarcoma 180 by hormone antisera and 5-fluor-ouracil.
Topics: Animals; Fluorouracil; Growth Hormone; Human Growth Hormone; Humans; Immune Sera; Sarcoma 180; Uraci | 1963 |
COORDINATED SURGICAL-CHEMICAL THERAPY OF CANCER.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cyclophosphamide; DNA; DNA, Neoplasm; Fluorouracil; | 1963 |
GROWTH INHIBITION OF A SPECTRUM OF TRANSPLANTED MOUSE TUMORS BY COMBINATIONS OF INHIBITORS OF NUCLEIC ACID BIOSYNTHESIS AND ALKYLATING AGENTS.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Azaguanine; Azaserine; Carcinoma, Ehrlich Tumor; | 1963 |
SUPPRESSION OF GROWTH OF SARCOMA 180 BY HORMONE ANTISERA IN CONJUNCTION WITH CHEMOTHERAPY.
Topics: Animals; Biological Phenomena; Fluorouracil; Growth Hormone; Human Growth Hormone; Immune Sera; Mice | 1964 |
INTERACTION BETWEEN 5-HYDROXYTRYPTAMINE AND ANTITUMOURAL DRUGS.
Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Cyclophosphamide; Fluorouracil; Melphalan; | 1964 |
Anti-tumor activities of decursinol angelate and decursin from Angelica gigas.
Topics: Angelica; Animals; Antineoplastic Agents, Phytogenic; Benzopyrans; Butyrates; Cell Line, Tumor; Fluo | 2003 |
[Salvianolic acid A inhibits nucleoside transport and potentiates the antitumor activity of chemotherapeutic drugs].
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Biological Transport; Caffeic Aci | 2004 |
In vivo growth-inhibition of S180 tumor by mixture of 5-Fu and low molecular lambda-carrageenan from Chondrus ocellatus.
Topics: Animals; Carrageenan; Chondrus; Drug Therapy, Combination; Fluorouracil; Growth Inhibitors; Mice; Mi | 2005 |
Enhancement of the anti-tumor activity of S-1 by low-dose cisplatin in mice bearing the sarcoma-180 model.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Cisplatin; Drug Combinations; | 2005 |
[Study of matrine's use on the reversion of obtained multi-drug resistance of mice S80 tumour cell].
Topics: Alkaloids; Animals; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocol | 2006 |
Nanoparticles of 5-fluorouracil (5-FU) loaded N-succinyl-chitosan (Suc-Chi) for cancer chemotherapy: preparation, characterization--in-vitro drug release and anti-tumour activity.
Topics: Animals; Antimetabolites, Antineoplastic; Chitosan; Colloids; Delayed-Action Preparations; Diffusion | 2006 |
In vitro and in vivo antitumor effect of 5-FU combined with piplartine and piperine.
Topics: Alanine Transaminase; Alkaloids; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Ph | 2008 |
Antitumor activity of biflorin, an o-naphthoquinone isolated from Capraria biflora.
Topics: Adjuvants, Immunologic; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; | 2007 |
Inhibition of the growth of sarcoma 180 ascites cells by combinations of inhibitors of nucleic acid biosynthesis and the cupric chelate of kethoxal bis-(thiosemicarbazone).
Topics: Animals; Antimetabolites; Antineoplastic Agents; Chelating Agents; Chlorides; Copper; DNA, Neoplasm; | 1967 |
The antineoplastic and biochemical effects of some 5-fluoropyrimidines.
Topics: Adenine Nucleotides; Animals; Antineoplastic Agents; Carbon Isotopes; DNA, Neoplasm; Female; Fluorin | 1967 |
Potentiation of the antitumor activity of tegafur in sarcoma 180-bearing mice by chlordiazepoxide, diazepam and oxazepam.
Topics: Animals; Anti-Anxiety Agents; Chlordiazepoxide; Diazepam; Drug Synergism; Fluorouracil; Male; Mice; | 1983 |
Potentiation of anticancer agents by new synthetic isoprenoids. II. Inhibition of the growth of transplantable murine tumors.
Topics: Animals; Antineoplastic Agents; Bleomycin; Doxorubicin; Drug Evaluation, Preclinical; Drug Synergism | 1984 |
Influence of some sulfhydryl compounds on the antineoplastic effectiveness of 5-fluorouracil and 6-mercaptopurine.
Topics: Animals; Cysteine; Drug Synergism; Fluorouracil; Glutathione; Insulin; Leukemia L1210; Mercaptopurin | 1984 |
[Studies on the mechanism of antitumor activity of 5-FU and its derivatives--relationship between the inhibition of tumor growth and the inhibition of thymidylate synthetase in vivo].
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Division; DNA, | 1984 |
Role of uridine phosphorylase for antitumor activity of 5'-deoxy-5-fluorouridine.
Topics: Animals; Biotransformation; Floxuridine; Fluorouracil; Leukemia L1210; Male; Mice; Pentosyltransfera | 1980 |
Tissue distribution of 5'-deoxy-5-fluorouridine and derived 5-fluorouracil in tumor-bearing mice and rats.
Topics: Animals; Carcinoma 256, Walker; Female; Floxuridine; Fluorouracil; Male; Mice; Rats; Sarcoma 180; Te | 1980 |
Relationship between antitumor effect and metabolites of 5-fluorouracil in combination treatment with 5-fluorouracil and guanosine in ascites sarcoma 180 tumor system.
Topics: Adenosine; Animals; Carbon Radioisotopes; Cytidine; Dose-Response Relationship, Drug; Female; Fluoro | 1983 |
Comparative study on the cytostatic effects and the tissue distribution of 5-fluorouracil in a free form and bound to polybutylcyanoacrylate nanoparticles in sarcoma 180-bearing mice.
Topics: Animals; Body Weight; Enbucrilate; Female; Fluorouracil; Leukopenia; Mice; Pharmaceutical Vehicles; | 1983 |
Relationship of cellular folate cofactor pools to the activity of 5-fluorouracil.
Topics: Animals; Carcinoma; Chromatography, Gel; Fibroblasts; Fluorouracil; Folic Acid; gamma-Glutamyl Hydro | 1983 |
Effect of coadministration of thymine or thymidine on the antitumor activity of 1-(2-tetrahydrofuryl)-5-fluorouracil and 5-fluorouracil.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Biodegradation, Environmental; Drug Synergism; | 1980 |
Biochemical interactions between N-(phosphonacetyl)-L-aspartate and 5-fluorouracil.
Topics: Animals; Aspartic Acid; Cells, Cultured; Deoxyuracil Nucleotides; Drug Interactions; Fluorodeoxyurid | 1982 |
Metabolic fate on 1-hexylcarbamoyl-5-fluorouracil and 5-fluorouracil in mice bearing ascites sarcoma 180.
Topics: Administration, Oral; Animals; Ascitic Fluid; Female; Fluorouracil; Kinetics; Mice; Sarcoma 180 | 1981 |
Combined treatments with vitamin A and 5-fluorouracil and the growth of allotransplantable and syngeneic tumors in mice.
Topics: Animals; Drug Therapy, Combination; Female; Fluorouracil; Mice; Mice, Inbred BALB C; Mice, Inbred IC | 1982 |
Antitumor activity of 1-alkoxycarbonylalkylcarbamoyl-5-fluorouracil derivatives by oral administration.
Topics: Adenocarcinoma; Administration, Oral; Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Fema | 1981 |
Pharmacokinetics of 1-alkylcarbamoyl-5-fluorouracils in plasma and ascites fluid after oral administration in mice.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Ascitic Fluid; Female; Fluorouracil; Kinetics; | 1980 |
[5'-deoxy-5-fluoruridine, a new antineoplastic pyrimidine antimetabolite].
Topics: Animals; Antimetabolites, Antineoplastic; Carcinoma, Squamous Cell; Fluorouracil; Lung Neoplasms; Mi | 1980 |
[The mechanism of biochemical modulation in methotrexate/5-fluorouracil sequential chemotherapy].
Topics: Animals; Drug Administration Schedule; Drug Synergism; Fluorouracil; Methotrexate; Mice; RNA, Neopla | 1994 |
In vivo 19F NMR comparative study of 5-fluorouracil, 1-(2-tetrahydrofuryl)-5-fluorouracil (FT) and an FT-uracil coadministration system in mouse tumors.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Fluorine; Fluorouracil; Liver; Magnetic Res | 1994 |
[Comparison between leucovorin and cisplatin as a modulator of 5-fluorouracil].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Dose-Response Relationship, Drug | 1993 |
Prevention by chitosan of myelotoxicity, gastrointestinal toxicity and immunocompetent organic toxicity induced by 5-fluorouracil without loss of antitumor activity in mice.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Chitin; Chitosan; Di | 1999 |
Use of 5-FU plus hyperbaric oxygen for treating malignant tumors: evaluation of antitumor effect and measurement of 5-FU in individual organs.
Topics: Animals; Antimetabolites, Antineoplastic; Body Weight; Combined Modality Therapy; Eating; Fluorourac | 2001 |
Effects of carp and tuna oils on 5-fluorouracil-induced antitumor activity and side effects in sarcoma 180-bearing mice.
Topics: Animals; Carps; Dietary Fats, Unsaturated; Drug Interactions; Fish Oils; Fluorouracil; Male; Mice; M | 2001 |
[Sensitivity tests of malignant tumours against cytostatic agents in vitro and in vivo/studies on the mouse sarcoma 180 (author's transl)].
Topics: Animals; Antineoplastic Agents; Biological Transport; Bleomycin; Cell Membrane Permeability; Cells, | 1975 |
Effect of antitumor agents on sarcoma-180 tumor cells transplanted to liver, kidney, and lung.
Topics: Animals; Antineoplastic Agents; Bleomycin; Cyclophosphamide; Dactinomycin; Daunorubicin; Fluorouraci | 1975 |
Dextran derivatives in single and combination chemotherapy against transplantable mouse ascites and solid tumors.
Topics: Animals; Antibody Formation; Antineoplastic Agents; Bleomycin; Carcinoma, Ehrlich Tumor; Cells, Cult | 1977 |
Effect of deoxyuridine coadministration on toxicity and antitumor activity of fluorouracil and floxuridine.
Topics: Animals; Antineoplastic Agents; Biological Assay; Deoxyuridine; Drug Combinations; Drug Synergism; F | 1975 |
Sensitivity tests of tumors to cytostatic agents. I. Comparative investigations on transplanted tumors in vivo and in vitro.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Carcinoma 256, Walker; Cell Division; Cricetinae; Da | 1975 |
Effect of coadministration of uracil or cytosine on the anti-tumor activity of clinical doses of 1-(2-tetrahydrofuryl)-5-fluorouracil and level of 5-fluorouracil in rodents.
Topics: Administration, Oral; Animals; Cytosine; Drug Synergism; Drug Therapy, Combination; Fluorouracil; Li | 1979 |
Fluorinated pyrimidine nucleosides. 3. Synthesis and antitumor activity of a series of 5'-deoxy-5-fluoropyrimidine nucleosides.
Topics: Animals; Antineoplastic Agents; Flucytosine; Fluorouracil; Mice; Pyrimidine Nucleosides; Sarcoma 180 | 1979 |
[Synthesis and study of the antitumor activity of glucuronide derivatives of 5-fluorouracil].
Topics: Animals; Antineoplastic Agents; Fluorouracil; Glucuronates; Male; Mice; Pyrimidine Nucleosides; Sarc | 1979 |
Autoradiographic distribution studies of 2-14C-fluorouracil following oral or intravenous administration in mice bearing solid sarcoma-180.
Topics: Administration, Oral; Animals; Autoradiography; Fluorouracil; Injections, Intravenous; Male; Mice; S | 1978 |
Antitumor activity of 1-alkylcarbamoyl derivatives of 5-fluorouracil in a variety of mouse tumors.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Fluorouracil; Leukemia, Ex | 1978 |
Effect of uracil and its derivatives on antitumor activity of 5-fluorouracil and 1-(2-tetrahydrofuryl)-5-fluorouracil.
Topics: Animals; Drug Therapy, Combination; Fluorouracil; Liver Neoplasms, Experimental; Male; Mice; Rats; S | 1978 |
Schedule-dependent antitumor effects of methotrexate and 5-fluorouracil.
Topics: Animals; Drug Administration Schedule; Drug Therapy, Combination; Female; Fluorouracil; Methotrexate | 1977 |
[Research on liu wei Rehmannia oral liquid against side-effect of drugs of anti-tumor chemotherapy].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Doxorubicin; Drugs, Chinese Herb | 1992 |
Antitumor activity of two novel low immunosuppressive fluoropyrimidines UK-21 and UK-25.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Body Weight; Fluorouracil; Glycine; Leukemia L | 1992 |
Hyperthermia enhances the inhibition of tumor growth by 1-(2-tetrahydrofuryl)-5-fluorouracil/uracil (1:4) in tumors in mice and humans.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Division; Combined Modality Therapy; D | 1992 |
[Significance of measuring 5-fluorouracil incorporated into RNA of tumor tissue as a parameter for the antitumor activity of 5-fluorouracil and its analogs].
Topics: Administration, Oral; Animals; Fluorouracil; Gas Chromatography-Mass Spectrometry; Male; Mice; Mice, | 1992 |
Efficacy of 5-fluorouracil in combination with methoxyphenyl maleamic acid in murine tumors.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Ehrlich Tumor; Drug Therapy, Com | 1991 |
[Studies of 5-fluorouracil nanocapsules].
Topics: Animals; Capsules; Carcinoma, Ehrlich Tumor; Drug Carriers; Enbucrilate; Female; Fluorouracil; Liver | 1991 |
Modulating effect of alpha-[N,N-[bis(2-hydroxyethyl)]-amino-N- (o-methoxyphenyl)-pyrrolidin-2,5-dione on the chemotherapy of murine tumours.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Ehrlich Tumor; Drug Synergism; F | 1990 |
Correlation between ribosomal RNA production and RNA-directed fluoropyrimidine cytotoxicity.
Topics: Animals; Cell Nucleus; Cell Survival; Cytoplasm; DNA; Floxuridine; Fluorouracil; Mice; RNA; RNA, Mes | 1987 |
Antitumor activity of BOF-A2, a new 5-fluorouracil derivative.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Fluorouracil; Mice; Mice, Inbred ICR; Pyridine | 1989 |
[Effect of cepharanthine on antitumor activity of 1-(2-tetrahydrofuryl)-5-fluorouracil (FT-207)--5-fluorouracil delivery into tumor tissue].
Topics: Alkaloids; Animals; Benzylisoquinolines; Drug Therapy, Combination; Fluorouracil; In Vitro Technique | 1989 |
Potentiation of antimetabolite antitumor activity in vivo by dipyridamole and amphotericin B.
Topics: Amphotericin B; Animals; Antimetabolites, Antineoplastic; Dipyridamole; Drug Evaluation, Preclinical | 1989 |
Modulation of the effects of fluoropyrimidines on toxicity and tumor inhibition in rodents by uridine and thymidine.
Topics: Animals; Dose-Response Relationship, Drug; Female; Floxuridine; Fluorouracil; Leukemia L1210; Lung N | 1986 |
[BOF-A1 and BOF-A2, new 5-FU degradation-inhibitory agents].
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Floxuridine; Fluorou | 1987 |
[Conversion of 5'-deoxy-5-fluorouridine to 5-FU by pyrimidine nucleoside phosphorylases in normal and tumor tissues from rodents bearing tumors and cancer patients].
Topics: Animals; Antineoplastic Agents; Carcinoma 256, Walker; Floxuridine; Fluorouracil; Humans; Leukemia L | 1987 |
[Comparative studies on the antitumor activity of the fluorinated pyrimidines 5'-DFUR, tegafur, UFT and FUra on various murine tumors].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Floxuridine; Fluorouraci | 1988 |
[Effects of krestin (PSK) on drug-metabolizing enzymes with special reference to the activation of FT-207].
Topics: Aminopyrine; Animals; Cytochrome b Group; Cytochrome P-450 Enzyme System; Cytochromes b5; Fluorourac | 1986 |
Inhibitory effects of pyrimidine, barbituric acid and pyridine derivatives on 5-fluorouracil degradation in rat liver extracts.
Topics: Animals; Barbiturates; Chromatography, High Pressure Liquid; Dihydrouracil Dehydrogenase (NAD+); Flu | 1987 |
[Potentiation of chemotherapeutic activity by a Chinese herb medicine juzen-taiho-toh].
Topics: Animals; Cisplatin; Cyclophosphamide; Doxorubicin; Drug Synergism; Drugs, Chinese Herbal; Female; Fi | 1988 |
Effect of PSK, a protein-bound polysaccharide from Coriolus versicolor, on drug-metabolizing enzymes in sarcoma-180 bearing and normal mice.
Topics: Adjuvants, Immunologic; Animals; Antibiotics, Antineoplastic; Female; Fluorouracil; Liver; Mice; Mic | 1988 |
Enhancement of 5-fluorouracil delivery to sarcoma 180 tissue under angiotensin II-induced hypertension chemotherapy.
Topics: Angiotensin II; Animals; Fluorouracil; Hypertension; Male; Mice; Sarcoma 180 | 1988 |
[Synchronization of tumor cells with 5-fluorouracil plus uracil and with vinblastine and irradiation of the synchronized cultures. A contribution to combined radio-chemotherapy].
Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Division; Combined Modality Therapy; Fluorouracil; In Vitro | 1988 |
[The significance of measuring inhibition of thymidylate synthase activity as a parameter for antitumor activity of 5-fluorouracil derivatives].
Topics: Animals; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Fluorouracil; Male; Mic | 1988 |
[Effect and toxicity of entrapped polysiloxane 5-Fu polycondensate].
Topics: Animals; Body Weight; Bone Marrow; Cell Count; Delayed-Action Preparations; Female; Fluorouracil; Le | 1987 |
Noninvasive spectroscopic analysis of fluoropyrimidine metabolism in cultured tumor cells.
Topics: Animals; Cells, Cultured; Fluorouracil; Humans; Leukemia, Myeloid, Acute; Magnetic Resonance Spectro | 1986 |
Urinary polyamine excretion by tumor-bearing and tumor-free mice exposed to cyclophosphamide, 5-fluorouracil and 6-mercaptopurine.
Topics: Animals; Carcinoma, Ehrlich Tumor; Creatinine; Cyclophosphamide; Female; Fluorouracil; Mercaptopurin | 1986 |
[Dose, administration time and route and hepatic function-dependent metabolism of 5-FU in mice].
Topics: Administration, Oral; Animals; Dihydrouracil Dehydrogenase (NAD+); Dose-Response Relationship, Drug; | 1986 |
Potentiation by vitamin A of the action of anticancer agents against murine tumors.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Diterpenes; Doxorubicin; Drug Ev | 1985 |
The effect of methotrexate pretreatment on 5-fluorouracil kinetics in sarcoma 180 in vivo.
Topics: Animals; Drug Administration Schedule; Female; Fluorouracil; Kinetics; Methotrexate; Mice; RNA, Neop | 1985 |
Enhancement of antitumor effect of cyclophosphamide by centrophenoxine.
Topics: Acetates; Animals; Antineoplastic Agents; Busulfan; Central Nervous System Stimulants; Cyclophospham | 1971 |
[Use of transplantability indices of tumor cells for evaluation of the cytotoxic effect of antineoplastic agents in vitro].
Topics: Animals; Cell Line; Cells, Cultured; Culture Media; Fluorouracil; Leukemia, Experimental; Male; Melp | 1972 |
[The state of parietal carbohydrate hydrolysis following a single administration of antitumor drugs to intact and tumorous animals].
Topics: Animals; Carcinoma; Cyclophosphamide; Digestion; Female; Fluorouracil; Furans; Hydrolysis; Intestine | 1972 |
Antitumor activity of cyclocytidine in a variety of tumors.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Cell Line; Cyclization; Cy | 1972 |
[Experimental studies on antineoplastic action of N 1 -(2'-tetrahydrofuryl)-5-fluorouracil (FT-207)--effect on experimental tumors].
Topics: Animals; Body Weight; Carcinoma, Ehrlich Tumor; Fluorouracil; Furans; Mice; Neoplasms, Experimental; | 1971 |
Synergistic antimicrobial and antitumor effects of phleomycin and fluorinated pyrimidines.
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Drug Synergism; Escherichia coli; Fluorouraci | 1965 |
[Problems in combined radio-cytostatic therapy. 7. Syncarcinolytic studies using 5-fluorouracil, natulan and proresid in Crocker sarcoma 180 of mice].
Topics: Alkylating Agents; Animals; Fluorouracil; Methods; Mice; Phytotherapy; Plants, Medicinal; Plants, To | 1969 |
[Experimental studies on the combined effect of cyclophosphamide and 5-fluorouracil on sarcoma 180 depending on dosage and timing].
Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Depression, Chemical; Drug Synergism; Female; Fluo | 1970 |
The place of 5-fluorouracil in experimental and clinical cancer chemotherapy.
Topics: Animals; Carcinoma, Ehrlich Tumor; Fluorouracil; Humans; Mice; Neoplasms; Sarcoma 180 | 1970 |
Enzymatic and chemical synthesis of 1-beta-D-arabinosyl-5-fluoropyrimidine 5'-phosphates. A comparative study.
Topics: Animals; Arabinose; Cytosine Nucleotides; Fluorouracil; Mice; Nucleosides; Nucleotides; Phosphotrans | 1968 |
[Antitumor immunity in mice bearing sarcoma 180 after treatment with the combination of diazoacetylglycine hydrazide and 5-fluorouracil].
Topics: Animals; Fluorouracil; Hydrazines; Immunosuppressive Agents; Mice; Neoplasm Regression, Spontaneous; | 1968 |
[Studies on the cell division inhibitory effect of some purine and pyrimidine derivatives on Paracentrotus lividus and on sarcoma 180 of mice].
Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Cell Division; Culture Techniques; Echinod | 1969 |
The synergistic anti-neoplastic activity of combinations of mitomycins with either 6-thioguanine or 5-fluorouracil.
Topics: Animals; Antineoplastic Agents; DNA, Neoplasm; Drug Synergism; Female; Fluorouracil; In Vitro Techni | 1965 |
Nucleosides. XXIX. 1-beta-D-arabinofuranosyl-5-fluorocytosine and related arabino nucleosides.
Topics: Animals; Arabinose; Chemistry, Organic; Cytosine; Fluorouracil; Furans; Idoxuridine; Keratitis, Dend | 1966 |