fluorouracil has been researched along with Sarcoma, Kaposi in 6 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Sarcoma, Kaposi: A multicentric, malignant neoplastic vascular proliferation characterized by the development of bluish-red cutaneous nodules, usually on the lower extremities, most often on the toes or feet, and slowly increasing in size and number and spreading to more proximal areas. The tumors have endothelium-lined channels and vascular spaces admixed with variably sized aggregates of spindle-shaped cells, and often remain confined to the skin and subcutaneous tissue, but widespread visceral involvement may occur. Kaposi's sarcoma occurs spontaneously in Jewish and Italian males in Europe and the United States. An aggressive variant in young children is endemic in some areas of Africa. A third form occurs in about 0.04% of kidney transplant patients. There is also a high incidence in AIDS patients. (From Dorland, 27th ed & Holland et al., Cancer Medicine, 3d ed, pp2105-7) HHV-8 is the suspected cause.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mucositis is a common toxicity of cancer chemotherapy." | 6.68 | Oral glutamine to prevent chemotherapy induced stomatitis: a pilot study. ( Anderson, PM; Skubitz, KM, 1996) |
| "At this juncture in the development of paclitaxel (Taxol; Bristol-Myers Squibb Company, Princeton, NJ), knowledge about the agent's pharmacologic behavior and clinical antitumor activity in less common neoplasms is being elucidated." | 4.79 | Paclitaxel pharmacology and other tumor types. ( Rowinsky, EK, 1997) |
| "Mucositis is a common toxicity of cancer chemotherapy." | 2.68 | Oral glutamine to prevent chemotherapy induced stomatitis: a pilot study. ( Anderson, PM; Skubitz, KM, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 3 (50.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dummer, R | 1 |
| Beyeler, M | 1 |
| Morcinek, J | 1 |
| Burg, G | 1 |
| Skubitz, KM | 1 |
| Anderson, PM | 1 |
| Rowinsky, EK | 1 |
| Podzamczer, D | 1 |
| Miralles, P | 1 |
| La Calle Md, Md | 1 |
| Zarco, C | 1 |
| Berenguer, J | 1 |
| López Aldeguer, J | 1 |
| Valencia, E | 1 |
| Rubio, R | 1 |
| Ribera, JM | 1 |
| Reiter, Z | 1 |
| Ozes, ON | 1 |
| Tomson, S | 1 |
| Blatt, LM | 1 |
| Taylor, MW | 1 |
| Falkson, G | 1 |
3 reviews available for fluorouracil and Sarcoma, Kaposi
| Article | Year |
|---|---|
[Cutaneous neoplasms].
Topics: Adjuvants, Immunologic; Aminoquinolines; Antimetabolites, Antineoplastic; Antineoplastic Agents; Bio | 2003 |
Paclitaxel pharmacology and other tumor types.
Topics: Alkylating Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols | 1997 |
[Recommendations of GESIDA/Spanish National Plan of AIDS on diagnosis and treatment of Kaposi's sarcoma and cervical cancer in HIV-infected patients].
Topics: Acquired Immunodeficiency Syndrome; Algorithms; Antimetabolites, Antineoplastic; Antineoplastic Agen | 2002 |
1 trial available for fluorouracil and Sarcoma, Kaposi
| Article | Year |
|---|---|
Oral glutamine to prevent chemotherapy induced stomatitis: a pilot study.
Topics: Acquired Immunodeficiency Syndrome; Administration, Oral; Antineoplastic Combined Chemotherapy Proto | 1996 |
2 other studies available for fluorouracil and Sarcoma, Kaposi
| Article | Year |
|---|---|
A dual anti-tumor effect of a combination of interferon-alpha and 5-flurouracil or 2-chlorodeoxyadenosine on natural killer (NK) cell mediated cytotoxicity.
Topics: 2-Chloroadenosine; Acquired Immunodeficiency Syndrome; Antimetabolites, Antineoplastic; Cell Divisio | 1991 |
Some aspects of the use of cytostatic drugs in dermatology.
Topics: Colchicine; Dactinomycin; Fluorouracil; Humans; Melanoma; Methotrexate; Mycosis Fungoides; Nitrogen | 1966 |