fluorouracil and Sarcoma, Ewing
fluorouracil has been researched along with Sarcoma, Ewing in 11 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Sarcoma, Ewing: A malignant tumor of the bone which always arises in the medullary tissue, occurring more often in cylindrical bones. The tumor occurs usually before the age of 20, about twice as frequently in males as in females.
Research Excerpts
Excerpt | Relevance | Reference |
---|---|---|
"5-Fluorouracil (5-FU) activity for various carcinomas of adults has been enhanced through the synergistic effect of leucovorin." | 5.07 | Phase II study of 5-fluorouracil/leucovorin for pediatric patients with malignant solid tumors. ( Bowman, LC; Douglass, EC; Houghton, JA; Howlett, N; Kun, LE; Meyer, WH; Mounce, K; Poe, D; Pratt, CB, 1994) |
Research
Studies (11)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 8 (72.73) | 18.7374 |
1990's | 3 (27.27) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors
Authors | Studies |
---|---|
CRESSY, NL | 1 |
SCHELL, HW | 1 |
Takeuchi, S | 1 |
Akahoshi, Y | 1 |
Kasai, C | 1 |
Nishimoto, Y | 1 |
Evans, RG | 1 |
Burgert, EO | 1 |
Gilchrist, GS | 1 |
Smithson, WA | 1 |
Pritchard, DJ | 1 |
Bruckman, JE | 1 |
Pratt, CB | 1 |
Meyer, WH | 1 |
Howlett, N | 1 |
Douglass, EC | 1 |
Bowman, LC | 1 |
Poe, D | 1 |
Mounce, K | 1 |
Kun, LE | 1 |
Houghton, JA | 1 |
Inedjian, JM | 1 |
Thomassin, JM | 1 |
Danoy, MC | 1 |
Sermet, M | 1 |
Geunoun, A | 1 |
Balis, FM | 1 |
Gillespie, A | 1 |
Belasco, J | 1 |
Reaman, GH | 1 |
Ettinger, LJ | 1 |
Murphy, RF | 1 |
Doherty, K | 1 |
Jeffries, S | 1 |
Horowitz, ME | 1 |
Poplack, DG | 1 |
Watt, J | 1 |
Seeber, S | 1 |
Gallmeier, WM | 1 |
Bruntsch, U | 1 |
Osieka, R | 1 |
Schmidt, CG | 1 |
Clément, F | 1 |
Banzet, P | 1 |
De la Caffinière, JY | 1 |
Dufourmentel, C | 1 |
Chakravorty, RC | 1 |
Sarkar, SK | 1 |
Mukerji, B | 1 |
Reviews
1 review available for fluorouracil and Sarcoma, Ewing
Article | Year |
---|---|
The use of cytotoxic drugs in the surgery of malignant disease.
Topics: Abdominal Neoplasms; Alkylating Agents; Animals; Antimetabolites; Antineoplastic Agents; Carcinoma, | 1968 |
Trials
1 trial available for fluorouracil and Sarcoma, Ewing
Article | Year |
---|---|
Phase II study of 5-fluorouracil/leucovorin for pediatric patients with malignant solid tumors.
Topics: Adolescent; Carcinoma; Child; Child, Preschool; Colorectal Neoplasms; Drug Administration Schedule; | 1994 |
Other Studies
9 other studies available for fluorouracil and Sarcoma, Ewing
Article | Year |
---|---|
EFFECTIVENESS AND TOXICITY OF PROLONGED INFUSIONS OF 5-FLUOROURACIL IN THE TREATMENT OF CANCER.
Topics: Adenocarcinoma; Adenocarcinoma, Bronchiolo-Alveolar; Antineoplastic Agents; Carcinoma; Carcinoma, Sq | 1965 |
[Clinical evaluation on the sensitivity test for anti-cancer agents in malignant bone and soft-tissue tumors].
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cyclophosphamide; | 1984 |
Sequential half-body irradiation (SHBI) and combination chemotherapy as salvage treatment for failed Ewing's sarcoma--a pilot study.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Carmustine; Child; Fluor | 1984 |
[Extraskeletal pharyngolaryngeal Ewing's sarcoma. Apropos of a case].
Topics: Adult; Cisplatin; Combined Modality Therapy; Diagnosis, Differential; Fluorouracil; Humans; Immunohi | 1991 |
Phase II trial of sequential methotrexate and 5-fluorouracil with leucovorin in children with sarcomas.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Chromato | 1990 |
[Recent advances in the treatment of Ewing's sarcoma (author's transl)].
Topics: Adolescent; Adult; Cyclophosphamide; Dactinomycin; Doxorubicin; Drug Synergism; Female; Fluorouracil | 1974 |
[The chemotherapy of cancer].
Topics: Adult; Alkylating Agents; Antimetabolites; Antineoplastic Agents; Dactinomycin; Female; Fluorouracil | 1967 |
[Apropos of 40 cases of malignant tumors treated by local-regional and general chemotherapy in a surgical department].
Topics: Adolescent; Adult; Aminopterin; Back; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Chemotherapy, | 1969 |
The use of parenteral 5-fluorouracil in solid tumours. A preliminary report.
Topics: Adenocarcinoma; Carcinoma, Squamous Cell; Female; Fluorouracil; Gastrointestinal Neoplasms; Genital | 1969 |