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fluorouracil and Sarcoma, Ewing

fluorouracil has been researched along with Sarcoma, Ewing in 11 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Sarcoma, Ewing: A malignant tumor of the bone which always arises in the medullary tissue, occurring more often in cylindrical bones. The tumor occurs usually before the age of 20, about twice as frequently in males as in females.

Research Excerpts

ExcerptRelevanceReference
"5-Fluorouracil (5-FU) activity for various carcinomas of adults has been enhanced through the synergistic effect of leucovorin."5.07Phase II study of 5-fluorouracil/leucovorin for pediatric patients with malignant solid tumors. ( Bowman, LC; Douglass, EC; Houghton, JA; Howlett, N; Kun, LE; Meyer, WH; Mounce, K; Poe, D; Pratt, CB, 1994)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19908 (72.73)18.7374
1990's3 (27.27)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
CRESSY, NL1
SCHELL, HW1
Takeuchi, S1
Akahoshi, Y1
Kasai, C1
Nishimoto, Y1
Evans, RG1
Burgert, EO1
Gilchrist, GS1
Smithson, WA1
Pritchard, DJ1
Bruckman, JE1
Pratt, CB1
Meyer, WH1
Howlett, N1
Douglass, EC1
Bowman, LC1
Poe, D1
Mounce, K1
Kun, LE1
Houghton, JA1
Inedjian, JM1
Thomassin, JM1
Danoy, MC1
Sermet, M1
Geunoun, A1
Balis, FM1
Gillespie, A1
Belasco, J1
Reaman, GH1
Ettinger, LJ1
Murphy, RF1
Doherty, K1
Jeffries, S1
Horowitz, ME1
Poplack, DG1
Watt, J1
Seeber, S1
Gallmeier, WM1
Bruntsch, U1
Osieka, R1
Schmidt, CG1
Clément, F1
Banzet, P1
De la Caffinière, JY1
Dufourmentel, C1
Chakravorty, RC1
Sarkar, SK1
Mukerji, B1

Reviews

1 review available for fluorouracil and Sarcoma, Ewing

ArticleYear
The use of cytotoxic drugs in the surgery of malignant disease.
    The Journal of bone and joint surgery. British volume, 1968, Volume: 50, Issue:3

    Topics: Abdominal Neoplasms; Alkylating Agents; Animals; Antimetabolites; Antineoplastic Agents; Carcinoma,

1968

Trials

1 trial available for fluorouracil and Sarcoma, Ewing

ArticleYear
Phase II study of 5-fluorouracil/leucovorin for pediatric patients with malignant solid tumors.
    Cancer, 1994, Nov-01, Volume: 74, Issue:9

    Topics: Adolescent; Carcinoma; Child; Child, Preschool; Colorectal Neoplasms; Drug Administration Schedule;

1994

Other Studies

9 other studies available for fluorouracil and Sarcoma, Ewing

ArticleYear
EFFECTIVENESS AND TOXICITY OF PROLONGED INFUSIONS OF 5-FLUOROURACIL IN THE TREATMENT OF CANCER.
    The American journal of the medical sciences, 1965, Volume: 249

    Topics: Adenocarcinoma; Adenocarcinoma, Bronchiolo-Alveolar; Antineoplastic Agents; Carcinoma; Carcinoma, Sq

1965
[Clinical evaluation on the sensitivity test for anti-cancer agents in malignant bone and soft-tissue tumors].
    Gan no rinsho. Japan journal of cancer clinics, 1984, Volume: 30, Issue:9 Suppl

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cyclophosphamide;

1984
Sequential half-body irradiation (SHBI) and combination chemotherapy as salvage treatment for failed Ewing's sarcoma--a pilot study.
    International journal of radiation oncology, biology, physics, 1984, Volume: 10, Issue:12

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Carmustine; Child; Fluor

1984
[Extraskeletal pharyngolaryngeal Ewing's sarcoma. Apropos of a case].
    Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Societe d'oto-laryngologie des hopitaux de Paris, 1991, Volume: 108, Issue:1

    Topics: Adult; Cisplatin; Combined Modality Therapy; Diagnosis, Differential; Fluorouracil; Humans; Immunohi

1991
Phase II trial of sequential methotrexate and 5-fluorouracil with leucovorin in children with sarcomas.
    Investigational new drugs, 1990, Volume: 8, Issue:2

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Chromato

1990
[Recent advances in the treatment of Ewing's sarcoma (author's transl)].
    Deutsche medizinische Wochenschrift (1946), 1974, Apr-26, Volume: 99, Issue:17

    Topics: Adolescent; Adult; Cyclophosphamide; Dactinomycin; Doxorubicin; Drug Synergism; Female; Fluorouracil

1974
[The chemotherapy of cancer].
    Praxis, 1967, Dec-07, Volume: 56, Issue:49

    Topics: Adult; Alkylating Agents; Antimetabolites; Antineoplastic Agents; Dactinomycin; Female; Fluorouracil

1967
[Apropos of 40 cases of malignant tumors treated by local-regional and general chemotherapy in a surgical department].
    Journal de chirurgie, 1969, Volume: 97, Issue:3

    Topics: Adolescent; Adult; Aminopterin; Back; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Chemotherapy,

1969
The use of parenteral 5-fluorouracil in solid tumours. A preliminary report.
    Journal of the Indian Medical Association, 1969, Jan-01, Volume: 52, Issue:1

    Topics: Adenocarcinoma; Carcinoma, Squamous Cell; Female; Fluorouracil; Gastrointestinal Neoplasms; Genital

1969
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