Page last updated: 2024-10-27

fluorouracil and Rift Valley Fever

fluorouracil has been researched along with Rift Valley Fever in 1 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Rift Valley Fever: An acute infection caused by the RIFT VALLEY FEVER VIRUS, an RNA arthropod-borne virus, affecting domestic animals and humans. In animals, symptoms include HEPATITIS; abortion (ABORTION, VETERINARY); and DEATH. In humans, symptoms range from those of a flu-like disease to hemorrhagic fever, ENCEPHALITIS, or BLINDNESS.

Research Excerpts

ExcerptRelevanceReference
"A live attenuated vaccine virus variant of Rift Valley fever (RVF) virus was developed by passaging a human isolate in tissue culture under the influence of the mutagen 5-fluorouracil."3.68Ability of a mutagenized virus variant to protect young lambs from Rift Valley fever. ( Baskerville, A; Hubbard, KA; Stephenson, JR, 1991)

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hubbard, KA1
Baskerville, A1
Stephenson, JR1

Other Studies

1 other study available for fluorouracil and Rift Valley Fever

ArticleYear
Ability of a mutagenized virus variant to protect young lambs from Rift Valley fever.
    American journal of veterinary research, 1991, Volume: 52, Issue:1

    Topics: Animals; Fluorouracil; Humans; Liver Diseases; Rift Valley Fever; Rift Valley fever virus; Sheep; Sh

1991