fluorouracil has been researched along with Retroperitoneal Neoplasms in 23 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Retroperitoneal Neoplasms: New abnormal growth of tissue in the RETROPERITONEAL SPACE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The patients included were 145 who had colorectal or appendiceal carcinomatosis resected using cytoreductive surgery prior to treatment with hyperthermic intraperitoneal chemotherapy with mitomycin C as part of a multidrug regimen." | 7.77 | Changes induced by surgical and clinical factors in the pharmacology of intraperitoneal mitomycin C in 145 patients with peritoneal carcinomatosis. ( Chang, D; Mahteme, H; Stuart, OA; Sugarbaker, PH; Van der Speeten, K, 2011) |
| "Ten percent of paragangliomas are malignant and one-third occurs in a genetic background." | 5.38 | A SDHB malignant paraganglioma with dramatic response to temozolomide-capecitabine. ( Borson-Chazot, F; Giraud, S; Joly, MO; Lombard-Bohas, C; Nozières, C; Riou, JP; Scoazec, JY; Simon, C; Walter, T, 2012) |
| "The patients included were 145 who had colorectal or appendiceal carcinomatosis resected using cytoreductive surgery prior to treatment with hyperthermic intraperitoneal chemotherapy with mitomycin C as part of a multidrug regimen." | 3.77 | Changes induced by surgical and clinical factors in the pharmacology of intraperitoneal mitomycin C in 145 patients with peritoneal carcinomatosis. ( Chang, D; Mahteme, H; Stuart, OA; Sugarbaker, PH; Van der Speeten, K, 2011) |
| "Ten percent of paragangliomas are malignant and one-third occurs in a genetic background." | 1.38 | A SDHB malignant paraganglioma with dramatic response to temozolomide-capecitabine. ( Borson-Chazot, F; Giraud, S; Joly, MO; Lombard-Bohas, C; Nozières, C; Riou, JP; Scoazec, JY; Simon, C; Walter, T, 2012) |
| "5-Fluorouracil (5-FU) was delivered in a dose-intensive schedule to 23 patients with metastatic or unresectable colorectal carcinoma." | 1.28 | A dose-intensive regimen of 5-fluorouracil for the treatment of metastatic colorectal carcinoma. ( Baker, L; Brodfuehrer, J; Kraut, M; Poplin, EA; Vaitkevicius, V, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (30.43) | 18.7374 |
| 1990's | 5 (21.74) | 18.2507 |
| 2000's | 6 (26.09) | 29.6817 |
| 2010's | 4 (17.39) | 24.3611 |
| 2020's | 1 (4.35) | 2.80 |
| Authors | Studies |
|---|---|
| Bockorny, B | 1 |
| Semenisty, V | 1 |
| Macarulla, T | 1 |
| Borazanci, E | 1 |
| Wolpin, BM | 1 |
| Stemmer, SM | 1 |
| Golan, T | 1 |
| Geva, R | 1 |
| Borad, MJ | 1 |
| Pedersen, KS | 1 |
| Park, JO | 1 |
| Ramirez, RA | 1 |
| Abad, DG | 1 |
| Feliu, J | 1 |
| Muñoz, A | 1 |
| Ponz-Sarvise, M | 1 |
| Peled, A | 1 |
| Lustig, TM | 1 |
| Bohana-Kashtan, O | 1 |
| Shaw, SM | 1 |
| Sorani, E | 1 |
| Chaney, M | 1 |
| Kadosh, S | 1 |
| Vainstein Haras, A | 1 |
| Von Hoff, DD | 1 |
| Hidalgo, M | 1 |
| Zhu, X | 1 |
| Zhao, X | 1 |
| Peng, W | 1 |
| Sun, S | 1 |
| Cao, J | 1 |
| Ji, D | 1 |
| Liu, X | 1 |
| Wang, C | 1 |
| Huang, M | 1 |
| Yu, H | 1 |
| Guo, W | 1 |
| Li, J | 1 |
| Yin, J | 1 |
| Izzo, L | 1 |
| Pietrasanta, D | 1 |
| Izzo, P | 1 |
| Caputo, M | 1 |
| Di Cello, P | 1 |
| Meloni, P | 1 |
| Bolognese, A | 1 |
| Trojan, J | 1 |
| Lubomierski, N | 1 |
| Lehnert, T | 1 |
| Engels, K | 1 |
| Zeuzem, S | 1 |
| Bechstein, WO | 1 |
| Nomura, M | 1 |
| Sasano, H | 1 |
| Okada, Y | 1 |
| Watanabe, T | 1 |
| Sakamoto, S | 1 |
| Sakiyama, Y | 1 |
| Sakamoto, R | 1 |
| Abe, I | 1 |
| Horiuchi, T | 1 |
| Yanase, T | 1 |
| Takayanagi, R | 1 |
| Van der Speeten, K | 1 |
| Stuart, OA | 1 |
| Chang, D | 1 |
| Mahteme, H | 1 |
| Sugarbaker, PH | 1 |
| Nozières, C | 1 |
| Walter, T | 1 |
| Joly, MO | 1 |
| Giraud, S | 1 |
| Scoazec, JY | 1 |
| Borson-Chazot, F | 1 |
| Simon, C | 1 |
| Riou, JP | 1 |
| Lombard-Bohas, C | 1 |
| Eveno, C | 1 |
| Goéré, D | 1 |
| Dartigues, P | 1 |
| Honoré, C | 1 |
| Dumont, F | 1 |
| Tzanis, D | 1 |
| Benhaim, L | 1 |
| Malka, D | 1 |
| Elias, D | 1 |
| HOLSTI, LR | 1 |
| Liu, JM | 1 |
| Chen, LT | 2 |
| Li, AF | 1 |
| Wu, CW | 1 |
| Lan, C | 1 |
| Chung, TR | 1 |
| Shiah, HS | 1 |
| Lee, KD | 1 |
| Liu, TW | 2 |
| Peng, JW | 1 |
| Hirano, A | 1 |
| Tanimoto, Y | 1 |
| Kimura, G | 1 |
| Kiura, K | 1 |
| Ueoka, H | 1 |
| Kataoka, M | 1 |
| Tanimoto, M | 1 |
| Chan, CH | 1 |
| Chang, JY | 1 |
| Whang-Peng, J | 1 |
| Kattan, J | 1 |
| Culine, S | 1 |
| Theodore, C | 1 |
| Droz, JP | 1 |
| Fujii, Y | 2 |
| Itoyanagi, H | 1 |
| Hirose, I | 1 |
| Hasumi, K | 2 |
| Eriguchi, M | 2 |
| Iwasa, H | 1 |
| Hirai, J | 1 |
| Samuels, ML | 2 |
| Holoye, PY | 1 |
| Johnson, DE | 2 |
| Bracken, RB | 1 |
| Ayala, AG | 1 |
| Montague, DK | 1 |
| Poplin, EA | 1 |
| Kraut, M | 1 |
| Baker, L | 1 |
| Brodfuehrer, J | 1 |
| Vaitkevicius, V | 1 |
| Nakatsu, T | 1 |
| Yokoyama, I | 1 |
| Tsuyuki, K | 1 |
| Soh, Y | 1 |
| Hanai, G | 1 |
| Matsumoto, H | 1 |
| Kubo, H | 1 |
| Matsumoto, K | 1 |
| Nohga, K | 1 |
| Koyanagi, H | 1 |
| Ohta, T | 1 |
| Yoshida, K | 1 |
| Iwata, K | 1 |
| Takara, T | 1 |
| Katada, T | 1 |
| Yamaguchi, S | 1 |
| Kataba, Y | 1 |
| Maruyama, Y | 1 |
| Watanabe, H | 1 |
| Kondou, K | 1 |
| Gordon, B | 1 |
| Vestfrid, MA | 1 |
| Castelleto, L | 1 |
| Giménez, PO | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase IIa, Multicenter, Open-label Study to Assess the Safety and Efficacy of the Combination of BL-8040 and Pembrolizumab in Patients With Metastatic Pancreatic Cancer, the COMBAT Study[NCT02826486] | Phase 2 | 80 participants (Actual) | Interventional | 2016-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 trials available for fluorouracil and Retroperitoneal Neoplasms
| Article | Year |
|---|---|
BL-8040, a CXCR4 antagonist, in combination with pembrolizumab and chemotherapy for pancreatic cancer: the COMBAT trial.
Topics: Aged; Aged, 80 and over; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Immunological; An | 2020 |
Epirubicin combined with oxaliplatin and 5-day continuous infusion of 5-fluorouracil as a first-line treatment for metastatic gastric cancer: treatment outcomes and analysis of prognostic factors.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Epirubicin; Female; Fluorou | 2015 |
Phase II trial of ifosfamide, fluorouracil, and folinic acid (FIFO regimen) in relapsed and refractory urothelial cancer.
Topics: Adrenal Gland Neoplasms; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms | 1995 |
[Oxytetracycline, vehicle for therapeutic drugs, fluorouracil and nitrogen mustard, in the treatment of gastrointestinal tumors].
Topics: Adenocarcinoma; Adult; Bile Duct Neoplasms; Clinical Trials as Topic; Drug Combinations; Esophagus; | 1970 |
19 other studies available for fluorouracil and Retroperitoneal Neoplasms
| Article | Year |
|---|---|
A case of relapsing secondary bladder adenocarcinoma after right colonic cancer.
Topics: Adenocarcinoma; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antimetabolites, An | 2008 |
Neoadjuvant treatment with cetuximab, 5-Fluorouracil, folinic Acid and oxaliplatin in unresectable retroperitoneal recurrent colon cancer.
Topics: Adenocarcinoma; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined C | 2008 |
Adrenal failure caused by a retroperitoneal malignant mesothelioma.
Topics: Adrenal Gland Neoplasms; Adrenal Insufficiency; Antineoplastic Combined Chemotherapy Protocols; Cisp | 2009 |
Changes induced by surgical and clinical factors in the pharmacology of intraperitoneal mitomycin C in 145 patients with peritoneal carcinomatosis.
Topics: Adult; Aged; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Ap | 2011 |
A SDHB malignant paraganglioma with dramatic response to temozolomide-capecitabine.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Capecitabine; Dacarbazine; | 2012 |
Ovarian metastasis is associated with retroperitoneal lymph node relapses in women treated for colorectal peritoneal carcinomatosis.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Combined Modality | 2013 |
COMBINED SPLIT-COURSE THERAPY WITH 5-FLUOROURACIL AND MEGAVOLTAGE IRRADIATION.
Topics: Colonic Neoplasms; Drug Therapy; Fluorouracil; Lung Neoplasms; Neoplasms; Radiography, Thoracic; Rad | 1964 |
Prognostic implications of the expression of erbB2, topoisomerase II alpha and thymidylate synthase in metastatic gastric cancer after fluorouracil-based therapy.
Topics: Adult; Aged; Antigens, Neoplasm; Antineoplastic Combined Chemotherapy Protocols; DNA Topoisomerases, | 2004 |
[A case of pneumonitis induced by CDDP and 5-FU].
Topics: Anti-Inflammatory Agents; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Cyclophosphamid | 2005 |
Long-term complete remission of metastatic gastric cancer after weekly docetaxel, 24 h infusion of high-dose 5-FU/leucovorin and cisplatin.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Digestive System Surgical Procedures; Doc | 2005 |
[Characterization of spontaneous liver metastatic model of BALB/c retroperitoneal sarcoma (LMFS) injected in footpad and antitumor effects of HCFU].
Topics: Animals; Antineoplastic Agents; Combined Modality Therapy; Fluorouracil; Liver; Liver Neoplasms; Mic | 1997 |
[Effects of HCFU and TNP 470 on liver metastasis of BALB/c retroperitoneal sarcoma (LMFS)].
Topics: Angiogenesis Inhibitors; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Cyclohexanes; | 1999 |
Bleomycin combination chemotherapy in the management of testicular neoplasia.
Topics: Abdominal Neoplasms; Adult; Bleomycin; Cyclophosphamide; Drug Therapy, Combination; Dysgerminoma; Fl | 1975 |
Retroperitoneal lymphadenectomy as adjunctive therapy in selected cases of advanced testicular carcinoma.
Topics: Adolescent; Adult; Bleomycin; Cyclophosphamide; Drug Therapy, Combination; Fluorouracil; Humans; Lym | 1976 |
Retroperitoneal germ cell tumors with no apparent testicular involvement.
Topics: Adult; Biopsy; Cyclophosphamide; Dysgerminoma; Fluorouracil; Follow-Up Studies; Humans; Male; Methot | 1975 |
A dose-intensive regimen of 5-fluorouracil for the treatment of metastatic colorectal carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Colorectal Neoplasms; Drug Administration Schedule; Female; Fluorour | 1991 |
[Clinical reevaluation of continuous intravenous infusion of 5-fluorouracil--plasma concentrations and clinical dose by continuous intravenous and 60-min infusions].
Topics: Adult; Aged; Drug Administration Schedule; Evaluation Studies as Topic; Female; Fluorouracil; Humans | 1990 |
[Continuous intra-arterial infusion chemotherapy for inoperable retroperitoneal liposarcoma--a case report].
Topics: Adult; Antineoplastic Agents; Doxorubicin; Female; Fluorouracil; Humans; Infusions, Intra-Arterial; | 1988 |
[Diffuse liver necrosis in treatment with 5-fluorouracil].
Topics: Adult; Chemical and Drug Induced Liver Injury; Fluorouracil; Humans; Liver; Male; Mesothelioma; Necr | 1972 |