fluorouracil has been researched along with Retinoblastoma in 7 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Retinoblastoma: A malignant tumor arising from the nuclear layer of the retina that is the most common primary tumor of the eye in children. The tumor tends to occur in early childhood or infancy and may be present at birth. The majority are sporadic, but the condition may be transmitted as an autosomal dominant trait. Histologic features include dense cellularity, small round polygonal cells, and areas of calcification and necrosis. An abnormal pupil reflex (leukokoria); NYSTAGMUS, PATHOLOGIC; STRABISMUS; and visual loss represent common clinical characteristics of this condition. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2104)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Harmaline and 5-FU were incubated with human retinoblastoma (Rb) cell line SO-Rb50 for 72 hours separately before subjected to sampling, viable cell counting and inhibition rate (IR) calculation." | 7.68 | [Effects of harmaline and fluorouracil (5-FU) on human retinoblastoma cell line SO-Rb 50]. ( Jin, YJ, 1990) |
| "Harmaline and 5-FU were incubated with human retinoblastoma (Rb) cell line SO-Rb50 for 72 hours separately before subjected to sampling, viable cell counting and inhibition rate (IR) calculation." | 3.68 | [Effects of harmaline and fluorouracil (5-FU) on human retinoblastoma cell line SO-Rb 50]. ( Jin, YJ, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (57.14) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 2 (28.57) | 2.80 |
| Authors | Studies |
|---|---|
| Yang, L | 1 |
| Zhang, L | 1 |
| Lu, L | 1 |
| Wang, Y | 1 |
| Tang, H | 1 |
| Long, Q | 1 |
| Zhuang, K | 1 |
| Han, K | 1 |
| Zhang, X | 1 |
| Guo, H | 1 |
| Lu, X | 1 |
| Kiribuchi, M | 2 |
| Kaneko, A | 1 |
| Kimball, JC | 1 |
| Cangir, A | 1 |
| Jin, YJ | 1 |
| Hasegawa, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An Open, Single-centre Non-randomized Phase II Clinical Trial on Intra-arterial Chemotherapy With Melphalan for the Treatment of Retinoblastoma (RTB) in Advanced Intraocular Stage[NCT01393769] | Phase 2 | 5 participants (Actual) | Interventional | 2009-11-30 | Terminated (stopped due to Only 5 subjects could be enrolled. Sample of 25 pat. not be achieved (rare disease).) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 other studies available for fluorouracil and Retinoblastoma
| Article | Year |
|---|---|
lncRNA
Topics: Antineoplastic Agents; Carboplatin; Cell Line, Tumor; Cell Proliferation; Cisplatin; Down-Regulation | 2020 |
Retinoblastoma tumor suppressor gene 1 enhances 5-Fluorouracil chemosensitivity through SDF-1/CXCR4 axis by regulating autophagy in gastric cancer.
Topics: Apoptosis; Autophagy; Cell Line, Tumor; Chemokine CXCL12; Drug Resistance, Neoplasm; Fluorouracil; H | 2021 |
[Retrograde infusion of anti-cancer drugs to ophthalmic artery for intraocular malignant tumors].
Topics: Eye Neoplasms; Female; Fluorouracil; Humans; Infant; Infusions, Parenteral; Lung Neoplasms; Male; Mi | 1966 |
[Drug therapy of retinoblastoma. The first report. Distribution of 5-fluorouracil and bleomycin in retinoblastoma and aqueous humor (author's transl)].
Topics: Aqueous Humor; Bleomycin; Child, Preschool; Eye Neoplasms; Fluorouracil; Humans; Infant; Retinoblast | 1977 |
Occurrence of testicular metastasis in a child with bilateral retinoblastoma.
Topics: Antineoplastic Agents; Child, Preschool; Cyclophosphamide; Dactinomycin; Doxorubicin; Drug Therapy, | 1979 |
[Effects of harmaline and fluorouracil (5-FU) on human retinoblastoma cell line SO-Rb 50].
Topics: Cell Division; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Eye Neoplasms; Fl | 1990 |
[Retrograde infusion of anti-cancer drugs to the ophthalmic artery for intra ocular malignant tumors].
Topics: Animals; Chemotherapy, Cancer, Regional Perfusion; Dogs; Eye Neoplasms; Female; Fluorouracil; Humans | 1968 |