fluorouracil has been researched along with Retinal Diseases in 20 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Retinal Diseases: Diseases involving the RETINA.
| Excerpt | Relevance | Reference |
|---|---|---|
| " 5-fluorouracil, a synthetic pyrimidine analog, is a potent inhibitor of fibroblast proliferation in cell culture and an animal model of tractional retinal detachment." | 7.67 | 5-fluorouracil: new applications in complicated retinal detachment for an established antimetabolite. ( Blumenkranz, M; Hernandez, E; Norton, EW; Ophir, A, 1984) |
| "To test the efficacy of a biodegradable device for the intravitreal sustained release of fluorouracil in the treatment of tractional retinal detachment due to proliferative vitreoretinopathy." | 3.69 | Prevention of experimental proliferative vitreoretinopathy with a biodegradable intravitreal implant for the sustained release of fluorouracil. ( Cousins, SW; Davis, PA; Hernandez, E; O'Grady, GE; Rubsamen, PE, 1994) |
| "The rate of retinal detachment in fellow control eyes of rabbits following fibroblast administration is progressively lower with increased dose of 5-Fluorouracil in the test eyes." | 3.68 | Further observations on the prevention of experimental proliferative vitreo-retinopathy by 5-fluorouracil. ( Ophir, A, 1991) |
| " 5-fluorouracil, a synthetic pyrimidine analog, is a potent inhibitor of fibroblast proliferation in cell culture and an animal model of tractional retinal detachment." | 3.67 | 5-fluorouracil: new applications in complicated retinal detachment for an established antimetabolite. ( Blumenkranz, M; Hernandez, E; Norton, EW; Ophir, A, 1984) |
| "Fluorouracil effectively inhibits epiretinal membrane formation and traction retinal detachment after vitrectomy surgery." | 3.66 | Fluorouracil therapy for proliferative vitreoretinopathy after vitrectomy. ( Anderson, DH; Erickson, PA; Fisher, SK; Guerin, CJ; Lewis, GP; O'Donnell, JJ; Stern, WH, 1983) |
| "Both patients had ocular hypotony and decreased visual acuity following these injections." | 1.29 | Hypotonic maculopathy after trabeculectomy with postoperative use of 5-fluorouracil. ( Altan, T; Bavbek, T; Kazokoglu, H; Temel, A, 1994) |
| "A 71-year-old white woman with primary open angle glaucoma received trabeculectomy with antimetabolite." | 1.29 | Profound long-term hypotony without maculopathy after trabeculectomy with antimetabolite. ( Kaufman, PL; Kee, C, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (40.00) | 18.7374 |
| 1990's | 10 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chao, D | 1 |
| Chen, WC | 1 |
| Thirkill, CE | 1 |
| Lee, AG | 1 |
| Gülden, O | 1 |
| Wiedmann, TS | 1 |
| Slezak, H | 1 |
| Sunalp, M | 1 |
| Wiedemann, P | 2 |
| Sorgente, N | 1 |
| Ryan, SJ | 1 |
| Blumenkranz, M | 2 |
| Hernandez, E | 2 |
| Ophir, A | 2 |
| Norton, EW | 1 |
| Kulnig, W | 1 |
| Binder, S | 1 |
| Riss, B | 1 |
| Skorpik, C | 1 |
| Stern, WH | 1 |
| Lewis, GP | 1 |
| Erickson, PA | 1 |
| Guerin, CJ | 1 |
| Anderson, DH | 1 |
| Fisher, SK | 1 |
| O'Donnell, JJ | 1 |
| Altan, T | 1 |
| Temel, A | 1 |
| Bavbek, T | 1 |
| Kazokoglu, H | 1 |
| Kee, C | 1 |
| Kaufman, PL | 1 |
| Rubsamen, PE | 1 |
| Davis, PA | 1 |
| O'Grady, GE | 1 |
| Cousins, SW | 1 |
| Ward, T | 1 |
| Hartzer, M | 1 |
| Lin, LR | 1 |
| Oppenheim, B | 1 |
| Ortiz, JM | 1 |
| White, TC | 1 |
| Stamper, RL | 1 |
| McMenemy, MG | 1 |
| Lieberman, MF | 1 |
| Maurice, D | 1 |
| Moorhead, LC | 1 |
| Sepahban, S | 1 |
| Armeniades, CD | 1 |
| Campochiaro, PA | 1 |
| Glaser, BM | 1 |
| Joondeph, BC | 1 |
| Peyman, GA | 1 |
| Khoobehi, B | 1 |
| Yue, BY | 1 |
| Heimann, K | 1 |
20 other studies available for fluorouracil and Retinal Diseases
| Article | Year |
|---|---|
Paraneoplastic optic neuropathy and retinopathy associated with colon adenocarcinoma.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Colonoscopy; Comb | 2013 |
Deposition of aerosol particles in a model vitreous chamber.
Topics: Administration, Ophthalmic; Aerosols; Cesium; Chemistry, Pharmaceutical; Chlorides; Drug Delivery Sy | 2012 |
[Drug-induced eye lesions in the aged].
Topics: Aged; Antipsychotic Agents; Aspirin; Cataract; Conjunctival Diseases; Corneal Diseases; Eye Diseases | 1983 |
Effects of cytotoxic drugs on proliferative vitreoretinopathy in the rabbit cell injection model.
Topics: Animals; Antineoplastic Agents; Disease Models, Animal; Doxorubicin; Eye Diseases; Female; Fibroblas | 1984 |
5-fluorouracil: new applications in complicated retinal detachment for an established antimetabolite.
Topics: Adolescent; Adult; Aged; Animals; Cell Division; Cells, Cultured; Female; Fluorouracil; Humans; Male | 1984 |
Inhibition of experimental intraocular proliferation with intravitreous 5-fluouracil. A transmission electron-microscopic study in rabbits.
Topics: Animals; Axons; Cell Division; Eye; Eye Diseases; Fluorouracil; Microscopy, Electron; Myelin Sheath; | 1984 |
Fluorouracil therapy for proliferative vitreoretinopathy after vitrectomy.
Topics: Animals; Autoradiography; Cells, Cultured; Disease Models, Animal; Drug Evaluation, Preclinical; Eye | 1983 |
Hypotonic maculopathy after trabeculectomy with postoperative use of 5-fluorouracil.
Topics: Adult; Female; Fluorescein Angiography; Fluorouracil; Fundus Oculi; Glaucoma, Open-Angle; Humans; Ma | 1994 |
Profound long-term hypotony without maculopathy after trabeculectomy with antimetabolite.
Topics: Aged; Female; Fluorescein Angiography; Fluorouracil; Fundus Oculi; Glaucoma, Open-Angle; Humans; Int | 1994 |
Prevention of experimental proliferative vitreoretinopathy with a biodegradable intravitreal implant for the sustained release of fluorouracil.
Topics: Animals; Biodegradation, Environmental; Chromatography, High Pressure Liquid; Delayed-Action Prepara | 1994 |
A comparison of 5-fluorouridine and 5-fluorouracil in an experimental model for the treatment of vitreoretinal scarring.
Topics: Animals; Cell Division; Cells, Cultured; Disease Models, Animal; Eye Diseases; Fibroblasts; Fluorour | 1993 |
Hypotonous maculopathy after trabeculectomy with subconjunctival 5-fluorouracil.
Topics: Adult; Fluorouracil; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Macula Lutea; Male; Ocular | 1993 |
Hypotonous maculopathy after trabeculectomy with subconjunctival 5-fluorouracil.
Topics: Fluorouracil; Glaucoma; Humans; Macula Lutea; Middle Aged; Ocular Hypotension; Retinal Diseases; Tra | 1993 |
Hypotonous maculopathy after trabeculectomy with subconjunctival 5-fluorouracil.
Topics: Adult; Aged; Aged, 80 and over; Female; Fluorescein Angiography; Fluorouracil; Fundus Oculi; Glaucom | 1992 |
Liposome suppression of proliferative vitreoretinopathy.
Topics: Animals; Biological Availability; Drug Carriers; Eye Diseases; Fluorouracil; Half-Life; Liposomes; R | 1992 |
Evaluation of drug treatments for proliferative vitreoretinopathy using vitreous microtensiometry.
Topics: Aminopropionitrile; Animals; Cattle; Disease Models, Animal; Drug Combinations; Equipment Design; Ev | 1991 |
Further observations on the prevention of experimental proliferative vitreo-retinopathy by 5-fluorouracil.
Topics: Animals; Disease Models, Animal; Eye Diseases; Fibroblasts; Fluorouracil; Follow-Up Studies; Rabbits | 1991 |
Mechanisms involved in retinal pigment epithelial cell chemotaxis.
Topics: Biomechanical Phenomena; Cell Movement; Chemotaxis; Colchicine; Cytochalasin B; Cytoskeleton; Dexame | 1986 |
Liposome-encapsulated 5-fluorouracil in the treatment of proliferative vitreoretinopathy.
Topics: Animals; Electroretinography; Fluorouracil; Liposomes; Rabbits; Retina; Retinal Diseases; Vitreous B | 1988 |
[Proliferative vitreoretinopathy. Pathogenesis and possibilities for treatment with cytostatic drugs].
Topics: Antineoplastic Agents; Cell Division; Daunorubicin; Eye Diseases; Fluorouracil; Humans; Pigment Epit | 1986 |