Page last updated: 2024-10-27

fluorouracil and Retinal Detachment

fluorouracil has been researched along with Retinal Detachment in 28 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Retinal Detachment: Separation of the inner layers of the retina (neural retina) from the pigment epithelium. Retinal detachment occurs more commonly in men than in women, in eyes with degenerative myopia, in aging and in aphakia. It may occur after an uncomplicated cataract extraction, but it is seen more often if vitreous humor has been lost during surgery. (Dorland, 27th ed; Newell, Ophthalmology: Principles and Concepts, 7th ed, p310-12).

Research Excerpts

ExcerptRelevanceReference
"To determine the efficacy of a combination of 5-fluorouracil (5FU) and low-molecular-weight heparin (LMWH) in the treatment of unselected rhegmatogenous retinal detachment (RRD) undergoing primary vitrectomy."9.12Randomized controlled trial of combined 5-Fluorouracil and low-molecular-weight heparin in the management of unselected rhegmatogenous retinal detachments undergoing primary vitrectomy. ( Bunce, C; Charteris, DG; McGurn, D; Wickham, L; Wong, D, 2007)
"To determine the efficacy of a combination of 5-fluorouracil and low-molecular-weight heparin (LMWH) to improve the outcome of surgery for established proliferative vitreoretinopathy (PVR)."9.11A randomized controlled trial of combined 5-fluorouracil and low-molecular-weight heparin in management of established proliferative vitreoretinopathy. ( Asaria, RH; Aylward, GW; Bunce, C; Charteris, DG; Groenewald, C; Wong, D, 2004)
"To assess the safety and efficacy of adjuvant combination therapy using 5-fluorouracil (5-FU) and low molecular weight heparin (LMWH) for prevention of proliferative vitreoretinopathy (PVR) after vitrectomy and retinal reattachment surgery."9.09Adjuvant 5-fluorouracil and heparin prevents proliferative vitreoretinopathy : Results from a randomized, double-blind, controlled clinical trial. ( Asaria, RH; Aylward, GW; Bunce, C; Charteris, DG; Khaw, PT; Kon, CH; Wong, D, 2001)
"To determine the potential of an intravitreal sustained release naproxen and 5-fluorouracil (NA/5-FU) codrug for the treatment of experimental proliferative vitreoretinopathy (PVR) in a model for trauma associated tractional retinal detachment (TRD)."7.72An intravitreal biodegradable sustained release naproxen and 5-fluorouracil system for the treatment of experimental post-traumatic proliferative vitreoretinopathy. ( Ashton, P; Cardillo, JA; Costa, RA; Farah, ME; Jorge, R; Kuppermann, B; Melo, LA; Mitre, J; Morales, PH, 2004)
" 5-fluorouracil, a synthetic pyrimidine analog, is a potent inhibitor of fibroblast proliferation in cell culture and an animal model of tractional retinal detachment."7.675-fluorouracil: new applications in complicated retinal detachment for an established antimetabolite. ( Blumenkranz, M; Hernandez, E; Norton, EW; Ophir, A, 1984)
"On day 2 of re-treatment, serous retinal detachment recurred and treatment was discontinued."5.72[A Case of Serous Retinal Detachment after Encorafenib, Binimetinib, and Cetuximab Treatment for BRAF V600E Mutant Colorectal Cancer]. ( Ajihara, T; Fukuya, Y; Hanada, M; Koike, T; Kono, T; Miyata, R; Naritomi, T; Shiozawa, S; Yoshimatsu, K, 2022)
"To determine the efficacy of a combination of 5-fluorouracil (5FU) and low-molecular-weight heparin (LMWH) in the treatment of unselected rhegmatogenous retinal detachment (RRD) undergoing primary vitrectomy."5.12Randomized controlled trial of combined 5-Fluorouracil and low-molecular-weight heparin in the management of unselected rhegmatogenous retinal detachments undergoing primary vitrectomy. ( Bunce, C; Charteris, DG; McGurn, D; Wickham, L; Wong, D, 2007)
"To determine the efficacy of a combination of 5-fluorouracil and low-molecular-weight heparin (LMWH) to improve the outcome of surgery for established proliferative vitreoretinopathy (PVR)."5.11A randomized controlled trial of combined 5-fluorouracil and low-molecular-weight heparin in management of established proliferative vitreoretinopathy. ( Asaria, RH; Aylward, GW; Bunce, C; Charteris, DG; Groenewald, C; Wong, D, 2004)
"To assess the safety and efficacy of adjuvant combination therapy using 5-fluorouracil (5-FU) and low molecular weight heparin (LMWH) for prevention of proliferative vitreoretinopathy (PVR) after vitrectomy and retinal reattachment surgery."5.09Adjuvant 5-fluorouracil and heparin prevents proliferative vitreoretinopathy : Results from a randomized, double-blind, controlled clinical trial. ( Asaria, RH; Aylward, GW; Bunce, C; Charteris, DG; Khaw, PT; Kon, CH; Wong, D, 2001)
"To determine the potential of an intravitreal sustained release naproxen and 5-fluorouracil (NA/5-FU) codrug for the treatment of experimental proliferative vitreoretinopathy (PVR) in a model for trauma associated tractional retinal detachment (TRD)."3.72An intravitreal biodegradable sustained release naproxen and 5-fluorouracil system for the treatment of experimental post-traumatic proliferative vitreoretinopathy. ( Ashton, P; Cardillo, JA; Costa, RA; Farah, ME; Jorge, R; Kuppermann, B; Melo, LA; Mitre, J; Morales, PH, 2004)
"To test the efficacy of a biodegradable device for the intravitreal sustained release of fluorouracil in the treatment of tractional retinal detachment due to proliferative vitreoretinopathy."3.69Prevention of experimental proliferative vitreoretinopathy with a biodegradable intravitreal implant for the sustained release of fluorouracil. ( Cousins, SW; Davis, PA; Hernandez, E; O'Grady, GE; Rubsamen, PE, 1994)
"Six patients, each with one eye that had previously undergone circular buckling surgery for the repair of retinal detachment before or followed by cataract extraction with or without intraocular lens implantation, underwent trabeculectomy with 5-fluorouracil (5-FU) for intractable glaucoma."3.68Trabeculectomy with 5-fluorouracil subsequent to circular buckling operation and cataract extraction. ( Ophir, A; Ticho, U, 1992)
"The rate of retinal detachment in fellow control eyes of rabbits following fibroblast administration is progressively lower with increased dose of 5-Fluorouracil in the test eyes."3.68Further observations on the prevention of experimental proliferative vitreo-retinopathy by 5-fluorouracil. ( Ophir, A, 1991)
" 5-fluorouracil, a synthetic pyrimidine analog, is a potent inhibitor of fibroblast proliferation in cell culture and an animal model of tractional retinal detachment."3.675-fluorouracil: new applications in complicated retinal detachment for an established antimetabolite. ( Blumenkranz, M; Hernandez, E; Norton, EW; Ophir, A, 1984)
"Fluorouracil effectively inhibits epiretinal membrane formation and traction retinal detachment after vitrectomy surgery."3.66Fluorouracil therapy for proliferative vitreoretinopathy after vitrectomy. ( Anderson, DH; Erickson, PA; Fisher, SK; Guerin, CJ; Lewis, GP; O'Donnell, JJ; Stern, WH, 1983)
"On day 2 of re-treatment, serous retinal detachment recurred and treatment was discontinued."1.72[A Case of Serous Retinal Detachment after Encorafenib, Binimetinib, and Cetuximab Treatment for BRAF V600E Mutant Colorectal Cancer]. ( Ajihara, T; Fukuya, Y; Hanada, M; Koike, T; Kono, T; Miyata, R; Naritomi, T; Shiozawa, S; Yoshimatsu, K, 2022)
"5-Fluorouracil (5-FU) is a potent inhibitor of the proliferation of fibroblasts, the main cell mediators of scar formation."1.28Effects of 5-fluorouracil on proliferating fibroblasts in vivo. ( Ophir, A, 1991)

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-19907 (25.00)18.7374
1990's6 (21.43)18.2507
2000's6 (21.43)29.6817
2010's6 (21.43)24.3611
2020's3 (10.71)2.80

Authors

AuthorsStudies
Schaub, F2
Schiller, P2
Hoerster, R2
Kraus, D2
Holz, FG1
Guthoff, R1
Agostini, H1
Spitzer, MS1
Wiedemann, P2
Lommatzsch, A1
Boden, KT1
Dimopoulos, S1
Bemme, S1
Tamm, S1
Maier, M1
Roider, J1
Enders, P1
Altay, L1
Fauser, S2
Kirchhof, B2
Kono, T1
Miyata, R1
Yoshimatsu, K1
Koike, T1
Shiozawa, S1
Hanada, M1
Ajihara, T1
Naritomi, T1
Fukuya, Y1
van Overdam, KA1
Sebag, J2
Felsch, M1
Zarrouk, M1
Sundaram, V2
Barsam, A2
Virgili, G2
Chiquet, C1
Rouberol, F1
Pérez-Alvarez, MJ1
Arriola-Villalobos, P1
Reche-Frutos, J1
García-Sánchez, J1
Wickham, L3
Ho-Yen, GO1
Bunce, C5
Wong, D5
Charteris, DG5
Cardillo, JA1
Farah, ME1
Mitre, J1
Morales, PH1
Costa, RA1
Melo, LA1
Kuppermann, B1
Jorge, R1
Ashton, P2
Aylward, GW2
Groenewald, C1
Asaria, RH2
McGurn, D1
Blumenkranz, MS1
Ophir, A6
Claflin, AJ1
Hajek, A1
Sunalp, M1
Sorgente, N1
Ryan, SJ1
Blumenkranz, M3
Hernandez, E3
Norton, EW1
Stern, WH1
Lewis, GP1
Erickson, PA1
Guerin, CJ1
Anderson, DH1
Fisher, SK1
O'Donnell, JJ1
Rubsamen, PE1
Davis, PA1
O'Grady, GE1
Cousins, SW1
Ward, T1
Hartzer, M1
Lin, LR1
Berger, AS1
Cheng, CK1
Pearson, PA1
Crooks, PA1
Cynkowski, T1
Cynkowska, G1
Jaffe, GJ1
Kon, CH1
Khaw, PT1
Ticho, U1
Orr, G1
Tervaert, DC1
Lean, JS1
Jarus, G1
Sossi, N1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Prophylactic Intravitreal 5-Fluorouracil and Heparin to Prevent PVR in High-risk Patients With Retinal Detachment.[NCT02834559]Phase 3326 participants (Actual)Interventional2016-10-27Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for fluorouracil and Retinal Detachment

ArticleYear
Intravitreal low molecular weight heparin and 5-Fluorouracil for the prevention of proliferative vitreoretinopathy following retinal reattachment surgery.
    The Cochrane database of systematic reviews, 2013, Jan-31, Issue:1

    Topics: Fluorouracil; Heparin, Low-Molecular-Weight; Humans; Intravitreal Injections; Postoperative Complica

2013
[Proliferative vitreoretinopathy: prophylactic treatment].
    Journal francais d'ophtalmologie, 2014, Volume: 37, Issue:9

    Topics: Antibiotics, Antineoplastic; Colchicine; Daunorubicin; Fibrinolytic Agents; Fluorouracil; Glucocorti

2014
Intravitreal low molecular weight heparin and 5-Fluorouracil for the prevention of proliferative vitreoretinopathy following retinal reattachment surgery.
    The Cochrane database of systematic reviews, 2010, Jul-07, Issue:7

    Topics: Fluorouracil; Heparin, Low-Molecular-Weight; Humans; Injections, Intraocular; Postoperative Complica

2010

Trials

8 trials available for fluorouracil and Retinal Detachment

ArticleYear
Intravitreal 5-Fluorouracil and Heparin to Prevent Proliferative Vitreoretinopathy: Results from a Randomized Clinical Trial.
    Ophthalmology, 2022, Volume: 129, Issue:10

    Topics: Dalteparin; Double-Blind Method; Fluorouracil; Heparin; Heparin, Low-Molecular-Weight; Humans; Retin

2022
Re: Schaub et al.: Intravitreal 5-fluorouracil and heparin to prevent proliferative vitreoretinopathy: results from a randomized clinical trial (Ophthalmology. 2022;129:1129-1141).
    Ophthalmology, 2023, Volume: 130, Issue:6

    Topics: Fluorouracil; Heparin; Humans; Retinal Detachment; Vitreoretinopathy, Proliferative

2023
Prophylactic intravitreal 5-fluorouracil and heparin to prevent proliferative vitreoretinopathy in high-risk patients with retinal detachment: study protocol for a randomized controlled trial.
    Trials, 2018, Jul-16, Volume: 19, Issue:1

    Topics: Data Interpretation, Statistical; Double-Blind Method; Endpoint Determination; Fluorouracil; Heparin

2018
Surgical failure following primary retinal detachment surgery by vitrectomy: risk factors and functional outcomes.
    The British journal of ophthalmology, 2011, Volume: 95, Issue:9

    Topics: Aged; Aged, 80 and over; Disease Progression; Drug Therapy, Combination; Female; Fibrinolytic Agents

2011
Retinal detachment repair by vitrectomy: simplified formulae to estimate the risk of failure.
    The British journal of ophthalmology, 2011, Volume: 95, Issue:9

    Topics: Adult; Aged; Antimetabolites; Female; Fibrinolytic Agents; Fluorouracil; Follow-Up Studies; Heparin,

2011
A randomized controlled trial of combined 5-fluorouracil and low-molecular-weight heparin in management of established proliferative vitreoretinopathy.
    Ophthalmology, 2004, Volume: 111, Issue:12

    Topics: Aged; Antimetabolites; Double-Blind Method; Drug Therapy, Combination; Female; Fibrinolytic Agents;

2004
Randomized controlled trial of combined 5-Fluorouracil and low-molecular-weight heparin in the management of unselected rhegmatogenous retinal detachments undergoing primary vitrectomy.
    Ophthalmology, 2007, Volume: 114, Issue:4

    Topics: Combined Modality Therapy; Cryotherapy; Dalteparin; Double-Blind Method; Drug Therapy, Combination;

2007
Adjuvant 5-fluorouracil and heparin prevents proliferative vitreoretinopathy : Results from a randomized, double-blind, controlled clinical trial.
    Ophthalmology, 2001, Volume: 108, Issue:7

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Double-Blind Method; Drug Therapy, Combination; Female;

2001

Other Studies

17 other studies available for fluorouracil and Retinal Detachment

ArticleYear
[A Case of Serous Retinal Detachment after Encorafenib, Binimetinib, and Cetuximab Treatment for BRAF V600E Mutant Colorectal Cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2022, Volume: 49, Issue:10

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Cetuximab; Colorectal Neoplasms;

2022
[Choroidal metastasis from a breast carcinoma. Diagnosis and follow-up with optical coherence tomography and fluorescein angiography and autofluorescence with HRA-II (Heidelberg Retina Angiograph)].
    Archivos de la Sociedad Espanola de Oftalmologia, 2009, Volume: 84, Issue:5

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma, Ductal, Breast; C

2009
An intravitreal biodegradable sustained release naproxen and 5-fluorouracil system for the treatment of experimental post-traumatic proliferative vitreoretinopathy.
    The British journal of ophthalmology, 2004, Volume: 88, Issue:9

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biodegradation, Environmental; Disease Models, Ani

2004
Fluorouracil for the treatment of massive periretinal proliferation.
    American journal of ophthalmology, 1982, Volume: 94, Issue:4

    Topics: Animals; Cells, Cultured; Fibroblasts; Fluorouracil; Neovascularization, Pathologic; Rabbits; Retina

1982
Effects of cytotoxic drugs on proliferative vitreoretinopathy in the rabbit cell injection model.
    Current eye research, 1984, Volume: 3, Issue:4

    Topics: Animals; Antineoplastic Agents; Disease Models, Animal; Doxorubicin; Eye Diseases; Female; Fibroblas

1984
Prevention of experimental massive peri-retinal proliferation by 5-fluoro-uracil.
    Metabolic, pediatric, and systemic ophthalmology, 1983, Volume: 7, Issue:2

    Topics: Animals; Fibroblasts; Fluorouracil; Humans; Methotrexate; Rabbits; Retinal Detachment; Vitreous Body

1983
5-fluorouracil: new applications in complicated retinal detachment for an established antimetabolite.
    Ophthalmology, 1984, Volume: 91, Issue:2

    Topics: Adolescent; Adult; Aged; Animals; Cell Division; Cells, Cultured; Female; Fluorouracil; Humans; Male

1984
Fluorouracil therapy for proliferative vitreoretinopathy after vitrectomy.
    American journal of ophthalmology, 1983, Volume: 96, Issue:1

    Topics: Animals; Autoradiography; Cells, Cultured; Disease Models, Animal; Drug Evaluation, Preclinical; Eye

1983
Prevention of experimental proliferative vitreoretinopathy with a biodegradable intravitreal implant for the sustained release of fluorouracil.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1994, Volume: 112, Issue:3

    Topics: Animals; Biodegradation, Environmental; Chromatography, High Pressure Liquid; Delayed-Action Prepara

1994
A comparison of 5-fluorouridine and 5-fluorouracil in an experimental model for the treatment of vitreoretinal scarring.
    Current eye research, 1993, Volume: 12, Issue:5

    Topics: Animals; Cell Division; Cells, Cultured; Disease Models, Animal; Eye Diseases; Fibroblasts; Fluorour

1993
Intravitreal sustained release corticosteroid-5-fluoruracil conjugate in the treatment of experimental proliferative vitreoretinopathy.
    Investigative ophthalmology & visual science, 1996, Volume: 37, Issue:11

    Topics: Animals; Antimetabolites; Delayed-Action Preparations; Dexamethasone; Disease Models, Animal; Drug C

1996
Shaken not stirred.
    Ophthalmology, 2001, Volume: 108, Issue:7

    Topics: Clinical Trials as Topic; Drug Therapy, Combination; Fluorouracil; Heparin, Low-Molecular-Weight; Hu

2001
Trabeculectomy with 5-fluorouracil subsequent to circular buckling operation and cataract extraction.
    Annals of ophthalmology, 1992, Volume: 24, Issue:10

    Topics: Adult; Aged; Atropine; Cataract Extraction; Female; Fluorouracil; Follow-Up Studies; Glaucoma, Open-

1992
Effects of 5-fluorouracil on proliferating fibroblasts in vivo.
    Experimental eye research, 1991, Volume: 53, Issue:6

    Topics: Animals; Cell Division; Cells, Cultured; Fibroblasts; Fluorouracil; Microscopy, Electron; Rabbits; R

1991
Further observations on the prevention of experimental proliferative vitreo-retinopathy by 5-fluorouracil.
    Ophthalmic research, 1991, Volume: 23, Issue:3

    Topics: Animals; Disease Models, Animal; Eye Diseases; Fibroblasts; Fluorouracil; Follow-Up Studies; Rabbits

1991
Aqueous concentrations of fluorouracil after intravitreal injection. Normal, vitrectomized, and silicone-filled eyes.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1986, Volume: 104, Issue:3

    Topics: Animals; Anterior Chamber; Aqueous Humor; Cornea; Eye; Fluorouracil; Postoperative Complications; Ra

1986
Clearance of intravitreal fluorouracil. Normal and aphakic vitrectomized eyes.
    Ophthalmology, 1985, Volume: 92, Issue:1

    Topics: Animals; Aphakia; Fluorouracil; Injections; Metabolic Clearance Rate; Rabbits; Retinal Detachment; V

1985