fluorouracil has been researched along with Respiratory Tract Neoplasms in 8 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Respiratory Tract Neoplasms: New abnormal growth of tissue in the RESPIRATORY SYSTEM.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The prognosis of upper thoracic esophageal cancer is poor when compared with middle and lower thoracic esophageal cancer because the tumor easily infiltrates the respiratory tract and surgical en-bloc resection is difficult." | 1.31 | Squamous cell carcinoma of the esophagus infiltrating the respiratory tract is less sensitive to preoperative concurrent radiation and chemotherapy. ( Doki, Y; Fujiwara, Y; Inoue, M; Monden, M; Shiozaki, H; Tsujinaka, T; Yano, M, 2000) |
| "A series of 344 patients with squamous cell carcinoma (oropharynx, larynx, hypopharynx, or buccal cavity) were treated between November 1982 and January 1985 by chemotherapy." | 1.27 | [Induction chemotherapy in cancers of the respiratory and digestive tracts by continuous infusions combining cisplatinum (C), fluorouracil (F), bleomycin (B) or C and F]. ( Bassot, V; Brasnu, D; Donnadieu, S; Fabre, A; Jacquillat, C; Lacau-St-Guily, J; Laccourreye, H; Menard, M, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (62.50) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| DOWD, JE | 1 |
| DIPAOLO, JA | 1 |
| WATNE, AL | 1 |
| Ramnath, N | 1 |
| Khushalani, N | 1 |
| Toth, K | 1 |
| Litwin, AM | 1 |
| Intengan, ME | 1 |
| Slocum, HK | 1 |
| Pendyala, L | 1 |
| Smith, PF | 1 |
| Stewart, CC | 1 |
| Hoffman, JL | 1 |
| Javle, MM | 1 |
| Berdzik, J | 1 |
| Creaven, PJ | 1 |
| Rustum, YM | 1 |
| Joveniaux, A | 1 |
| Caty, A | 1 |
| Adenis, L | 1 |
| Yano, M | 1 |
| Shiozaki, H | 1 |
| Tsujinaka, T | 1 |
| Inoue, M | 1 |
| Doki, Y | 1 |
| Fujiwara, Y | 1 |
| Monden, M | 1 |
| Cappelaere, P | 1 |
| Vignoud, J | 1 |
| Fargeot, P | 1 |
| Metz, R | 1 |
| Chauvergne, J | 1 |
| Meeus, L | 1 |
| Schneider, M | 1 |
| Chazard, M | 1 |
| Bassot, V | 1 |
| Brasnu, D | 1 |
| Lacau-St-Guily, J | 1 |
| Fabre, A | 1 |
| Menard, M | 1 |
| Donnadieu, S | 1 |
| Jacquillat, C | 1 |
| Laccourreye, H | 1 |
| Cachin, Y | 1 |
| Domenge, C | 1 |
| Maisin, H | 1 |
| Salamon, E | 1 |
| Deckers, C | 1 |
| Longueville, J | 1 |
| Wambersie, A | 1 |
2 trials available for fluorouracil and Respiratory Tract Neoplasms
| Article | Year |
|---|---|
S-phase modulation by irinotecan: pilot studies in advanced solid tumors.
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic C | 2005 |
[Palliative chemotherapy of epidermoid carcinoma of the upper respiratory and digestive tracts with a combination of carboplatin and 5-fluorouracil].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, Squamous Cell; | 1990 |
6 other studies available for fluorouracil and Respiratory Tract Neoplasms
| Article | Year |
|---|---|
INDIVIDUALIZED CHEMOTHERAPY BY IN VITRO DRUG SELECTION.
Topics: Antineoplastic Agents; Bone Neoplasms; Dactinomycin; Female; Floxuridine; Fluorouracil; Genital Neop | 1964 |
[Combination of cisplatin with 5-fluorouracil in the primary treatment of advanced carcinoma of the upper respiratory and digestive tract].
Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Digestive System Neoplasms; Fluorouracil; | 1984 |
Squamous cell carcinoma of the esophagus infiltrating the respiratory tract is less sensitive to preoperative concurrent radiation and chemotherapy.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Chemotherapy, | 2000 |
[Induction chemotherapy in cancers of the respiratory and digestive tracts by continuous infusions combining cisplatinum (C), fluorouracil (F), bleomycin (B) or C and F].
Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Carcinoma, Squamous Cell; Cisplatin; Dige | 1986 |
[Chemotherapy of carcinoma of the upper respiratory and digestive tract].
Topics: Cisplatin; Combined Modality Therapy; Digestive System Neoplasms; Fluorouracil; Humans; Otorhinolary | 1986 |
[Association of cytotoxic agents with radiotherapy: experimental bases and initial results in solid tumors].
Topics: Antineoplastic Agents; Breast Neoplasms; Cyclophosphamide; Drug Synergism; Female; Fluorouracil; Gas | 1969 |