fluorouracil has been researched along with Purine Pyrimidine Metabolism, Inborn Errors in 12 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Carnitine acts as a carrier of long chain fatty acid to mitochondria and to beta-oxidation, thus an important molecule for energy production by beta-oxidation and maintenance of mitochondrial function." | 2.45 | Children's toxicology from bench to bed--Liver injury (1): Drug-induced metabolic disturbance--toxicity of 5-FU for pyrimidine metabolic disorders and pivalic acid for carnitine metabolism. ( Ito, T, 2009) |
| " We speculate that 5-FU cytotoxic effects, both anti-tumor effects and adverse reactions, would be weak when a patient with hereditary orotic aciduria was treated with 5-FU." | 1.31 | Decreased fluorouracil cytotoxic effect on EB-virus transformed lymphocytes from hereditary orotic aciduria. ( Andou, M; Sumi, S; Togari, H; Wada, Y, 2000) |
| "In addition to this study we analyzed a DPD deficiency case and a DHPuria case." | 1.30 | Possible prediction of adverse reactions to fluorouracil by the measurement of urinary dihydrothymine and thymine. ( Dobashi, K; Hayashi, K; Kidouchi, K; Kondou, M; Kouwaki, M; Sumi, S; Togari, H; Wada, Y, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (16.67) | 18.7374 |
| 1990's | 4 (33.33) | 18.2507 |
| 2000's | 6 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ito, T | 1 |
| Fischer, J | 1 |
| Schwab, M | 1 |
| Eichelbaum, M | 1 |
| Zanger, UM | 1 |
| van Kuilenburg, AB | 4 |
| Meinsma, R | 2 |
| Zonnenberg, BA | 1 |
| Zoetekouw, L | 1 |
| Baas, F | 1 |
| Matsuda, K | 1 |
| Tamaki, N | 1 |
| van Gennip, AH | 4 |
| Stroomer, AE | 1 |
| Van Lenthe, H | 1 |
| Abeling, NG | 1 |
| Al-Sanna'a, NA | 1 |
| Atrak, TM | 1 |
| Abdul-Jabbar, MA | 1 |
| Gonzalez, FJ | 1 |
| Fernandez-Salguero, P | 1 |
| Milano, G | 1 |
| Etienne, MC | 1 |
| Vreken, P | 1 |
| Sumi, S | 2 |
| Kidouchi, K | 1 |
| Kondou, M | 1 |
| Hayashi, K | 1 |
| Dobashi, K | 1 |
| Kouwaki, M | 1 |
| Togari, H | 2 |
| Wada, Y | 2 |
| Andou, M | 1 |
| Tuchman, M | 1 |
| Stoeckeler, JS | 1 |
| Kiang, DT | 1 |
| O'Dea, RF | 1 |
| Ramnaraine, ML | 1 |
| Mirkin, BL | 1 |
| Diasio, RB | 1 |
| Beavers, TL | 1 |
| Carpenter, JT | 1 |
3 reviews available for fluorouracil and Purine Pyrimidine Metabolism, Inborn Errors
| Article | Year |
|---|---|
Children's toxicology from bench to bed--Liver injury (1): Drug-induced metabolic disturbance--toxicity of 5-FU for pyrimidine metabolic disorders and pivalic acid for carnitine metabolism.
Topics: Amidohydrolases; Animals; Anti-Bacterial Agents; Antineoplastic Agents; Carnitine; Cephalosporins; C | 2009 |
Diagnostic analysis, clinical importance and molecular basis of dihydropyrimidine dehydrogenase deficiency.
Topics: Antineoplastic Agents; Dihydrouracil Dehydrogenase (NADP); Fluorouracil; Humans; Oxidoreductases; Pu | 1995 |
Potential importance of dihydropyrimidine dehydrogenase (DPD) in cancer chemotherapy.
Topics: Antineoplastic Agents; Dihydrouracil Dehydrogenase (NADP); Female; Fluorouracil; Genetics, Populatio | 1994 |
9 other studies available for fluorouracil and Purine Pyrimidine Metabolism, Inborn Errors
| Article | Year |
|---|---|
Mutational analysis of the human dihydropyrimidine dehydrogenase gene by denaturing high-performance liquid chromatography.
Topics: Alleles; Antimetabolites, Antineoplastic; Base Sequence; Chromatography, High Pressure Liquid; Dihyd | 2003 |
Dihydropyrimidinase deficiency and severe 5-fluorouracil toxicity.
Topics: Amidohydrolases; Amino Acid Sequence; Antimetabolites, Antineoplastic; Blotting, Western; Breast Neo | 2003 |
New insights in dihydropyrimidine dehydrogenase deficiency: a pivotal role for beta-aminoisobutyric acid?
Topics: Aminoisobutyric Acids; beta-Alanine; Brain Diseases, Metabolic, Inborn; Dihydropyrimidine Dehydrogen | 2004 |
Dihydropyrimidine dehydrogenase deficiency presenting at birth.
Topics: Age of Onset; Antimetabolites; Binding Sites; Digestive System Abnormalities; Dihydropyrimidine Dehy | 2005 |
Dihydropyrimidine dehydrogenase (DPD) deficiency: identification and expression of missense mutations C29R, R886H and R235W.
Topics: Adult; Antimetabolites, Antineoplastic; Cloning, Molecular; Dihydrouracil Dehydrogenase (NADP); DNA, | 1997 |
Possible prediction of adverse reactions to fluorouracil by the measurement of urinary dihydrothymine and thymine.
Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Child; Child, Preschool; Dihydropyrimidine Dehyd | 1998 |
Decreased fluorouracil cytotoxic effect on EB-virus transformed lymphocytes from hereditary orotic aciduria.
Topics: Antimetabolites; Cell Line, Transformed; Cell Survival; Fluorouracil; Herpesvirus 4, Human; Heterozy | 2000 |
Familial pyrimidinemia and pyrimidinuria associated with severe fluorouracil toxicity.
Topics: Adult; Breast Neoplasms; Carcinoma, Intraductal, Noninfiltrating; Female; Fluorouracil; Humans; Male | 1985 |
Familial deficiency of dihydropyrimidine dehydrogenase. Biochemical basis for familial pyrimidinemia and severe 5-fluorouracil-induced toxicity.
Topics: Adult; Chromatography, High Pressure Liquid; Dihydrouracil Dehydrogenase (NADP); Female; Fluorouraci | 1988 |