fluorouracil has been researched along with Prostatic Neoplasms, Castration-Resistant in 2 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Prostatic Neoplasms, Castration-Resistant: Tumors or cancer of the PROSTATE which can grow in the presence of low or residual amount of androgen hormones such as TESTOSTERONE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Flubendazole is a well-known anti-malarial drug that is recently reported to be a potential anti-tumor agent in various types of human cancer cells." | 1.62 | Flubendazole, FDA-approved anthelmintic, elicits valid antitumor effects by targeting P53 and promoting ferroptosis in castration-resistant prostate cancer. ( Cen, S; Chen, W; Li, C; Luo, J; Mao, X; Shu, F; Tan, X; Wu, K; Yang, T; Yang, Y; Zhou, X; Zou, L, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhou, X | 1 |
| Zou, L | 1 |
| Chen, W | 1 |
| Yang, T | 1 |
| Luo, J | 1 |
| Wu, K | 1 |
| Shu, F | 1 |
| Tan, X | 1 |
| Yang, Y | 1 |
| Cen, S | 1 |
| Li, C | 1 |
| Mao, X | 1 |
| Manogue, C | 1 |
| Ledet, E | 1 |
| Guddati, AK | 1 |
| Lewis, B | 1 |
| Sartor, O | 1 |
2 other studies available for fluorouracil and Prostatic Neoplasms, Castration-Resistant
| Article | Year |
|---|---|
Flubendazole, FDA-approved anthelmintic, elicits valid antitumor effects by targeting P53 and promoting ferroptosis in castration-resistant prostate cancer.
Topics: Amino Acid Transport System y+; Animals; Anthelmintics; Antineoplastic Agents; Antineoplastic Combin | 2021 |
Extreme Prostate-Specific Antigen Response to Infusional 5-Flourouracil in Castrate-Resistant Prostate Cancer.
Topics: Aged; Antimetabolites, Antineoplastic; Biomarkers, Tumor; Fluorouracil; Humans; Male; Neoplasm Metas | 2018 |