fluorouracil and Pregnancy studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.

Research Excerpts

Excerpt	Relevance	Reference
"To compare the efficiency and safety of uterine artery embolization (UAE) combined with local infusion of methotrexate (MTX) or MTX and 5-fluorouracil (5-FU) in the treatment of ectopic pregnancy (EP)."	9.27	Uterine artery embolization combined with local infusion of methotrexate and 5- fluorouracil in treating ectopic pregnancy: A CONSORT-compliant article. ( Chen, J; Gao, J; Gong, W; Li, X; Wu, Z; Yue, K, 2018)
"A combination of 5-fluorouracil plus actinomycin D (5FU plus Act D) is the regimen that has been commonly administered to Chinese and Japanese gestational trophoblastic neoplasia patients as the first or second line of treatment with an excellent outcome."	7.78	Resistant gestational trophoblastic neoplasia patients treated with 5-fluorouracil plus actinomycin D. ( Manopunya, M; Suprasert, P, 2012)
" The absence of any abnormalities in the infant makes irinotecan and fluorouracil a valid therapeutic option for colon cancer during pregnancy."	7.78	Irinotecan during pregnancy in metastatic colon cancer. ( Cassandrini, PA; Cirillo, M; Lunardi, G; Musola, M; Venturini, M, 2012)
" We present a case of an ongoing 19-week-long pregnancy which was diagnosed in a 39-year-old woman who was being treated with CEF (cyclophosphamide, epirubicin, 5-fluorouracil) chemotherapy for an infiltrating ductal carcinoma of the breast."	7.77	Specific congenital malformations after exposure to cyclophosphamide, epirubicin and 5-fluorouracil during the first trimester of pregnancy. ( Breugelmans, M; De Greve, J; Foulon, W; Keymolen, K; Laubach, M; Leyder, M, 2011)
" As a model toxicant, we chose 5-fluorouracil (5-FU), since we previously observed that maternal administration at 20-40 mg/kg on gestational day (GD) 14 produced fetal anemia on GD 16-17, as evidenced by dose-dependent decreases in the cell counts, hematocrit, and hemoglobin content of fetal blood obtained by cardiac puncture."	7.69	Flow cytometric detection of abnormal fetal erythropoiesis: application to 5-fluorouracil-induced anemia. ( Elstein, KH; Rogers, JM; Shuey, DL; Zucker, RM, 1995)
" We should pay attention to the dosage of 5-FU and ActD, monitor adverse reactions strictly, to reduce occurrence of skin malignant events."	6.82	5-Fluorouracil and actinomycin D lead to erythema multiforme drug eruption in chemotherapy of invasive mole: Case report and literature review. ( Li, T; Liu, Y; Wang, M; Wang, S; Wang, Y; Zhang, L; Zhang, X, 2022)
"A case of metastatic infiltrating breast cancer in a young multiparous lady with 33 weeks pregnancy is presented who was treated with combination chemotherapy and hemostatic radiotherapy and had successful pregnancy outcome."	5.35	Successful pregnancy outcome with 5-flurouracil, epirubicin, cyclophosphamide chemotherapy, and hemostatic radiotherapy with abdominal shielding for metastatic invasive intraductal breast carcinoma. ( Kumar, S; Malhotra, N; Pushparaj, M; Raina, V; Roy, KK; Sharma, JB, 2009)
"5-Fluorouracil (5-FU) is a cytostatic anti-tumor drug which is known to have immunosuppressive activities."	5.31	Effects on fetal thymocyte populations and postnatal T-cell-dependent immune functions after maternal exposure to 5-fluorouracil during pregnancy in mice. ( Horii, I; Inoue, T, 2002)
"Seventeen women with unruptured tubal pregnancy were given 5-FU through salpingo-catheter under hysteroscopy."	5.29	[Injection of 5-fluorouracil in the treatment of tubal pregnancy through salpingo-catheter under hysteroscopy]. ( Liu, SY; Liu, XC; Xie, QH, 1994)
"To compare the efficiency and safety of uterine artery embolization (UAE) combined with local infusion of methotrexate (MTX) or MTX and 5-fluorouracil (5-FU) in the treatment of ectopic pregnancy (EP)."	5.27	Uterine artery embolization combined with local infusion of methotrexate and 5- fluorouracil in treating ectopic pregnancy: A CONSORT-compliant article. ( Chen, J; Gao, J; Gong, W; Li, X; Wu, Z; Yue, K, 2018)
"Fifty-seven pregnant breast cancer patients were treated on a single-arm, multidisciplinary, institutional review board-approved protocol with FAC (5-fluorouracil, doxorubicin, cyclophosphamide) in the adjuvant (n = 32) or neoadjuvant (n = 25) setting."	5.12	Treatment of pregnant breast cancer patients and outcomes of children exposed to chemotherapy in utero. ( Gordon, N; Hahn, KM; Hortobagyi, GN; Johnson, PH; Kuerer, H; Middleton, L; Perkins, G; Ramirez, M; Theriault, RL; Yang, W, 2006)
"This case involved a 33-year-old female suffering from gestational trophoblastic neoplasia and 5-fluorouracil + actinomycin-D chemotherapy."	4.95	Early pregnancy following multidrug regimen chemotherapy in a gestational trophoblastic neoplasia patient: A case report. ( Gong, FQ; Niu, G; Shen, HW; Yang, J; Yuan, LJ; Zhu, CX, 2017)
"Chemotherapeutic agents such as methotrexate (MTX), raltitrexed (RTX), 5-fluorouracil (5-FU), hydroxyurea (HU), and retinoic acid (RA), and valproic acid (VPA), an antiepileptic drug, all can cause malformations in the developing central nervous system (CNS), such as neural tube defects (NTDs)."	4.12	Unraveling the Mechanisms of Clinical Drugs-Induced Neural Tube Defects Based on Network Pharmacology and Molecular Docking Analysis. ( Guan, Z; Li, S; Liang, Y; Niu, B; Wang, J; Wang, X; Yang, A; Yu, J; Zhu, Z, 2022)
"The study aimed to compare the efficacy of methotrexate (MTX) cervical injections + actinomycin-D (ACT-D)(MACT) and 5-fluorouracil (5-Fu) + actinomycin-D (5-Fu plus ACT-D) chemotherapy regimens for low-risk gestational trophoblastic neoplasia (LR-GTN)."	3.83	Comparison of MACT and 5Fu+ACT-D chemotherapy regimens in the treatment of low-risk gestational trophoblastic neoplasia. ( Duan, W; Kong, WM; Miao, JW; Su, L; Wang, T; Wang, Y; Wu, YM, 2016)
"Between 1992 and 2010, 81 pregnant patients with breast cancer were treated in a single-arm, institutional review board-approved study with 5-fluorouracil, doxorubicin, and cyclophosphamide (FAC) in the adjuvant or neoadjuvant setting."	3.80	Outcomes of children exposed in utero to chemotherapy for breast cancer. ( Barnett, CM; Hodge, S; Hortobagyi, GN; Litton, JK; Milbourne, A; Murthy, RK; Ramirez, MM; Rimes, SA; Theriault, RL; Valero, V, 2014)
"A combination of 5-fluorouracil plus actinomycin D (5FU plus Act D) is the regimen that has been commonly administered to Chinese and Japanese gestational trophoblastic neoplasia patients as the first or second line of treatment with an excellent outcome."	3.78	Resistant gestational trophoblastic neoplasia patients treated with 5-fluorouracil plus actinomycin D. ( Manopunya, M; Suprasert, P, 2012)
" The absence of any abnormalities in the infant makes irinotecan and fluorouracil a valid therapeutic option for colon cancer during pregnancy."	3.78	Irinotecan during pregnancy in metastatic colon cancer. ( Cassandrini, PA; Cirillo, M; Lunardi, G; Musola, M; Venturini, M, 2012)
" We present a case of an ongoing 19-week-long pregnancy which was diagnosed in a 39-year-old woman who was being treated with CEF (cyclophosphamide, epirubicin, 5-fluorouracil) chemotherapy for an infiltrating ductal carcinoma of the breast."	3.77	Specific congenital malformations after exposure to cyclophosphamide, epirubicin and 5-fluorouracil during the first trimester of pregnancy. ( Breugelmans, M; De Greve, J; Foulon, W; Keymolen, K; Laubach, M; Leyder, M, 2011)
" Treatment with oral contraceptive (OC) for endometriosis and later with cyclophosphamide, methotrexate, fluorouracil (CMF) for breast cancer produced a higher number of attacks."	3.74	Influence of physiologic hormonal modification and of hormonal treatment in a patient with a history of migraine with aura. ( Maggioni, F; Palmieri, A; Tropea, M; Zanchin, G, 2008)
"We present a case of a 28-year-old female with extensive, bulky malignant peritoneal epitheliod mesothelioma who underwent optimal cytoreduction with peritonectomy followed by intraoperative hyperthermic cisplatin and postoperative intraperitoneal paclitaxel and fluorouracil."	3.73	Spontaneous pregnancy following cytoreduction with peritonectomy and hyperthermic intraperitoneal chemotherapy. ( Bidus, MA; Elkas, JC; Kyser, K; Rodriguez, M; Rose, GS, 2006)
"We report the case of a 35-year-old pregnant woman with inflammatory breast carcinoma initially treated with 5-fluorouracil/doxorubicin/cyclophosphamide beginning her 13th week of pregnancy."	3.73	Docetaxel administered during pregnancy for inflammatory breast carcinoma. ( Aramendía, JM; Fernández-Hidalgo, O; García-Manero, M; López, G; Nieto, Y; Santisteban, M, 2006)
" His mother became pregnant while receiving chemotherapy (cyclophosphamide, 5-fluorouracil, and adriamycin) for breast cancer, and the fetus was exposed to these drugs from conception to the 16th week of pregnancy."	3.73	Combined chemotherapy and teratogenicity. ( de Camargo Pinto, LL; Gazzola Zen, PR; Graziadio, C; Paskulin, GA; Rosa, R, 2005)
"A 33-year-old woman with T(4c)N(3) breast cancer with metastases in the skeleton (M(1)) received five cycles of 5-fluorouracil, epirubicin, and cyclophosphamide (FEC regimen) before conception and during the first trimester."	3.72	Combined chemotherapy and radiotherapy during conception and first two trimesters of gestation in a woman with metastatic breast cancer. ( Andreadis, C; Charalampidou, M; Chouchos, N; Diamantopoulos, N; Mouratidou, D, 2004)
" The chemotherapy included fluorouracil (1,000 mg/m2), doxorubicin (50 mg/m2), and cyclophosphamide (500 mg/m2), administered every 3 to 4 weeks after the first trimester of pregnancy."	3.70	Management of breast cancer during pregnancy using a standardized protocol. ( Berry, DL; Booser, DJ; Buzdar, AU; Holmes, FA; Hortobagyi, GN; Parisi, VM; Singletary, SE; Theriault, RL, 1999)
" As a model toxicant, we chose 5-fluorouracil (5-FU), since we previously observed that maternal administration at 20-40 mg/kg on gestational day (GD) 14 produced fetal anemia on GD 16-17, as evidenced by dose-dependent decreases in the cell counts, hematocrit, and hemoglobin content of fetal blood obtained by cardiac puncture."	3.69	Flow cytometric detection of abnormal fetal erythropoiesis: application to 5-fluorouracil-induced anemia. ( Elstein, KH; Rogers, JM; Shuey, DL; Zucker, RM, 1995)
"We report the case of a 39-year-old para-4 gravida-4 who received polychemotherapy 5-fluorouracil 600 mg/m2, cyclophosphamide 600 mg/m2 and epirubicin 50 mg/m2 for invasive breast cancer (pT2N2Mo) with extensive metastatic involvement of all 23 axillary lymph nodes removed at 29 gestational weeks."	3.69	Eclampsia after polychemotherapy for nodal-positive breast cancer during pregnancy. ( Hofmann, J; Müller, T; Steck, T, 1996)
" It has been found that maternal administration of hydroxyurea, mitomycin C, or 5-fluorouracil on day 9 of pregnancy, that is, when the fetal neural tube is in the final stages of closure, leads to a significant reduction in the proportion of NTD (to 15 to 20%) in the offspring, while total litter size is unaffected."	3.66	The cause of neural tube defects: some experiments and a hypothesis. ( Seller, MJ, 1983)
" We should pay attention to the dosage of 5-FU and ActD, monitor adverse reactions strictly, to reduce occurrence of skin malignant events."	2.82	5-Fluorouracil and actinomycin D lead to erythema multiforme drug eruption in chemotherapy of invasive mole: Case report and literature review. ( Li, T; Liu, Y; Wang, M; Wang, S; Wang, Y; Zhang, L; Zhang, X, 2022)
"There were 64 women with Stage II breast carcinoma and 36 women with UICC Stage III breast carcinoma."	2.72	Gonadotropin-releasing hormone analogues added to adjuvant chemotherapy protect ovarian function and improve clinical outcomes in young women with early breast carcinoma. ( Amiconi, G; Candeloro, G; Cesta, A; Di Blasio, A; Rea, S; Recchia, F; Saggio, G, 2006)
"From 1979 to 1988, 152 patients with trophoblastic tumor were treated with combination chemotherapy using nitrocaphanum and 5-FU."	2.69	Chemotherapy using 5-fluorouracil and nitrocaphanum in malignant trophoblastic tumor. ( Guan, Y; Jiu, L; Qiu, D; Wang, Y, 1998)
"Choriocarcinoma is an aggressive malignancy of trophoblastic tissue, typically of gestational etiology."	2.66	Primary colon adenocarcinoma with choriocarcinoma differentiation: a case report and review of the literature. ( Boyce, J; Cole, JT; Tawagi, K, 2020)
"We relate 2 cases reports about rectal cancer and pregnancy."	2.43	[Management of rectal cancer in pregnant women]. ( Benouna, J; Classe, JM; Dravet, F; Dupré, PF; Mahé, MA; Pigeau, H; Pioud, R, 2005)
"No case of epidermoid (squamous cell) cancer of the colon has been previously described in a pregnant woman."	2.42	[Colon cancer in pregnancy]. ( Fermeaux, V; Mathonnet, M, 2003)
"The concurrent diagnosis of breast cancer and pregnancy is a challenging clinical situation that historically has placed the welfare of the mother in conflict with that of the fetus."	2.41	Breast cancer during pregnancy. ( Gwyn, KM; Theriault, RL, 2000)
"A biologically-based dose-response (BBDR) model is a mathematical description of the biological events leading to expression of a toxic response."	2.39	Biological modeling of 5-fluorouracil developmental toxicity. ( Elstein, KH; Kavlock, RJ; Lau, C; Narotsky, MG; Rogers, JM; Setzer, RW; Shuey, DL; Zucker, RM, 1995)
"The implantation of cervical cancer in an episiotomy scar is very rare."	2.38	Squamous cell carcinoma of the cervix implanting in the episiotomy site. ( Issa, PY; Khalil, AM; Khatib, RA; Mufarrij, AA; Tawil, AN, 1993)
" Our data suggested that 5-FU has negative impact on ovarian function, oocyte and early embryonic development, but the adverse effect could be reversed after withdrawal of 5-FU administration."	1.62	The reversible reproductive toxicity of 5-fluorouracil in mice. ( Cheng, L; Guo, J; Naren, G; Nashun, B; Wang, L; Yang, J; Yang, S; Zhang, X, 2021)
"The management of breast cancer during pregnancy is a challenge for physicians due to mother´s desire to carry the pregnancy to term despite the need for chemotherapy."	1.62	[Chemotherapy for breast cancer during pregnancy: about a case]. ( Andrianandrasana, NO; Rafaramino, F; Rakotomalala, HM; Ramahandrisoa, AVN; Razakanaivo, M, 2021)
"Intussusception is a common in pediatric age group."	1.51	[Intussusception Caused by Colon Cancer in Pregnancy]. ( Jung, YJ; Kim, CL; Kim, K; Kim, TO; Ko, M; Sim, HC, 2019)
"Fluorouracil is used for treatment of breast cancer even in pregnant women, except during fetal organogenesis."	1.46	Contribution of equilibrative nucleoside transporter (ENT) 2 to fluorouracil transport in rat placental trophoblast cells. ( Akashi, T; Nakashima, E; Nishimura, T; Takagi, A; Tomi, M, 2017)
"We herein describe a case of gastric cancer during pregnancy."	1.43	Laparoscopic Gastrectomy Followed by Chemotherapy for Advanced Gastric Cancer Diagnosed During Pregnancy: A Case Report. ( Chin, HM; Jo, YS; Jun, KH; Jung, JH; Kim, EY, 2016)
"Anal cancer was diagnosed in a 36-year-old nulliparous woman."	1.43	Successful Delivery in a 39-Year-Old Patient with Anal Cancer after Fertility-Preserving Surgery Followed by Primary Chemoradiation and Low Anti-Mullerian Hormone Level. ( Biel, P; Cordes, T; Köhler, C; Marnitz, S, 2016)
"Colon cancer during pregnancy is not easily detected and is difficult to manage."	1.42	Chemotherapeutic treatment of colorectal cancer in pregnancy: case report. ( Al-Khatani, K; Al-Mohaisen, F; Makoshi, Z; Perrott, C, 2015)
"A retrospective analysis of 20 patients treated for hepatocellular carcinoma between 1994 and 2007."	1.42	Hepatic arterial infusion in hepatocellular carcinoma: a single center experience. ( Dvorak, J; Ferko, A; Kamaradova, K; Krajina, A; Melichar, B, 2015)
"Among them, 3 patients with bladder metastasis received intravesical chemotherapy of fluorouracil."	1.40	[Analysis of the treatment and prognosis for gestational trophoblastic neoplasia patients with urinary system and adrenal glands metastasis]. ( Feng, F; Ren, T; Wan, X; Wang, D; Xiang, Y; Yang, J, 2014)
"Medical records of 62 patients with gestational trophoblastic neoplasia who underwent pulmonary lobectomy or limited resection were reviewed."	1.35	Surgical resection in the management of pulmonary metastatic disease of gestational trophoblastic neoplasia. ( Cao, Y; Feng, F; Wan, X; Xiang, Y; Yang, X, 2009)
"A case of metastatic infiltrating breast cancer in a young multiparous lady with 33 weeks pregnancy is presented who was treated with combination chemotherapy and hemostatic radiotherapy and had successful pregnancy outcome."	1.35	Successful pregnancy outcome with 5-flurouracil, epirubicin, cyclophosphamide chemotherapy, and hemostatic radiotherapy with abdominal shielding for metastatic invasive intraductal breast carcinoma. ( Kumar, S; Malhotra, N; Pushparaj, M; Raina, V; Roy, KK; Sharma, JB, 2009)
"Oral mucositis is a frequent and significant side effect of chemotherapy and/or radiation therapy."	1.35	Homogenous amniotic membrane as a biological dressing for oral mucositis in rats: histomorphometric analysis. ( Gomes, MF; Niccoli-Filho, W; Rangel, DC; Teixeira, RT; Vilela-Goulart, Md, 2008)
"Medical records of 42 patents with drug-resistant GTN who were treated by chemotherapy combined with surgical management at Peking Union Medical College Hospital from Jan 1996 to Jan 2006 were reviewed."	1.35	[Efficacy of surgical management combined with chemotherapy in the treatment of drug-resistant gestational trophoblastic neoplasm]. ( Cao, Y; Feng, FZ; Li, L; Wan, XR; Xiang, Y; Yang, XY, 2008)
"The association between breast cancer and pregnancy is a rare but not exceptional."	1.33	[Breast cancers associated with pregnancy. About two cases]. ( Bal, A; Mahmoud, GO; Ndioubnane, MD, 2005)
"5-Fluorouracil is an antineoplastic drug, which has not been adequately studied."	1.33	Teratogenic effects of 5-fluorouracil on rat brain. ( Dubey, AK; Kumar, S; Lobo, SW; Pandey, SK, 2006)
"The rare association between breast cancer and pregnancy means that few oncologists gain an expertise in this area."	1.33	Chemotherapy for breast cancer during pregnancy: an 18-year experience from five London teaching hospitals. ( Ellis, PA; Galani, E; Jones, A; Ring, AE; Shannon, C; Smith, IE, 2005)
"Biologically based dose-response (BBDR) models represent an emerging approach to improving the current practice of human health-risk assessment."	1.31	Toward a biologically based dose-response model for developmental toxicity of 5-fluorouracil in the rat: acquisition of experimental data. ( Cameron, AM; Copeland, MF; Ellis, DH; Kavlock, RJ; Lau, C; Logsdon, TR; Merriman, J; Mole, ML; Rogers, JM; Setzer, RW; Shuey, DL, 2001)
"Biologically based dose-response (BBDR) models comprise one way to incorporate mechanistic information into a dose-response assessment to be used for risk assessments."	1.31	Toward a biologically based dose-response model for developmental toxicity of 5-fluorouracil in the rat: a mathematical construct. ( Copeland, MF; Kavlock, RJ; Lau, C; Mole, ML; Rogers, JM; Setzer, RW, 2001)
"5-Fluorouracil (5-FU) is a cytostatic anti-tumor drug which is known to have immunosuppressive activities."	1.31	Effects on fetal thymocyte populations and postnatal T-cell-dependent immune functions after maternal exposure to 5-fluorouracil during pregnancy in mice. ( Horii, I; Inoue, T, 2002)
"5-Fluorouracil (5-FU) is a chemotherapeutic agent known to retard embryonic growth and induce cleft palate and limb deformities."	1.30	Nucleoside-mediated mitigation of 5-fluorouracil-induced toxicity in synchronized murine erythroleukemic cells. ( Elstein, KH; Kavlock, RJ; Lau, C; Mole, ML; Rogers, JM; Setzer, RW; Zucker, RM, 1997)
"Seventeen women with unruptured tubal pregnancy were given 5-FU through salpingo-catheter under hysteroscopy."	1.29	[Injection of 5-fluorouracil in the treatment of tubal pregnancy through salpingo-catheter under hysteroscopy]. ( Liu, SY; Liu, XC; Xie, QH, 1994)
"Primary hepatocellular carcinoma is a very rare disease, especially in association with a pregnancy."	1.29	[Hepatocellular carcinoma in pregnancy]. ( Brucker, C; Debus-Thiede, G; Genz, T; Maassen, V; Schweiberer, L; Weiss, M, 1994)
"Radically excised ovarian cancers present an unsolved problem with regard to the value of routine second-look operation."	1.29	Second-look laparotomy in the management of patients after radical surgery for ovarian cancer. ( Hansen, M; Hansen, OP; Lund, B; Tuxen, MK, 1993)
" The incidence of cardiotoxicity might be reduced with emphasis on strict observance of the treatment regimen in regard to the dosage used, the speed of the infusion and attention to the treatment of any side-effects."	1.29	[Cardiotoxicity of 5-fluorouracil]. ( Pan, L; Song, H; Yang, X, 1996)
"In 6 cases of gestational trophoblastic neoplasms admitted to our hospital from March to December 1993, cardiotoxicity was found to have occurred after chemotherapies in 10/21 courses."	1.29	[Clinical analysis of 6 cases of gestational trophoblastic neoplasms complicated by cardiotoxicity after chemotherapies]. ( Qian, H; Wu, Y, 1995)
"The mechanism of formation of pseudomembranous colitis, the causative agents and method of diagnosis and treatment were discussed."	1.28	[Colitis due to chemotherapeutic agent]. ( Yang, XY, 1990)
" with 950 mg/kg of OTC 4 hours before dosing with 5-FU."	1.28	Effects of L-2-oxothiazolidine-4-carboxylate, a cysteine pro-drug, on teratogenicity of 5-fluorouracil in mice. ( Deguchi, T; Mataki, Y; Naya, M; Noguchi, M; Yasuda, M, 1990)
"Pretreatment with phorone or BSO decreased fetal weight and increased the frequency and severity of oligodactyly induced by 5-FU, as well as the reduction of maternal GSH levels."	1.28	Effects of phorone and/or buthionine sulfoximine on teratogenicity of 5-fluorouracil in mice. ( Deguchi, T; Mataki, Y; Naya, M; Takahira, H; Yasuda, M, 1990)
"The choriocarcinoma was one of the most curable malignant neoplasms."	1.28	[The treatment of refractory choriocarcinoma]. ( Inaba, N; Matsui, H; Takamizawa, Y, 1990)
"Inflammatory breast cancer was diagnosed in 72 (87."	1.27	Results of combined treatment of patients with locally advanced breast cancer. ( Brandys, A; Pawlicki, M; Skolyszewski, J, 1983)
"Large dosage of 5-fluorouracil given by slow intravenous infusion has proved to be very effective in the treatment of gestational trophoblastic neoplasms."	1.27	Reevaluation of 5-fluorouracil as a single therapeutic agent for gestational trophoblastic neoplasms. ( Sung, HC; Wu, PC; Yang, HY, 1984)
"7 of 8 with brain metastases treated by the same modality gave complete remission."	1.27	[Combination therapy of advanced choriocarcinoma--an analysis of 60 patients]. ( Cai, SM; Ding, YQ; Wang, RY, 1986)

Timeframe	Studies, this research(%)	All Research%
pre-1990	83 (39.90)	18.7374
1990's	42 (20.19)	18.2507
2000's	46 (22.12)	29.6817
2010's	26 (12.50)	24.3611
2020's	11 (5.29)	2.80

Trial	Phase	Enrollment	Study Type	Start Date	Status
Multimodality Treatment of Primary Breast Cancer Occurring Concomitant With Pregnancy[NCT00510367]	Early Phase 1	61 participants (Actual)	Interventional	2001-08-07	Completed
Oncological Treatment During Pregnancy: Pharmacokinetics of Chemotherapy and Long Term Follow up of the Offspring[NCT00330447]		5,000 participants (Anticipated)	Observational [Patient Registry]	2005-08-31	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
5-Fluorouracil and actinomycin D lead to erythema multiforme drug eruption in chemotherapy of invasive mole: Case report and literature review. Medicine, 2022, Nov-25, Volume: 101, Issue:47 Topics: Dactinomycin; Drug Eruptions; Erythema Multiforme; Female; Fluorouracil; Humans; Hydatidiform Mole,	2022
5-Fluorouracil and actinomycin D lead to erythema multiforme drug eruption in chemotherapy of invasive mole: Case report and literature review. Medicine, 2022, Nov-25, Volume: 101, Issue:47 Topics: Dactinomycin; Drug Eruptions; Erythema Multiforme; Female; Fluorouracil; Humans; Hydatidiform Mole,	2022
5-Fluorouracil and actinomycin D lead to erythema multiforme drug eruption in chemotherapy of invasive mole: Case report and literature review. Medicine, 2022, Nov-25, Volume: 101, Issue:47 Topics: Dactinomycin; Drug Eruptions; Erythema Multiforme; Female; Fluorouracil; Humans; Hydatidiform Mole,	2022
5-Fluorouracil and actinomycin D lead to erythema multiforme drug eruption in chemotherapy of invasive mole: Case report and literature review. Medicine, 2022, Nov-25, Volume: 101, Issue:47 Topics: Dactinomycin; Drug Eruptions; Erythema Multiforme; Female; Fluorouracil; Humans; Hydatidiform Mole,	2022
Primary colon adenocarcinoma with choriocarcinoma differentiation: a case report and review of the literature. Journal of medical case reports, 2020, Nov-16, Volume: 14, Issue:1 Topics: Adenocarcinoma; Adult; Antineoplastic Combined Chemotherapy Protocols; Choriocarcinoma; Colon; Femal	2020
Early pregnancy following multidrug regimen chemotherapy in a gestational trophoblastic neoplasia patient: A case report. Medicine, 2017, Volume: 96, Issue:51 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Chorionic Gonadotropin; Dactinomycin; Dose-Re	2017
Gastroesophageal Cancer During Pregnancy: a Case Report and Review of the Literature. Journal of gastrointestinal cancer, 2019, Volume: 50, Issue:3 Topics: Adenocarcinoma; Adult; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Chemoradiotherapy; Do	2019
Discovery of asymptomatic Krukenberg tumors diagnosed during caesarean section: therapy with hyperthermic intraperitoneal chemotherapy. Postgraduate medicine, 2013, Volume: 125, Issue:4 Topics: Adult; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Combined Chemotherap	2013
Successful twin pregnancy outcome after in utero exposure to FOLFOX for metastatic colon cancer: a case report and review of the literature. Clinical colorectal cancer, 2011, Volume: 10, Issue:4 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Female; Fluorouracil; Huma	2011
[Colon cancer in pregnancy]. Journal de chirurgie, 2003, Volume: 140, Issue:4 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cesarean Section; C	2003
[Management of rectal cancer in pregnant women]. Bulletin du cancer, 2005, Volume: 92, Issue:11 Topics: Adenocarcinoma; Adult; Antineoplastic Agents; Case Management; Cesarean Section; Chemotherapy, Adjuv	2005
The unsolved problem of cellular ageing. Monographs in developmental biology, 1984, Volume: 17 Topics: Cell Line; Cell Survival; DNA Replication; DNA-Directed DNA Polymerase; Female; Fibroblasts; Fluorou	1984
The deoxyuridine suppression test: a review of its clinical and research applications. Clinical and laboratory haematology, 1981, Volume: 3, Issue:1 Topics: Alcoholism; Anemia, Hemolytic; Anticonvulsants; Bone Marrow Cells; Bone Marrow Diseases; Cells; Deox	1981
Biological modeling of 5-fluorouracil developmental toxicity. Toxicology, 1995, Sep-01, Volume: 102, Issue:1-2 Topics: Animals; Antimetabolites; Cell Cycle; Dose-Response Relationship, Drug; Female; Fluorouracil; Hindli	1995
[Human papillomavirus infections in pregnancy]. La Clinica terapeutica, 1994, Volume: 145, Issue:10 Topics: Adolescent; Adult; Cryosurgery; Electrocoagulation; Female; Fluorouracil; Humans; Interferons; Laser	1994
Squamous cell carcinoma of the cervix implanting in the episiotomy site. Gynecologic oncology, 1993, Volume: 51, Issue:3 Topics: Adult; Carcinoma, Squamous Cell; Cicatrix; Cisplatin; Doxorubicin; Episiotomy; Female; Fluorouracil;	1993
Breast cancer during pregnancy. Current treatment options in oncology, 2000, Volume: 1, Issue:3 Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Clinical Trials as Topic; Combined	2000
Single-agent chemotherapy for nonmetastatic gestational trophoblastic neoplasia. Perspectives for the 21st century after three decades of use. The Journal of reproductive medicine, 1991, Volume: 36, Issue:1 Topics: Chorionic Gonadotropin; Dactinomycin; Etoposide; Female; Fluorouracil; Humans; Methotrexate; Pregnan	1991
[Antiandrogens]. Ceskoslovenska farmacie, 1970, Volume: 19, Issue:3 Topics: Acetates; Adrenal Cortex Hormones; Androgen Antagonists; Animals; Antimetabolites; Castration; Chick	1970
The use of cytotoxic drugs in the surgery of malignant disease. The Journal of bone and joint surgery. British volume, 1968, Volume: 50, Issue:3 Topics: Abdominal Neoplasms; Alkylating Agents; Animals; Antimetabolites; Antineoplastic Agents; Carcinoma,	1968
An assessment of massive-dose chemotherapy of malignant disease. Canadian Medical Association journal, 1971, Jan-09, Volume: 104, Issue:1 Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Bone Marrow; Bone Marrow Cells; Cell Division; Cyclo	1971
Current cancer chemotherapy in obstetrics and gynecology. American journal of obstetrics and gynecology, 1971, Feb-01, Volume: 109, Issue:3 Topics: Alkaloids; Alkylating Agents; Anti-Bacterial Agents; Antimetabolites; Blood Cell Count; Bone Marrow;	1971
Abnormalities of intrauterine development in non-human primates. Acta endocrinologica. Supplementum, 1972, Volume: 166 Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Abortion, Spontaneous; Animals; Antineoplastic	1972
[Carcinogenesis and teratogenesis. Comparative studies from the viewpoint of teratology]. Arzneimittel-Forschung, 1970, Volume: 20, Issue:5 Topics: Abnormalities, Drug-Induced; Alkylating Agents; Animals; Antineoplastic Agents; Carcinogens; Cycloph	1970
[An inducible enzyme: tryptophan pyrrolase]. Revista clinica espanola, 1971, Jan-31, Volume: 120, Issue:2 Topics: Age Factors; Animals; Carcinoma, Ehrlich Tumor; Enzyme Induction; Enzyme Repression; Female; Fetus;	1971
The metabolism and pharmacology of 5-fluorouracil. Journal of surgical oncology, 1971, Volume: 3, Issue:3 Topics: Adenocarcinoma; Alopecia; Animals; Breast Neoplasms; Carbon Isotopes; Cell Division; Chromosome Aber	1971

Article	Year
The efficacy evaluation of initial chemotherapy for high-risk gestational trophoblastic neoplasm. Current problems in cancer, 2022, Volume: 46, Issue:3 Topics: Antineoplastic Combined Chemotherapy Protocols; Female; Fluorouracil; Gestational Trophoblastic Dise	2022
The therapeutic effect of bovine colostrum on 5-Fluorouracil-Induced oral mucositis in rats. Journal of stomatology, oral and maxillofacial surgery, 2022, Volume: 123, Issue:6 Topics: Animals; Cattle; Colostrum; Female; Fluorouracil; Humans; Male; Mouth Mucosa; Pregnancy; Rats; Rats,	2022
Unraveling the Mechanisms of Clinical Drugs-Induced Neural Tube Defects Based on Network Pharmacology and Molecular Docking Analysis. Neurochemical research, 2022, Volume: 47, Issue:12 Topics: Animals; Anticonvulsants; Antineoplastic Agents; Class I Phosphatidylinositol 3-Kinases; ErbB Recept	2022
Chemotherapy During Pregnancy for Advanced Colon Cancer: A Case Report. Clinical colorectal cancer, 2020, Volume: 19, Issue:2 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cesarean Section; Chemotherapy, Adjuvant; Col	2020
Exogenous and Endogenous Sources of Serine Contribute to Colon Cancer Metabolism, Growth, and Resistance to 5-Fluorouracil. Cancer research, 2021, 05-01, Volume: 81, Issue:9 Topics: Aged; Animals; Antimetabolites, Antineoplastic; Colonic Neoplasms; Diet; DNA Damage; Drug Resistance	2021
The reversible reproductive toxicity of 5-fluorouracil in mice. Reproductive toxicology (Elmsford, N.Y.), 2021, Volume: 101 Topics: Animals; Antineoplastic Agents; Embryonic Development; Female; Fluorouracil; Mice, Inbred ICR; Oocyt	2021
Insulin reverses choriocarcinoma 5- fluorouracil resistance. Bioengineered, 2021, Volume: 12, Issue:1 Topics: Animals; Cell Line, Tumor; Choriocarcinoma; Drug Resistance, Neoplasm; Female; Fluorouracil; Humans;	2021
[Chemotherapy for breast cancer during pregnancy: about a case]. The Pan African medical journal, 2021, Volume: 38 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Epirubici	2021
The Lancet regional health. Europe, 2021, Volume: 2 Topics: Adult; Airports; Antifibrotic Agents; Bacterial Typing Techniques; Bacteroidetes; Bangladesh; Bleomy	2021
[Data review and analysis of 22 cases of gastric cancer associated with pregnancy]. Zhonghua zhong liu za zhi [Chinese journal of oncology], 2018, Aug-23, Volume: 40, Issue:8 Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carcinoma	2018
[Intussusception Caused by Colon Cancer in Pregnancy]. The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, 2019, Jun-25, Volume: 73, Issue:6 Topics: Adenocarcinoma; Adult; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Colonoscop	2019
Hepatic arterial infusion in hepatocellular carcinoma: a single center experience. Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia, 2015, Volume: 159, Issue:1 Topics: Adult; Aged; Antineoplastic Agents; Carcinoma, Hepatocellular; Cisplatin; Czech Republic; Disease-Fr	2015
[Analysis of the treatment and prognosis for gestational trophoblastic neoplasia patients with urinary system and adrenal glands metastasis]. Zhonghua fu chan ke za zhi, 2014, Volume: 49, Issue:10 Topics: Adrenal Gland Neoplasms; Adrenal Glands; Antineoplastic Combined Chemotherapy Protocols; China; Fema	2014
Outcomes of children exposed in utero to chemotherapy for breast cancer. Breast cancer research : BCR, 2014, Dec-30, Volume: 16, Issue:6 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Child; Clubfoot; Congenital	2014
Chemotherapeutic treatment of colorectal cancer in pregnancy: case report. Journal of medical case reports, 2015, Jun-13, Volume: 9 Topics: Adenocarcinoma; Adult; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Female;	2015
Tegafur Substitution for 5-Fu in Combination with Actinomycin D to Treat Gestational Trophoblastic Neoplasm. PloS one, 2015, Volume: 10, Issue:11 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Dactinomycin; Female; Fluorouracil; Gestation	2015
Comparison of MACT and 5Fu+ACT-D chemotherapy regimens in the treatment of low-risk gestational trophoblastic neoplasia. Journal of chemotherapy (Florence, Italy), 2016, Volume: 28, Issue:2 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Dactinomycin; Female; Fluorouracil; Gestation	2016
Paradoxical Reductions in Serum Anti-p53 Autoantibody Levels by Chemotherapy in Unresectable Colorectal Cancer: An Observational Study. Oncology, 2016, Volume: 91, Issue:3 Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Autoantibodies; Bevacizumab; C	2016
Laparoscopic Gastrectomy Followed by Chemotherapy for Advanced Gastric Cancer Diagnosed During Pregnancy: A Case Report. Anticancer research, 2016, Volume: 36, Issue:9 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Female; Fluorouracil; Gastrectomy; Humans; La	2016
Successful Delivery in a 39-Year-Old Patient with Anal Cancer after Fertility-Preserving Surgery Followed by Primary Chemoradiation and Low Anti-Mullerian Hormone Level. Oncology, 2016, Volume: 91, Issue:5 Topics: Adult; Anti-Mullerian Hormone; Antineoplastic Combined Chemotherapy Protocols; Anus Neoplasms; Carci	2016
Contribution of equilibrative nucleoside transporter (ENT) 2 to fluorouracil transport in rat placental trophoblast cells. Drug metabolism and pharmacokinetics, 2017, Volume: 32, Issue:2 Topics: Animals; Biological Transport; Equilibrative-Nucleoside Transporter 2; Female; Fluorouracil; Oocytes	2017
Successful pregnancy outcome with 5-flurouracil, epirubicin, cyclophosphamide chemotherapy, and hemostatic radiotherapy with abdominal shielding for metastatic invasive intraductal breast carcinoma. Archives of gynecology and obstetrics, 2009, Volume: 279, Issue:3 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma, Intraductal, Non	2009
Homogenous amniotic membrane as a biological dressing for oral mucositis in rats: histomorphometric analysis. Archives of oral biology, 2008, Volume: 53, Issue:12 Topics: Acetic Acid; Amnion; Animals; Antimetabolites, Antineoplastic; Biological Dressings; Female; Fluorou	2008
Priorities and uncertainties of administering chemotherapy in a pregnant woman with newly diagnosed colorectal cancer. Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2009, Volume: 15, Issue:1 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Female; Fluorouracil; H	2009
[Efficacy of surgical management combined with chemotherapy in the treatment of drug-resistant gestational trophoblastic neoplasm]. Zhonghua fu chan ke za zhi, 2008, Volume: 43, Issue:10 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Chorionic Gonadotropin, beta Subunit, Human;	2008
Management of gestational trophoblastic neoplasia with 5-fluorouracil and actinomycin D in northern China. The Journal of reproductive medicine, 2009, Volume: 54, Issue:2 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; China; Cohort Studies; Dactinomycin; Female;	2009
Breast cancer and pregnancy: how safe is trastuzumab? Nature reviews. Clinical oncology, 2009, Volume: 6, Issue:6 Topics: Adult; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemothera	2009
Surgical resection in the management of pulmonary metastatic disease of gestational trophoblastic neoplasia. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 2009, Volume: 19, Issue:4 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Dactinomycin; Drug	2009
Wound complications from surgery in pregnancy-associated breast cancer (PABC). Breast disease, 2010, Volume: 31, Issue:1 Topics: Abscess; Adult; Antineoplastic Combined Chemotherapy Protocols; Axilla; Breast Diseases; Breast Neop	2010
Transplacental transfer of anthracyclines, vinblastine, and 4-hydroxy-cyclophosphamide in a baboon model. Gynecologic oncology, 2010, Volume: 119, Issue:3 Topics: Amniotic Fluid; Animals; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chromatography,	2010
Specific congenital malformations after exposure to cyclophosphamide, epirubicin and 5-fluorouracil during the first trimester of pregnancy. Gynecologic and obstetric investigation, 2011, Volume: 71, Issue:2 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Ductal, Breast; Cyclophosphamide;	2011
[Analysis of prophylactic chemotherapy outcome and clinical characteristics in patients of high-risk hydatidiform mole]. Zhonghua fu chan ke za zhi, 2011, Volume: 46, Issue:1 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Chorionic Gonadotropin, beta Subunit, Human;	2011
Disseminated intravascular coagulation as the presenting sign of gastric cancer during pregnancy. The journal of obstetrics and gynaecology research, 2011, Volume: 37, Issue:11 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Neoplasms; Carcinoma, Signet Ring	2011
Resistant gestational trophoblastic neoplasia patients treated with 5-fluorouracil plus actinomycin D. Asian Pacific journal of cancer prevention : APJCP, 2012, Volume: 13, Issue:1 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cohort Studies; Dactinomycin; Female; Fluorou	2012
Rectal cancer in pregnancy: a case report and review of the literature. Journal of gastrointestinal cancer, 2013, Volume: 44, Issue:3 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Female; Fluorouracil; Humans; Leucovorin; Neo	2013
Adjuvant therapy for intrahepatic cholangiocarcinoma: the debate continues. The oncologist, 2012, Volume: 17, Issue:12 Topics: Adenocarcinoma; Adult; alpha-Fetoproteins; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Biomarkers	2012
Irinotecan during pregnancy in metastatic colon cancer. Tumori, 2012, Volume: 98, Issue:6 Topics: Adenocarcinoma; Adult; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineopl	2012
Sigmoid colon cancer during pregnancy. European journal of obstetrics, gynecology, and reproductive biology, 2002, Aug-05, Volume: 104, Issue:1 Topics: Adenocarcinoma; Adult; Antineoplastic Combined Chemotherapy Protocols; Cesarean Section; Female; Flu	2002
Salvage combination chemotherapy with 5-fluorouracil and actinomycin D for patients with refractory, high-risk gestational trophoblastic tumors. Cancer, 2002, Sep-01, Volume: 95, Issue:5 Topics: Adult; Dactinomycin; Drug Resistance, Multiple; Female; Fluorouracil; Humans; Leukopenia; Neoplasm R	2002
Delays in diagnosing breast cancer--the impact of concurrent pregnancy and lactation. The Australian & New Zealand journal of obstetrics & gynaecology, 2002, Volume: 42, Issue:5 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Combined Modality Therapy;	2002
Cell proliferation is necessary for the determination of male fate in the gonad. Developmental biology, 2003, Jun-15, Volume: 258, Issue:2 Topics: Animals; Antigens, CD; Antigens, Differentiation, B-Lymphocyte; Apoptosis; Carrier Proteins; Cell Di	2003
POLYDACTYLISM IN THE OFFSPRING OF MICE INJECTED WITH 5-BROMODEOXYURIDINE. Science (New York, N.Y.), 1964, Jul-31, Volume: 145, Issue:3631 Topics: Abnormalities, Drug-Induced; Animals; Blood Chemical Analysis; Bromodeoxyuridine; Family; Female; Fl	1964
ANTICANCER AGENTS. Investigative ophthalmology, 1964, Volume: 3 Topics: Alkylating Agents; Aminopterin; Antineoplastic Agents; Chemotherapy, Cancer, Regional Perfusion; Cor	1964
Effects of 5-fluorodeoxyuridine and related halogenated pyrimidines on the sand-dollar embryo. The Journal of biophysical and biochemical cytology, 1960, Volume: 7 Topics: Cytidine; DNA; Female; Floxuridine; Fluorouracil; Humans; Orotic Acid; Pregnancy; Pyrimidines; Thymi	1960
Hoxb4-deficient mice undergo normal hematopoietic development but exhibit a mild proliferation defect in hematopoietic stem cells. Blood, 2004, Jun-01, Volume: 103, Issue:11 Topics: Animals; Antimetabolites; Bone Marrow Cells; Cell Count; Cell Division; Female; Fetal Tissue Transpl	2004
Pregnancy associated breast cancer: a case report. European journal of gynaecological oncology, 2004, Volume: 25, Issue:2 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Combined Modality Therapy;	2004
Combined chemotherapy and radiotherapy during conception and first two trimesters of gestation in a woman with metastatic breast cancer. Gynecologic oncology, 2004, Volume: 95, Issue:1 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Breast Neoplasms; Combined Mo	2004
[The necessity of attaching importance to canonical treatment of gestationcal trophoblastic tumors]. Zhonghua fu chan ke za zhi, 2005, Volume: 40, Issue:2 Topics: Antineoplastic Agents; Cyclophosphamide; Diagnosis, Differential; Drug Resistance, Neoplasm; Female;	2005
[Assessment of staging and prognostic scoring system for malignant trophoblastic neoplasia]. Zhonghua fu chan ke za zhi, 2005, Volume: 40, Issue:2 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Choriocarcinoma; Chorionic Gonadotropin; Dact	2005
Therapy for colorectal cancer. The New England journal of medicine, 2005, Apr-28, Volume: 352, Issue:17 Topics: Adenocarcinoma; Adult; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Colorectal Neoplasms	2005
Hypersensitivity reactions to oxaliplatin in two asian patients. The Annals of pharmacotherapy, 2005, Volume: 39, Issue:6 Topics: Adult; Anti-Allergic Agents; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant;	2005
Chemotherapy for breast cancer during pregnancy: an 18-year experience from five London teaching hospitals. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2005, Jun-20, Volume: 23, Issue:18 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Cyc	2005
Chemotherapy for breast cancer during pregnancy. European journal of obstetrics, gynecology, and reproductive biology, 2005, Dec-01, Volume: 123, Issue:2 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma, Ductal, Breast;	2005
Combined chemotherapy and teratogenicity. Birth defects research. Part A, Clinical and molecular teratology, 2005, Volume: 73, Issue:9 Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Antibiotics, Antineoplastic; Antimetabo	2005
[Breast cancers associated with pregnancy. About two cases]. La Tunisie medicale, 2005, Volume: 83, Issue:6 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Doxorubic	2005
Spontaneous pregnancy following cytoreduction with peritonectomy and hyperthermic intraperitoneal chemotherapy. Gynecologic oncology, 2006, Volume: 100, Issue:1 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Female; Fertility; Fluorouracil; H	2006
Neuroembryotoxic effect of 5- Fluorouracil in rat: injecting in late phase of gestation. Nepal Medical College journal : NMCJ, 2005, Volume: 7, Issue:2 Topics: Animals; Antimetabolites, Antineoplastic; Cerebral Cortex; Female; Fetus; Fluorouracil; Microcephaly	2005
Docetaxel administered during pregnancy for inflammatory breast carcinoma. Clinical breast cancer, 2006, Volume: 6, Issue:6 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma; Cyclophosphamide	2006
Treatment of giant keratoacanthoma with intralesional 5-fluorouracil. Journal of drugs in dermatology : JDD, 2006, Volume: 5, Issue:5 Topics: Adult; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fluorouracil; Gestati	2006
Recurrent gestational trophoblastic tumor: management and risk factors for recurrence. Gynecologic oncology, 2006, Volume: 103, Issue:2 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Chorionic Gonadotropin, beta Subunit, Human;	2006
[Factors related to recurrence of choriocarcinoma and evaluation of treatment outcomes]. Zhonghua fu chan ke za zhi, 2006, Volume: 41, Issue:5 Topics: Antineoplastic Combined Chemotherapy Protocols; Choriocarcinoma; Chorionic Gonadotropin; Chorionic G	2006
Teratogenic effects of 5-fluorouracil on rat brain. Nepal Medical College journal : NMCJ, 2006, Volume: 8, Issue:1 Topics: Abnormalities, Drug-Induced; Animals; Antimetabolites, Antineoplastic; Brain; Female; Fluorouracil;	2006
[A case of gastric endocrine cell carcinoma with liver metastasis showing rapid growth during pregnancy and marked reduction by systemic chemotherapy after delivery]. Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 2006, Volume: 103, Issue:7 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Cisplatin; Delivery, Obstetric; Dr	2006
[Management and prognosis in stage IV gestational trophoblastic neoplasia patients]. Zhonghua fu chan ke za zhi, 2006, Volume: 41, Issue:10 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Dactinomycin; Fema	2006
G2/M checkpoint gene expression in developing germ cells. Molecular reproduction and development, 2007, Volume: 74, Issue:5 Topics: Adaptor Proteins, Signal Transducing; Animals; Animals, Newborn; Antimetabolites; Apoptosis; CDC2 Pr	2007
[Outcome of gestational trophoblastic neoplasia patients with residual lung tumor after completion of treatment]. Zhonghua fu chan ke za zhi, 2007, Volume: 42, Issue:1 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Chorionic Gonadotropin, beta Subunit, Human;	2007
Successful salvage of a relapsed high risk gestational trophoblastic neoplasia patient using capecitabine. Gynecologic oncology, 2007, Volume: 106, Issue:1 Topics: Adult; Antimetabolites, Antineoplastic; Capecitabine; Choriocarcinoma; Deoxycytidine; Female; Fluoro	2007
Influence of physiologic hormonal modification and of hormonal treatment in a patient with a history of migraine with aura. The journal of headache and pain, 2008, Volume: 9, Issue:2 Topics: Amitriptyline; Analgesics; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Pro	2008
Treatment of breast cancer with trastuzumab during pregnancy. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2008, Mar-20, Volume: 26, Issue:9 Topics: Adult; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemothera	2008
Administration of oxaliplatin to a pregnant woman with rectal cancer. Cancer chemotherapy and pharmacology, 2009, Volume: 63, Issue:2 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Disease-Free Survival	2009
Discussion from symposium on cancer of the breast. Cancer, 1967, Volume: 20, Issue:7 Topics: Adult; Breast Neoplasms; Female; Fluorouracil; Humans; Mastectomy; Pregnancy; Pregnancy Complication	1967
Combined action of fluorouracil and two mutant genes on limb development in the mouse. The Journal of experimental zoology, 1967, Volume: 164, Issue:3 Topics: Abnormalities, Drug-Induced; Animals; Female; Fluorouracil; Genes; Mice; Mutation; Pregnancy; Pregna	1967
Reevaluation of 5-fluorouracil as a single therapeutic agent for gestational trophoblastic neoplasms. American journal of obstetrics and gynecology, 1984, Sep-01, Volume: 150, Issue:1 Topics: Choriocarcinoma; Diarrhea; Female; Fluorouracil; Follow-Up Studies; Humans; Hydatidiform Mole, Invas	1984
Re-evaluation of 5-fluorouracil as a single agent for gestational malignant trophoblastic neoplasms. Advances in experimental medicine and biology, 1984, Volume: 176 Topics: Enterocolitis, Pseudomembranous; Female; Fluorouracil; Follow-Up Studies; Humans; Liver; Pregnancy;	1984
Vitamins - cytotoxic drug interaction. International journal for vitamin and nutrition research. Supplement = Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Supplement, 1983, Volume: 24 Topics: Animals; Antineoplastic Agents; Avitaminosis; Bleomycin; Female; Fluorouracil; Humans; Liver; Neopla	1983
Symbrachydactyly: pathogenesis of 5-fluorouracil induced model in mice. Hiroshima journal of medical sciences, 1980, Volume: 29, Issue:4 Topics: Abnormalities, Drug-Induced; Animals; Disease Models, Animal; Female; Fluorouracil; Mice; Pregnancy;	1980
5-Fluorouracil in malignant trophoblastic tumors. report of 350 cases. Chinese medical journal, 1983, Volume: 96, Issue:2 Topics: Digestive System; Female; Fluorouracil; Hematopoiesis; Humans; Neoplasm Metastasis; Pregnancy; Troph	1983
[Treatment of malignant trophoblastic tumors with 5-fluorouracil--report of 314 cases]. Zhonghua fu chan ke za zhi, 1983, Volume: 18, Issue:3 Topics: Female; Fluorouracil; Humans; Pregnancy; Trophoblastic Neoplasms; Uterine Neoplasms	1983
Vascular pattern and limb development. 1. Normal development of the hindlimb vasculature in the mouse and its aberrations induced by 5-fluorouracil. Hiroshima journal of medical sciences, 1983, Volume: 32, Issue:4 Topics: Abnormalities, Drug-Induced; Animals; Blood Vessels; Extremities; Female; Fluorouracil; Mice; Mice,	1983
Results of combined treatment of patients with locally advanced breast cancer. Tumori, 1983, Jun-30, Volume: 69, Issue:3 Topics: Breast Neoplasms; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Female; Fluorouracil; Hu	1983
Pathogenesis of limb malformations in mice: an electron microscopic study. Progress in clinical and biological research, 1983, Volume: 110 Pt A Topics: Abnormalities, Drug-Induced; Animals; Cell Communication; Cell Survival; Ectoderm; Extremities; Fema	1983
The cause of neural tube defects: some experiments and a hypothesis. Journal of medical genetics, 1983, Volume: 20, Issue:3 Topics: Animals; Disease Models, Animal; DNA; Female; Fluorouracil; Gestational Age; Hydroxyurea; Mice; Mice	1983
5-fluorouracil. IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans, 1981, Volume: 26 Topics: Animals; Carcinogens; Chemical Phenomena; Chemistry; Drug Interactions; Female; Fetal Death; Fluorou	1981
Randomized versus historical controls for clinical trials. The American journal of medicine, 1982, Volume: 72, Issue:2 Topics: Abortion, Habitual; Anticoagulants; BCG Vaccine; Clinical Trials as Topic; Colonic Neoplasms; Corona	1982
Analysis of results from a collaborative study of the dominant lethal assay. Mutation research, 1982, Volume: 97, Issue:4 Topics: Animals; Blastocyst; Cyclophosphamide; Embryo Implantation; Ethanol; Female; Fluorouracil; Genes, Do	1982
[Effects of immunosuppressive drugs on the fetal-placental unit]. Minerva ginecologica, 1980, Volume: 32, Issue:9 Topics: Animals; Body Weight; Female; Fetal Death; Fetal Resorption; Fluorouracil; Immunosuppressive Agents;	1980
Multiple congenital anomalies in a fetus exposed to 5-fluorouracil during the first trimester. American journal of obstetrics and gynecology, 1980, Jul-15, Volume: 137, Issue:6 Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Bone and Bones; Digestive System Abnorm	1980
[Hepatocellular carcinoma in pregnancy]. Geburtshilfe und Frauenheilkunde, 1994, Volume: 54, Issue:5 Topics: Adult; Carcinoma, Hepatocellular; Cesarean Section; Chemotherapy, Adjuvant; Combined Modality Therap	1994
Flow cytometric detection of abnormal fetal erythropoiesis: application to 5-fluorouracil-induced anemia. Teratology, 1995, Volume: 51, Issue:1 Topics: Anemia; Animals; Erythrocyte Count; Erythroid Precursor Cells; Erythropoiesis; Female; Fetal Blood;	1995
[Clinical analysis of 6 cases of gestational trophoblastic neoplasms complicated by cardiotoxicity after chemotherapies]. Zhonghua fu chan ke za zhi, 1995, Volume: 30, Issue:6 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cardiac Output, Low; Chest Pain; Dactinomycin	1995
Early events following maternal exposure to 5-fluorouracil lead to dysmorphology in cultured embryonic tissues. Teratology, 1994, Volume: 50, Issue:6 Topics: Alcian Blue; Animals; DNA; Female; Fluorouracil; Hindlimb; Maternal Exposure; Organ Culture Techniqu	1994
[Injection of 5-fluorouracil in the treatment of tubal pregnancy through salpingo-catheter under hysteroscopy]. Zhonghua fu chan ke za zhi, 1994, Volume: 29, Issue:2 Topics: Adult; Catheterization; Fallopian Tubes; Female; Fluorouracil; Humans; Hysteroscopy; Pregnancy; Preg	1994
Fetal anemia following maternal exposure to 5-fluorouracil in the rat. Teratology, 1994, Volume: 49, Issue:4 Topics: Anemia; Animals; Embryonic and Fetal Development; Erythropoiesis; Female; Fetal Diseases; Fluorourac	1994
Effects of 5-fluorouracil on collagen synthesis in the developing palate of hamster. Anti-cancer drugs, 1994, Volume: 5, Issue:1 Topics: Animals; Collagen; Cricetinae; Electrophoresis, Polyacrylamide Gel; Female; Fluorouracil; Mesocricet	1994
[A study of first and second line chemotherapies in gestational choriocarcinoma]. Nihon Sanka Fujinka Gakkai zasshi, 1993, Volume: 45, Issue:11 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Choriocarcinoma; Dactinomycin; Drug Administr	1993
Second-look laparotomy in the management of patients after radical surgery for ovarian cancer. Annals of oncology : official journal of the European Society for Medical Oncology, 1993, Volume: 4, Issue:2 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Cyclophosphamid	1993
[Selective arterial catheterization in the management of drug-resistant choriocarcinoma]. Zhonghua fu chan ke za zhi, 1996, Volume: 31, Issue:4 Topics: Antineoplastic Combined Chemotherapy Protocols; Choriocarcinoma; Drug Resistance, Neoplasm; Female;	1996
[Combination chemotherapy of 5-fluorouracil and nitrocaphane for the treatment of malignant trophoblastic tumor]. Zhonghua fu chan ke za zhi, 1996, Volume: 31, Issue:4 Topics: Antineoplastic Combined Chemotherapy Protocols; Choriocarcinoma; Female; Fluorouracil; Follow-Up Stu	1996
[Cardiotoxicity of 5-fluorouracil]. Zhonghua fu chan ke za zhi, 1996, Volume: 31, Issue:2 Topics: Adult; Antimetabolites, Antineoplastic; Creatine Kinase; Electrocardiography; Female; Fluorouracil;	1996
VIII. Women's health perception and breast cancer: issues of fertility, hormone substitution, and cancer prevention. Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 1996, Volume: 140 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Cyc	1996
Eclampsia after polychemotherapy for nodal-positive breast cancer during pregnancy. European journal of obstetrics, gynecology, and reproductive biology, 1996, Volume: 67, Issue:2 Topics: Adult; Antibiotics, Antineoplastic; Anticonvulsants; Antihypertensive Agents; Antineoplastic Combine	1996
Cytokine-mediated expansion does not deplete cord blood cells with stem cell characteristics. Hematology and cell therapy, 1997, Volume: 39, Issue:3 Topics: Antigens, CD34; Cell Division; Cell Nucleus; Cytokines; Drug Resistance; Drug Therapy, Combination;	1997
Nucleoside-mediated mitigation of 5-fluorouracil-induced toxicity in synchronized murine erythroleukemic cells. Toxicology and applied pharmacology, 1997, Volume: 146, Issue:1 Topics: Animals; Antimetabolites, Antineoplastic; Cell Cycle; Deoxycytidine; Deoxyguanine Nucleotides; Embry	1997
A comparison of the in vivo and in vitro response of rat embryos to 5-fluorouracil. The Journal of veterinary medical science, 1998, Volume: 60, Issue:1 Topics: Abnormalities, Drug-Induced; Animals; Anophthalmos; Embryo, Mammalian; Embryonic and Fetal Developme	1998
Forty-five year's experience of the treatment of choriocarcinoma and invasive mole. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 1998, Volume: 60 Suppl 1 Topics: Antimetabolites, Antineoplastic; Brain Neoplasms; Choriocarcinoma; Female; Fluorouracil; Humans; Hyd	1998
Management of breast cancer during pregnancy using a standardized protocol. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1999, Volume: 17, Issue:3 Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Apgar Score; Birth Weight; Breast	1999
Toward a biologically based dose-response model for developmental toxicity of 5-fluorouracil in the rat: acquisition of experimental data. Toxicological sciences : an official journal of the Society of Toxicology, 2001, Volume: 59, Issue:1 Topics: Abnormalities, Drug-Induced; Animals; Cell Cycle; Deoxyribonucleotides; DNA; Dose-Response Relations	2001
Toward a biologically based dose-response model for developmental toxicity of 5-fluorouracil in the rat: a mathematical construct. Toxicological sciences : an official journal of the Society of Toxicology, 2001, Volume: 59, Issue:1 Topics: Abnormalities, Drug-Induced; Animals; Area Under Curve; Deoxyribonucleotides; Dose-Response Relation	2001
Pregnancy outcome of patients conceiving within one year after chemotherapy for gestational trophoblastic tumor: a clinical report of 22 cases. Chinese medical journal, 1998, Volume: 111, Issue:11 Topics: Abortion, Threatened; Adult; Antimetabolites, Antineoplastic; Choriocarcinoma; Female; Fluorouracil;	1998
[Pregnancy of patients conceived within one year after chemotherapy for gestational trophoblastic tumor]. Zhonghua fu chan ke za zhi, 1999, Volume: 34, Issue:10 Topics: Adult; Antineoplastic Agents; Choriocarcinoma; Dactinomycin; Female; Fluorouracil; Humans; Hydatidif	1999
Clinical characteristics and treatment of gestational trophoblastic tumor with vaginal metastasis. Gynecologic oncology, 2002, Volume: 84, Issue:3 Topics: Angiography; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Choriocarcinoma; Embolization,	2002
Effects on fetal thymocyte populations and postnatal T-cell-dependent immune functions after maternal exposure to 5-fluorouracil during pregnancy in mice. The Journal of toxicological sciences, 2002, Volume: 27, Issue:2 Topics: Animals; Animals, Newborn; Body Weight; Female; Flow Cytometry; Fluorouracil; Immune System; Immunos	2002
Tumoral drugs as possible blastogenic agents the problem of anti-blastic medication. Osterreichische Zeitschrift fur Onkologie. Austrian journal of oncology, 1976, Sep-13, Volume: 3, Issue:3 Topics: Animals; Antineoplastic Agents; Bleomycin; Carcinogens; Cyclophosphamide; Dactinomycin; Daunorubicin	1976
The effects of 5-fluorouracil and 5-fluorodeoxyuridine used alone and in combination with normal nucleic acid precursors on development of mice in lines selected for low and high expression of Strong's luxoid gene. Teratology, 1975, Volume: 11, Issue:1 Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Cell Survival; Drug Synergism; Female; Fetal Deat	1975
Effects of cancer chemotherapeutic agents on endocrine organs and serum levels of estrogens, progesterone, prolactin, and luteinizing hormone. Cancer research, 1975, Volume: 35, Issue:8 Topics: Animals; Antineoplastic Agents; Dehydroepiandrosterone; Endocrine Glands; Estradiol; Estrogens; Estr	1975
[Involution of the mammary gland. Enzyme histochemistry, elektron microscopy and radioautography (author's transl)]. Progress in histochemistry and cytochemistry, 1976, Volume: 9, Issue:2 Topics: Aminopeptidases; Animals; Bromocriptine; Esterases; Estrogens; Female; Fluorouracil; Glycoside Hydro	1976
[Comparative teratological studies with organic fluroine compounds, their bases and amines]. Deutsche zahnarztliche Zeitschrift, 1977, Volume: 32, Issue:11 Topics: Abnormalities, Drug-Induced; Amines; Animals; Deoxycytidine; Female; Fluorides; Fluorides, Topical;	1977
[Fluorouracil locally in pregnancy?]. Deutsche medizinische Wochenschrift (1946), 1979, Nov-30, Volume: 104, Issue:48 Topics: Female; Fluorouracil; Humans; Pregnancy; Pregnancy Complications; Warts	1979
Penetrance and expressivity of limb malformations. Birth defects original article series, 1979, Volume: 15, Issue:5B Topics: Abnormalities, Drug-Induced; Adult; Animals; Breech Presentation; Congenital Abnormalities; Extrachr	1979
Teratological evaluation of 5-fluorouracil and 5-bromo-2-deoxyuridine on hamster fetuses. Journal of embryology and experimental morphology, 1978, Volume: 43 Topics: Animals; Bromodeoxyuridine; Cricetinae; Female; Fetus; Fluorouracil; Gestational Age; Injections, In	1978
The effect of 5-fluorouracil on [3H]nucleoside incorporation into the DNA of mouse embryos and maternal tissues. Experimental and molecular pathology, 1978, Volume: 29, Issue:3 Topics: Animals; DNA; Embryo, Mammalian; Female; Fluorouracil; Intestinal Mucosa; Intestines; Mice; Mice, In	1978
Topical treatment of vaginal intraepithelial neoplasia. Obstetrics and gynecology, 1977, Volume: 49, Issue:3 Topics: Adult; Age Factors; Carcinoma, Squamous Cell; Female; Fluorouracil; Humans; Pregnancy; Vaginal Neopl	1977
[Cytostatic therapy of inoperable carcinomas]. Wiener medizinische Wochenschrift (1946), 1976, Jan-30, Volume: 126, Issue:5 Topics: Breast Neoplasms; Bronchial Neoplasms; Chlorambucil; Choriocarcinoma; Cyclophosphamide; Dactinomycin	1976
[Induction of cleft palate in ball mice: the comparative effect of 5-fluorouracil, phenylbutazone and water and food deprivation (author's transl)]. Revista medica de Chile, 1976, Volume: 104, Issue:9 Topics: Abnormalities, Drug-Induced; Animals; Cleft Palate; Female; Fluorouracil; Food Deprivation; Maternal	1976
Intraepithelial vaginal neoplasia following immunosuppressive therapy treated with topical 5-Fu. Obstetrics and gynecology, 1975, Volume: 46, Issue:3 Topics: Administration, Topical; Adult; Azathioprine; Biopsy; Carcinoma, Squamous Cell; Cervix Uteri; Female	1975
[Diagnosis and treatment of hemothorax in malignant trophoblastic tumors]. Zhonghua fu chan ke za zhi, 1992, Volume: 27, Issue:3 Topics: Female; Fluorouracil; Hemothorax; Humans; Lung Neoplasms; Pregnancy; Trophoblastic Neoplasms; Uterin	1992
Treatment of malignant trophoblastic tumors. An analysis of 209 cases. Chinese medical journal, 1991, Volume: 104, Issue:2 Topics: Adult; Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Prot	1991
Accidental use of low-dose 5-fluorouracil in pregnancy. The Journal of reproductive medicine, 1991, Volume: 36, Issue:12 Topics: Abnormalities, Drug-Induced; Administration, Intravaginal; Adolescent; Adult; Female; Fluorouracil;	1991
[Neural pattern and limb development--normal development of the hindlimb nerve in the mouse and its aberrations induced by 5-fluorouracil]. Nihon Seikeigeka Gakkai zasshi, 1990, Volume: 64, Issue:7 Topics: Animals; Female; Fluorouracil; Foot Deformities, Congenital; Hindlimb; Mice; Peripheral Nerves; Preg	1990
Periconceptional exposure to topical 5-fluorouracil. American journal of obstetrics and gynecology, 1992, Volume: 166, Issue:1 Pt 1 Topics: Abnormalities, Drug-Induced; Administration, Topical; Adult; Female; Fertilization; Fluorouracil; Hu	1992
High total dose 5-fluorouracil treatment during pregnancy. Wisconsin medical journal, 1991, Volume: 90, Issue:10 Topics: Adult; Breast Neoplasms; Female; Fluorouracil; Humans; Liver Neoplasms; Pregnancy; Pregnancy Complic	1991
Emesis during past pregnancy: a new prognostic factor in chemotherapy-induced emesis. Annals of oncology : official journal of the European Society for Medical Oncology, 1990, Volume: 1, Issue:2 Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Doxorubicin	1990
Inadvertent 5-fluorouracil treatment in early pregnancy: a report of three cases. Reproductive toxicology (Elmsford, N.Y.), 1990, Volume: 4, Issue:3 Topics: Adult; Female; Fluorouracil; Humans; Infant, Newborn; Male; Pregnancy	1990
[Nursing care of trophoblastic cell tumor treated with 5-fluorouracil]. Zhonghua hu li za zhi = Chinese journal of nursing, 1990, Volume: 25, Issue:4 Topics: Adult; Female; Fluorouracil; Humans; Middle Aged; Pregnancy; Trophoblastic Neoplasms; Uterine Neopla	1990
5-fluorouracil exposure during the period of conception: report on two cases. American journal of obstetrics and gynecology, 1990, Volume: 163, Issue:1 Pt 1 Topics: Administration, Intravaginal; Adult; Female; Fertilization; Fluorouracil; Humans; Infant, Newborn; P	1990
[Colitis due to chemotherapeutic agent]. Zhonghua fu chan ke za zhi, 1990, Volume: 25, Issue:5 Topics: Adult; Antineoplastic Agents; Enterocolitis; Enterocolitis, Pseudomembranous; Female; Fluorouracil;	1990
Effects of L-2-oxothiazolidine-4-carboxylate, a cysteine pro-drug, on teratogenicity of 5-fluorouracil in mice. Hiroshima journal of medical sciences, 1990, Volume: 39, Issue:3 Topics: Animals; Body Weight; Cystine; Drug Synergism; Female; Fluorouracil; Glutathione; Limb Deformities,	1990
Pregnancy and offspring after adjuvant chemotherapy in breast cancer patients. Cancer, 1990, Feb-15, Volume: 65, Issue:4 Topics: Abortion, Incomplete; Adolescent; Adult; Amenorrhea; Antineoplastic Combined Chemotherapy Protocols;	1990
Effects of phorone and/or buthionine sulfoximine on teratogenicity of 5-fluorouracil in mice. Teratology, 1990, Volume: 41, Issue:3 Topics: Animals; Buthionine Sulfoximine; Drug Interactions; Female; Fluorouracil; Glutathione; Ketones; Limb	1990
Treatment of large lower genital tract condylomata acuminata with topical 5-fluorouracil. The Journal of reproductive medicine, 1990, Volume: 35, Issue:4 Topics: Administration, Topical; Adolescent; Adult; Condylomata Acuminata; Female; Fluorouracil; Genital Neo	1990
[The treatment of refractory choriocarcinoma]. Gan to kagaku ryoho. Cancer & chemotherapy, 1990, Volume: 17, Issue:9 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Choriocarcinoma; Cyclophosphamide; Dactinomyc	1990
[Combination therapy of advanced choriocarcinoma--an analysis of 60 patients]. Zhonghua zhong liu za zhi [Chinese journal of oncology], 1986, Volume: 8, Issue:6 Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Choriocarcinoma; Combined Modality	1986
Palatal shelf reorientation in hamster embryos following treatment with 5-fluorouracil. Histology and histopathology, 1989, Volume: 4, Issue:4 Topics: Abnormalities, Drug-Induced; Animals; Cricetinae; DNA; Embryo, Mammalian; Epithelial Cells; Female;	1989
[Treatment of the side effects of the chemotherapy of trophoblastic tumor with traditional Chinese medicine and western medicine]. Zhong xi yi jie he za zhi = Chinese journal of modern developments in traditional medicine, 1985, Volume: 5, Issue:4 Topics: Adult; Dactinomycin; Female; Fluorouracil; Humans; Leukopenia; Medicine, Chinese Traditional; Medici	1985
Chemotherapy in a pregnant rat model. 2.5-fluorouracil: nonlinear kinetics and placental transfer. Gynecologic oncology, 1989, Volume: 34, Issue:2 Topics: Animals; Chromatography, High Pressure Liquid; Female; Fetal Blood; Fluorouracil; Kinetics; Maternal	1989
[Combined treatment of malignant trophoblastic tumor with 5-fluorouracil and nitrocaphane]. Zhonghua yi xue za zhi, 1988, Volume: 68, Issue:12 Topics: Antineoplastic Combined Chemotherapy Protocols; Choriocarcinoma; Female; Fluorouracil; Humans; Hydat	1988
[Breast carcinoma and pregnancy. A case report]. Ginecologia y obstetricia de Mexico, 1988, Volume: 56 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma, Intraductal, Non	1988
[Chromosomal studies in patients with trophoblastic diseases before and after chemotherapy]. Zhonghua fu chan ke za zhi, 1986, Volume: 21, Issue:1 Topics: Antineoplastic Combined Chemotherapy Protocols; Chromosome Aberrations; Chromosomes, Human, 1-3; Fem	1986
Cellular reactions during drug-induced cleft palate. Journal of craniofacial genetics and developmental biology. Supplement, 1986, Volume: 2 Topics: Acid Phosphatase; Animals; Cleft Palate; Cricetinae; Cyclic AMP; Female; Fluorouracil; Gestational A	1986
Thymic stromal elements defined by M.Abs: ontogeny, and modulation in vivo by immunosuppression. Advances in experimental medicine and biology, 1988, Volume: 237 Topics: Age Factors; Animals; Antibodies, Monoclonal; Cell Differentiation; Female; Fluorouracil; Immunohist	1988
Functional maturation of murine B lymphocyte precursors. I. Selection of adherent cell-dependent precursors from bone marrow and fetal liver. Journal of immunology (Baltimore, Md. : 1950), 1987, Apr-15, Volume: 138, Issue:8 Topics: Animals; B-Lymphocytes; Bone Marrow; Bone Marrow Cells; Cell Differentiation; Cells, Cultured; Femal	1987
A cytotoxic DNA precursor is taken up selectively by human cancer xenografts. British journal of cancer, 1987, Volume: 55, Issue:3 Topics: Animals; Choriocarcinoma; Colon; DNA; Female; Fluorouracil; Humans; Hydroxyurea; Idoxuridine; Methot	1987
[Embryopathy caused by antineoplastic agents]. Revista medica de Chile, 1986, Volume: 114, Issue:9 Topics: Abnormalities, Drug-Induced; Breast Neoplasms; Chemical Phenomena; Chemistry; Cyclophosphamide; Fema	1986
Circadian modification of 5-fluorouracil-induced teratogenesis in mice. Chronobiology international, 1986, Volume: 3, Issue:3 Topics: Abnormalities, Drug-Induced; Animals; Circadian Rhythm; Female; Fluorouracil; Gestational Age; Pregn	1986
Malignant gynecologic tumors in children: current approaches to treatment. American journal of obstetrics and gynecology, 1973, May-15, Volume: 116, Issue:2 Topics: Age Factors; Child; Child, Preschool; Choriocarcinoma; Cyclophosphamide; Dactinomycin; Dysgerminoma;	1973
Chemotherapy and hormone therapy in gynecologic cancer. Southern medical journal, 1973, Volume: 66, Issue:6 Topics: Adenocarcinoma; Antibiotics, Antineoplastic; Antineoplastic Agents; Choriocarcinoma; Dactinomycin; F	1973
The use of uterine vascular clamping in the pregnant rat to modify the embryotoxic effects of anticancer drugs. Cancer research, 1968, Volume: 28, Issue:10 Topics: Aminopterin; Animals; Chemotherapy, Cancer, Regional Perfusion; Female; Fetus; Floxuridine; Fluorour	1968
Incorporation of thymidine after administration of fluorouracil and fluorouridine to adult and embryo mice. Research communications in chemical pathology and pharmacology, 1971, Volume: 2, Issue:6 Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Cleft Palate; Dose-Response Relationship, Drug; E	1971
Current problems in the use of the oncolytic drugs. Acta geneticae medicae et gemellologiae, 1968, Volume: 17, Issue:1 Topics: Antineoplastic Agents; Busulfan; Carcinoma, Squamous Cell; Child; Chlorambucil; Choriocarcinoma; Dac	1968
Enzyme ontogeny in normal and hemimelic limbs of mice. Journal of embryology and experimental morphology, 1968, Volume: 20, Issue:3 Topics: Abnormalities, Drug-Induced; Animals; Ectromelia; Electrophoresis; Embryo, Mammalian; Esterases; Fem	1968
A re-examination of the renal blastema graft model for Wilms tumor production. The Journal of urology, 1974, Volume: 111, Issue:6 Topics: Animals; Autopsy; Cell Differentiation; Cyclophosphamide; Dactinomycin; Disease Models, Animal; Drug	1974
Observations on chemotherapy of granulosa cell carcinomas and malignant ovarian teratomas. Obstetrics and gynecology, 1974, Volume: 44, Issue:6 Topics: Adolescent; Adult; Antineoplastic Agents; Castration; Child; Cyclophosphamide; Dactinomycin; Fallopi	1974
The effects on mouse development of interactions of 5-fluorouracil with Strong's luxoid gene and its plus and minus modifiers. Teratology, 1972, Volume: 6, Issue:1 Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Bone and Bones; Cleft Palate; Embryo,	1972
Pharmacodynamic principles in chemical teratology: dose-effect relationships. The Journal of pharmacology and experimental therapeutics, 1972, Volume: 183, Issue:3 Topics: Abnormalities, Drug-Induced; Adsorption; Cyclophosphamide; Dose-Response Relationship, Drug; Drug-Re	1972
Advanced cancer: New concepts of medical therapy. Geriatrics, 1973, Volume: 28, Issue:11 Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Breast Neoplasms; Choriocarcinoma; Colonic Neopl	1973
Androgen-induced sexual differentiation of the brain is blocked by inhibitors of DNA and RNA synthesis. Nature, 1974, Jan-11, Volume: 247, Issue:5436 Topics: Animals; Animals, Newborn; Brain; Dactinomycin; Depression, Chemical; DNA; Estrus; Female; Fluoroura	1974
[Progress in chemotherapy of solid tumors and malignant lymphomas (continued)]. Praxis, 1967, Dec-07, Volume: 56, Issue:49 Topics: Adult; Antineoplastic Agents; Carcinoma; Choriocarcinoma; Female; Fluorouracil; Gonadal Steroid Horm	1967
Cytotoxic agents in the treatment of malignant disease. British medical journal, 1968, Nov-16, Volume: 4, Issue:5628 Topics: Antimetabolites; Antineoplastic Agents; Breast Neoplasms; Carcinoma; Chlorambucil; Choriocarcinoma;	1968
[Effect of antineoplastic agents on the hypophysis-ovarian system in rats with transplantable mammary neoplasms]. Voprosy onkologii, 1971, Volume: 17, Issue:8 Topics: Adrenal Glands; Animals; Cyclophosphamide; Estrus; Female; Fluorouracil; Mammary Neoplasms, Experime	1971
Independent effects of fluorouracil and two mutant genes in mouse embryos. Teratology, 1972, Volume: 5, Issue:3 Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Female; Fluorouracil; Genes; Genotype	1972
Fluorouracil in pregnancy: effect on the neonate. JAMA, 1971, Jul-12, Volume: 217, Issue:2 Topics: Cyanosis; Female; Fetus; Fluorouracil; Humans; Infant, Newborn; Infant, Newborn, Diseases; Injection	1971
[Experimental findings on the effects of administration of fluorouracil in pregnancy. II. Treatment of mice and rabbits with FU]. Minerva ginecologica, 1970, Mar-15, Volume: 22, Issue:5 Topics: Abortion, Spontaneous; Animals; Female; Fetal Death; Fetus; Fluorouracil; Mice; Pregnancy; Pregnancy	1970
Paraquat poisoning in a pregnant woman. British medical journal, 1968, Sep-21, Volume: 3, Issue:5620 Topics: Adult; Female; Fluorouracil; Herbicides; Humans; Lung; Pregnancy; Pregnancy Complications; Pyridines	1968
[Experimental studies of the effects of administration of fluorouracil in the early stages of pregnancy. I. Treatment of gravid rats with fluorouracil]. Archivio di ostetricia e ginecologia, 1968, Volume: 73, Issue:2 Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Animals; Extraembryonic Membranes; Female; Fetus	1968
Transplacental passage of nucleotides, nucleosides, and bases. American journal of obstetrics and gynecology, 1968, Dec-15, Volume: 102, Issue:8 Topics: Alkalies; Animals; Carbon Isotopes; Colchicine; Female; Fetus; Fluorouracil; Injections, Intraperito	1968
Estradiol induction of pyruvate kinase in the rat uterus. Biochimica et biophysica acta, 1968, Dec-23, Volume: 170, Issue:2 Topics: Animals; Castration; Cycloheximide; Dactinomycin; Enzyme Induction; Estradiol; Estrus; Female; Fluor	1968
Potentiation of the teratogenic effects of 5-fluorouracil by natural pyrimidines. I. Biological aspects. Teratology, 1969, Volume: 2, Issue:2 Topics: Abnormalities, Drug-Induced; Animals; Carbon Isotopes; Carbon Tetrachloride Poisoning; Drug Synergis	1969
Potentiation of the teratogenic effects of 5-fluorouracil by natural pyrimidines. II. Biochemical aspects. Teratology, 1969, Volume: 2, Issue:2 Topics: Animals; Carbon Isotopes; Depression, Chemical; DNA; Drug Synergism; Embryo, Mammalian; Extraembryon	1969
[Possible applications of antivitamins and antimetabolites in therapy]. Bibliotheca nutritio et dieta, 1966, Volume: 8 Topics: Aminopterin; Antimetabolites; Azaserine; Child; Child, Preschool; Choriocarcinoma; Diazooxonorleucin	1966
Incorporation of 5-fluorouracil-2-C-14 by mouse embryos. Biologia neonatorum. Neo-natal studies, 1966, Volume: 10, Issue:1 Topics: Abnormalities, Drug-Induced; Animals; Embryo, Mammalian; Female; Fluorouracil; Maternal-Fetal Exchan	1966
Polygenic control of the teratogenicity of 5-fluorouracil in mice. Genetics, 1966, Volume: 53, Issue:6 Topics: Abnormalities, Drug-Induced; Animals; Cleft Palate; Female; Fluorouracil; Foot Deformities, Congenit	1966

fluorouracil and Pregnancy

Research Excerpts

Research

Studies (208)

Authors

Clinical Trials (2)

Trial Overview

Reviews

Trials

Other Studies

Authors	Studies
Li, Y	2
Chen, D	1
Yu, H	1
Xia, R	1
Zhang, X	6
Zheng, W	1
Çelebi, A	1
Dörtbudak, MB	1
Keskinrüzgar, A	1
Yüksel, H	1
Guan, Z	1
Liang, Y	1
Wang, X	1
Zhu, Z	1
Yang, A	1
Li, S	1
Yu, J	1
Niu, B	1
Wang, J	1
Wang, S	3
Li, T	3
Wang, Y	7
Wang, M	3
Liu, Y	3
Zhang, L	3
Frydenberg, H	1
Harsem, NK	1
Ofigsbø, Å	1
Skoglund, H	1
Brændengen, M	1
Kaasa, S	1
Guren, MG	1
Boyce, J	1
Tawagi, K	1
Cole, JT	1
Montrose, DC	1
Saha, S	1
Foronda, M	1
McNally, EM	1
Chen, J	2
Zhou, XK	1
Ha, T	1
Krumsiek, J	1
Buyukozkan, M	1
Verma, A	1
Elemento, O	1
Yantiss, RK	1
Chen, Q	1
Gross, SS	1
Galluzzi, L	1
Dow, LE	1
Dannenberg, AJ	1
Naren, G	1
Wang, L	1
Cheng, L	1
Yang, S	1
Yang, J	4
Guo, J	1
Nashun, B	1
Shan, Y	1
Han, H	1
Jiang, C	1
Zhang, H	2
Hu, J	1
Sun, H	1
Zhu, J	1
Rakotomalala, HM	1
Ramahandrisoa, AVN	1
Razakanaivo, M	1
Andrianandrasana, NO	1
Rafaramino, F	1
Van Belle, E	1
Manigold, T	1
Piérache, A	1
Furber, A	1
Debry, N	1
Luycx-Bore, A	1
Bauchart, JJ	1
Nugue, O	1
Huchet, F	1
Bic, M	1
Vinchon, F	1
Sayah, S	1
Fournier, A	1
Decoulx, E	1
Mouhammad, U	1
Clerc, J	1
Manchuelle, A	1
Lazizi, T	1
Chmait, A	1
Jeannetteau, J	1
Hénon, P	1
Bonin, M	1
Dupret-Minet, M	1
Tirouvanziam, A	1
Molcard, D	1
Arabucki, F	1
Py, A	1
Prunier, F	1
Delhaye, C	1
Lemesle, G	1
Schurtz, G	1
Cosenza, A	1
Spillemaeker, H	1
Verdier, B	1
Denimal, T	1
Pamart, T	1
Sylla, H	1
Janah, D	1
Aouate, D	1
Porouchani, S	1
Guillez, V	1
Bonnet, G	1
Ternacle, J	1
Labreuche, J	1
Cayla, G	1
Vincent, F	1
Arbache, S	1
Arbache, ST	1
Hirata, SH	1
Ten, LN	1
Li, W	1
Kim, MK	1
Kang, IK	1
Lee, SY	1
Jung, HY	1
Mitsunami, M	1
Salas-Huetos, A	1
Mínguez-Alarcón, L	1
Attaman, JA	1
Ford, JB	1
Kathrins, M	1
Souter, I	1
Chavarro, JE	1
Chowdhury, H	1
Chowdhury, T	1
Hossain, N	1
Chowdhury, P	1
Dos Santos Mascarenhas, J	1
Bhuiya, MMK	1
Gao, J	1
Li, X	1
Gong, W	1
Yue, K	1
Wu, Z	1
Niu, G	1
Yuan, LJ	1
Gong, FQ	1
Zhu, CX	1
Shen, HW	1
Bozkurt, M	1
Antonoff, M	1
Jaramillo, S	1
Sagebiel, T	1
Murphy, MB	1
Jiang, ZC	1
Chi, Y	1
Kim, K	1
Ko, M	1
Sim, HC	1
Kim, CL	1
Jung, YJ	1
Kim, TO	1
Burgazli, KM	1
Mericliler, M	1
Kavukcu, E	1
Erdogan, A	1
Ertan, AK	1
Melichar, B	1
Dvorak, J	1
Ferko, A	1
Kamaradova, K	1
Krajina, A	1
Ren, T	1
Wang, D	1
Feng, F	2
Wan, X	3
Xiang, Y	10
Murthy, RK	1
Theriault, RL	5
Barnett, CM	1
Hodge, S	1
Ramirez, MM	2
Milbourne, A	1
Rimes, SA	1
Hortobagyi, GN	5
Valero, V	1
Litton, JK	2
Makoshi, Z	1
Perrott, C	1
Al-Khatani, K	1
Al-Mohaisen, F	1
Peng, M	1
Ding, Y	1
Yu, L	1
Deng, Y	1
Lai, W	1
Hu, Y	1
Wu, X	1
Fan, H	1
Ding, H	1
Wu, Y	2
Tao, G	1
Miao, JW	1
Wang, T	1
Wu, YM	1
Kong, WM	1
Su, L	1
Duan, W	2
Nozawa, H	1
Ishihara, S	1
Kawai, K	1
Murono, K	1
Yasuda, K	1
Otani, K	1
Nishikawa, T	1
Tanaka, T	1
Kiyomatsu, T	1
Hata, K	1
Watanabe, T	1
Kim, EY	1
Jun, KH	1
Jung, JH	1
Jo, YS	1
Chin, HM	1
Köhler, C	1
Marnitz, S	1
Biel, P	1
Cordes, T	1
Takagi, A	1
Nishimura, T	1
Akashi, T	1
Tomi, M	1
Nakashima, E	1
Sharma, JB	1
Pushparaj, M	1
Kumar, S	3
Roy, KK	1
Raina, V	1
Malhotra, N	1
Vilela-Goulart, Md	1
Teixeira, RT	1
Rangel, DC	1
Niccoli-Filho, W	1
Gomes, MF	1
Kanate, AS	1
Auber, ML	1
Higa, GM	1
Feng, FZ	2
Cao, Y	2
Li, L	1
Wan, XR	5
Yang, XY	8
Zhao, Y	1
Zhang, W	1
Azim, HA	1
Peccatori, FA	1
Liptrott, SJ	1
Catania, C	1
Goldhirsch, A	1
Yang, X	7
Dominici, LS	1
Kuerer, HM	1
Babiera, G	1
Hahn, KM	2
Perkins, G	2
Middleton, L	2
Yang, W	2
Van Calsteren, K	1
Verbesselt, R	1
Beijnen, J	1
Devlieger, R	1
De Catte, L	1
Chai, DC	1
Van Bree, R	1
Heyns, L	1
de Hoon, J	1
Amant, F	1
Leyder, M	1
Laubach, M	1
Breugelmans, M	1
Keymolen, K	1
De Greve, J	1
Foulon, W	1
Geng, S	1
Zhou, Y	1
Takai, H	1
Kondoh, E	1
Sato, Y	1
Kakui, K	1
Tatsumi, K	1
Konishi, I	1
Jeppesen, JB	1
Østerlind, K	1
Manopunya, M	1
Suprasert, P	1
Dogan, NU	1
Tastekin, D	1
Kerimoglu, OS	1
Pekin, A	1
Celik, C	1
Zhu, AX	1
Knox, JJ	1
Cirillo, M	1
Musola, M	1
Cassandrini, PA	1
Lunardi, G	1
Venturini, M	1
Vitoratos, N	1
Salamalekis, E	1
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