fluorouracil has been researched along with Porphyrias in 4 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Porphyrias: A diverse group of metabolic diseases characterized by errors in the biosynthetic pathway of HEME in the LIVER, the BONE MARROW, or both. They are classified by the deficiency of specific enzymes, the tissue site of enzyme defect, or the clinical features that include neurological (acute) or cutaneous (skin lesions). Porphyrias can be hereditary or acquired as a result of toxicity to the hepatic or erythropoietic marrow tissues.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Keczkes, K | 1 |
| Barker, DJ | 1 |
| Kappas, A | 1 |
| Granick, S | 1 |
| Thompson, RP | 1 |
| Nicholson, DC | 1 |
| Farnan, T | 1 |
| Whitmore, DN | 1 |
| Williams, R | 1 |
| Markoff, N | 1 |
1 review available for fluorouracil and Porphyrias
| Article | Year |
|---|---|
[Long-term therapy of liver diseases].
Topics: Aged; Anabolic Agents; Chronic Disease; Cortisone; Diet Therapy; Fatty Liver; Female; Fluorouracil; | 1972 |
3 other studies available for fluorouracil and Porphyrias
| Article | Year |
|---|---|
Malignant hepatoma associated with acquired hepatic cutaneous porphyria.
Topics: Carcinoma, Hepatocellular; Chemotherapy, Cancer, Regional Perfusion; Feces; Female; Fluorouracil; Hu | 1976 |
Steroid induction of porphyrin synthesis in liver cell culture. II. The effects of heme, uridine diphosphate glucuronic acid, and inhibitors of nucleic acid and protein synthesis on the induction process.
Topics: Acetates; Amides; Animals; Azaserine; Azo Compounds; Chick Embryo; Culture Techniques; Cycloheximide | 1968 |
Cutaneous porphyria due to a malignant primary hepatoma.
Topics: Aged; Carcinoma, Hepatocellular; Feces; Female; Fluorouracil; Humans; Liver Neoplasms; Photosensitiv | 1970 |