fluorouracil has been researched along with Porokeratosis in 18 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Porokeratosis: A heritable disorder of faulty keratinization characterized by the proliferation of abnormal clones of KERATINOCYTES and lesions showing varying atrophic patches surrounded by an elevated, keratotic border. These keratotic lesions can progress to overt cutaneous neoplasm. Several clinical variants are recognized, including porokeratosis of Mibelli, linear porokeratosis, disseminated superficial actinic porokeratosis, palmoplantar porokeratosis, and punctate porokeratosis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Topical 5-fluorouracil has been used as an effective treatment for porokeratosis." | 7.72 | Systemic 5-fluorouracil producing an inflammatory response in porokeratosis. ( Badiavas, E; Danahy, JF; Donohue, KG; Falanga, V; Nahm, WK, 2003) |
| "We describe the successful treatment of porokeratosis of Mibelli of the left calf in an 83-year-old man with topical 5 percent imiquimod and topical 5 percent 5-fluorouracil." | 5.36 | Porokeratosis of Mibelli: Successful treatment with 5 percent topical imiquimod and topical 5 percent 5-fluorouracil. ( LeLeux, TM; Orengo, I; Rosen, T; Venkatarajan, S; Yang, D, 2010) |
| "A case of actinic disseminated porokeratosis was treated with a combination of a 70% glycolic peel and a 5% 5-fluorouracil solution (Drogaderma) every 2 weeks for 4 months." | 3.73 | The use of fluor-hydroxy pulse peel in actinic porokeratosis. ( Bagatin, E; de Nascimento, MM; Hassun, KM; Michalany, N; Talarico, S; Teixeira, SP, 2005) |
| "Topical 5-fluorouracil has been used as an effective treatment for porokeratosis." | 3.72 | Systemic 5-fluorouracil producing an inflammatory response in porokeratosis. ( Badiavas, E; Danahy, JF; Donohue, KG; Falanga, V; Nahm, WK, 2003) |
| "A 58-year-old woman with linear porokeratosis involving the right hand and arm had distal digital narrowing and nail dystrophy with radiographic changes." | 2.41 | Linear porokeratosis with underlying bony abnormalities. ( Garzon, MC; Grossman, ME; Ilarda, I; Levit, EK; Tseng, SS, 2002) |
| "We describe the successful treatment of porokeratosis of Mibelli of the left calf in an 83-year-old man with topical 5 percent imiquimod and topical 5 percent 5-fluorouracil." | 1.36 | Porokeratosis of Mibelli: Successful treatment with 5 percent topical imiquimod and topical 5 percent 5-fluorouracil. ( LeLeux, TM; Orengo, I; Rosen, T; Venkatarajan, S; Yang, D, 2010) |
| "The typical presentation of porokeratosis of Mibelli is of a solitary plaque with a prominent raised border cleaved by a central furrow." | 1.32 | Verrucous porokeratosis of Mibelli on the buttocks mimicking psoriasis. ( Brice, SL; Fitzpatrick, JE; Wallner, JS, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (16.67) | 18.2507 |
| 2000's | 9 (50.00) | 29.6817 |
| 2010's | 5 (27.78) | 24.3611 |
| 2020's | 1 (5.56) | 2.80 |
| Authors | Studies |
|---|---|
| Maredia, H | 1 |
| Simkin, D | 1 |
| Soni, A | 1 |
| Loss, MJ | 1 |
| Al-Haseni, A | 1 |
| Chitgopeker, P | 1 |
| Ho, JD | 1 |
| Goldberg, LJ | 1 |
| Sahni, D | 1 |
| D'souza, P | 1 |
| Dhali, TK | 1 |
| Arora, S | 1 |
| Gupta, H | 1 |
| Khanna, U | 1 |
| Schiffman, LA | 1 |
| Berry, R | 1 |
| Watsky, M | 1 |
| Heilman, E | 1 |
| Levitt, J | 1 |
| Emer, JJ | 1 |
| Emanuel, PO | 1 |
| Skupsky, H | 1 |
| Skupsky, J | 1 |
| Goldenberg, G | 1 |
| Venkatarajan, S | 1 |
| LeLeux, TM | 1 |
| Yang, D | 1 |
| Rosen, T | 1 |
| Orengo, I | 1 |
| Nahm, WK | 1 |
| Donohue, KG | 1 |
| Danahy, JF | 1 |
| Badiavas, E | 1 |
| Falanga, V | 1 |
| Wallner, JS | 1 |
| Fitzpatrick, JE | 1 |
| Brice, SL | 1 |
| Danby, W | 1 |
| Teixeira, SP | 1 |
| de Nascimento, MM | 1 |
| Bagatin, E | 1 |
| Hassun, KM | 1 |
| Talarico, S | 1 |
| Michalany, N | 1 |
| Grover, C | 1 |
| Goel, A | 1 |
| Nanda, S | 1 |
| Khurana, N | 1 |
| Reddy, BS | 1 |
| Perlis, C | 1 |
| Robinson-Bostom, L | 1 |
| Telang, GH | 1 |
| DiGiovanna, J | 1 |
| Dippel, E | 1 |
| Haas, N | 1 |
| Czarnetzki, BM | 1 |
| Sander, CA | 1 |
| Pfeiffer, C | 1 |
| Kligman, AM | 1 |
| Plewig, G | 1 |
| Götz, A | 1 |
| Kopera, D | 1 |
| Wach, F | 1 |
| Hohenleutner, U | 1 |
| Landthaler, M | 1 |
| Tseng, SS | 1 |
| Levit, EK | 1 |
| Ilarda, I | 1 |
| Garzon, MC | 1 |
| Grossman, ME | 1 |
3 reviews available for fluorouracil and Porokeratosis
| Article | Year |
|---|---|
Disseminated superficial actinic porokeratosis: a treatment review.
Topics: Aminolevulinic Acid; Aminoquinolines; Anti-Inflammatory Agents, Non-Steroidal; Cholecalciferol; Dicl | 2012 |
[Porokeratosis Mibelli gigantea: case report and literature review].
Topics: Acitretin; Aged; Calcitriol; Dermatologic Agents; Drug Combinations; Female; Fluorouracil; Humans; P | 1999 |
Linear porokeratosis with underlying bony abnormalities.
Topics: Anti-Inflammatory Agents; Bone and Bones; Female; Fluorouracil; Humans; Immunosuppressive Agents; Mi | 2002 |
15 other studies available for fluorouracil and Porokeratosis
| Article | Year |
|---|---|
Eruptive porokeratosis during pembrolizumab treatment of invasive cutaneous squamous cell carcinoma.
Topics: Administration, Cutaneous; Administration, Intravenous; Aged; Antibodies, Monoclonal, Humanized; Bio | 2020 |
Amelanotic melanoma arising within a lesion of disseminated superficial actinic porokeratosis: An unusual presentation leading to a novel therapeutic approach.
Topics: Administration, Cutaneous; Aged; Antimetabolites, Antineoplastic; Bandages; Biopsy; Cell Transformat | 2018 |
Porokeratosis ptychotropica: a rare variant of porokeratosis.
Topics: Adult; Biopsy; Buttocks; Drug Therapy, Combination; Epidermis; Fluorouracil; Humans; Isotretinoin; M | 2014 |
Annular patches and plaques on the scrotum and buttocks. Genital porokeratosis.
Topics: Administration, Topical; Biopsy, Needle; Black or African American; Buttocks; Fluorouracil; Genital | 2009 |
Treatment of porokeratosis of mibelli with combined use of photodynamic therapy and Fluorouracil cream.
Topics: Aminolevulinic Acid; Fluorouracil; Humans; Immunosuppressive Agents; Male; Middle Aged; Photochemoth | 2010 |
Porokeratosis of Mibelli: Successful treatment with 5 percent topical imiquimod and topical 5 percent 5-fluorouracil.
Topics: Administration, Cutaneous; Aged, 80 and over; Aminoquinolines; Antimetabolites; Carcinoma, Basal Cel | 2010 |
Systemic 5-fluorouracil producing an inflammatory response in porokeratosis.
Topics: Administration, Oral; Aged; Antimetabolites, Antineoplastic; Breast Neoplasms; Female; Fluorouracil; | 2003 |
Verrucous porokeratosis of Mibelli on the buttocks mimicking psoriasis.
Topics: Buttocks; Diagnosis, Differential; Fluorouracil; Humans; Male; Middle Aged; Porokeratosis; Psoriasis | 2003 |
Treatment of porokeratosis with fluorouracil and salicylic acid under occlusion.
Topics: Administration, Cutaneous; Drug Therapy, Combination; Fluorouracil; Foot Dermatoses; Humans; Male; M | 2003 |
Topical diclofenac: new preparation. Moderate efficacy in actinic keratosis.
Topics: Administration, Cutaneous; Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal | 2004 |
The use of fluor-hydroxy pulse peel in actinic porokeratosis.
Topics: Biopsy; Chemexfoliation; Female; Fluorouracil; Glycolates; Humans; Keratolytic Agents; Middle Aged; | 2005 |
A case of extensive linear porokeratosis with evaluation of topical tretinoin versus 5-flourouracil as treatment modalities.
Topics: Administration, Topical; Adult; Biopsy, Needle; Dose-Response Relationship, Drug; Drug Administratio | 2005 |
A thick lichenified plaque on the ventral penile shaft. Penile porokeratosis of Mibelli.
Topics: Administration, Cutaneous; Diagnosis, Differential; Fluorouracil; Humans; Male; Middle Aged; Penis; | 2006 |
Porokeratosis of Mibelli associated with active chronic hepatitis and vitiligo.
Topics: Female; Fluorouracil; Hepatitis, Chronic; Humans; Leg Dermatoses; Middle Aged; Porokeratosis; Vitili | 1994 |
Chemotherapy for disseminated actinic keratoses with 5-fluorouracil and isotretinoin.
Topics: Administration, Oral; Administration, Topical; Aged; Aged, 80 and over; Drug Therapy, Combination; F | 1997 |