fluorouracil and Polysyndactyly studies

fluorouracil and Polysyndactyly

fluorouracil has been researched along with Polysyndactyly in 4 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Research Excerpts

Excerpt	Relevance	Reference
" His mother became pregnant while receiving chemotherapy (cyclophosphamide, 5-fluorouracil, and adriamycin) for breast cancer, and the fetus was exposed to these drugs from conception to the 16th week of pregnancy."	3.73	Combined chemotherapy and teratogenicity. ( de Camargo Pinto, LL; Gazzola Zen, PR; Graziadio, C; Paskulin, GA; Rosa, R, 2005)

Research

Studies (4)

Timeframe	Studies, this research(%)	All Research%
pre-1990	3 (75.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (25.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Timeframe

Studies, this research(%)

All Research%

pre-1990

3 (75.00)

18.7374

1990's

0 (0.00)

18.2507

2000's

1 (25.00)

29.6817

2010's

0 (0.00)

24.3611

2020's

0 (0.00)

2.80

Authors

Authors	Studies
Paskulin, GA	1
Gazzola Zen, PR	1
de Camargo Pinto, LL	1
Rosa, R	1
Graziadio, C	1
Imagawa, S	1
Long, SY	1
Johnson, EM	1
Baden, HP	1
Rex, IH	1

Studies

Paskulin, GA

Gazzola Zen, PR

de Camargo Pinto, LL

Rosa, R

Graziadio, C

Imagawa, S

Long, SY

Johnson, EM

Baden, HP

Rex, IH

Other Studies

4 other studies available for fluorouracil and Polysyndactyly

Article	Year
Combined chemotherapy and teratogenicity. Birth defects research. Part A, Clinical and molecular teratology, 2005, Volume: 73, Issue:9 Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Antibiotics, Antineoplastic; Antimetabo	2005
Symbrachydactyly: pathogenesis of 5-fluorouracil induced model in mice. Hiroshima journal of medical sciences, 1980, Volume: 29, Issue:4 Topics: Abnormalities, Drug-Induced; Animals; Disease Models, Animal; Female; Fluorouracil; Mice; Pregnancy;	1980
Enzyme ontogeny in normal and hemimelic limbs of mice. Journal of embryology and experimental morphology, 1968, Volume: 20, Issue:3 Topics: Abnormalities, Drug-Induced; Animals; Ectromelia; Electrophoresis; Embryo, Mammalian; Esterases; Fem	1968
Linear ichthyosis associated with skeletal abnormalities. Archives of dermatology, 1970, Volume: 102, Issue:1 Topics: Abnormalities, Multiple; Bone and Bones; Child; Female; Fluocinolone Acetonide; Fluorouracil; Hand D	1970

Article

Year

Combined chemotherapy and teratogenicity.

Birth defects research. Part A, Clinical and molecular teratology, 2005, Volume: 73, Issue:9

Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Antibiotics, Antineoplastic; Antimetabo

2005

Symbrachydactyly: pathogenesis of 5-fluorouracil induced model in mice.

Hiroshima journal of medical sciences, 1980, Volume: 29, Issue:4

Topics: Abnormalities, Drug-Induced; Animals; Disease Models, Animal; Female; Fluorouracil; Mice; Pregnancy;

1980

Enzyme ontogeny in normal and hemimelic limbs of mice.

Journal of embryology and experimental morphology, 1968, Volume: 20, Issue:3

Topics: Abnormalities, Drug-Induced; Animals; Ectromelia; Electrophoresis; Embryo, Mammalian; Esterases; Fem

1968

Linear ichthyosis associated with skeletal abnormalities.

Archives of dermatology, 1970, Volume: 102, Issue:1

Topics: Abnormalities, Multiple; Bone and Bones; Child; Female; Fluocinolone Acetonide; Fluorouracil; Hand D

1970